Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia

Critical Care Medicine

Volumn 37, Issue 2, 2009, Pages 642-649

  Witzenrath, Martin ^a   Schmeck, Bernd ^a   Doehn, Jan M ^a   Tschernig, Thomas ^b   Zahlten, Janine ^a   Loeffler, Jutta M ^c   Zemlin, Maren ^a   Müller, Holger ^a   Gutbier, Birgitt ^a   Schütte, Hartwig ^a   Hippenstiel, Stefan ^a   Fischetti, Vincent A ^c   Suttorp, Norbert ^a   Rosseau, Simone ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Bacteriophage; Cpl 1; Endolysin; Mouse; Pneumococcal pneumonia

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; CEFOTAXIME; CPL 1 LYSIN; CYTOKINE; LACTIC ACID; OXYGEN; PENICILLIN G; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; BACTEREMIA; BACTERIAL COUNT; BACTERIAL VIABILITY; BACTERIOLYSIS; BLOOD SAMPLING; C57BL 6 MOUSE; CELL DEATH; CONTROLLED STUDY; CONVALESCENCE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; DRUG POTENCY; EPITHELIUM CELL; FATALITY; FEMALE; HUMAN CELL CULTURE; HYPOTENSION; IN VIVO STUDY; LACTATE BLOOD LEVEL; LUNG; LUNG COMPLIANCE; MORPHOLOGY; MOUSE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; SEPSIS; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; SYSTEMIC THERAPY; WEIGHT REDUCTION;

AMOXICILLIN; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED C57BL; MURAMIDASE; PNEUMONIA, PNEUMOCOCCAL;

EID: 64349102620     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819586a6     Document Type: Article

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