Relation of progesterone and DHEAS serum levels to 5-HT1A receptor binding potential in pre- and postmenopausal women

Psychoneuroendocrinology

Volumn 46, Issue , 2014, Pages 52-63

  Stein, Patrycja ^a   Baldinger, Pia ^a   Kaufmann, Ulrike ^b   Christina, Rami Mark ^a   Hahn, Andreas ^a   Höflich, Anna ^a   Kranz, Georg S ^a   Savli, Markus ^a   Wadsak, Wolfgang ^a   Mitterhauser, Markus ^a   Winkler, Dietmar ^a   Kasper, Siegfried ^a   Lanzenberger, Rupert ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIV KLIN FÜR FRAUENHEILKUNDE   (Austria)

Author keywords

5 HT1A receptor; DHEAS; Estradiol; Human; Menopause; PET; Postmenopause; Progesterone; Serotonin; Women

Indexed keywords

N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE C 11; PRASTERONE SULFATE; PROGESTERONE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; ESTRADIOL; HYDROCORTISONE;

ADULT; AGED; ARTICLE; BRAIN REGION; CONTROLLED STUDY; FEMALE; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN EXPERIMENT; MOOD; NEUROTRANSMISSION; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROSPECTIVE STUDY; RAPHE NUCLEUS; REPRODUCTION; BLOOD; FOLLICULAR PHASE; MENOPAUSE; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; DEHYDROEPIANDROSTERONE SULFATE; ESTRADIOL; FEMALE; FOLLICULAR PHASE; HUMANS; HYDROCORTISONE; MENOPAUSE; MIDDLE AGED; POSTMENOPAUSE; PROGESTERONE; PROSPECTIVE STUDIES; RECEPTOR, SEROTONIN, 5-HT1A; YOUNG ADULT;

EID: 84901399996     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2014.04.008     Document Type: Article

References (50)

1. Andréen L., Nyberg S., Turkmen S., van Wingen G., Fernández G., Bäckström T. Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators. Psychoneuroendocrinology 2009, 34:1121-1132.
2. Asaba H., Hosoya K., Takanaga H., Ohtsuki S., Tamura E., Takizawa T., Terasaki T. Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2. J. Neurochem. 2000, 75:1907-1916.
3. Balthazart J., Ball G.F. Is brain estradiol a hormone or a neurotransmitter?. Trends Neurosci. 2006, 29:241-249.
4. Bäckström T., Haage D., Löfgren M., Johansson I.M., Strömberg J., Nyberg S., Andréen L., Ossewaarde L., van Wingen G.A., Turkmen S., Bengtsson S.K. Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons. Neuroscience 2011, 191:46-54.
5. Benmansour S., Weaver R.S., Barton A.K., Adeniji O.S., Frazer A. Comparison of the effects of estradiol and progesterone on serotonergic function. Biol. Psychiatry 2012, 71:633-641.
6. Bennett H.A., Einarson A., Taddio A., Koren G., Einarson T.R. Prevalence of depression during pregnancy: systematic review. Obstet. Gynecol. 2004, 103:698-709.
7. Bethea C.L., Lu N.Z., Gundlah C., Streicher J.M. Diverse actions of ovarian steroids in the serotonin neural system. Front. Neuroendocrinol. 2002, 23:41-100.
8. Bitran D., Purdy R.H., Kellog C.K. Anxiolytic effect of progesterone is associated with increases in cortical alloprenanolone and GABAA receptor function. Pharmacol. Biochem. Behav. 1993, 45:423-428.
9. Calabrese E.J., Baldwin L.A. Hormesis: U-shaped dose responses and their centrality in toxicology. Trends Pharmacol. Sci. 2001, 22:285-291.
10. Cohen L.S., Soares C.N., Vitonis A.F., Otto M.W., Harlow B.L. Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles. Arch. Gen. Psychiatry 2006, 63:385-390.
11. Drevets W.C., Thase M.E., Moses-Kolko E.L., Price J., Frank E., Kupfer D.J., Mathis C. Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nucl. Med. Biol. 2007, 34:865-877.
12. Fink M., Wadsak W., Savli M., Stein P., Moser U., Hahn A., Mien L.-K., Kletter K., Mitterhauser M., Kasper S., Lanzenberger R. Lateralization of the serotonin-1A receptor distribution in language areas revealed by PET. Neuroimage 2009, 45:598-605.
13. Hahn A., Lanzenberger R., Wadsak W., Spindelegger C., Moser U., Mien L.-K., et al. Escitalopram enhances the association of serotonin-1A autoreceptors to heteroreceptors in anxiety disorders. J. Neurosci. 2010, 30:14482-14489.
14. Hahn A., Wadsak W., Windischberger C., Baldinger P., Höflich A.S., Losak J., Nics L., Philippe C., Kranz G.S., Kraus C., Mitterhauser M., Karanikas G., Kasper S., Lanzenberger R. Differential modulation of the default mode network via serotonin-1A receptors. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:2619-2624.
15. Huber P.J. Robust Statistics 2004, John Wiley & Sons, Hoboken, NJ.
16. Jovanovic H., Cerin A., Karlsson P., Lundberg J., Halldin C., Nordström A.-L. A PET study of 5-HT1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria. Psychiatry Res. 2006, 148:185-193.
17. Jovanovic H., Karlsson P., Cerin A., Halldin C., Nordström A.-L. 5-HT(1A) receptor and 5-HTT binding during the menstrual cycle in healthy women examined with [(11)C] WAY100635 and [(11)C] MADAM PET. Psychiatry Res. 2009, 172:31-37.
18. Kasper S., Wehr T.A., Bartko J.J., Gaist P.A., Rosenthal N.E. Epidemiological findings of seasonal changes in mood and behavior. A telephone survey of Montgomery County, Maryland. Arch. Gen. Psychiatry 1989, 46:823-833.
19. Kranz G.S., Hahn A., Savli M., Lanzenberger R. Challenges in the differentiation of midbrain raphe nuclei in neuroimaging research. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E2000.
20. Kranz G.S., Rami-Mark C., Kaufmann U., Baldinger P., Hahn A., Höflich A., Savli M., Stein P., Wadsak W., Mitterhauser M., Winkler D., Lanzenberger R., Kasper S. Effects of hormone replacement therapy on cerebral serotonin-1A receptor binding in postmenopausal women examined with [carbonyl-11C]WAY-100635. Psychoneuroendocrinology 2014, 10.1016/j.psyneuen.2014.03.004.
21. Lammertsma A.A., Hume S.P. Simplified reference tissue model for PET receptor studies. Neuroimage 1996, 4:153-158.
22. Lanzenberger R., Baldinger P., Hahn A., Ungersboeck J., Mitterhauser M., Winkler D., Micskei Z., Stein P., Karanikas G., Wadsak W., Kasper S., Frey R. Global decrease of serotonin-1A receptor binding after electroconvulsive therapy in major depression measured by PET. Mol. Psychiatry 2013, 18:93-100.
23. Lanzenberger R., Mitterhauser M., Kranz G.S., Spindelegger C., Wadsak W., Stein P., Moser U., Savli M., Kletter K., Kasper S. Progesterone level predicts serotonin-1a receptor binding in the male human brain. Neuroendocrinology 2011, 94:84-88.
24. Lanzenberger R.R., Mitterhauser M., Spindelegger C., Wadsak W., Klein N., Mien L.-K., Holik A., Attarbaschi T., Mossaheb N., Sacher J., Geiss-Granadia T., Kletter K., Kasper S., Tauscher J. Reduced serotonin-1A receptor binding in social anxiety disorder. Biol. Psychiatry 2007, 61:1081-1089.
25. Mani S.K. Signaling mechanisms in progesterone-neurotransmitter interactions. Neuroscience 2006, 138:773-781.
26. Mani S.K., Mermelstein P.G., Tetel M.J., Anesetti G. Convergence of multiple mechanisms of steroid hormone action. Horm. Metab. Res. 2012, 44:569-576.
27. Maninger N., Wolkowitz O.M., Reus V.I., Epel E.S., Mellon S.H. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front. Neuroendocrinol. 2009, 30:65-91.
28. Meltzer C.C., Drevets W.C., Price J.C., Mathis C.A., Lopresti B., Greer P.J., Villemagne V.L., Holt D., Mason N.S., Houck P.R., Reynolds C.F., DeKosky S.T. Gender-specific aging effects on the serotonin 1A receptor. Brain Res. 2001, 895:9-17.
29. Micevych P., Sinchak K. Estradiol regulation of progesterone synthesis in the brain. Mol. Cell. Endocrinol. 2008, 290:44-50.
30. Moser U., Wadsak W., Spindelegger C., Mitterhauser M., Mien L.-K., Bieglmayer C., Kletter K., Kasper S., Lanzenberger R. Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women. Neurosci. Lett. 2010, 476:161-165.
31. Moses-Kolko E.L., Price J.C., Shah N., Berga S., Sereika S.M., Fisher P.M., Coleman R., Becker C., Mason N.S., Loucks T., Meltzer C.C. Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy population. Neuropsychopharmacology 2011, 36:2729-2740.
32. Moses-Kolko E.L., Wisner K.L., Price J.C., Berga S.L., Drevets W.C., Hanusa B.H., Loucks T.L., Meltzer C.C. Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study. Fertil. Steril. 2008, 89:685-692.
33. Panjari M., Davis S.R. DHEA for postmenopausal women: a review of the evidence. Maturitas 2010, 66:172-179.
34. Parsey R.V., Ogden R.T., Miller J.M., Tin A., Hesselgrave N., Goldstein E., et al. Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations. Biol. Psychiatry 2010, 68:170-178.
35. Pecins-Thompson M., Bethea C.L. Ovarian steroid regulation of serotonin-1A autoreceptor messenger RNA expression in the dorsal raphe of rhesus macaques. Neuroscience 1999, 89:267-277.
36. R Core Team R: A Language and Environment for Statistical Computing 2013, Vienna, Austria.
37. Rabiner E.A., Messa C., Sargent P.A., Husted-Kjaer K., Montgomery A., Lawrence A.D., Bench C.J., Gunn R.N., Cowen P., Grasby P.M. A database of [(11)C]WAY-100635 binding to 5-HT(1A) receptors in normal male volunteers: normative data and relationship to methodological, demographic, physiological, and behavioral variables. Neuroimage 2002, 15:620-632.
38. Robichaud M., Debonnel G. Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids. J. Endocrinol. 2004, 182:11-21.
39. Savli M., Bauer A., Mitterhauser M., Ding Y.-S., Hahn A., Kroll T., Neumeister A., Haeusler D., Ungersboeck J., Henry S., Isfahani S.A., Rattay F., Wadsak W., Kasper S., Lanzenberger R. Normative database of the serotonergic system in healthy subjects using multi-tracer PET. Neuroimage 2012, 63:447-459.
40. Schumacher M., Coirini H., Robert F., Guennoun R., El-Etr M. Genomic and membrane actions of progesterone: implications for reproductive physiology and behavior. Behav. Brain Res. 1999, 105:37-52.
41. Soares C.N., Almeida O.P., Joffe H., Cohen L.S. Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial. Arch. Gen. Psychiatry 2001, 58:529-534.
42. Spindelegger C., Lanzenberger R., Wadsak W., Mien L.K., Stein P., Mitterhauser M., Moser U., Holik A., Pezawas L., Kletter K., Kasper S. Influence of escitalopram treatment on 5-HT 1A receptor binding in limbic regions in patients with anxiety disorders. Mol. Psychiatry 2009, 14:1040-1050.
43. Stein P., Savli M., Wadsak W., Mitterhauser M., Fink M., Spindelegger C., Mien L.-K., Moser U., Dudczak R., Kletter K., Kasper S., Lanzenberger R. The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635. Eur. J. Nucl. Med. Mol. Imaging 2008, 35:2159-2168.
44. Sullivan G.M., Ogden R.T., Oquendo M.A., Kumar J.S.D., Simpson N., Huang Y.-Y., Mann J.J., Parsey R.V. Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. Biol. Psychiatry 2009, 66:223-230.
45. Sundström I., Bäckström T. Citalopram increases pregnanolone sensitivity in patients with premenstrual syndrome: an open trial. Psychoneuroendocrinology 1998, 23:73-88.
46. Tzourio-Mazoyer N., Landeau B., Papathanassiou D., Crivello F., Etard O., Delcroix N., Mazoyer B., Joliot M. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002, 15:273-289.
47. Wadsak W., Mien L.-K., Ettlinger D.E., Lanzenberger R.R., Haeusler D., Dudczak R., Mitterhauser M. Simple and fully automated preparation of carbonyl-11C-WAY-10035. Radiochimica Acta 2007, 95:417-422.
48. Weissman M.M., Olfson M. Depression in women: implications for health care research. Science 1995, 269:799-801.
49. Wolkowitz O.M., Reus V.I., Keebler A., Nelson N., Friedland M., Brizendine L., Roberts E. Double-blind treatment of major depression with dehydroepiandrosterone. Am. J. Psychiatry 1999, 156:646-649.
50. Wyatt K., Dimmock P., Jones P., Obhrai M., O'Brien S. Efficacy of progesterone and progestogens in management of premenstrual syndrome: systematic review. BMJ 2001, 323:776.