-
1
-
-
33745807267
-
Obesity: The disease
-
Bray, G.A. Obesity: The disease. J. Med. Chem. 2006, 49, 4001-4007.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 4001-4007
-
-
Bray, G.A.1
-
2
-
-
51849146897
-
Global burden of obesity in 2005 and projections to 2030
-
Kelly, T.; Yang, W.; Chen, C.-S.; Reynolds, K.; He, J. Global burden of obesity in 2005 and projections to 2030. Int. J. Obesity. 2008, 32, 1431-1437.
-
(2008)
Int. J. Obesity.
, vol.32
, pp. 1431-1437
-
-
Kelly, T.1
Yang, W.2
Chen, C.-S.3
Reynolds, K.4
He, J.5
-
3
-
-
0036936442
-
The extent of the problem of obesity
-
O'Brien, P.E.; Dixon, J.B. The extent of the problem of obesity. Am. J. Surg. 2002, 184, S4-S8.
-
(2002)
Am. J. Surg.
, vol.184
-
-
O'Brien, P.E.1
Dixon, J.B.2
-
4
-
-
0027437262
-
Medical hazards of obesity
-
Pi-Sunyer, F.X. Medical hazards of obesity. Ann. Intern. Med. 1993, 119, 655-660.
-
(1993)
Ann. Intern. Med.
, vol.119
, pp. 655-660
-
-
Pi-Sunyer, F.X.1
-
5
-
-
84862895756
-
Epidemic trends of obesity with impact on metabolism and digestive diseases
-
Feneberg, A.; Malfertheiner, P. Epidemic trends of obesity with impact on metabolism and digestive diseases. Digest. Dis. 2012, 30, 143-147.
-
(2012)
Digest. Dis.
, vol.30
, pp. 143-147
-
-
Feneberg, A.1
Malfertheiner, P.2
-
6
-
-
33750454286
-
Alanine aminotransferase as a marker of non-Alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease
-
Schindhelm, R.K.; Diamant, M.; Dekker, J.M.; Tushuizen, M.E.; Teerlink, T.; Heine, R.J. Alanine aminotransferase as a marker of non-Alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease. Diabetes. Metab. Res. Rev. 2006, 22, 437-443.
-
(2006)
Diabetes. Metab. Res. Rev.
, vol.22
, pp. 437-443
-
-
Schindhelm, R.K.1
Diamant, M.2
Dekker, J.M.3
Tushuizen, M.E.4
Teerlink, T.5
Heine, R.J.6
-
7
-
-
0028070562
-
Nonalcoholic steatohepatitis: An expanded clinical entity
-
Bacon, B.R.; Farahvash, M.J.; Janney, C.G.; Neuschwander-Tetri, B.A. Nonalcoholic steatohepatitis: An expanded clinical entity. Gastroenterology 1994, 107, 1103-1109.
-
(1994)
Gastroenterology
, vol.107
, pp. 1103-1109
-
-
Bacon, B.R.1
Farahvash, M.J.2
Janney, C.G.3
Neuschwander-Tetri, B.A.4
-
8
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of nafld and obesity
-
Henao-Mejia, J.; Elinav, E.; Jin, C.; Hao, L.; Mehal, W.Z.; Strowig, T.; Thaiss, C.A.; Kau, A.L.; Eisenbarth, S.C.; Jurczak, M.J.; et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482, 179-186.
-
(2012)
Nature
, vol.482
, pp. 179-186
-
-
Henao-Mejia, J.1
Elinav, E.2
Jin, C.3
Hao, L.4
Mehal, W.Z.5
Strowig, T.6
Thaiss, C.A.7
Kau, A.L.8
Eisenbarth, S.C.9
Jurczak, M.J.10
-
9
-
-
0037129380
-
Nonalcoholic fatty liver disease
-
Angulo, P. Nonalcoholic fatty liver disease. N. Engl. J. Med. 2002, 346, 1221-1231.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 1221-1231
-
-
Angulo, P.1
-
10
-
-
4043077961
-
Molecular mediators of hepatic steatosis and liver injury
-
Browning, J.D.; Horton, J.D. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 2004, 114, 147-152.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 147-152
-
-
Browning, J.D.1
Horton, J.D.2
-
11
-
-
0036293591
-
Leptin signaling, adiposity, and energy balance
-
Jéquier, E. Leptin signaling, adiposity, and energy balance. Ann. N. Y. Acad. Sci. 2002, 967, 379-388.
-
(2002)
Ann. N. Y. Acad. Sci.
, vol.967
, pp. 379-388
-
-
Jéquier, E.1
-
12
-
-
2342439732
-
Leptin signaling in the central nervous system and the periphery
-
Børbaek, C.; Kahn, B.B. Leptin signaling in the central nervous system and the periphery. Prog. Horm. Res. 2004, 59, 305-331.
-
(2004)
Prog. Horm. Res.
, vol.59
, pp. 305-331
-
-
Børbaek, C.1
Kahn, B.B.2
-
13
-
-
84873702138
-
Bmi-independent inverse relationship of plasma leptin levels with outcome in patients with acute pulmonary embolism
-
Dellas, C.; Lankeit, M.; Reiner, C.; Schäfer, K.; Hasenfuβ, G.; Konstantinides, S. BMI-independent inverse relationship of plasma leptin levels with outcome in patients with acute pulmonary embolism. Int. J. Obes. (Lond.) 2013, 37, 204-210.
-
(2013)
Int. J. Obes. (Lond.
, vol.37
, pp. 204-210
-
-
Dellas, C.1
Lankeit, M.2
Reiner, C.3
Schäfer, K.4
Hasenfu, G.5
Konstantinides, S.6
-
14
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
Considine, R.V.; Sinha, M.K.; Heiman, M.L.; Kriauciunas, A.I.; Stephens, T.W.; Nyce, M.R.; Ohannesian, J.P.; Marco, C.C.; Mckee, L.J.; Bauer, T.L.; et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 1996, 334, 292-295.
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
Kriauciunas, A.I.4
Stephens, T.W.5
Nyce, M.R.6
Ohannesian, J.P.7
Marco, C.C.8
Mckee, L.J.9
Bauer, T.L.10
-
15
-
-
34247643846
-
Pediatric nonalcoholic fatty liver disease (nafld): A "growing" problem?
-
Roberts, E.A. Pediatric nonalcoholic fatty liver disease (NAFLD): A "growing" problem? J. Hepatol. 2007, 46, 1133-1142.
-
(2007)
J. Hepatol.
, vol.46
, pp. 1133-1142
-
-
Roberts, E.A.1
-
16
-
-
0842331606
-
Leptin impairs insulin signaling in rat adipocytes
-
Pérez, C.; Fernández-Galaz, C.; Fernández- Agulló, T.; Arribas, C.; Andrés, A.; Ros, M.; Carrascosa, J.M. Leptin impairs insulin signaling in rat adipocytes. Diabetes 2004, 53, 347-353.
-
(2004)
Diabetes
, vol.53
, pp. 347-353
-
-
Pérez, C.1
Fernández-Galaz, C.2
Fernández-Agulló, T.3
Arribas, C.4
Andrés, A.5
Ros, M.6
Carrascosa, J.M.7
-
17
-
-
0029860791
-
Modulation of insulin activities by leptin
-
Cohen, B.; Novick, D.; Rubinstein, M. Modulation of insulin activities by leptin. Science 1996, 274, 1185-1188.
-
(1996)
Science
, vol.274
, pp. 1185-1188
-
-
Cohen, B.1
Novick, D.2
Rubinstein, M.3
-
18
-
-
0040381066
-
Leptin impairs metabolic actions of insulin in isolated rat adipocytes
-
Muller, G.; Ertl, J.; Gerl, M.; Preibish, G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J. Biol. Chem. 1997, 272, 10585-10593.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10585-10593
-
-
Muller, G.1
Ertl, J.2
Gerl, M.3
Preibish, G.4
-
19
-
-
33845262498
-
Leptin free leptin index, insulin resistance and liver fibrosis in children with non-Alcoholic fatty liver disease
-
Valerio, N.; Melania, M.; Paolo, C.; Vincenzo, D.; Rita, D.; Fiorella, P.; Roberto, C.; Donatella, G.; Matilde, M. Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-Alcoholic fatty liver disease. Eur. J. Endocrinol. 2006, 155, 735-743.
-
(2006)
Eur. J. Endocrinol.
, vol.155
, pp. 735-743
-
-
Valerio, N.1
Melania, M.2
Paolo, C.3
Vincenzo, D.4
Rita, D.5
Fiorella, P.6
Roberto, C.7
Donatella, G.8
Matilde, M.9
-
20
-
-
0036217052
-
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
-
Lewis, G.F.; Carpentier, A.; Adeli, K.; Giacca, A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr. Rev. 2002, 23, 201-229.
-
(2002)
Endocr. Rev.
, vol.23
, pp. 201-229
-
-
Lewis, G.F.1
Carpentier, A.2
Adeli, K.3
Giacca, A.4
-
21
-
-
0036022846
-
Leptin is essential for the hepatic fibrogenic response to chronic liver injury
-
Leclercq, I.A.; Farrell, G.C.; Schriemer, R.; Robertson, G.R. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J. Hepatol. 2002, 37, 206-213.
-
(2002)
J. Hepatol.
, vol.37
, pp. 206-213
-
-
Leclercq, I.A.1
Farrell, G.C.2
Schriemer, R.3
Robertson, G.R.4
-
22
-
-
84863508993
-
Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling
-
Imajo, K.; Fujita, K.; Yoneda, M.; Nozaki, Y.; Ogawa, Y.; Shinohara, Y.; Kato, S.; Mawatari, H.; Shibata, W.; Kitani, H.; et al. Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. Cell. MeTable 2012, 16, 44-54.
-
(2012)
Cell. MeTable
, vol.16
, pp. 44-54
-
-
Imajo, K.1
Fujita, K.2
Yoneda, M.3
Nozaki, Y.4
Ogawa, Y.5
Shinohara, Y.6
Kato, S.7
Mawatari, H.8
Shibata, W.9
Kitani, H.10
-
23
-
-
0038071488
-
A link between leptin and steatosis in chronic hepatitis c? Time to weigh up the fats
-
Patel, K.; Muir, A., McHutchison, J.G.; Patton, H.M. A link between leptin and steatosis in chronic hepatitis C? Time to weigh up the fats. Am. J. Gastroenterol. 2003, 98, 952-955.
-
(2003)
Am. J. Gastroenterol.
, vol.98
, pp. 952-955
-
-
Patel, K.1
Muir, A.2
McHutchison, J.G.3
Patton, H.M.4
-
24
-
-
0035321014
-
The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes
-
Freemark, M.; Bursey, D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics 2001, 107, E55.
-
(2001)
Pediatrics
, vol.107
-
-
Freemark, M.1
Bursey, D.2
-
25
-
-
37549047166
-
Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (nafld) not responding to lifestyle interventions
-
Duseja, A.; Das, A.; Dhiman, R.K.; Chawla, Y.K.; Thumburu, K.T.; Bhadada, S.; Bhansali, A. Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions. Ann. Hepatol. 2007, 6, 222-226.
-
(2007)
Ann. Hepatol.
, vol.6
, pp. 222-226
-
-
Duseja, A.1
Das, A.2
Dhiman, R.K.3
Chawla, Y.K.4
Thumburu, K.T.5
Bhadada, S.6
Bhansali, A.7
-
26
-
-
73949147212
-
Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status
-
Stein, L.L.; Dong, M.H.; Loomba, R. Insulin Sensitizers in Nonalcoholic Fatty Liver Disease and Steatohepatitis: Current Status. Adv. Ther. 2009, 26, 893-907.
-
(2009)
Adv. Ther.
, vol.26
, pp. 893-907
-
-
Stein, L.L.1
Dong, M.H.2
Loomba, R.3
-
27
-
-
0033022510
-
Troglitazone: A review of its use in themanagement of type 2 diabetes mellitus
-
Plosker, GL.; Faulds, D. Troglitazone: A review of its use in themanagement of type 2 diabetes mellitus. Drugs 1999, 57, 409-438.
-
(1999)
Drugs
, vol.57
, pp. 409-438
-
-
Plosker, G.L.1
Faulds, D.2
-
28
-
-
63249131066
-
Investigating drug-induced mitochondrial toxicity: A biosensor to increase drug safety?
-
Pereira, C.V.; Moreira, A.C.; Pereira, S.P.; Machado, N.G.; Carvalho, F.S.; Sardao, V.A.; Oliveira, P.J. Investigating Drug-induced Mitochondrial Toxicity: A Biosensor to Increase Drug Safety? Curr. Drug Saf. 2009, 4, 34-54.
-
(2009)
Curr. Drug Saf.
, vol.4
, pp. 34-54
-
-
Pereira, C.V.1
Moreira, A.C.2
Pereira, S.P.3
Machado, N.G.4
Carvalho, F.S.5
Sardao, V.A.6
Oliveira, P.J.7
-
29
-
-
79953276995
-
Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1
-
Venier, O.; Pascal, C.; Braun, A.; Namane, C.; Mougenot, P.; Crespin, O.; Pacquet, F.; Mougenot, C.; Monseau, C.; Onofri, B.; et al. Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid- dehydrogenase type 1. Bioorg. Med. Chem. Lett. 2011, 21, 2244-2251.
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 2244-2251
-
-
Venier, O.1
Pascal, C.2
Braun, A.3
Namane, C.4
Mougenot, P.5
Crespin, O.6
Pacquet, F.7
Mougenot, C.8
Monseau, C.9
Onofri, B.10
-
30
-
-
38149070200
-
Fluorine in medicinal chemistry
-
Sophie, P.; Peter, R.M.; Steve, S.; Veronique, G. Fluorine in medicinal chemistry. Chem. Soc. Rev. 2008, 37, 320-330.
-
(2008)
Chem. Soc. Rev.
, vol.37
, pp. 320-330
-
-
Sophie, P.1
Peter, R.M.2
Steve, S.3
Veronique, G.4
-
31
-
-
73349142691
-
Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in c57bl/6j mice
-
Hoffler, U.; Hobbie, K.; Wilson, R.; Bai, R.; Rahman, A.; Malarkey, D.; Travlos, G.; Ghanayem, B.I. Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in C57Bl/6J mice. Endocrine 2009, 36, 311-325.
-
(2009)
Endocrine
, vol.36
, pp. 311-325
-
-
Hoffler, U.1
Hobbie, K.2
Wilson, R.3
Bai, R.4
Rahman, A.5
Malarkey, D.6
Travlos, G.7
Ghanayem, B.I.8
-
32
-
-
79960416891
-
Transcriptional profiling reveals a role for rora in regulating gene expression in obesity-Associated inflammation and hepatic steatosis
-
Kang, H.S.; Okamoto, K.; Takeda, Y.; Beak, J.Y.; Gerrish, K.; Bortner, C.D.; DeGraff, L.M.; Wada, T.; Xie, W.; Jetten, A.M. Transcriptional profiling reveals a role for RORa in regulating gene expression in obesity-Associated inflammation and hepatic steatosis. Physiol. Genomics 2011, 43, 818-828.
-
(2011)
Physiol. Genomics
, vol.43
, pp. 818-828
-
-
Kang, H.S.1
Okamoto, K.2
Takeda, Y.3
Beak, J.Y.4
Gerrish, K.5
Bortner, C.D.6
DeGraff, L.M.7
Wada, T.8
Xie, W.9
Jetten, A.M.10
-
33
-
-
39549093795
-
High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-Activated protein kinase
-
Adachi, M.; Brenner, D.A. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-Activated protein kinase. Hepatology 2008, 47, 677-685.
-
(2008)
Hepatology
, vol.47
, pp. 677-685
-
-
Adachi, M.1
Brenner, D.A.2
-
34
-
-
77952049390
-
The role of adiponectin in the pathogenesis and treatment of non-Alcoholic fatty liver disease
-
Polyzos, S.A.; Kountouras, J.; Zavos, C.; Tsiaousi, E. The role of adiponectin in the pathogenesis and treatment of non-Alcoholic fatty liver disease. Diabetes Obes. Metab. 2010, 12, 365-383.
-
(2010)
Diabetes Obes. Metab.
, vol.12
, pp. 365-383
-
-
Polyzos, S.A.1
Kountouras, J.2
Zavos, C.3
Tsiaousi, E.4
-
35
-
-
67649411827
-
Protective roles of adiponectin in obesity-related fatty liver diseases: Mechanisms and therapeutic implications
-
Wang, Y.; Zhou, M.; Lam, K.S.; Xu, A. Protective roles of adiponectin in obesity-related fatty liver diseases: Mechanisms and therapeutic implications. Arq. Bras. Endocrinol. Metabol. 2009, 53, 201-212.
-
(2009)
Arq. Bras. Endocrinol. Metabol.
, vol.53
, pp. 201-212
-
-
Wang, Y.1
Zhou, M.2
Lam, K.S.3
Xu, A.4
-
36
-
-
82655179950
-
A tissue-specific approach to the analysis of metabolic changes in caenorhabditis elegans
-
Hench, J.; Hench, I.B.; Pujol, C.; Ipsen, S.; Brodesser, S.; Mourier, A.; Tolnay, M.; Frank, S.; Trifunovic, A. A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans. PLoS One 2011, 6, e28417.
-
(2011)
PLoS One
, vol.6
-
-
Hench, J.1
Hench, I.B.2
Pujol, C.3
Ipsen, S.4
Brodesser, S.5
Mourier, A.6
Tolnay, M.7
Frank, S.8
Trifunovic, A.9
-
37
-
-
0030761837
-
Origins of tinctorial methods in histology
-
Cook, H.C. Origins of Tinctorial methods in histology. J. Lin. Pathol. 1997, 50, 716-720.
-
(1997)
J. Lin. Pathol.
, vol.50
, pp. 716-720
-
-
Cook, H.C.1
|