Lipid-lowering effects of Danhong injection on hyperlipidemia rats

Journal of Ethnopharmacology

Volumn 154, Issue 2, 2014, Pages 437-442

  Chen, Juan ^a   Deng, Jun ^b   Zhang, Yuyan ^a   Yang, Jiehong ^a   He, Yu ^a   Fu, Wei ^c   Xing, Panke ^c   Wan, Hai Tong ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c Shanxi Buchang Pharmaceutical Co Ltd   (China)

Author keywords

Danhong injection; Fatty acid synthesis; Hyperlipidemia; Hypolipidemic; Lipolysis

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ANTILIPEMIC AGENT; CARNITINE PALMITOYLTRANSFERASE I; CHINESE DRUG; CHOLESTEROL; DANHONG INJECTION; FATTY ACID SYNTHASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; DANHONG; GLUCOSE BLOOD LEVEL; HERBACEOUS AGENT; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOSCLEROSIS; ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY ACID SYNTHESIS; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERLIPIDEMIA; INSULIN SENSITIVITY; LIPID DIET; MALE; METABOLIC PARAMETERS; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; THERAPY EFFECT; TRIACYLGLYCEROL BLOOD LEVEL; ANALYSIS; ANIMAL; BLOOD; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; ETHNOPHARMACOLOGY; HYPERLIPIDEMIAS; ISOLATION AND PURIFICATION; LIVER; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD GLUCOSE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ETHNOPHARMACOLOGY; GENE EXPRESSION; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; INSULIN; LIPIDS; LIVER; MALE; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84901388053     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.04.023     Document Type: Article

References (33)

1. A.A. Alsheikh-Ali, J.T. Kuvin, and R.H. Karas Risk of adverse events with fibrates American Journal of Cardiology 94 2004 935 938
2. C. Cannon, E. Braunwald, H.C. McCahe, D.J. Rader, J.L. Rouleau, R. Belder, S.V. Joyal, K.A. Hill, M.A. Pfeffer, and A.M. Skene Intensive versus moderate lipid lowering with stains after acute coronary syndromes New England Journal of Medicine 350 2004 1495 1504
3. W.P. Castelli, J.T. Doyle, T. Gordon, C.G. Hames, M.C. Hjortland, S.B. Hulley, A. Kagan, and W.J. Zukel HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study Circulation 55 1977 767 772
4. I.J. Cho, J.Y. Ahn, S. Kim, M.S. Choi, and T.Y. Ha Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters Biochemical Biophysical Research Communications 367 2008 190 194
5. M.I. Choudhary, S. Naheed, S. Jalil, J.M. Alam, and R. Attaur Effects of ethanolic extract of Iris Germanica on lipid profile of rats fed on a high-fat diet Ethnopharmacol 98 2005 217 220
6. L.J. Feng, C.H. Yu, K.J. Ying, J. Hua, and X.Y. Dai Hypolipidemic and antioxidant effects of total flavonoids of Perilla Frutescens leaves in hyperlipidemia rats induced by high-fat diet Food Research International 44 2011 404 409
7. D.J. Gordon, J.L. Probstfield, R.J. Garrison, J.D. Neaton, W.P. Castelli, J.D. Knoke, D.R. Jacobs, S. Bangdiwala, and H.A. Tyroler High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies Circulation 79 1989 8 15
8. Y. He, H.T. Wan, Y.G. Du, X.D. Bie, T. Zhao, W. Fu, and P.K. Xing Protective effect of Danhong injection on cerebra lischemia-reperfusion injury in rats Journal of Ethnopharmacology 144 2012 387 394
9. J.Z. Jin Observation of the therapeutic effect of Danhong injection intreatment of bertebrob asilararterial insufficiency Chinese Journal of Gerontology 23 2003 839
10. B.B. Kahn, and J.S. Flier Obesity and insulin resistance Journal of Clinical Investigation 106 2000 473 481
11. Y.H. Kao, H.H. Chang, M.J. Lee, and C.L. Chen Tea, obesity, and diabetes Molecular Nutrition and Food Research 50 2006 188 210
12. Y. Kazama, T. Takamura, M. Sakurai, H. Shindo, E. Ohkubo, K. Aida, N. Harii, K. Taki, M. Kaneshige, S. Tanaka, H. Shimura, T. Endo, and T. Kobayashi New insulin sensitivity index from the oral glucose tolerance test Diabetes Research and Clinical Practice 79 2008 24 30
13. S. Kersten, J. Seydoux, J.M. Peters, F.J. Gonzalez, B. Desvergne, and W.J. Wahli Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting Journal of Clinical Investigation 103 1999 1489 1498
14. A.C. Li, and C.K. Glass PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis Lipid Research 45 2004 2161 2173
15. G. Li, Y. Hu, W. Yang, Y. Jiang, J. Wang, J. Xiao, Z. Hu, X. Pan, B.V. Howard, and P.H. Bennett Effects of insulin resistance and insulin secretion on the efficacy of interventions to retard development of type 2 diabetes mellitus: The DA Qing IGT and diabetes study Diabetes Research and Clinical Practice 58 2002 193 200
16. L. Li, and G.L. Xu Fufang danshen pill prevent atherosclerosis by decreasing plasma lipid and modifying vascular endothelial function in rabbits Journal of Molecular and Cellular Cardiology 44 2008 747 748
17. J. Liu, D. Zhang, J. Li, J. Feng, X. Yang, D. Shi, and X. Liang Effectsof Salvia miltiorrhiza and Carthamus tinctorius aqueous extracts and compatibility on rat myocardial ischemic reperfusion injury China Journal of Chinese Materia Medica 36 2011 189 194
18. C. Mascaro, E. Acosta, J.A. Ortiz, P.F. Marrero, F.G. Hegardt, and D. Haro Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor Journal of Biological Chemistry 273 1998 8560 8563
19. N.E. Miller, D.S. Thelle, O.H. Forde, and O.D. Mjos The Troms heart-study. High-density lipoprotein and coronary heart disease: a prospective case-control study Lancet 1 1977 965 968
20. H. Nakamura, K. Amkma, H. Itakura, A. Kitabatake, Y. Goto, T. Toyota, N. Nakaya, S. Nishimoto, M. Muranaka, A. Yamamoto, K. Mizuno, and Y. Ohashi Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled tria1 Lancet 368 2006 1155 1163
21. T. Panda, and V. Amutha Devi Regulation and degradation of HMGCoA reductase Applied Microbiology Biotechnology 66 2004 143 152
22. K. Schoonjans, J. Peinado-Onsurbe, A.M. Lefebvre, R.A. Heyman, M. Briggs, S. Deeb, B. Staels, and J. Auwerx PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene EMBO Journal. 1996 15 1996 5336 5348
23. K. Schoonjans, B. Staels, and J. Auwerx Role of the peroxisome proliferators activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression Journal of Lipid Research 37 1996 907 925
24. E. Sucajtys-Szulc, J. Turyn, E. Goyke, J. Korczynska, E. Stelmanska, E. Slominska, R.T. Smolenski, B. Rutkowski, and J. Swierczynski Differential effect of prolonged food restriction and fasting on hypothalamic malonyl-CoA concentration and expression of orexigenic and anorexigenic neuropeptides genes in rats Neuropeptides 44 2010 17 23
25. M. Sun, J.J. Zhang, J.Z. Shan, H. Zhang, C.Y. Jin, S. Xu, and Y.L. Wang Clinical observation of Danhong Injection (herbal TCM product from Radix Salviae miltiorrhizae and Flos Carthami tinctorii) in the treatment of traumatic intracranial hematoma Phytomedicine 16 2009 683 689
26. M.H. Tai, L.M. Liu, R.Q. Ma, X. Li, J.X. Pang, and J.P. Xu General pharmacology of Danhong injection Journal of Southern Medical University 25 2005 335 338
27. P.P. Toth Reverse cholesterol transport: high-density lipoprotein's magnificent mile Current Atherosclerosis Reports 5 2003 386 393
28. M. Vinaixa, M. Angel Rodriguez, A. Rull, R. Beltran, C. Blade, J. Brezmes, N. Canellas, J. Joven, and X. Correig Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease Journal of Proteome Research 9 2010 2527 2538
29. S. Wakil Fatty acid synthase, a proficient multifunctional enzyme Biochemistry 28 1989 4523 4530
30. T. Wang, D. Zhang, Y. Li, H. Liu, Z. Liu, C. Zhao, L. Hu, and X. Gao Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine Journal of Ethnopharmacology 128 2010 575 582
31. A. Witkowski, V.S. Rangan, Z.I. Randhawa, C.M. Amy, and S. Smith Structural organization of the multifunctional animal fatty-acid synthase International Journal of Biochemistry 198 1991 571 579
32. Z.R. Xu, M.Q. Wang, H.X. Mao, X.A. Zhan, and C.H. Hu Effects of l-carnitine on growth performance, carcass composition, and metabolism of lipids in male broilers Poultry Science 82 2003 408 413
33. Y. Zhan, J.P. Xu, J.B. Liang, L.S. Sheng, B.R. Xiang, Q.G. Zou, and Z.J. Zhang Simultaneous LC-MS-MS analysis of danshensu, salvianolic acid B, and hydro- xysafflor yellow A in beagle dog plasma, and application of the method to a pharmacokinetic study of danhong lyophilized powder for injection Chromatographia 68 2008 71 79