AAV-mediated delivery of zinc finger nucleases targeting hepatitis B virus inhibits active replication

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Weber, Nicholas D ^a,b   Stone, Daniel ^a   Sedlak, Ruth Hall ^b   De Silva Feelixge, Harshana S ^a   Roychoudhury, Pavitra ^a   Schiffer, Joshua T ^a,b   Aubert, Martine ^b   Jerome, Keith R ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARVOVIRUS VECTOR; ZINC FINGER NUCLEASE; ANTIVIRUS AGENT; CORE PROTEIN; ENDONUCLEASE; HEPATITIS B VIRUS X PROTEIN; P PROTEIN, HEPATITIS B VIRUS; POL PROTEIN; TRANSACTIVATOR PROTEIN; VIRUS DNA; ZINC FINGER PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA END JOINING REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; FRAMESHIFT MUTATION; GENE MUTATION; GENETIC CONSERVATION; GENETIC HETEROGENEITY; HEPATITIS B; HEPATITIS B VIRUS; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; LIVER CELL; MUTAGENESIS; NONHUMAN; OPEN READING FRAME; PLASMID; POLYADENYLATION; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; START CODON; VIRION; VIRUS GENOME; VIRUS REACTIVATION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DEPENDOPARVOVIRUS; GENE TARGETING; GENE VECTOR; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN ENGINEERING; TUMOR CELL LINE; VIROLOGY;

ANTIVIRAL AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; DEPENDOVIRUS; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA, VIRAL; ENDONUCLEASES; GENE PRODUCTS, POL; GENE TARGETING; GENETIC VECTORS; HEK293 CELLS; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; TRANS-ACTIVATORS; VIRAL CORE PROTEINS; VIRUS REPLICATION; ZINC FINGERS;

EID: 84901375803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097579     Document Type: Article

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