Inflammatory biomarker profiles of mental disorders and their relation to clinical, social and lifestyle factors

Social Psychiatry and Psychiatric Epidemiology

Volumn 49, Issue 6, 2014, Pages 841-849

  Baumeister, David ^a   Russell, Alice ^a   Pariante, Carmine M ^a   Mondelli, Valeria ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Bipolar disorder; Cytokine; Depression; Inflammation; Interleukin; Psychosis

Indexed keywords

BIOLOGICAL MARKER;

ANIMAL; HUMAN; INFLAMMATION; LIFESTYLE; MENTAL DISEASE; METABOLISM; PSYCHOLOGICAL ASPECT; REVIEW; SOCIAL ENVIRONMENT;

ANIMALS; BIOLOGICAL MARKERS; HUMANS; INFLAMMATION; LIFE STYLE; MENTAL DISORDERS; SOCIAL ENVIRONMENT;

EID: 84901357523     PISSN: 09337954     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00127-014-0887-z     Document Type: Review

References (88)

1. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9(1):46-56
2. Raison CL, Demetrashvili M, Capuron L, Miller AH (2005) Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs 19(2):105-123
3. Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65(9):732-741
4. Herbert J, Goodyer IM, Grossman AB, Hastings MH, de Kloet ER, Lightman SL, Lupien SJ, Roozendaal B, Seckl JR (2006) Do corticosteroids damage the brain? J Neuroendocrinol 18(6):393-411
5. Pariante CM (2006) The glucocorticoid receptor: part of the solution or part of the problem? J Psychopharmacol 20(4 Suppl):79-84
6. Pariante CM, Lightman SL (2008) The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31(9):464-468
7. Pariante CM, Miller AH (2001) Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 49(5):391-404
8. Borges S, Gayer-Anderson C, Mondelli V (2013) A systematic review of the activity of the hypothalamic-pituitary-adrenal axis in first episode psychosis. Psychoneuroendocrinology 38(5):603-611
9. Mondelli V, Dazzan P, Hepgul N, Di Forti M, Aas M, D'Albenzio A, Di Nicola M, Fisher H, Handley R, Marques TR, Morgan C, Navari S, Taylor H, Papadopoulos A, Aitchison KJ, Murray RM, Pariante CM (2010) Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: the role of stress and of antipsychotic treatment. Schizophr Res 116(2-3):234-242
10. Duffy A, Lewitzka U, Doucette S, Andreazza A, Grof P (2012) Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic-pituitary-adrenal axis and immune system. Early Interv Psychiatry 6(2):128-137
11. Pace TW, Hu F, Miller AH (2007) Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain Behav Immun 21(1):9-19
12. Silverman MN, Mukhopadhyay P, Belyavskaya E, Tonelli LH, Revenis BD, Doran JH, Ballard BE, Tam J, Pacher P, Sternberg EM (2013) Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice. Mol Psychiatry 18(9):1006-1017
13. Tsao CW, Lin YS, Cheng JT, Lin CF, Wu HT, Wu SR, Tsai WH (2008) Interferon-alpha-induced serotonin uptake in Jurkat T cells via mitogen-activated protein kinase and transcriptional regulation of the serotonin transporter. J Psychopharmacol 22(7):753-760
14. Zhu CB, Blakely RD, Hewlett WA (2006) The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology 31(10):2121-2131
15. Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD (2005) p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. J Biol Chem 280(16):15649-15658
16. Zhu CB, Lindler KM, Owens AW, Daws LC, Blakely RD, Hewlett WA (2010) Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology 35(13):2510-2520
17. Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246:199-229
18. Zunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM (2010) Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuropsychopharmacol Biol Psychiatry 35(3):722-729
19. Zunszain PA, Anacker C, Cattaneo A, Choudhury S, Musaelyan K, Myint AM, Thuret S, Price J, Pariante CM (2012) Interleukin-1beta: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology 37(4):939-949
20. Berk M, Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M, Yucel M, Gama CS, Dodd S, Dean B, Magalhaes PV, Amminger P, McGorry P, Malhi GS (2011) Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 35(3):804-817
21. Leonard B, Maes M (2012) Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 36(2):764-785
22. Moylan S, Maes M, Wray NR, Berk M (2013) The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications. Mol Psychiatry 18(5):595-606
23. Bitanihirwe BK, Woo TU (2011) Oxidative stress in schizophrenia: an integrated approach. Neurosci Biobehav Rev 35(3):878-893
24. Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 455(7215):894-902
25. Dedon PC, Tannenbaum SR (2004) Reactive nitrogen species in the chemical biology of inflammation. Arch Biochem Biophys 423(1):12-22
26. Grinberg YY, Dibbern ME, Levasseur VA, Kraig RP (2013) Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-alpha responses to spreading depression. J Neurochem 126(5):662-672
27. Cunha AB, Frey BN, Andreazza AC, Goi JD, Rosa AR, Goncalves CA, Santin A, Kapczinski F (2006) Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neurosci Lett 398(3):215-219
28. Sen S, Duman R, Sanacora G (2008) Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 64(6):527-532
29. Pirildar S, Gonul AS, Taneli F, Akdeniz F (2004) Low serum levels of brain-derived neurotrophic factor in patients with schizophrenia do not elevate after antipsychotic treatment. Prog Neuropsychopharmacol Biol Psychiatry 28(4):709-713
30. Patas K, Penninx BW, Bus BA, Vogelzangs N, Molendijk ML, Elzinga BM, Bosker FJ, Oude Voshaar RC (2014) Association between serum brain-derived neurotrophic factor and plasma interleukin-6 in major depressive disorder with melancholic features. Brain Behav Immun 36:71-79
31. Schulte-Herbrüggen O, Nassenstein C, Lommatzsch M, Quarcoo D, Renz H, Braun A (2005) Tumor necrosis factor-alpha and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes. J Neuroimmunol 160(1-2):204-209
32. Mondelli V, Cattaneo A, Belvederi Murri M, Di Forti M, Handley R, Hepgul N, Miorelli A, Navari S, Papadopoulos AS, Aitchison KJ, Morgan C, Murray RM, Dazzan P, Pariante CM (2011) Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. J Clin Psychiatry 72(12):1677-1684
33. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67(5):446-457
34. Liu Y, Ho RC, Mak A (2012) Interleukin (IL)-6, tumour necrosis factor alpha (TNF-alpha) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J Affect Disord 139(3):230-239
35. Howren MB, Lamkin DM, Suls J (2009) Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 71(2):171-186
36. Hiles SA, Baker AL, de Malmanche T, Attia J (2012) A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity. Brain Behav Immun 26(7):1180-1188
37. Banks WA, Kastin AJ, Gutierrez EG (1994) Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci Lett 179(1-2):53-56
38. Yang ZZ, Grote DM, Ziesmer SC, Manske MK, Witzig TE, Novak AJ, Ansell SM (2011) Soluble IL-2Ralpha facilitates IL-2-mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma. Blood 118(10):2809-2820
39. Valkanova V, Ebmeier KP, Allan CL (2013) CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord 150(3):736-744
40. Eisenhardt SU, Thiele JR, Bannasch H, Stark GB, Peter K (2009) C-reactive protein: how conformational changes influence inflammatory properties. Cell Cycle 8(23):3885-3892
41. Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E (2008) Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 63(8):801-808
42. Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B (2011) Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 70(7):663-671
43. Munkholm K, Braüner JV, Kessing LV, Vinberg M (2013) Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis. J Psychiatr Res 47(9):1119-1133
44. Modabbernia A, Taslimi S, Brietzke E, Ashrafi M (2013) Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry 74(1):15-25
45. Rose-John S, Waetzig GH, Scheller J, Grotzinger J, Seegert D (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets 11(5):613-624
46. World Health Organization (1993) The ICD-10 Classification of Mental and Behavioural Disorders: diagnostic criteria for research. World Health Organization, Geneva
47. Lamers F, Vogelzangs N, Merikangas KR, de Jonge P, Beekman AT, Penninx BW (2012) Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psychiatry 18(6):692-699
48. Lanquillon S, Krieg JC, Bening-Abu-Shach U, Vedder H (2000) Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 22(4):370-379
49. Eller T, Vasar V, Shlik J, Maron E (2008) Pro-inflammatory cytokines and treatment response to escitalopram in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 32(2):445-450
50. Serafini G, Pompili M, Elena Seretti M, Stefani H, Palermo M, Coryell W, Girardi P (2013) The role of inflammatory cytokines in suicidal behavior: a systematic review. Eur Neuropsychopharmacol 23(12):1672-1686
51. Hiles SA, Baker AL, de Malmanche T, Attia J (2012) Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis. Psychol Med 42(10):2015-2026
52. Dickerson F, Stallings C, Origoni A, Boronow J, Yolken R (2007) C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia. Schizophr Res 93(1-3):261-265
53. Garcia-Rizo C, Fernandez-Egea E, Oliveira C, Justicia A, Bernardo M, Kirkpatrick B (2012) Inflammatory markers in antipsychotic-naive patients with nonaffective psychosis and deficit vs. nondeficit features. Psychiatry Res 198(2):212-215
54. Munkholm K, Vinberg M, Kessing LV (2012) Cytokines in bipolar disorder: a systematic review and meta-analysis. J Affect Disord 144(1-2):16-27
55. Tsai S-YM, Yang Y-Y, Kuo C-J, Chen C-C, Leu S-JC (2001) Effects of symptomatic severity on elevation of plasma soluble interleukin-2 receptor in bipolar mania. J Affect Disord 64(2-3):185-193
56. Tsai S-Y, Chen K-P, Yang Y-Y, Chen C-C, Lee J-C, Singh VK, Leu S-JC (1999) Activation of indices of cell-mediated immunity in bipolar mania. Biol Psychiatry 45(8):989-994
57. Dickerson F, Stallings C, Origoni A, Boronow J, Yolken R (2007) Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 31(4):952-955
58. Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Yolken R (2013) Elevated C-reactive protein and cognitive deficits in individuals with bipolar disorder. J Affect Disord 150(2):456-459
59. Hope S, Dieset I, Agartz I, Steen NE, Ueland T, Melle I, Aukrust Pål, Andreassen OA (2011) Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. J Psychiatric Res 45(12):1608-1616
60. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R (2007) Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci USA 104(4):1319-1324
61. Pace TW, Mletzko TC, Alagbe O, Musselman DL, Nemeroff CB, Miller AH, Heim CM (2006) Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry 163(9):1630-1633
62. Coelho R, Viola TW, Walss-Bass C, Brietzke E, Grassi-Oliveira R (2014) Childhood maltreatment and inflammatory markers: a systematic review. Acta Psychiatr Scand 129(3):180-192
63. Miller GE, Chen E, Fok AK, Walker H, Lim A, Nicholls EF, Cole S, Kobor MS (2009) Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc Natl Acad Sci USA 106(34):14716-14721
64. Chen E, Miller GE, Kobor MS, Cole SW (2011) Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Mol Psychiatry 16(7):729-737
65. Raison CL, Capuron L, Miller AH (2006) Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27(1):24-31
66. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M, Turecki G, Meaney MJ (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12(3):342-348
67. Lu S, Gao W, Wei Z, Wu W, Liao M, Ding Y, Zhang Z, Li L (2013) Reduced cingulate gyrus volume associated with enhanced cortisol awakening response in young healthy adults reporting childhood trauma. PLoS One 8(7):e69350
68. Mangold D, Wand G, Javors M, Mintz J (2010) Acculturation, childhood trauma and the cortisol awakening response in Mexican-American adults. Horm Behav 58(4):637-646
69. Carpenter LL, Ross NS, Tyrka AR, Anderson GM, Kelly M, Price LH (2009) Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls. Psychoneuroendocrinology 34(8):1208-1213
70. Heim C, Nemeroff CB (2002) Neurobiology of early life stress: clinical studies. Semin Clin Neuropsychiatry 7(2):147-159
71. Heim C, Mletzko T, Purselle D, Musselman DL, Nemeroff CB (2008) The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biol Psychiatry 63(4):398-405
72. Putnam KT, Harris WW, Putnam FW (2013) Synergistic childhood adversities and complex adult psychopathology. J Trauma Stress 26(4):435-442
73. Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, Read J, van Os J, Bentall RP (2012) Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull 38(4):661-671
74. Subica AM (2013) Psychiatric and physical sequelae of childhood physical and sexual abuse and forced sexual trauma among individuals with serious mental illness. J Trauma Stress 26(5):588-596
75. Steptoe A, Hamer M, Chida Y (2007) The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav Immun 21(7):901-912
76. Bylsma LM, Taylor-Clift A, Rottenberg J (2011) Emotional reactivity to daily events in major and minor depression. J Abnorm Psychol 120(1):155-167
77. Miller GE, Rohleder N, Stetler C, Kirschbaum C (2005) Clinical depression and regulation of the inflammatory response during acute stress. Psychosom Med 67(5):679-687
78. Wieck A, Grassi-Oliveira R, do Prado CH, Rizzo LB, de Oliveira AS, Kommers-Molina J, Viola TW, Teixeira AL, Bauer ME (2013) Differential neuroendocrine and immune responses to acute psychosocial stress in women with type 1 bipolar disorder. Brain Behav Immun 34:47-55
79. Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH (2010) Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 35(13):2617-2623
80. Myin-Germeys I, Delespaul P, van Os J (2005) Behavioural sensitization to daily life stress in psychosis. Psychol Med 35(5):733-741
81. Berk M, Williams LJ, Jacka FN, O'Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M (2013) So depression is an inflammatory disease, but where does the inflammation come from? BMC Med 11:200
82. Pedersen MS, Benros ME, Agerbo E, Borglum AD, Mortensen PB (2012) Schizophrenia in patients with atopic disorders with particular emphasis on asthma: a Danish population-based study. Schizophr Res 138(1):58-62
83. Eltas A, Kartalci S, Eltas SD, Dundar S, Uslu MO (2013) An assessment of periodontal health in patients with schizophrenia and taking antipsychotic medication. Int J Dent Hyg 11(2):78-83
84. Wei J, Hemmings GP (2005) Gene, gut and schizophrenia: the meeting point for the gene-environment interaction in developing schizophrenia. Med Hypotheses 64(3):547-552
85. O'Connor MF, Bower JE, Cho HJ, Creswell JD, Dimitrov S, Hamby ME, Hoyt MA, Martin JL, Robles TF, Sloan EK, Thomas KS, Irwin MR (2009) To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers. Brain Behav Immun 23(7):887-897
86. Kirkpatrick B, Miller BJ (2013) Inflammation and schizophrenia. Schizophr Bull 39(6):1174-1179
87. Goldstein BI, Kemp DE, Soczynska JK, McIntyre RS (2009) Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry 70(8):1078-1090
88. Hamdani N, Doukhan R, Kurtlucan O, Tamouza R, Leboyer M (2013) Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications. Curr Psychiatry Rep 15(9):387