Childhood maltreatment and inflammatory markers: A systematic review

Acta Psychiatrica Scandinavica

Volumn 129, Issue 3, 2014, Pages 180-192

  Coelho, R ^a   Viola, T W ^a   Walss Bass, C ^b   Brietzke, E ^c   Grassi Oliveira, R ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b University of Texas Health Science Center at San Antonio   (United States)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Child abuse; Childhood trauma; Cytokines; Immune system; Inflammation; Stress

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; FIBRINOGEN; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER;

CHILD ABUSE; CHILD NEGLECT; CHILDHOOD INJURY; CHILDHOOD MALTREATMENT; DISEASE MARKER; EARLY LIFE STRESS; EMOTIONAL STRESS; HUMAN; INFLAMMATION; MENTAL STRESS; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; BLOOD; CHILD; PSYCHOLOGY;

BIOLOGICAL MARKERS; CHILD; CHILD ABUSE; HUMANS; INFLAMMATION;

EID: 84893756037     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/acps.12217     Document Type: Review

References (77)

1. Daruy-Filho L, Brietzke E, Lafer B, Grassi-Oliveira R. Childhood maltreatment and clinical outcomes of bipolar disorder. Acta Psychiatr Scand 2011;124:427-434.
2. Kelly-Irving M, Lepage B, Dedieu D et al. Adverse childhood experiences and premature all-cause mortality. Eur J Epidemiol 2013;28:721-734.
3. Moffitt TE, Caspi A, Taylor A et al. How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. Psychol Med 2010;40:899-909.
4. Hovens JG, Giltay EJ, Wiersma JE, Spinhoven P, Penninx BW, Zitman FG. Impact of childhood life events and trauma on the course of depressive and anxiety disorders. Acta Psychiatr Scand 2012;126:198-207.
5. Wigman JT, van Winkel R, Ormel J, Verhulst FC, van Os J, Vollebergh WA. Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence. Acta Psychiatr Scand 2012;126:266-273.
6. Shonkoff JP, Garner AS, Committee on Psychosocial Aspects of Child and Family Health; Committee on Early Childhood, Adoption, and Dependent Care; Section on Developmental and Behavioral Pediatrics. The lifelong effects of early childhood adversity and toxic stress. Pediatrics 2012;129:e232-e246.
7. Miller GE, Chen E, Parker KJ. Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull 2011;137:959-997.
8. Slopen N, Koenen KC, Kubzansky LD. Childhood adversity and immune and inflammatory biomarkers associated with cardiovascular risk in youth: a systematic review. Brain Behav Immun 2012;26:239-250.
9. Tyrka AR, Burgers DE, Philip NS, Price LH, Carpenter LL. The neurobiological correlates of childhood adversity and implications for treatment. Acta Psychiatr Scand 2013;128:434-447.
10. Danese A, McEwen BS. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav 2012;106:29-39.
11. Hunter AL, Minnis H, Wilson P. Altered stress responses in children exposed to early adversity: a systematic review of salivary cortisol studies. Stress 2011;14:614-626.
12. Seldenrijk A, Hamer M, Lahiri A, Penninx BW, Steptoe A. Psychological distress, cortisol stress response and subclinical coronary calcification. Psychoneuroendocrinology 2012;37:48-55.
13. Carpenter LL, Shattuck TT, Tyrka AR, Geracioti TD, Price LH. Effect of childhood physical abuse on cortisol stress response. Psychopharmacology 2011;214:367-375.
14. Lee R, Geracioti TD Jr, Kasckow JW, Coccaro EF. Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrations. Am J Psychiatry 2005;162:995-997.
15. Graham JE, Christian LM, Kiecolt-Glaser JK. Stress, age, and immune function: toward a lifespan approach. J Behav Med 2006;29:389-400.
16. Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 2005;5:243-251.
17. Webster JI, Tonelli L, Sternberg EM. Neuroendocrine regulation of immunity. Annu Rev Immunol 2002;20: 125-163.
18. Bertone-Johnson ER, Whitcomb BW, Missmer SA, Karlson EW, Rich-Edwards JW. Inflammation and early-life abuse in women. Am J Prev Med 2012;43:611-620.
19. Pace TW, Wingenfeld K, Schmidt I, Meinlschmidt G, Hellhammer DH, Heim CM. Increased peripheral NF-kappaB pathway activity in women with childhood abuse-related posttraumatic stress disorder. Brain Behav Immun 2012;26:13-17.
20. Lu S, Peng H, Wang L et al. Elevated specific peripheral cytokines found in major depressive disorder patients with childhood trauma exposure: a cytokine antibody array analysis. Compr Psychiatry 2013;54:953-961.
21. Danese A, Moffitt TE, Pariante CM, Ambler A, Poulton R, Caspi A. Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 2008;65:409-415.
22. Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH. Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 2010;35:2617-2623.
23. Lopes RP, Grassi-Oliveira R, de Almeida LR et al. Neuroimmunoendocrine interactions in patients with recurrent major depression, increased early life stress and long-standing posttraumatic stress disorder symptoms. NeuroImmunoModulation 2012;19:33-42.
24. Laudenslager ML, Reite M, Harbeck RJ. Suppressed immune response in infant monkeys associated with maternal separation. Behav Neural Biol 1982;36:40-48.
25. Fagundes CP, Glaser R, Kiecolt-Glaser JK. Stressful early life experiences and immune dysregulation across the lifespan. Brain Behav Immun 2013;27:8-12.
26. Fisher HL, Hosang GM. Childhood maltreatment and bipolar disorder: a critical review of the evidence. Mind Brain J Psychiatr 2010;1:1-11.
27. Grassi-Oliveira R, Brietzke E, Pezzi JC, Lopes RP, Teixeira AL, Bauer ME. Increased soluble tumor necrosis factor-alpha receptors in patients with major depressive disorder. Psychiatry Clin Neurosci 2009;63:202-208.
28. Pace TW, Mletzko TC, Alagbe O et al. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry 2006;163:1630-1633.
29. Zeugmann S, Quante A, Popova-Zeugmann L, Kossler W, Heuser I, Anghelescu I. Pathways linking early life stress, metabolic syndrome, and the inflammatory marker fibrinogen in depressed inpatients. Psychiatr Danub 2012;24:57-65.
30. Dennison U, McKernan D, Cryan J, Dinan T. Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype. Psychol Med 2012;42: 1865-1871.
31. Carpenter LL, Gawuga CE, Tyrka AR, Price LH. C-reactive protein, early life stress, and wellbeing in healthy adults. Acta Psychiatr Scand 2012;126:402-410.
32. Levandowski ML, Viola TW, Tractenberg SG et al. Adipokines during early abstinence of crack cocaine in dependent women reporting childhood maltreatment. Psychiatry Res 2013;210:536-540.
33. Bernstein DP, Stein JA, Newcomb MD et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 2003;27:169-190.
34. Roy CA, Perry JC. Instruments for the assessment of childhood trauma in adults. J Nerv Ment Dis 2004;192:343-351.
35. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R. Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci USA 2007;104:1319-1324.
36. Danese A, Moffitt TE, Harrington H et al. Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med 2009;163:1135-1143.
37. Taylor SE, Lehman BJ, Kiefe CI, Seeman TE. Relationship of early life stress and psychological functioning to adult C-reactive protein in the coronary artery risk development in young adults study. Biol Psychiatry 2006;60: 819-824.
38. Miller GE, Chen E. Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychol Sci 2010;21:848-856.
39. Felitti VJ, Anda RF, Nordenberg D et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med 1998;14:245-258.
40. Loucks EB, Almeida ND, Taylor SE, Matthews KA. Childhood family psychosocial environment and coronary heart disease risk. Psychosom Med 2011;73:563-571.
41. Rooks C, Veledar E, Goldberg J, Bremner JD, Vaccarino V. Early trauma and inflammation: role of familial factors in a study of twins. Psychosom Med 2012;74:146-152.
42. Bremner JD, Vermetten E, Mazure CM. Development and preliminary psychometric properties of an instrument for the measurement of childhood trauma: the Early Trauma Inventory. Depress Anxiety 2000;12:1-12.
43. Tietjen GE, Khubchandani J, Herial NA, Shah K. Adverse childhood experiences are associated with migraine and vascular biomarkers. Headache 2012;52:920-929.
44. Lehto SM, Elomaa AP, Niskanen L et al. Serum adipokine levels in adults with a history of childhood maltreatment. Prog Neuropsychopharmacol Biol Psychiatry 2012;37: 217-221.
45. Hepgul N, Pariante CM, Dipasquale S et al. Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients. Psychol Med 2012;42:1893-1901.
46. Brown GW, Craig TK, Harris TO, Handley RV, Harvey AL. Validity of retrospective measures of early maltreatment and depressive episodes using the Childhood Experience of Care and Abuse (CECA) instrument - a life-course study of adult chronic depression - 2. J Affect Disord 2007;103:217-224.
47. Smith N, Lam D, Bifulco A, Checkley S. Childhood Experience of Care and Abuse Questionnaire (CECA.Q). Validation of a screening instrument for childhood adversity in clinical populations. Soc Psychiatry Psychiatr Epidemiol 2002;37:572-579.
48. Chen E, Hanson MD, Paterson LQ, Griffin MJ, Walker HA, Miller GE. Socioeconomic status and inflammatory processes in childhood asthma: the role of psychological stress. J Allergy Clin Immunol 2006;117:1014-1020.
49. Adrian C, Hammen C. Stress exposure and stress generation in children of depressed mothers. J Consult Clin Psychol 1993;61:354-359.
50. Brietzke E, Mansur RB, Grassi-Oliveira R, Soczynska JK, McIntyre RS. Inflammatory cytokines as an underlying mechanism of the comorbidity between bipolar disorder and migraine. Med Hypotheses 2012;78:601-605.
51. Song XQ, Lv LX, Li WQ, Hao YH, Zhao JP. The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia. Biol Psychiatry 2009;65:481-488.
52. Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 2011;1813:878-888.
53. Modabbernia A, Taslimi S, Brietzke E, Ashrafi M. Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry 2013;74:15-25.
54. Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 2011;70:663-671.
55. Berk M, Kapczinski F, Andreazza AC et al. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 2011;35:804-817.
56. Stertz L, Magalhaes PV, Kapczinski F. Is bipolar disorder an inflammatory condition? The relevance of microglial activation. Curr Opin Psychiatry 2013;26:19-26.
57. Schuitemaker A, Kropholler MA, Boellaard R et al. Microglial activation in Alzheimer's disease: an (R)-[(1)(1)C]PK11195 positron emission tomography study. Neurobiol Aging 2013;34:128-136.
58. Dantzer R, O'connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008;9:46-56.
59. Bilbo SD, Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system. Horm Behav 2013;63:684-691.
60. Dean B. Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies. Int J Neuropsychopharmacol 2011;14: 997-1012.
61. Chen DY, Hsieh TY, Chen YM, Hsieh CW, Lan JL, Lin FJ. Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: a comparison with younger-onset disease. Gerontology 2009;55:250-258.
62. Tanida M, Shen J, Horii Y et al. Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats. Exp Biol Med (Maywood) 2007;232:390-397.
63. Bassi M, do Carmo JM, Hall JE, da Silva AA. Chronic effects of centrally administered adiponectin on appetite, metabolism and blood pressure regulation in normotensive and hypertensive rats. Peptides 2012;37:1-5.
64. Bierhaus A, Wolf J, Andrassy M et al. A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci USA 2003;100:1920-1925.
65. Nagabhushan M, Mathews HL, Witek-Janusek L. Aberrant nuclear expression of AP-1 and NFkappaB in lymphocytes of women stressed by the experience of breast biopsy. Brain Behav Immun 2001;15:78-84.
66. Christen V, Meili N, Fent K. Microcystin-LR induces endoplasmatic reticulum stress and leads to induction of NFkappaB, interferon-alpha, and tumor necrosis factor-alpha. Environ Sci Technol 2013;47:3378-3385.
67. Barazzoni R, Zanetti M, Gortan Cappellari G et al. Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-kappaB inhibitor (IkappaB)-nuclear factor-kappaB (NFkappaB) activation in rat muscle, in the absence of mitochondrial dysfunction. Diabetologia 2012;55:773-782.
68. Urtasun R, Lopategi A, George J et al. Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin alpha(V)beta(3) engagement and PI3K/pAkt/NFkappaB signaling. Hepatology 2012;55:594-608.
69. Khoo CM, Sairazi S, Taslim S et al. Ethnicity modifies the relationships of insulin resistance, inflammation, and adiponectin with obesity in a multiethnic Asian population. Diabetes Care 2011;34:1120-1126.
70. Feinberg AP. Epigenetics at the epicenter of modern medicine. JAMA 2008;299:1345-1350.
71. Cohen-Woods S, Schosser A, McGuffin P. From age correction to genome-wide association. Acta Psychiatr Scand 2009;120:355-362.
72. Krukowski K, Eddy J, Kosik KL, Konley T, Janusek LW, Mathews HL. Glucocorticoid dysregulation of natural killer cell function through epigenetic modification. Brain Behav Immun 2011;25:239-249.
73. Mathews HL, Janusek LW. Epigenetics and psychoneuroimmunology: mechanisms and models. Brain Behav Immun 2011;25:25-39.
74. Crack PJ, Bray PJ. Toll-like receptors in the brain and their potential roles in neuropathology. Immunol Cell Biol 2007;85:476-480.
75. Garate I, Garcia-Bueno B, Madrigal JL et al. Stress-induced neuroinflammation: role of the Toll-like receptor-4 pathway. Biol Psychiatry 2013;73:32-43.
76. Caso JR, Pradillo JM, Hurtado O, Leza JC, Moro MA, Lizasoain I. Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke. Stroke 2008;39:1314-1320.
77. Wegman HL, Stetler C. A meta-analytic review of the effects of childhood abuse on medical outcomes in adulthood. Psychosom Med 2009;71:805-812.