메뉴 건너뛰기




Volumn 10, Issue 4, 2014, Pages

Protein Quantitative Trait Loci Identify Novel Candidates Modulating Cellular Response to Chemotherapy

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; PACLITAXEL; PROTEOME; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTOME; ANTINEOPLASTIC AGENT; PROTEIN;

EID: 84901334162     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004192     Document Type: Article
Times cited : (23)

References (66)
  • 1
    • 83755207567 scopus 로고    scopus 로고
    • Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation
    • Wheeler HE, Dolan ME, (2012) Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation. Pharmacogenomics 13: 55-70.
    • (2012) Pharmacogenomics , vol.13 , pp. 55-70
    • Wheeler, H.E.1    Dolan, M.E.2
  • 2
    • 84872549256 scopus 로고    scopus 로고
    • Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy
    • Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, et al. (2013) Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy. Clin Cancer Res 19: 491-499.
    • (2013) Clin Cancer Res , vol.19 , pp. 491-499
    • Wheeler, H.E.1    Gamazon, E.R.2    Wing, C.3    Njiaju, U.O.4    Njoku, C.5
  • 3
    • 80053148504 scopus 로고    scopus 로고
    • Genetic variants in cytosolic 5′-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia
    • Mitra AK, Crews KR, Pounds S, Cao X, Feldberg T, et al. (2011) Genetic variants in cytosolic 5′-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia. J Pharmacol Exp Ther 339: 9-23.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 9-23
    • Mitra, A.K.1    Crews, K.R.2    Pounds, S.3    Cao, X.4    Feldberg, T.5
  • 4
    • 79954535834 scopus 로고    scopus 로고
    • Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers
    • Ziliak D, O'Donnell PH, Im HK, Gamazon ER, Chen P, et al. (2011) Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers. Transl Res 157: 265-272.
    • (2011) Transl Res , vol.157 , pp. 265-272
    • Ziliak, D.1    O'Donnell, P.H.2    Im, H.K.3    Gamazon, E.R.4    Chen, P.5
  • 5
    • 80051689137 scopus 로고    scopus 로고
    • Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients
    • Huang RS, Johnatty SE, Gamazon ER, Im HK, Ziliak D, et al. (2011) Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients. Clin Cancer Res 17: 5490-5500.
    • (2011) Clin Cancer Res , vol.17 , pp. 5490-5500
    • Huang, R.S.1    Johnatty, S.E.2    Gamazon, E.R.3    Im, H.K.4    Ziliak, D.5
  • 6
    • 84866515205 scopus 로고    scopus 로고
    • Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study
    • Niu N, Schaid DJ, Abo RP, Kalari K, Fridley BL, et al. (2012) Genetic association with overall survival of taxane-treated lung cancer patients- a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. BMC Cancer 12: 422.
    • (2012) BMC Cancer , vol.12 , pp. 422
    • Niu, N.1    Schaid, D.J.2    Abo, R.P.3    Kalari, K.4    Fridley, B.L.5
  • 7
    • 84867542479 scopus 로고    scopus 로고
    • A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT
    • Brown CC, Havener TM, Medina MW, Auman JT, Mangravite LM, et al. (2012) A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT. Pharmacogenet Genomics 22: 796-802.
    • (2012) Pharmacogenet Genomics , vol.22 , pp. 796-802
    • Brown, C.C.1    Havener, T.M.2    Medina, M.W.3    Auman, J.T.4    Mangravite, L.M.5
  • 8
    • 84864661973 scopus 로고    scopus 로고
    • Identification of novel germline polymorphisms governing capecitabine sensitivity
    • O'Donnell PH, Stark AL, Gamazon ER, Wheeler HE, McIlwee BE, et al. (2012) Identification of novel germline polymorphisms governing capecitabine sensitivity. Cancer 118: 4063-4073.
    • (2012) Cancer , vol.118 , pp. 4063-4073
    • O'Donnell, P.H.1    Stark, A.L.2    Gamazon, E.R.3    Wheeler, H.E.4    McIlwee, B.E.5
  • 9
    • 84872934592 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
    • Wheeler HE, Gamazon ER, Stark AL, O'Donnell PH, Gorsic LK, et al. (2013) Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Pharmacogenomics J 13: 35-43.
    • (2013) Pharmacogenomics J , vol.13 , pp. 35-43
    • Wheeler, H.E.1    Gamazon, E.R.2    Stark, A.L.3    O'Donnell, P.H.4    Gorsic, L.K.5
  • 10
    • 63849194095 scopus 로고    scopus 로고
    • Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity
    • Hartford CM, Duan S, Delaney SM, Mi S, Kistner EO, et al. (2009) Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. Blood 113: 2145-2153.
    • (2009) Blood , vol.113 , pp. 2145-2153
    • Hartford, C.M.1    Duan, S.2    Delaney, S.M.3    Mi, S.4    Kistner, E.O.5
  • 11
    • 34547438105 scopus 로고    scopus 로고
    • A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity
    • Huang RS, Duan S, Bleibel WK, Kistner EO, Zhang W, et al. (2007) A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity. Proc Natl Acad Sci U S A 104: 9758-9763.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 9758-9763
    • Huang, R.S.1    Duan, S.2    Bleibel, W.K.3    Kistner, E.O.4    Zhang, W.5
  • 12
    • 42749097422 scopus 로고    scopus 로고
    • Genetic architecture of transcript-level variation in humans
    • Duan S, Huang RS, Zhang W, Bleibel WK, Roe CA, et al. (2008) Genetic architecture of transcript-level variation in humans. Am J Hum Genet 82: 1101-1113.
    • (2008) Am J Hum Genet , vol.82 , pp. 1101-1113
    • Duan, S.1    Huang, R.S.2    Zhang, W.3    Bleibel, W.K.4    Roe, C.A.5
  • 15
    • 55449112450 scopus 로고    scopus 로고
    • High-resolution mapping of expression-QTLs yields insight into human gene regulation
    • Veyrieras JB, Kudaravalli S, Kim SY, Dermitzakis ET, Gilad Y, et al. (2008) High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet 4: e1000214.
    • (2008) PLoS Genet , vol.4
    • Veyrieras, J.B.1    Kudaravalli, S.2    Kim, S.Y.3    Dermitzakis, E.T.4    Gilad, Y.5
  • 16
    • 77950460661 scopus 로고    scopus 로고
    • Understanding mechanisms underlying human gene expression variation with RNA sequencing
    • Pickrell JK, Marioni JC, Pai AA, Degner JF, Engelhardt BE, et al. (2010) Understanding mechanisms underlying human gene expression variation with RNA sequencing. Nature 464: 768-772.
    • (2010) Nature , vol.464 , pp. 768-772
    • Pickrell, J.K.1    Marioni, J.C.2    Pai, A.A.3    Degner, J.F.4    Engelhardt, B.E.5
  • 17
    • 79960688508 scopus 로고    scopus 로고
    • DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
    • Bell JT, Pai AA, Pickrell JK, Gaffney DJ, Pique-Regi R, et al. (2011) DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol 12: R10.
    • (2011) Genome Biol , vol.12
    • Bell, J.T.1    Pai, A.A.2    Pickrell, J.K.3    Gaffney, D.J.4    Pique-Regi, R.5
  • 18
    • 84868154284 scopus 로고    scopus 로고
    • The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels
    • Pai AA, Cain CE, Mizrahi-Man O, De Leon S, Lewellen N, et al. (2012) The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels. PLoS Genet 8: e1003000.
    • (2012) PLoS Genet , vol.8
    • Pai, A.A.1    Cain, C.E.2    Mizrahi-Man, O.3    De Leon, S.4    Lewellen, N.5
  • 19
    • 84857111200 scopus 로고    scopus 로고
    • DNase I sensitivity QTLs are a major determinant of human expression variation
    • Degner JF, Pai AA, Pique-Regi R, Veyrieras JB, Gaffney DJ, et al. (2012) DNase I sensitivity QTLs are a major determinant of human expression variation. Nature 482: 390-394.
    • (2012) Nature , vol.482 , pp. 390-394
    • Degner, J.F.1    Pai, A.A.2    Pique-Regi, R.3    Veyrieras, J.B.4    Gaffney, D.J.5
  • 20
    • 84862114807 scopus 로고    scopus 로고
    • Genetic architecture of microRNA expression: implications for the transcriptome and complex traits
    • Gamazon ER, Ziliak D, Im HK, LaCroix B, Park DS, et al. (2012) Genetic architecture of microRNA expression: implications for the transcriptome and complex traits. Am J Hum Genet 90: 1046-1063.
    • (2012) Am J Hum Genet , vol.90 , pp. 1046-1063
    • Gamazon, E.R.1    Ziliak, D.2    Im, H.K.3    LaCroix, B.4    Park, D.S.5
  • 21
    • 84865552982 scopus 로고    scopus 로고
    • Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death
    • Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, et al. (2012) Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Proc Natl Acad Sci U S A 109: E2343-2352.
    • (2012) Proc Natl Acad Sci U S A , vol.109
    • Ko, D.C.1    Gamazon, E.R.2    Shukla, K.P.3    Pfuetzner, R.A.4    Whittington, D.5
  • 22
    • 82255192925 scopus 로고    scopus 로고
    • Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder
    • Kato T, Hayashi-Takagi A, Toyota T, Yoshikawa T, Iwamoto K, (2011) Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder. J Hum Genet 56: 779-783.
    • (2011) J Hum Genet , vol.56 , pp. 779-783
    • Kato, T.1    Hayashi-Takagi, A.2    Toyota, T.3    Yoshikawa, T.4    Iwamoto, K.5
  • 23
    • 84865322046 scopus 로고    scopus 로고
    • Genome-wide miRNA expression profiling of human lymphoblastoid cell lines identifies tentative SSRI antidepressant response biomarkers
    • Oved K, Morag A, Pasmanik-Chor M, Oron-Karni V, Shomron N, et al. (2012) Genome-wide miRNA expression profiling of human lymphoblastoid cell lines identifies tentative SSRI antidepressant response biomarkers. Pharmacogenomics 13: 1129-1139.
    • (2012) Pharmacogenomics , vol.13 , pp. 1129-1139
    • Oved, K.1    Morag, A.2    Pasmanik-Chor, M.3    Oron-Karni, V.4    Shomron, N.5
  • 24
    • 84880609050 scopus 로고    scopus 로고
    • Sex differences in human lymphoblastoid cells sensitivities to antipsychotic drugs
    • Morag A, Oved K, Gurwitz D, (2013) Sex differences in human lymphoblastoid cells sensitivities to antipsychotic drugs. J Mol Neurosci 49: 554-558.
    • (2013) J Mol Neurosci , vol.49 , pp. 554-558
    • Morag, A.1    Oved, K.2    Gurwitz, D.3
  • 25
    • 77952697081 scopus 로고    scopus 로고
    • Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci
    • Gamazon ER, Huang RS, Cox NJ, Dolan ME, (2010) Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci. Proc Natl Acad Sci U S A 107: 9287-9292.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9287-9292
    • Gamazon, E.R.1    Huang, R.S.2    Cox, N.J.3    Dolan, M.E.4
  • 27
    • 0033016717 scopus 로고    scopus 로고
    • Correlation between protein and mRNA abundance in yeast
    • Gygi SP, Rochon Y, Franza BR, Aebersold R, (1999) Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19: 1720-1730.
    • (1999) Mol Cell Biol , vol.19 , pp. 1720-1730
    • Gygi, S.P.1    Rochon, Y.2    Franza, B.R.3    Aebersold, R.4
  • 28
    • 10744226821 scopus 로고    scopus 로고
    • Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays
    • Nishizuka S, Charboneau L, Young L, Major S, Reinhold WC, et al. (2003) Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays. Proc Natl Acad Sci U S A 100: 14229-14234.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14229-14234
    • Nishizuka, S.1    Charboneau, L.2    Young, L.3    Major, S.4    Reinhold, W.C.5
  • 29
    • 34147115178 scopus 로고    scopus 로고
    • Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study
    • Shankavaram UT, Reinhold WC, Nishizuka S, Major S, Morita D, et al. (2007) Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study. Mol Cancer Ther 6: 820-832.
    • (2007) Mol Cancer Ther , vol.6 , pp. 820-832
    • Shankavaram, U.T.1    Reinhold, W.C.2    Nishizuka, S.3    Major, S.4    Morita, D.5
  • 30
    • 77956261738 scopus 로고    scopus 로고
    • Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line
    • Vogel C, Abreu Rde S, Ko D, Le SY, Shapiro BA, et al. (2010) Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line. Mol Syst Biol 6: 400.
    • (2010) Mol Syst Biol , vol.6 , pp. 400
    • Vogel, C.1    de Abreu, R.S.2    Ko, D.3    Le, S.Y.4    Shapiro, B.A.5
  • 31
    • 70249145839 scopus 로고    scopus 로고
    • Dose-modified oral chemotherapy in the treatment of AIDS-related non-Hodgkin's lymphoma in East Africa
    • Mwanda WO, Orem J, Fu P, Banura C, Kakembo J, et al. (2009) Dose-modified oral chemotherapy in the treatment of AIDS-related non-Hodgkin's lymphoma in East Africa. J Clin Oncol 27: 3480-3488.
    • (2009) J Clin Oncol , vol.27 , pp. 3480-3488
    • Mwanda, W.O.1    Orem, J.2    Fu, P.3    Banura, C.4    Kakembo, J.5
  • 33
    • 80054752352 scopus 로고    scopus 로고
    • Targeted protein-omic methods are bridging the gap between proteomic and hypothesis-driven protein analysis approaches
    • Hause RJ, Kim HD, Leung KK, Jones RB, (2011) Targeted protein-omic methods are bridging the gap between proteomic and hypothesis-driven protein analysis approaches. Expert Rev Proteomics 8: 565-575.
    • (2011) Expert Rev Proteomics , vol.8 , pp. 565-575
    • Hause, R.J.1    Kim, H.D.2    Leung, K.K.3    Jones, R.B.4
  • 34
    • 0018568039 scopus 로고
    • Mechanism of action of cis-dichlorodiammineplatinum(II)
    • Zwelling LA, Kohn KW, (1979) Mechanism of action of cis-dichlorodiammineplatinum(II). Cancer Treat Rep 63: 1439-1444.
    • (1979) Cancer Treat Rep , vol.63 , pp. 1439-1444
    • Zwelling, L.A.1    Kohn, K.W.2
  • 37
    • 33645760938 scopus 로고    scopus 로고
    • Chemotherapeutic approaches for targeting cell death pathways
    • Ricci MS, Zong WX, (2006) Chemotherapeutic approaches for targeting cell death pathways. Oncologist 11: 342-357.
    • (2006) Oncologist , vol.11 , pp. 342-357
    • Ricci, M.S.1    Zong, W.X.2
  • 38
    • 84859185340 scopus 로고    scopus 로고
    • Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer
    • Im HK, Gamazon ER, Stark AL, Huang RS, Cox NJ, et al. (2012) Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer. PLoS Genet 8: e1002525.
    • (2012) PLoS Genet , vol.8
    • Im, H.K.1    Gamazon, E.R.2    Stark, A.L.3    Huang, R.S.4    Cox, N.J.5
  • 39
    • 41149161113 scopus 로고    scopus 로고
    • Evaluation of genetic variation contributing to differences in gene expression between populations
    • Zhang W, Duan S, Kistner EO, Bleibel WK, Huang RS, et al. (2008) Evaluation of genetic variation contributing to differences in gene expression between populations. Am J Hum Genet 82: 631-640.
    • (2008) Am J Hum Genet , vol.82 , pp. 631-640
    • Zhang, W.1    Duan, S.2    Kistner, E.O.3    Bleibel, W.K.4    Huang, R.S.5
  • 41
    • 22544457600 scopus 로고    scopus 로고
    • Death inducer obliterator protein 1 in the context of DNA regulation. Sequence analyses of distant homologues point to a novel functional role
    • Rojas AM, Sanchez-Pulido L, Futterer A, van Wely KH, Martinez AC, et al. (2005) Death inducer obliterator protein 1 in the context of DNA regulation. Sequence analyses of distant homologues point to a novel functional role. FEBS J 272: 3505-3511.
    • (2005) FEBS J , vol.272 , pp. 3505-3511
    • Rojas, A.M.1    Sanchez-Pulido, L.2    Futterer, A.3    van Wely, K.H.4    Martinez, A.C.5
  • 42
    • 84860400947 scopus 로고    scopus 로고
    • Src family kinases and paclitaxel sensitivity
    • Le XF, Bast RC Jr, (2011) Src family kinases and paclitaxel sensitivity. Cancer Biol Ther 12: 260-269.
    • (2011) Cancer Biol Ther , vol.12 , pp. 260-269
    • Le, X.F.1    Bast Jr., R.C.2
  • 43
    • 14844333242 scopus 로고    scopus 로고
    • Src inhibition enhances paclitaxel cytotoxicity in ovarian cancer cells by caspase-9-independent activation of caspase-3
    • Chen T, Pengetnze Y, Taylor CC, (2005) Src inhibition enhances paclitaxel cytotoxicity in ovarian cancer cells by caspase-9-independent activation of caspase-3. Mol Cancer Ther 4: 217-224.
    • (2005) Mol Cancer Ther , vol.4 , pp. 217-224
    • Chen, T.1    Pengetnze, Y.2    Taylor, C.C.3
  • 44
    • 0029763897 scopus 로고    scopus 로고
    • Effects of c-myc oncogene modulation on drug resistance in human small cell lung carcinoma cell lines
    • Van Waardenburg RC, Prins J, Meijer C, Uges DR, De Vries EG, et al. (1996) Effects of c-myc oncogene modulation on drug resistance in human small cell lung carcinoma cell lines. Anticancer Res 16: 1963-1970.
    • (1996) Anticancer Res , vol.16 , pp. 1963-1970
    • Van Waardenburg, R.C.1    Prins, J.2    Meijer, C.3    Uges, D.R.4    De Vries, E.G.5
  • 45
    • 0030049639 scopus 로고    scopus 로고
    • Tumour cells surviving in vivo cisplatin chemotherapy display elevated c-myc expression
    • Walker TL, White JD, Esdale WJ, Burton MA, DeCruz EE, (1996) Tumour cells surviving in vivo cisplatin chemotherapy display elevated c-myc expression. Br J Cancer 73: 610-614.
    • (1996) Br J Cancer , vol.73 , pp. 610-614
    • Walker, T.L.1    White, J.D.2    Esdale, W.J.3    Burton, M.A.4    DeCruz, E.E.5
  • 46
    • 77349109465 scopus 로고    scopus 로고
    • Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma
    • Gu F, Ma Y, Zhang Z, Zhao J, Kobayashi H, et al. (2010) Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. Oncol Rep 23: 671-676.
    • (2010) Oncol Rep , vol.23 , pp. 671-676
    • Gu, F.1    Ma, Y.2    Zhang, Z.3    Zhao, J.4    Kobayashi, H.5
  • 47
    • 16244412004 scopus 로고    scopus 로고
    • Overexpression of constitutive signal transducer and activator of transcription 3 mRNA in cisplatin-resistant human non-small cell lung cancer cells
    • Ikuta K, Takemura K, Kihara M, Nishimura M, Ueda N, et al. (2005) Overexpression of constitutive signal transducer and activator of transcription 3 mRNA in cisplatin-resistant human non-small cell lung cancer cells. Oncol Rep 13: 217-222.
    • (2005) Oncol Rep , vol.13 , pp. 217-222
    • Ikuta, K.1    Takemura, K.2    Kihara, M.3    Nishimura, M.4    Ueda, N.5
  • 48
    • 0034618521 scopus 로고    scopus 로고
    • Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells
    • Kato K, Nomoto M, Izumi H, Ise T, Nakano S, et al. (2000) Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells. Biochim Biophys Acta 1493: 91-100.
    • (2000) Biochim Biophys Acta , vol.1493 , pp. 91-100
    • Kato, K.1    Nomoto, M.2    Izumi, H.3    Ise, T.4    Nakano, S.5
  • 49
    • 84870310032 scopus 로고    scopus 로고
    • PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells
    • Su WP, Cheng FY, Shieh DB, Yeh CS, Su WC, (2012) PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells. Int J Nanomedicine 7: 4269-4283.
    • (2012) Int J Nanomedicine , vol.7 , pp. 4269-4283
    • Su, W.P.1    Cheng, F.Y.2    Shieh, D.B.3    Yeh, C.S.4    Su, W.C.5
  • 50
    • 79952224367 scopus 로고    scopus 로고
    • STAT3 Inhibition by Microtubule-Targeted Drugs: Dual Molecular Effects of Chemotherapeutic Agents
    • Walker SR, Chaudhury M, Frank DA, (2011) STAT3 Inhibition by Microtubule-Targeted Drugs: Dual Molecular Effects of Chemotherapeutic Agents. Mol Cell Pharmacol 3: 13-19.
    • (2011) Mol Cell Pharmacol , vol.3 , pp. 13-19
    • Walker, S.R.1    Chaudhury, M.2    Frank, D.A.3
  • 51
    • 53249143989 scopus 로고    scopus 로고
    • Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms
    • Wu H, Cao Y, Weng D, Xing H, Song X, et al. (2008) Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms. Cancer Lett 271: 260-271.
    • (2008) Cancer Lett , vol.271 , pp. 260-271
    • Wu, H.1    Cao, Y.2    Weng, D.3    Xing, H.4    Song, X.5
  • 52
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
    • Kim ST, Xu B, Kastan MB, (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev 16: 560-570.
    • (2002) Genes Dev , vol.16 , pp. 560-570
    • Kim, S.T.1    Xu, B.2    Kastan, M.B.3
  • 53
    • 74049092772 scopus 로고    scopus 로고
    • Spectrum and consequences of SMC1A mutations: the unexpected involvement of a core component of cohesin in human disease
    • Mannini L, Liu J, Krantz ID, Musio A, (2010) Spectrum and consequences of SMC1A mutations: the unexpected involvement of a core component of cohesin in human disease. Hum Mutat 31: 5-10.
    • (2010) Hum Mutat , vol.31 , pp. 5-10
    • Mannini, L.1    Liu, J.2    Krantz, I.D.3    Musio, A.4
  • 54
    • 40849149557 scopus 로고    scopus 로고
    • Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers
    • Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, et al. (2008) Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci U S A 105: 3443-3448.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 3443-3448
    • Barber, T.D.1    McManus, K.2    Yuen, K.W.3    Reis, M.4    Parmigiani, G.5
  • 55
    • 84355166398 scopus 로고    scopus 로고
    • SMC1A codon 496 mutations affect the cellular response to genotoxic treatments
    • Mannini L, Menga S, Tonelli A, Zanotti S, Bassi MT, et al. (2012) SMC1A codon 496 mutations affect the cellular response to genotoxic treatments. Am J Med Genet A 158A: 224-228.
    • (2012) Am J Med Genet A , vol.158 A , pp. 224-228
    • Mannini, L.1    Menga, S.2    Tonelli, A.3    Zanotti, S.4    Bassi, M.T.5
  • 56
    • 77953163141 scopus 로고    scopus 로고
    • Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib
    • Chen S, Blank JL, Peters T, Liu XJ, Rappoli DM, et al. (2010) Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib. Cancer Res 70: 4318-4326.
    • (2010) Cancer Res , vol.70 , pp. 4318-4326
    • Chen, S.1    Blank, J.L.2    Peters, T.3    Liu, X.J.4    Rappoli, D.M.5
  • 57
    • 35948959950 scopus 로고    scopus 로고
    • The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases
    • Yamaguchi H, Durell SR, Chatterjee DK, Anderson CW, Appella E, (2007) The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases. Biochemistry 46: 12594-12603.
    • (2007) Biochemistry , vol.46 , pp. 12594-12603
    • Yamaguchi, H.1    Durell, S.R.2    Chatterjee, D.K.3    Anderson, C.W.4    Appella, E.5
  • 58
    • 33745191407 scopus 로고    scopus 로고
    • ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway
    • Huang X, Yuan W, Huang W, Bai Y, Deng Y, et al. (2006) ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. Biochem Biophys Res Commun 346: 621-628.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 621-628
    • Huang, X.1    Yuan, W.2    Huang, W.3    Bai, Y.4    Deng, Y.5
  • 59
    • 80054716488 scopus 로고    scopus 로고
    • PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer
    • Zhu C, Qi X, Chen Y, Sun B, Dai Y, et al. (2011) PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer. J Cancer Res Clin Oncol 137: 1587-1594.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1587-1594
    • Zhu, C.1    Qi, X.2    Chen, Y.3    Sun, B.4    Dai, Y.5
  • 60
    • 0026300429 scopus 로고
    • Taxol: a new and effective anti-cancer drug
    • Slichenmyer WJ, Von Hoff DD, (1991) Taxol: a new and effective anti-cancer drug. Anticancer Drugs 2: 519-530.
    • (1991) Anticancer Drugs , vol.2 , pp. 519-530
    • Slichenmyer, W.J.1    Von Hoff, D.D.2
  • 61
    • 84858221025 scopus 로고    scopus 로고
    • An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers
    • Wen Y, Gamazon ER, Bleibel WK, Wing C, Mi S, et al. (2012) An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. Hum Mol Genet 21: 1470-1480.
    • (2012) Hum Mol Genet , vol.21 , pp. 1470-1480
    • Wen, Y.1    Gamazon, E.R.2    Bleibel, W.K.3    Wing, C.4    Mi, S.5
  • 62
    • 77951439152 scopus 로고    scopus 로고
    • Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS
    • Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, et al. (2010) Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet 6: e1000888.
    • (2010) PLoS Genet , vol.6
    • Nicolae, D.L.1    Gamazon, E.2    Zhang, W.3    Duan, S.4    Dolan, M.E.5
  • 64
    • 84857487802 scopus 로고    scopus 로고
    • Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression
    • Fu J, Wolfs MG, Deelen P, Westra HJ, Fehrmann RS, et al. (2012) Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet 8: e1002431.
    • (2012) PLoS Genet , vol.8
    • Fu, J.1    Wolfs, M.G.2    Deelen, P.3    Westra, H.J.4    Fehrmann, R.S.5
  • 65
    • 34548256353 scopus 로고    scopus 로고
    • Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach
    • Huang RS, Duan S, Shukla SJ, Kistner EO, Clark TA, et al. (2007) Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach. Am J Hum Genet 81: 427-437.
    • (2007) Am J Hum Genet , vol.81 , pp. 427-437
    • Huang, R.S.1    Duan, S.2    Shukla, S.J.3    Kistner, E.O.4    Clark, T.A.5
  • 66
    • 84862760137 scopus 로고    scopus 로고
    • Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel
    • Njiaju UO, Gamazon ER, Gorsic LK, Delaney SM, Wheeler HE, et al. (2012) Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel. Pharmacogenet Genomics 22: 498-507.
    • (2012) Pharmacogenet Genomics , vol.22 , pp. 498-507
    • Njiaju, U.O.1    Gamazon, E.R.2    Gorsic, L.K.3    Delaney, S.M.4    Wheeler, H.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.