Indirubin-3'-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice

Bone

Volumn 65, Issue , 2014, Pages 60-68

  Zahoor, Muhammad ^a   Cha, Pu Hyeon ^a   Choi, Kang Yell ^a  

^a Yonsei University   (South Korea)

Author keywords

Abdominal fat; Bone loss; GSK3 inhibitor; Indirubin 3' oxime; Obesity; Wnt catenin

Indexed keywords

ALKALINE PHOSPHATASE; ANTIOBESITY AGENT; BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN; COLLAGEN TYPE 1; FATTY ACID; GLYCOGEN SYNTHASE KINASE 3BETA; INDIRUBIN 3' OXIME; LITHIUM CHLORIDE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SERINE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VALPROIC ACID; WNT PROTEIN; INDIRUBIN-3'-MONOXIME; INDOLE DERIVATIVE; OXIME;

ABDOMINAL FAT; ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE MARROW CELL; BONE MASS; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; FEMUR; GENE EXPRESSION; HISTOPATHOLOGY; IN VITRO STUDY; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; OSTEOBLAST; OSTEOLYSIS; SIGNAL TRANSDUCTION; ST2 CELL LINE; STROMA CELL; TRABECULAR BONE; ANIMAL; DRUG EFFECTS; METABOLISM; WNT SIGNALING PATHWAY;

ADIPOGENESIS; ANIMALS; BETA CATENIN; CELL LINE; DIET, HIGH-FAT; GENE EXPRESSION; INDOLES; MALE; MICE; OBESITY; OSTEOGENESIS; OXIMES; WNT SIGNALING PATHWAY;

EID: 84901327250     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.05.003     Document Type: Article

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