Glycogen synthase kinase-3α/β inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage

Journal of Bone and Mineral Research

Volumn 26, Issue 4, 2011, Pages 811-821

  Gambardella, Alessandra ^a   Nagaraju, Chandan K ^a   O'Shea, Patrick J ^b   Mohanty, Sindhu T ^a   Kottam, Lucksy ^a   Pilling, James ^b   Sullivan, Michael ^b   Djerbi, Mounira ^c   Koopmann, Witte ^d   Croucher, Peter I ^a   Bellantuono, Ilaria ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c StraZeneca RandD Södertälje   (Sweden)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

bone formation; GSK 3 inhibitor; Mesenchymal stem cells; osteogenic differentiation; self renewal

Indexed keywords

AR 28; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; UNCLASSIFIED DRUG; WNT PROTEIN;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MASS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL RENEWAL; CELL TYPE; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FIBROBLAST; GENE AMPLIFICATION; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OBESITY; OSSIFICATION; OSTEOBLAST; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; TREATMENT DURATION;

ACID PHOSPHATASE; ADIPOCYTES; ALKALINE PHOSPHATASE; ANIMALS; BETA CATENIN; BONE MARROW; BONE MARROW CELLS; CALCIFICATION, PHYSIOLOGIC; CELL COUNT; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; FIBROBLASTS; GENE EXPRESSION; GLYCOGEN SYNTHASE KINASE 3; ISOENZYMES; LIPOPROTEIN LIPASE; MESENCHYMAL STEM CELLS; MICE; OSTEOBLASTS; OSTEOCALCIN; OSTEOCLASTS; OSTEOGENESIS; PPAR GAMMA; PROTEIN KINASE INHIBITORS; TIBIA;

EID: 79953042169     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.266     Document Type: Article

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