Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cells

Antiviral Research

Volumn 107, Issue 1, 2014, Pages 102-109

  Johnson, Joshua C ^a   Martinez, Osvaldo ^b,c   Honko, Anna N ^a   Hensley, Lisa E ^a,d   Olinger, Gene G ^a,d   Basler, Christopher F ^b  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c WINONA STATE UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Antigen presenting cell; Dendritic cell; Ebola virus; Entry; p38 MAPK; THP 1

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; IMIDAZOLE DERIVATIVE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; P 38INHK III; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; ENZYME INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL VIABILITY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOSE RESPONSE; EBOLA HEMORRHAGIC FEVER; EBOLA VIRUS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INTERFERON INDUCTION; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PINOCYTOSIS; PRIORITY JOURNAL; VIRUS ENTRY; VIRUS LIKE AGENT; VIRUS REPLICATION; ZAIRE EBOLAVIRUS; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; IC50; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; VIROLOGY;

CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; EBOLAVIRUS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; P38 MITOGEN-ACTIVATED PROTEIN KINASES; VIRUS INTERNALIZATION;

EID: 84901313870     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.04.014     Document Type: Article

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