The ERK mitogen-activated protein kinase pathway contributes to ebola virus glycoprotein-induced cytotoxicity

Journal of Virology

Volumn 81, Issue 3, 2007, Pages 1230-1240

  Zampieri, Carisa A ^a   Fortin, Jean Francois ^b,c   Nolan, Garry P ^b   Nabel, Gary J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GENE PRODUCT; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUCIN; SMALL INTERFERING RNA; VIRUS GLYCOPROTEIN;

ARTICLE; CELL DEATH; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; EBOLA VIRUS; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HEMORRHAGIC FEVER; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VIRUS VIRULENCE;

CELL PROLIFERATION; EBOLAVIRUS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, VIRAL; VIRAL ENVELOPE PROTEINS;

EBOLA VIRUS; PRIMATES;

EID: 33846557891     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01586-06     Document Type: Article

References (49)

1. Akula, S. M., P. W. Ford, A. G. Whitman, K. E. Hamden, J. G. Shelton, and J. A. McCubrey. 2004. Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection. Oncogene 23:5227-5241.
2. Alazard-Dany, N., V. Volchkova, O. Reynard, C. Carbonnelle, O. Dolnik, M. Ottmann, A. Khromykh, and V. E. Volchkov. 2006. Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate level. J. Gen. Virol. 87:1247-1257.
3. Aplin, A. E., B. P. Hogan, J. Tomeu, and R. L. Juliano. 2002. Cell adhesion differentially regulates the nucleocytoplasmic distribution of active MAP kinases. J. Cell Sci. 115:2781-2790.
4. Aplin, A. E., S. A. Stewart, R. K. Assoian, and R. L. Juliano. 2001. Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. J. Cell Biol. 153:273-282.
5. Assoian, R. K., and M. A. Schwartz. 2001. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr. Opin. Genet. Dev. 11:48-53.
6. Barber, S. A., L. Bruett, B. R. Douglass, D. S. Herbst, M. C. Zink, and J. E. Clements. 2002. Visna virus-induced activation of MAPK is required for virus replication and correlates with virus-induced neuropathology. J. Virol. 76:817-828.
7. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
8. Chan, S. Y., M. C. Ma, and M. A. Goldsmith. 2000. Differential induction of cellular detachment by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. J. Gen. Virol. 81:2155-2159.
9. Chan, S. Y., R. F. Speck, M. C. Ma, and M. A. Goldsmith. 2000. Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. J. Virol. 74:4933-4937.
10. Cobb, M. H., J. E. Hepler, M. Cheng, and D. Robbins. 1994. The mitogen-activated protein kinases, ERK1 and ERK2. Semin. Cancer Biol. 5:261-268.
11. Danilkovitch, A., S. Donley, A. Skeel, and E. J. Leonard. 2000. Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells. Mol. Cell. Biol. 20:2218-2227.
12. del Pozo, M. A., N. Balasubramanian, N. B. Alderson, W. B. Kiosses, A. Grande-Garcia, R. G. Anderson, and M. A. Schwartz. 2005. Phosphocaveolin-1 mediates integrin-regulated membrane domain internalization. Nat. Cell Biol. 7:901-908.
13. de Magalhaes, J. C., A. A. Andrade, P. N. Silva, L. P. Sousa, C. Ropert, P. C. Ferreira, E. G. Kroon, R. T. Gazzinelli, and C. A. Bonjardim. 2001. A mitogenic signal triggered at an early stage of vaccinia virus infection: implication of MEK/ERK and protein kinase A in virus multiplication. J. Biol. Chem. 276:38353-38360.
14. Echarri, A., and M. A. del Pozo. 2006. Caveolae internalization regulates integrin-dependent signaling pathways. Cell Cycle 5:2179-2182.
15. Eliceiri, B. P., R. Klemke, S. Stromblad, and D. A. Cheresh. 1998. Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J. Cell Biol. 140:1255-1263.
16. Fischer, A. M., C. D. Katayama, G. Pages, J. Pouyssegur, and S. M. Hedrick. 2005. The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23:431-443.
17. Gao, X., K. Ikuta, M. Tajima, and T. Sairenji. 2001. 12-O-Tetradecanoyl-phorbol-13-acetate induces Epstein-Barr virus reactivation via NF-kappaB and AP-1 as regulated by protein kinase C and mitogen-activated protein kinase. Virology 286:91-99.
18. Geisbert, T. W., H. A. Young, P. B. Jahrling, K. J. Davis, E. Kagan, and L. E. Hensley. 2003. Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event. J. Infect. Dis. 188:1618-1629.
19. Giancotti, F. G., and E. Ruoslahti. 1999. Integrin signaling. Science 285:1028-1032.
20. Hatano, N., Y. Mori, M. Oh-hora, A. Kosugi, T. Fujikawa, N. Nakai, H. Niwa, J. Miyazaki, T. Hamaoka, and M. Ogata. 2003. Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8:847-856.
21. Hinshaw, J. E. 2006. Filling the GAP for dynamin. Nat. Cell Biol. 8:432-433.
22. Howe, A. K., A. E. Aplin, and R. L. Juliano. 2002. Anchorage-dependent ERK signaling-mechanisms and consequences. Curr. Opin. Genet. Dev. 12:30-35.
23. Kiley, M. P., E. T. Bowen, G. A. Eddy, M. Isaacson, K. M. Johnson, J. B. McCormick, F. A. Murphy, S. R. Pattyn, D. Peters, O. W. Prozesky, R. L. Regnery, D. I. Simpson, W. Slenczka, P. Sureau, G. G. van der, P. A. Webb, and H. Wulff. 1982. Filoviridae: a taxonomic home for Marburg and Ebola viruses? Intervirology 18:24-32.
24. Le Gall, M., D. Grail, J. C. Chambard, J. Pouyssegur, and E. Obberghen-Schilling. 1998. An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression. Oncogene 17:1271-1277.
25. Li, Y. Q., C. S. Hii, C. J. Der, and A. Ferrante. 1999. Direct evidence that ERK regulates the production/secretion of interleukin-2 in PHA/PMA-stimulated T lymphocytes. Immunity 96:524-528.
26. Luo, H., B. Yanagawa, J. Zhang, Z. Luo, M. Zhang, M. Esfandiarei, C. Carthy, J. E. Wilson, D. Yang, and B. M. McManus. 2002. Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase signaling pathway. J. Virol. 76:3365-3373.
27. Macdonald, A., J. K. Chan, and M. Harris. 2005. Perturbation of epidermal growth factor receptor complex formation and Ras signalling in cells harbouring the hepatitis C virus subgenomic replicon. J. Gen. Virol. 86:1027-1033.
28. Montes, M., N. E. Tagieva, N. Heveker, C. Nahmias, F. Baleux, and A. Trautmann. 2000. SDF-1-induced activation of ERK enhances HIV-1 expression. Eur. Cytokine Netw. 11:470-477.
29. Pages, G., S. Guerin, D. Grall, F. Bonino, A. Smith, F. Anjuere, P. Auberger, and J. Pouyssegur. 1999. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286:1374-1377.
30. Planz, O., S. Pleschka, and S. Ludwig. 2001. MEK-specific inhibitor U0126 blocks spread of Borna disease virus in cultured cells. J. Virol. 75:4871-4877.
31. Pleschka, S., T. Wolff, C. Ehrhardt, G. Hobom, O. Planz, U. R. Rapp, and S. Ludwig. 2001. Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nat. Cell Biol. 3:301-305.
32. Robinson, M. J., S. A. Stippec, E. Goldsmith, M. A. White, and M. H. Cobb. 1998. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Curr. Biol. 8:1141-1150.
33. Rodems, S. M., and D. H. Spector. 1998. Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection. J. Virol. 72:9173-9180.
34. Roovers, K., G. Davey, X. Zhu, M. E. Bottazzi, and R. K. Assoian. 1999. Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. Mol. Biol. Cell 10:3197-3204.
35. Rvabchikova, E. I., L. V. Kolesnikova, and S. V. Netesov. 1999. Animal pathology of filoviral infections. Curr. Top. Microbiol. Immunol. 235:145-173.
36. Saba-El-Leil, M. K., F. D. Vella, B. Vernay, L. Voisin, L. Chen, N. Labrecque, S. L. Ang, and S. Meloche. 2003. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 4:964-968.
37. Sanchez, A., A. S. Khan, S. R. Zald, G. J. Nabel, T. G. Ksiazek, and C. J. Peters. 2001. Filoviridae: Marburg and Ebola viruses, p. 1279-1304. In D. M. Knipe and P. M. Howley (ed.), Fields virology. Lippincott, Williams & Wilkins, Philadelphia, PA.
38. Schwartz, M. A., and V. Baron. 1999. Interactions between mitogenic stimuli, or, a thousand and one connections. Curr. Opin. Cell Biol. 11:197-202.
39. Schwartz, M. A., and M. H. Ginsberg. 2002. Networks and crosstalk: integrin signalling spreads. Nat. Cell Biol. 4:E65-E68.
40. Simmons, G., R. J. Wool-Lewis, F. Baribaud, R. C. Netter, and P. Bates. 2002. Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence. J. Virol. 76:2518-2528.
41. Sullivan, N. J., M. Peterson, Z. Y. Yang, W. P. Kong, H. Duckers, E. Nabel, and G. J. Nabel. 2005. Ebola virus glycoprotein toxicity is mediated by a dynamin-dependent protein-trafficking pathway. J. Virol. 79:547-553.
42. Takada, A., S. Watanabe, H. Ito, K. Okazaki, H. Kida, and Y. Kawaoka. 2000. Downregulation of b1 integrins by Ebola virus glycoprotein: implication for virus entry. Virology 278:20-26.
43. Vantaggiato, C., I. Formentini, A. Bondanza, C. Bonini, L. Naldini, and R. Brambilla. 2006. ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. J. Biol. 5:14.
44. Volchkov, V. E., H. Feldmann, V. A. Volchkova, and H.-D. Klenk. 1998. Processing of the Ebola virus glycoprotein by the proprotein convertase furin. Proc. Natl. Acad. Sci. USA 95:5762-5767.
45. Wool-Lewis, R. J., and P. Bates. 1998. Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines. J. Virol. 72:3155-3160.
46. Yang, Z.-Y., R. Delgado, L. Xu, R. F. Todd, E. G. Nabel, A. Sanchez, and G. J. Nabel. 1998. Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science 279:1034-1037.
47. Yang, Z.-Y., H. J. Duckers, N. J. Sullivan, A. Sanchez, E. G. Nabel, and G. J. Nabel. 2000. Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury. Nat. Med. 6:886-889.
48. Yoon, S., and R. Seger. 2006. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24:21-44.
49. Yoshizuka, N., Y. Yoshizuka-Chadani, V. Krishnan, and S. L. Zeichner. 2005. Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway. J. Virol. 79:11366-11381.