A cell-based biosensor system HepG2CDKN1A-DsRed for rapid and simple detection of genotoxic agents

Biosensors and Bioelectronics

Volumn 61, Issue , 2014, Pages 102-111

  Blagus, Tanja ^a   Zager, Valerija ^a   Cemazar, Maja ^a,b   Sersa, Gregor ^a   Kamensek, Urska ^a   Zegura, Bojana ^c   Nunic, Jana ^c   Filipic, Metka ^c  

^a INSTITUTE OF ONCOLOGY   (Slovenia)

^b UNIVERSITY OF PRIMORSKA   (Slovenia)

^c NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

Author keywords

CDKN1A promoter; DsRed reporter protein; Genotoxicity; Spectrofluorimetry; Whole cell biosensor system

Indexed keywords

ASSAYS; DIAGNOSIS; GENES; MOLECULAR BIOLOGY; PROTEINS;

CDKN1A PROMOTER; GENOTOXICITIES; REPORTER PROTEIN; SPECTROFLUORIMETRY; WHOLE-CELL BIOSENSORS;

BIOSENSORS;

CYCLIN DEPENDENT KINASE INHIBITOR 1A; FLUORESCENT PROTEIN 583; MUTAGENIC AGENT; PHOTOPROTEIN;

CYTOLOGY; DEVICES; DRUG EFFECTS; FLUOROMETRY; GENETIC PROCEDURES; GENETICS; HEPG2 CELL LINE; HUMAN; METABOLISM; MUTAGEN TESTING; PROMOTER REGION; TOXICITY;

BIOSENSING TECHNIQUES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FLUOROMETRY; HEP G2 CELLS; HUMANS; LUMINESCENT PROTEINS; MUTAGENICITY TESTS; MUTAGENS; PROMOTER REGIONS, GENETIC;

EID: 84901311454     PISSN: 09565663     EISSN: 18734235     Source Type: Journal    
DOI: 10.1016/j.bios.2014.05.002     Document Type: Article

References (57)

1. Afanassiev V., Sefton M., Anantachaiyong T., Barker G., Walmsley R., Wolfl S. Mutat. Res.: Genet. Toxicol. Environ. 2000, 464:297-308.
2. Ahn J.M., Gu M.B. Appl. Biochem. Biotechnol. 2012, 168:752-760.
3. Beranek D.T. Mutat. Res. 1990, 231:11-30.
4. Beyersmann D., Hartwig A. Arch. Toxicol. 2008, 82:493-512.
5. Billinton N., Barker M.G., Michel C.E., Knight A.W., Heyer W.D., Goddard N.J., Fielden P.R., Walmsley R.M. Biosens. Bioelectron. 1998, 13:831-838.
6. Billinton N., Knight A.W. Anal. Biochem. 2001, 291:175-197.
7. Biran A., Yagur-Kroll S., Pedahzur R., Buchinger S., Reifferscheid G., Ben-Yoav H., Shacham-Diamand Y., Belkin S. Microbiol. Biotechnol. 2010, 3:412-427.
8. Birrell L., Cahill P., Hughes C., Tate M., Walmsley R.M. Mutat. Res.: Genet. Toxicol. Environ. 2010, 695:87-95.
9. Bressac B., Galvin K.M., Liang T.J., Isselbacher K.J., Wands J.R., Ozturk M. Proc. Natl. Acad. Sci. USA 1990, 87:1973-1977.
10. Corda Y., Job C., Anin M.F., Leng M., Job D. Biochemistry 1993, 32:8582-8588.
11. CCRIS, 2014. US National Library of Medicine Toxicology Data Network (TOXNET), Chemical Carcinogenesis Research Information System. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen? CCRIS (accessed January 2014.). http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?
12. EFSA A.N.S.Panel (EFSA Panel on Food Additives and Nutrient Sources Added to Food) EFSA J. 3407 2013, 11(10):52.
13. Elad T., Belkin S. Water Res. 2013, 47:3782-3790.
14. Elespuru R.K., Agarwal R., Atrakchi A.H., Bigger C.A.H., Heflich R.H., Jagannath D.R., Levy D.D., Moore M.M., Ouyang Y.L., Robison T.W., Sotomayor R.E., Cimino M.C., Dearfield K.L. Toxicol. Sci. 2009, 109:172-179.
15. Ellinger-Ziegelbauer H., Stuart B., Wahle B., Bomann W., Ahr H.J. Mutat. Res.: Fundam. Mol. Mech. 2005, 575:61-84.
16. Fabarius A., Giehl M., Frank O., Spiess B., Zheng C., Muller M.C., Weiss C., Duesberg P., Hehlmann R., Hochhaus A., Seifarth W. Brit. J. Haematol. 2007, 138:369-373.
17. Fatur T., Tusek M., Falnoga I., Scancar J., Lah T.T., Filipic M. Food Chem. Toxicol. 2002, 40:1069-1076.
18. Filipic M. Mutat. Res.: Fundam. Mol. Mech. 2012, 733:69-77.
19. GENETOX, 2014. US National Library of Medicine Toxicology Data Network (TOXNET) Chemical Carcinogenesis Research Information System. http://toxnet.nlm.nih.gov/cgi-bin/sis/search (accessed January 2014.). http://toxnet.nlm.nih.gov/cgi-bin/sis/search.
20. Hastwell P.W., Chai L.L., Roberts K.J., Webster T.W., Harvey J.S., Rees R.W., Walmsley R.M. Mutat. Res.: Genet. Toxicol. Environ. 2006, 607:160-175.
21. Hreljac I., Zajc I., Lah T., Filipic M. Environ. Mol. Mutagen. 2008, 49:360-367.
22. ICH, 2011 Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use. S2(R1). http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S2_R1/Step4/S2R1_Step4.pdf (accessed January 2014.). http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S2_R1/Step4/S2R1_Step4.pdf.
23. Jaiswal A.S., Narayan S. Mutat. Res. 2002, 500:17-30.
24. Jakobs S., Subramaniam V., Schonle A., Jovin T.M., Hell S.W. FEBS Lett. 2000, 479:131-135.
25. Kamensek U., Sersa G., Vidic S., Tevz G., Kranjc S., Cemazar M. Mol. Imaging Biol. 2011, 13:43-52.
26. Kirkland D., Aardema M., Henderson L., Muller L. Mutat. Res.: Genet. Toxicol. Environ. 2005, 584:1-256.
27. Kirkland D., Kasper P., Muller L., Corvi R., Speit G. Mutat. Res.: Genet. Toxicol. Environ. 2008, 653:99-108.
28. Kirkland D., Reeve L., Gatehouse D., Vanparys P. Mutat. Res.: Genet. Toxicol. Environ. 2011, 721:27-73.
29. Knasmuller S., Mersch-Sundermann V., Kevekordes S., Darroudi F., Huber W.W., Hoelzl C., Bichler J., Majer B.J. Toxicology 2004, 198:315-328.
30. Kolomeichuk S.N., Bene A., Upreti M., Dennis R.A., Lyle C.S., Rajasekaran M., Chambers T.C. Mol. Pharmacol. 2008, 73:128-136.
31. Liu X., Kramer J.A., Hu Y., Schmidt J.M., Jiang J., Wilson A.G. Int. J. Toxicol. 2009, 28:162-176.
32. Melamed S., Elad T., Belkin S. Curr. Opin. Biotechnol. 2012, 23:2-8.
33. Mizota T., Ohno K., Yamada T. Mutat. Res.: Genet. Toxicol. Environ. 2011, 724:76-85.
34. Moldovan G.L., Pfander B., Jentsch S. Cell 2007, 129:665-679.
35. Ohno K., Tanaka-Azuma Y., Yoneda Y., Yamada T. Mutat. Res.: Genet. Toxicol. Environ. 2005, 588:47-57.
36. Ohno K., Ishihata K., Tanaka-Azuma Y., Yamada T. Mutat. Res.: Genet. Toxicol. Environ. 2008, 656:27-35.
37. Owais W.M., Kleinhofs A. Mutat. Res. 1988, 197:313-323.
38. Owellen R.J., Hartke C.A., Dickerson R.M., Hains F.O. Cancer Res. 1976, 36:1499-1502.
39. Pabla N., Huang S., Mi Q.S., Daniel R., Dong Z. J. Biol. Chem. 2008, 283:6572-6583.
40. Perlow R.A., Kolbanovskii A., Hingerty B.E., Geacintov N.E., Broyde S., Scicchitano D.A. J. Mol. Biol. 2002, 321:29-47.
41. Petkovic J., Zegura B., Stevanovic M., Drnovsek N., Uskokovic D., Novak S., Filipic M. Nanotoxicology 2011, 5:341-353.
42. Pezdirc M., Zegura B., Filipic M. Food Chem. Toxicol. 2013, 59:386-394.
43. Pichler C., Filipic M., Kundi M., Rainer B., Knasmueller S., Misik M. Chemosphere 2014, in press. http://dx.doi.org/10.1016/j.chemosphere.2014.01.010.
44. Plazar J., Zegura B., Lah T.T., Filipic M. Mutat. Res.: Genet. Toxicol. Environ. 2007, 632:1-8.
45. Sadikovic B., Rodenhiser D.I. Toxicol. Appl. Pharmacol. 2006, 216:458-468.
46. Schindelin J., Arganda-Carreras I., Frise E., Kaynig V., Longair M., Pietzsch T., Preibisch S., Rueden C., Saalfeld S., Schmid B., Tinevez J.Y., White D.J., Hartenstein V., Eliceiri K., Tomancak P., Cardona A. Nat. Methods 2012, 9:676-682.
47. Straser A., Filipic M., Zegura B. Arch. Toxicol. 2011, 85:1617-1626.
48. Tishler R.B., Lamppu D.M., Park S., Price B.D. Cancer Res. 1995, 55:6021-6025.
49. Towhidi L., Firoozabadi S.M., Mozdarani H., Miklavcic D. Radiol. Oncol. 2012, 46:119-125.
50. Vogelstein B., Lane D., Levine A.J. Nature 2000, 408:307-310.
51. Van Delft J.H.M., van Agen E., van Breda S.G.J., Herwijnen M.H., Staal Y.C.M., Kleinjans J.C.S. Carcinogenesis 2004, 25:1265-1276.
52. Walmsley R.M., Billinton N., Heyer W.D. Yeast 1997, 13:1535-1545.
53. Westerink W.M.A., Stevenson J.C.R., Horbach G.J., Schoonen W. Mutat. Res.: Genet. Toxicol. Environ. 2010, 696:21-40.
54. Zager V., Cemazar M., Hreljac I., Lah T.T., Sersa G., Filipic M. Radiol. Oncol. 2010, 44:42-51.
55. Zegura B., Zajc I., Lah T.T., Filipic M. Toxicon 2008, 51:615-623.
56. Zegura B., Straser A., Filipic M. Mutat. Res. Rev. Mutat. 2011, 727:16-41.
57. Zhang R., Niu Y.J., Do H.R., Cao X.W., Shi D., Hao Q.L., Zhou Y.L. Toxicol. in vitro 2009, 23:158-165.