Genotoxicity test system based on p53R2 gene expression in human cells: Examination with 80 chemicals

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 588, Issue 1, 2005, Pages 47-57

  Ohno, Katsutoshi ^a   Tanaka Azuma, Yukimasa ^a   Yoneda, Yukio ^a   Yamada, Toshihiro ^a  

^a Shiga 525 0055   (Japan)

Author keywords

Ames test; Genotoxicity; Luciferase reporter gene assay; p53; p53R2

Indexed keywords

6 CHLORO 9 [3 (2 CHLOROETHYL)AMINOPROPYLAMINO] 2 METHOXYACRIDINE; ACETONE; ALCOHOL; ANILINE; ATROPINE; BENZOIC ACID; BLEOMYCIN; CAFFEINE; CHLORAMPHENICOL; CHLOROFORM; CISPLATIN; DAUNORUBICIN; DOXORUBICIN; FLUOROURACIL; FORMALDEHYDE; LUCIFERASE; MANNITOL; MENTHOL; NAPHTHALENE; PROPANOL; PROTEIN P53; QUERCETIN; RESORCINOL; RIBONUCLEOTIDE REDUCTASE; STREPTOZOCIN; THIOUREA; TOLUENE; UNINDEXED DRUG; URETHAN; XYLENE;

AMES TEST; ARTICLE; BIOASSAY; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; GAMMA RADIATION; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; LUMINESCENCE; MAMMAL CELL; PRIORITY JOURNAL; REPORTER GENE; SCREENING TEST; TOXICITY TESTING; ULTRAVIOLET RADIATION; WILD TYPE;

DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, P53; GENES, REPORTER; HUMANS; LUCIFERASES; MUTAGENICITY TESTS; RIBONUCLEOTIDE REDUCTASES; TUMOR CELLS, CULTURED;

MAMMALIA; MINK CELL FOCUS-FORMING VIRUS;

EID: 27744581861     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2005.09.002     Document Type: Article

References (64)

1. B.N. Ames, F.D. Lee, and W.E. Durston An improved bacterial test system for the detection and classification of mutagens andcarcinogens Proc. Natl. Aca. Sci. U.S.A. 70 1973 782 786
2. P. Quillardet, O. Huisman, R. d'Ari, and M. Hofung SOS-Chromotest, a direct assay of induction of a SOS function in Escherichia coli K-12 to measure genotoxicity Proc. Natl. Acad. Sci. U.S.A. 79 1982 5971 5975
3. S. Muto, H. Baba, and Y. Uno Evaluation of the Vitotox™ test as a high-throughput genotoxicity assay Environ. Mutagen. Res. 25 2003 69 75
4. Y. Oda, S. Nakamura, T. Shimada, I. Oki, T. Kato, and H. Shinagawa Evaluation of the new system (umu-test) for the detection of environmental mutagens and Mutat. Res. 147 1985 219 229
5. S.M. Galloway, A.D. Bloom, M. Resnick, B.H. Margolin, F. Nakamura, P. Archer, and E. Zeiger Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories Environ. Mutagen. 7 1985 1 51
6. D. Clive, and J.F.S. Spector Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells Mutat. Res. 31 1975 17 29
7. N.P. Singh, M.T. McCoy, R.R. Tice, and E.L. Schneider A simple technique for quantitation of low levels of DNA damage in individual cells Exp. Cell Res. 175 1988 184 191
8. W.S. El-Deiry, S.E. Kern, J.A. Pietenpol, K.W. Kinzler, and B. Vogelstein Human genomic DNA sequences define a consensus DNA binding site for p53 Nat. Genet. 1 1992 45 49
9. A.J. Levine p53, the cellular gatekeeper for growth and division Cell 88 1997 323 331
10. Y. Nakamura Isolation of p53-target genes and their functional analysis Cancer Sci. 95 2004 7 11
11. W.D. Funk, D.T. Pak, R.H. Karas, W.E. Wright, and J.W. Shay A transcriptionally active DNA-binding site for human p53 protein complexes Mol. Cell. Biol. 12 1992 2866 2871
12. Y. Wang, J.F. Schwedes, D. Parks, K. Mann, and P. Tegtmeyer Interactions of p53 with its consensus DNA-binding site Mol. Cell. Biol. 15 1995 2157 2165
13. K. Sakaguchi, J. Herrera, S. Saito, T. Miki, M. Bustin, A. Vassilev, C. Anderson, and E. Appella DNA damage activates p53 through a phosphorylation- acetylation cascade Genes Dev. 12 1998 2831 2841
14. N. Lakin, and S. Jackson Regulation of p53 in response to DNA damage Oncogene 18 1999 7644 7655
15. W.S. el-Deiry, T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, W.E. Mercer, K.W. Kinzler, and B. Vogelstein WAF1, a potential mediator of p53 tumor suppression Cell 75 1993 817 825
16. H. Tanaka, H. Arakawa, T. Yamaguchi, K. Shiraishi, S. Fukuda, K. Matsui, Y. Takei, and Y. Nakamura A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage Nature 404 2000 42 49
17. O. Guittet, P. Hakansson, N. Voevodskaya, S. Fridd, A. Graslund, H. Arakawa, Y. Nakamura, and L. Thelander Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells J. Biol. Chem. 276 2001 40647 40653
18. K. Oda, H. Arakawa, T. Tanaka, K. Matsuda, C. Tanikawa, T. Mori, H. Nishimori, K. Tamai, T. Tokino, Y. Nakamura, and Y. Taya P53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 Cell 102 2000 849 862
19. E.C. Thornborrow, S. Patel, A.E. Mastropietro, E.M. Schwartzfarb, and J.J. Manfredi A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes Oncogene 21 2002 990 999
20. K. Sumida, N. Ooe, H. Nagahori, K. Saito, N. Isobe, H. Kaneko, and I. Nakatsuka An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes Biochem. Biophys. Res. Commun. 280 2001 85 91
21. A. Hartmann, A. Elhajouji, E. Kiskinis, F. Poetter, H.J. Martus, A. Fjallman, W. Frieauff, and W. Suter Use of alkaline comet assay for industrial genotoxicity screening: comparative investigation with the micronucleus test Food Chem. Toxicol. 39 2001 843 858
22. C. Cullinane, S.M. Cutts, A. vanRosmalen, and D.R. Phillips Formation of adriamycin-DNA adducts in vitro Nucleic Acids Res. 22 1994 2296 2303
23. S.M. Zeman, D.R. Phillips, and D.M. Crothers Characterization of covalent adriamycin-DNA adducts Proc. Natl. Acad. Sci. U.S.A. 95 1997 11561 11565
24. 20 J. Biol. Chem. 276 2001 39115 39122
25. J. McCann, E. Choi, E. Yamasaki, and B.N. Ames Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals Proc. Nat. Acad. Sci. U.S.A. 72 1975 5135 5139
26. F.K. Zimmermann, R.C. von Borstel, E.S. von Halle, J.M. Parry, D. Siebert, G. Zetterberg, R. Barale, and N. Loprieno Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U.S. Environmental Protection Agency Gene-Tox Program Mutat. Res. 133 1984 199 244
27. K.H. Mavournin, D.H. Blakey, M.C. Cimino, M.F. Salamone, and J.A. Heddle The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program Mutat. Res. 239 1990 29 80
28. E. Dybing, E.J. Soederlund, W.P. Gordon, J.A. Holme, T. Christensen, G. Becher, E. Riverdal, and S.S. Thorgeirsson Studies on the mechanism of acetamide hepatocarcinogenicity Pharmacol. Toxicol. 60 1987 9 16
29. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, International Agency for Research on Cancer, Lyon, France.
30. A.G. Knaap, P.G. Kramers, C.E. Voogd, W.G. Bergkamp, M.G. Groot, P.G. Langebroek, H.C. Mout, J.J. van der Stel, and H.W. Verharen Mutagenic activity of acrylamide in eukaryotic systems but not in bacteria Mutagenesis 3 1988 263 268
31. National Toxicology Program (NTP) Study Data, the U.S. Department of Health and Human Services, the National Institutes of Health's National Institute of Environmental Health Sciences (NIEHS) Research Triangle Park, NC.
32. K.A. Johnson, S.J. Gorzinski, K.M. Bodner, R.A. Campbell, C.H. Wolf, M.A. friedman, and R.W. Mast Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats Toxicol. Appl. Pharmacol. 85 1986 154 168
33. E. Zeiger, B. Anderson, S. Haworth, T. Lawlor, K. Mortelmans, and W. Speck Salmonella mutagenicity tests. III. Results from the testing of 255 chemicals Environ. Mol. Mutagen. 9 Suppl. 9 1987 1 110
34. Y.F. Sasaki, F. Izumiyama, E. Nishidate, N. Matsusaka, and S. Tsuda Detection of rodent liver carcinogen genotoxicity by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) Mutat. Res. 391 1997 201 214
35. A. Ozaki, M. Kitano, N. Itoh, K. Kuroda, N. Furusawa, T. Matsuda, and H. Yamaguchi Mutagenicity and DNA-damaging activity of decomposed products of food colours under UV irradiation Food Chem. Toxicol. 36 1998 811 817
36. J.P. Brown, G.W. Roehm, and R.J. Brown Mutagenicity testing of certified food colours and related azo, xanthene and triphenylmethane dyes with the Salmonella/microsome system Mutat. Res. 56 1978 249 271
37. K.H. Mavournin, D.H. Blakey, M.C. Cimino, M.F. Salamone, and J.A. Heddle The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program Mutat. Res. 239 1990 29 80
38. H.L. Hesselbach, and R.W. O'ara Fast green- and light green-induced tumors. Induction, morphology, and effect on host J. Natl. Cancer Inst. 24 1960 769 793
39. D. Clive, R. McCuen, J.F. Spector, C. Piper, and K.H. Mavournin Specific gene mutations in L5178Y cells in culture Mutat. Res. 115 1983 225 251
40. D.B. McGregor, A.G. Brown, S. Howgate, D. McBride, C. Riach, and W.J. Caspary Response of the L5178Y mouse lymphoma cell forward mutation assay. V. 27 coded chemicals Environ. Mol. Mutagen. 17 1991 196 219
41. M.O. Bradley, B. Bhuyan, M.C. Francis, R. Langenbach, A. Peterson, and E. Huberman Mutagenesis by chemical agents in V79 chinese hamster cells: a review and analysis of the literature. A report of the Gene-Tox Program Mutat. Res. 87 1981 81 142
42. M. Nakajima, M. Iwanari, and T. Yokoi Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells Toxicol. Lett. 30 2003 247 256
43. D.W. Kufe, and P.P. Major 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity J. Biol. Chem. 256 1981 9802 9805
44. D.B. Longley, J. Boyer, W.L. Allen, T. Latif, P.R. Ferguson, P.J. Maxwell, U. McDermott, M. Lynch, D.P. Harkin, and P.G. Johnston The role of thymidylate synthase induction in modulating p53-reulated gene expression in response to 5-fluorouracil and antifolates Cancer Res. 62 2002 2644 2649
45. S. Nesnow, M. Argus, H. Bergman, K. Chu, C. Frith, T. Helmes, R. McGaughy, V. Ray, T.J. Slaga, and R. Tennant Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox carcinogen data base. A report of the U.S. Environmental Protection Agency Gene-Tox Program Mutat. Res. 185 1987 1 195
46. J.P. Brown, and R.J. Brown Mutagenesis by 9,10-anthraquinone derivatives and related compounds in Salmonella typhimurium Mutat. Res. 40 1976 203 224
47. D.A. Levin, M. Hollstein, M.F. Christman, E.A. Schwiers, and B.N. Ames A new Salmonella tester strain (TA102) with AT base pairs at the site of mutation detects oxidative mutagens Proc. Natl. Acad. Sci. U.S.A. 79 1982 7445 7449
48. T. Kada, and M. Ishidate Environmental Mutagens Data Book 1981 SCIENTIST INC Tokyo
49. L.D. Kier, D.J. Brusick, A.E. Auletta, E.S. Von Halle, M.M. Brown, V.F. Simmon, V. Dunkel, J. McCann, K. Mortelmans, M. Prival, T.K. Rao, and V. Ray The Salmonella typhimurium/mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program Mutat. Res. 168 1986 69 240
50. H. Tokiwa, R. Nakagawa, and Y. Ohnishi Mutagenic assay of aromatic nitrocompounds with Salmonella typhimurium Mutat. Res. 91 1981 321 325
51. H.S. Rosenkranz, D.K. Kiriazides, and R. Mermelstein Isolation, identification and reduction of mutagenic impurities in carbon black and toners Science 209 1980 1039 1043
52. C. Smith, V. Payne, D.J. Doolittle, A.K. Debnath, T. Lawlor, and C. Hansch Mutagenic activity of a series of synthetic and naturally occurring heterocyclic amines in Salmonella Mutat. Res. 279 1992 61 73
53. S.J. Rinks, and M.S. Legator Chemical characterization of 465 known or suspected carcinogens and their correlation with mutagenic activity in the Salmonella typhimurium system Cancer Res. 39 1979 3289 3318
54. T. Sugimura Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process Mutat. Res. 150 1985 33 41
55. H. Uehleke, T. Werner, H. Greim, and M. Kramer Metabolic activation of haloalkanes and tests in vitro for mutagenicity Xenobiotica 7 1977 393 400
56. J. Ashby, F.J. de Serres, M. Draper, M. Ishidate, B.H. Margolin, and B.E. Matter M. program on chemical safety's collaborative study on in vitro assays, in: Progress in Mutation Research vol. 5 1985 Elsevier Amsterdam 752
57. Z. Kowalski, E. Spiechowicz, and B. Baranski Absence of mutagenicity of trioxane and dioxolane in Salmonella typhimurium Mutat. Res. 136 1984 169 171
58. Y. Seino, M. Nagao, T. Yahagi, A. Hoshino, T. Kawachi, and T. Sugimura Mutagenicity of several classes of antitumor agents to Salmonella typhimurium TA98, TA100, and TA92 Cancer Res. 38 1978 2148 2156
59. S. Haworth, T. Lawlor, K. Mortelmans, W. Speck, and E. Zeiger Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Suppl. 1 1983 3 142
60. B.J. Dean Genetic toxicology of benzene, toluene, xylene, and phenols Mutat. Res. 47 1978 75 97
61. R.S. Baker, G.A. Mitchell, K.M. Meher-Homji, and E. Podobna Sensitivity of two chinese hamster cell lines to SCE induction by a variety of chemical mutagens Mutat. Res. 118 1993 103 116
62. K. Toyoda, M. Shibutani, H. Sato, C. Uneyama, M. Takahashi, Y. Hayashi, and M. Hirose Lack of carcinogenicity and increased survival in F344 rats treated with 5-fluorouracil for two years Food Chem. Toxicol. 38 2000 187 193
63. J.D. Tucker, A. Auletta, M.C. Cimino, K.L. Dearfield, D. Jacobson-Kram, R.R. Tice, and A.V. Carrano Sister-chromatid exchange: second report of the Gene-Tox Program Mutat. Res. 297 1993 101 180
64. L.A. Malley, T.W. Slone Jr., C. Van Pelt, G.S. Elliott, P.E. Ross, J.C. Stadler, and G.L. Kennedy Jr. Chronic toxicity/oncogenicity of dimethylformamide in rats and mice following inhalation exposure Fundam. Appl. Toxicol. 23 1994 268 279