Assessment of genotoxicity and acute toxic effect of the imatinib mesylate in plant bioassays

Chemosphere

Volumn 115, Issue 1, 2014, Pages 54-58

  Pichler, Clemens ^a   Filipič, Metka ^b   Kundi, Michael ^a   Rainer, Bernhard ^a   Knasmueller, Siegfried ^a   Mišík, Miroslav ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

Author keywords

Allium; Imatinib; Micronucleus; Pollen abortion; Root growth; Tradescantia

Indexed keywords

BIOASSAY; CELL PROLIFERATION; COMMERCE; HEAVY METALS; INDUSTRIAL POISONS;

ALLIUM; IMATINIB; MICRONUCLEUS; POLLEN ABORTION; ROOT GROWTH; TRADESCANTIA;

PLANTS (BOTANY);

IMATINIB; BENZAMIDE DERIVATIVE; MUTAGENIC AGENT; PIPERAZINE DERIVATIVE; POLLUTANT; PYRIMIDINE DERIVATIVE;

ASSESSMENT METHOD; BIOASSAY; CONCENTRATION (COMPOSITION); DRUG; ECOTOXICOLOGY; GENOTOXICITY; HERB; POLLUTION EFFECT;

ACUTE TOXICITY; ARABIDOPSIS THALIANA; ARTICLE; BIOASSAY; CELL DIVISION; CELL GROWTH; CENTROSOME; CHELIDONIUM; CHROMOSOME BREAKAGE; CONTROLLED STUDY; FERTILITY; FIBROBLAST CULTURE; GENOTOXICITY; MICRONUCLEUS; NONHUMAN; ONION; PHYTOTOXICITY; PLANT; PLANT CELL; PLANT CELL CULTURE; PLANT CHROMOSOME; PLANT ROOT; POLLEN; ROOT GROWTH; TRADESCANTIA; TRADESCANTIA PALLUDOSA; VASCULAR PLANT; ALLIUM; ARABIDOPSIS; DNA DAMAGE; DRUG EFFECTS; MERISTEM; MICRONUCLEUS TEST; PHYSIOLOGY; PLANT PHYSIOLOGY; POLLUTANT; TOXICITY;

EUROPE;

ALLIUM; ALLIUM CEPA; ARABIDOPSIS THALIANA; CHELIDONIUM MAJUS; EMBRYOPHYTA; TRADESCANTIA;

ALLIUM; ARABIDOPSIS; BENZAMIDES; DNA DAMAGE; ENVIRONMENTAL POLLUTANTS; MERISTEM; MICRONUCLEUS TESTS; MUTAGENS; ONIONS; PIPERAZINES; PLANT PHYSIOLOGICAL PHENOMENA; PLANT ROOTS; PLANTS; POLLEN; PYRIMIDINES; TRADESCANTIA;

EID: 84921644707     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2014.01.010     Document Type: Article

References (28)

1. Besse J.P., Latour J.F., Garric J. Anticancer drugs in surface waters: what can we say about the occurrence and environmental significance of cytotoxic, cytostatic and endocrine therapy drugs?. Environ. Int. 2012, 39:73-86.
2. Bickham J.W., Sandhu S., Hebert P.D., Chikhi L., Athwal R. Effects of chemical contaminants on genetic diversity in natural populations: implications for biomonitoring and ecotoxicology. Mutat. Res. 2000, 463:33-51.
3. Calzoni G.L., Antognoni F., Pari E., Fonti P., Gnes A., Speranza A. Active biomonitoring of heavy metal pollution using Rosa rugosa plants. Environ. Pollut. 2007, 149:239-245.
4. Carneiro M.F.H., Ribeiro F.Q., Fernandes-Filho F.N., Lobo D.J.A., Barbosa F., Rhoden C.R., Mauad T., Saldiva P.H.N., Carvalho-Oliveira R. Pollen abortion rates, nitrogen dioxide by passive diffusive tubes and bioaccumulation in tree barks are effective in the characterization of air pollution. Environ. Exp. Bot. 2011, 72:272-277.
5. Cohen M.H., Williams G., Johnson J.R., Duan J., Gobburu J., Rahman A., Benson K., Leighton J., Kim S.K., Wood R., Rothmann M., Chen G., U K.M., Staten A.M., Pazdur R Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin. Cancer. Res. 2002, 8:935-942.
6. Fabarius A., Giehl M., Frank O., Duesberg P., Hochhaus A., Hehlmann R., Seifarth W. Induction of centrosome and chromosome aberrations by imatinib in vitro. Leukemia 2005, 19:1573-1578.
7. Fabarius A., Giehl M., Frank O., Spiess B., Zheng C., Muller M.C., Weiss C., Duesberg P., Hehlmann R., Hochhaus A., Seifarth W. Centrosome aberrations after nilotinib and imatinib treatment in vitro are associated with mitotic spindle defects and genetic instability. Br. J. Haematol. 2007, 138:369-373.
8. Fiskesjo G. Allium test. Methods Mol. Biol. 1995, 43:119-127.
9. Johnson J.R., Bross P., Cohen M., Rothmann M., Chen G., Zajicek A., Gobburu J., Rahman A., Staten A., Pazdur R. Approval summary: imatinib mesylate capsules for treatment of adult patients with newly diagnosed philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Clin. Cancer. Res. 2003, 9:1972-1979.
10. Kümmer, K., Schuster, A., Haiss, A., Günther, A., Jacobs, J., Mohring, S., Hamsher, G., Simon, D., 2009. Umweltrisikobewertung von Zytostatika. In: Umweltbundesamt, f., UBA-FB001256 (Ed.), Dessau-Roßlau.
11. Leme D.M., Marin-Morales M.A. Allium cepa test in environmental monitoring: a review on its application. Mutat. Res. 2009, 682:71-81.
12. Ma T.H., Cabrera G.L., Chen R., Gill B.S., Sandhu S.S., Vandenberg A.L., Salamone M.F. Tradescantia micronucleus bioassay. Mutat. Res. 1994, 310:221-230.
13. Ma T.H., Xu Z., Xu C., McConnell H., Rabago E.V., Arreola G.A., Zhang H. The improved Allium/Vicia root tip micronucleus assay for clastogenicity of environmental pollutants. Mutat. Res. 1995, 334:185-195.
14. Majer B.J., Tscherko D., Paschke A., Wennrich R., Kundi M., Kandeler E., Knasmuller S. Effects of heavy metal contamination of soils on micronucleus induction in Tradescantia and on microbial enzyme activities: a comparative investigation. Mutat. Res. 2002, 515:111-124.
15. Mazzeo D.E., Fernandes T.C., Marin-Morales M.A. Cellular damages in the Allium cepa test system, caused by BTEX mixture prior and after biodegradation process. Chemosphere 2011, 85:13-18.
16. Medina M.H., Correa J.A., Barata C. Micro-evolution due to pollution: possible consequences for ecosystem responses to toxic stress. Chemosphere 2007, 67:2105-2114.
17. Mičieta K., Murin G. Retrospective biomonitoring: a 100year of environmental pollution at selected areas in Slovakia. J. Environ. Pathol. Toxicol. Oncol. 1999, 18:335-338.
18. Mičieta K., Murin G. Wild plant species in practical use for bioindication of polluted environment. Ekologia (Bratisl.) 1997, 16:193-202.
19. Mičieta K., Murín G. Microspore analysis for genotoxicity of a polluted environment. Environ. Exp. Bot. 1996, 36:21-27.
20. Misik M., Ma T.H., Nersesyan A., Monarca S., Kim J.K., Knasmueller S. Micronucleus assays with Tradescantia pollen tetrads: an update. Mutagenesis 2011, 26:215-221.
21. Murali Achary V.M., Panda B.B. Aluminium-induced DNA damage and adaptive response to genotoxic stress in plant cells are mediated through reactive oxygen intermediates. Mutagenesis 2010, 25:201-209.
22. Negreira N., Lopez de Alda M., Barcelo D. On-line solid phase extraction-liquid chromatography-tandem mass spectrometry for the determination of 17 cytostatics and metabolites in waste, surface and ground water samples. J. Chromatogr. A 2013, 1280:64-74.
23. Norppa H., Falck G.C. What do human micronuclei contain?. Mutagenesis 2003, 18:221-233.
24. Novartis, 2003. Material Safety Data Sheet - Gleevec TM 100mg.
25. Pichler C. Impact of cytostatic drugs on the DNA stability of higher plants 2013, Department of Ecology Vienna University, Vienna, Master Thesis.
26. Rainer B. Untersuchungen der akuttoxischen und genotoxischen effekte der zytostatika etoposid und 5-fluorouracil mit pflanzlichen biomonitoringverfahren 2013, Fachhochschul-Masterstudiengang Biotechnische Verfahren am Standort Tulln an der Donau, Vienna.
27. Sandhu S.S., Ma T.H., Peng Y., Zhou X.D. Clastogenicity evaluation of seven chemicals commonly found at hazardous industrial waste sites. Mutat. Res. 1989, 224:437-445.
28. Steinkellner H., Mun-Sik K., Helma C., Ecker S., Ma T.H., Horak O., Kundi M., Knasmuller S. Genotoxic effects of heavy metals: comparative investigation with plant bioassays. Environ. Mol. Mutagen. 1998, 31:183-191.