Studies on the effect of quercetin and nitrates on the redox homeostasis using in vitro model

Environmental Toxicology and Pharmacology

Volumn 38, Issue 1, 2014, Pages 24-30

  Kurzeja, Ewa ^a   Stec, Małgorzata ^a   Synowiec Wojtarowicz, Agnieszka ^a   Jowsa, Andrzej ^a   Pawłowska Góral, Katarzyna ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Fibroblasts; Quercetin; Redox homeostasis; Sodium nitrate

Indexed keywords

GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; QUERCETIN; SODIUM NITRATE; SUPEROXIDE DISMUTASE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; NITRIC ACID DERIVATIVE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST CULTURE; IN VITRO STUDY; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; DRUG EFFECTS; FIBROBLAST; HOMEOSTASIS; METABOLISM; OXIDATION REDUCTION REACTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; FIBROBLASTS; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HOMEOSTASIS; MICE, INBRED BALB C; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION; QUERCETIN; SUPEROXIDE DISMUTASE;

EID: 84901300643     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.04.024     Document Type: Article

References (34)

1. Arredondo F., Echeverry C., Abin-Carriquiry J.A., Blasina F., Antuez K., Jones D.P., Go Y.-M., Liang Y.-L., Dajas F. After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radic. Biol. Med. 2010, 49:738-747.
2. Beauchamp C., Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal. Biochem. 1971, 44:276-287.
3. Crespo I., Garcia-Mediavilla M.V., Almar M., Gonzalez P., Tunon M.J., Sanchez-Campos S., Gonzalez-Gallego J. Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chans Liver cells. Food Chem. Toxicol. 2008, 46(5):1555-1569.
4. Dihal A.A., Woutersen R.A., van Ommen B., Rietjens I.M., Stierum R.H. Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2. Cancer Lett. 2006, 238(2):248-259.
5. EFSA Nitrate in vegetables: scientific option of the panel on contaminants in the food chain. EFSA Journal 2008, 1-79.
6. Eggler A.L., Gay K.A., Mesecar A.D. Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2. Mol. Nutr. Food Res. 2008, 55:84-94.
7. Gangolli S.D., van den Brandt P.A., Feron V.J., Janzowsky C., Koeman J.H., Speijers G.J., Spiegelhalder B., Walker R., Wisnok J.S. Nitrate, nitrite and N-nitroso compounds. Eur. J. Pharmacol. 1994, 292:1-38.
8. Gilchrist M., Winyard P.G., Benjamin N. Dietary nitrate - good or bad?. Nitric Oxide 2010, 22(2):104-109.
9. Gliszczyńska-Świgło A., van der Woude H., de Haan L., Tyrakowska B., Aarts J.M., Rietjens I.M. The role of quinine reductase (NQO1) and quinine chemistry on quercetin cytotoxicity. Toxicol. In Vitro 2003, 17(4):423-431.
10. Goldberg M.D., Spooner J.R. Glutathione reductase. Methods Enzyme Analysis 1983, vol. 3:258-265. Academic Press, Inc., Florida. 3rd ed.
11. Gotoh T., Mori M. Nitric oxide and endoplasmic reticulum stress. Arterioscler. Thromb. Vasc. Biol. 2006, 26(7):1439-1446.
12. Granado-Serrano A.B., Martin M.A., Bravo L., Goya L., Ramos S. Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: involvement of p38. Chem. Biol. Interact. 2012, 195:154-164.
13. Harwood M., Danielewska-Nikiel B., Borzelleca J.F., Flamm G.W., Williams G.M., Lines T.C. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem. Toxicol. 2007, 45(11):2179-2205.
14. Hord N.G., Tang Y., Bryan N.S. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am. J. Clin. Nutr. 2009, 90:1-10.
15. Jovanovic S.V., Simic M.G. Antioxidants in nutrition. Ann. N.Y. Acad. Sci. 2000, 899:326-334.
16. Kebieche M., Lakroun Z., Lahouel M., Bouayed J., Meraihi Z., Soulimani R. Evaluation of epirubicin-induced acute oxidative stress toxicity in rat liver cells and mitochondria, and the prevention of toxicity through quercetin administration. Exp. Toxicol. Pathol. 2009, 61(2):161-167.
17. Kuo S.M. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett. 1996, 110:41-48.
18. Lakhanpal P., Rai D.K. Quercetin: a versatile flavonoid. Internet J. Med. Update 2007, 2(2):22-37.
19. Lopez-Lopez G., Moreno L., Cogolludo A., Galisteo M., Ibarra M., Duarte J., Lodi F., Tamargo J., Perez-Vizcaino F. Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle. Mol. Pharmacol. 2004, 65(4):851-859.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
21. Lundberg J.O., Feelisch M., Bjorne H., Jansson E.A., Weitzberg E. Cardioprotective effects of vegetables: is nitrate the answer?. Nitric Oxide 2006, 15(4):359-362.
22. Mensinga T.T., Speijers J., Meulenbelt J. Health implications of exposure to environmental nitrogenous compounds. Toxicol. Rev. 2003, 22(1):41-51.
23. Murakami A., Ashida H., Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett. 2008, 269(2):315-325.
24. Naidu P.S., Singh A., Kulkarni S.K. Quercetin, a bioflavonoid, attenuates haloperidol-induced orofacial dyskinesia. Neuropharmacology 2003, 44:1100-1106.
25. Oh S.J., Kim O., Lee J.S., Kim J.A., Kim M.R., Choi H.S., Shim J.H., Kang K.W., Kim Y.C. Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells. Food Chem. Toxicol. 2010, 48(11):3227-3234.
26. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70:158-169.
27. Philips D.J. Dye exclusion test for cell viability. Tissue, Culture, Methods and Application 1978, 406-408. Acad. Press.
28. Porebska M. The role of nitric oxide in the cardiovascular system. Adv. Clin. Exp. Med. 2008, 17(1):101-107.
29. Schroeter H., Boyd C., Spencer J.P., Williams R.J., Cadenas E., Rice-Evans C. MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide. Neurobiol. Aging 2002, 23(5):861-880.
30. Shiomi K., Kuriyama I., Yoshida H., Mizyshina Y. Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer proliferation. Food Chem. 2013, 139:910-918.
31. Sun S., Chen W., Cao W., Zhang F., Song J., Tian C. Research on the chelation between quercetin and Cr(III) ion by Density Functional Theory (DFT) method. J. Mol. Struct.: THEOCHEM 2008, 860:40-44.
32. Thatcher G.R., Weldon H. NO problem for nitroglycerin: organic nitrate chemistry and therapy. Chem. Soc. Rev. 1998, 27:331-337.
33. van Acker S.A., van den Berg D.J., Tromp M.N., Griffioen D.H., van Bennekom W.P., van der Vijgh W.J., Bast A. Structural aspects of antioxidant activity of flavonoids. Free Radic. Biol. Med. 1996, 20(3):331-342.
34. Yousef M.I., Omar S.A., El-Guendi M.I., Abdelmegid L.A. Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem. Toxicol. 2010, 48(11):3246-3261.