Oxidative stress promotes D-GalN/LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3β activity

Inflammation Research

Volumn 63, Issue 6, 2014, Pages 485-494

  Wei, Linlin ^a   Ren, Feng ^a   Zhang, Xiangying ^a   Wen, Tao ^a   Shi, Hongbo ^a   Zheng, Sujun ^a   Zhang, Jing ^a   Chen, Yu ^a   Han, Yuanping ^b   Duan, Zhongping ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Acute liver failure; GSK3 ; N acetylcysteine; Oxidative stress; SB216763

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; ACETYLCYSTEINE; CASPASE 3; CYTOCHROME C; GALACTOSAMINE; GLUTATHIONE; GLYCOGEN SYNTHASE KINASE 3BETA; LIPOPOLYSACCHARIDE; SUPEROXIDE DISMUTASE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ACUTE LIVER FAILURE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HEPATITIS B; HUMAN; HUMAN CELL; LIVER; LIVER CELL; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; ANIMAL; BLOOD; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; IMMUNOLOGY; MIDDLE AGED;

ADULT; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CELL LINE; FEMALE; GALACTOSAMINE; GLYCOGEN SYNTHASE KINASE 3; HEPATITIS B, CHRONIC; HUMANS; LIPOPOLYSACCHARIDES; LIVER FAILURE, ACUTE; MALE; MICE, INBRED C57BL; MIDDLE AGED; OXIDATIVE STRESS;

EID: 84901275553     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-014-0720-x     Document Type: Article

References (34)

1. Hoofnagle JH, Carithers RLJ, Shapiro C, Ascher N. Acute hepatic failure: summary of a workshop. Hepatology. 1995;21:240-52.
2. Gunning K. Hepatic failure. Anaesth Intensive Care. 2009;10(3):124-6.
3. Lee WM. Recent developments in acute liver failure. Best Pract Res Clin Gastroenterol. 2012;26(1):3-16.
4. Mignon A, Rouquet N, Fabre M, Martin S, Pagès JC, Dhainaut JF, et al. LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med. 1999;159:1308-15. (Pubitemid 29202572)
5. Nakama T, Hirono S, Moriuchi A, Hasuike S, Nagata K, Hori T, et al. Etoposide prevents apoptosis inmouse liver with D-GalN/LPS-induced fulminant hepatic failure resulting inreduction of lethality. Hepatology. 2001;33:1441-50. (Pubitemid 32496981)
6. Rayasam GV, Tulasi VK, Sodhi R, Davis JA, Ray A. Glycogen synthase kinase 3: more than a namesake. Br J Pharmacol. 2009;156:885-98.
7. Beurel E, Michalek SM, Jope RS. Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). Trends Immunol. 2010;31:24-31.
8. Rehani K, Wang H, Garcia CA, Kinane DF, Martin M. IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta. J Immunol. 2008;181:6797-802.
9. Martin M, Rehani K, Jope RS, Michalek SM. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol. 2005;6:777-84. (Pubitemid 43090463)
10. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. Requirement for glycogen synthase kinase-3β in cell survival and NF-kappaB activation. Nature. 2000;406:86-90. (Pubitemid 30460216)
11. Eleonore B, Richard SJ. The paradoxical pro-and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol. 2006;79:173-89.
12. Chen L, Ren F, Zhang H, Wen T, Piao Z, Zhou L, et al. Inhibition of glycogen synthase kinase 3b ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum Stress-triggered apoptosis. PLoS One. 2012;7:45202.
13. Dryden GW Jr, Deaciuc I, Arteel G, McClain CJ. Clinical implications of oxidative stress and antioxidant therapy. Curr Gastroenterol Rep. 2005;7:308-16. (Pubitemid 41223343)
14. Han D, Hanawa N, Saberi B, Kaplowitz N. Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006;291:G1-7. (Pubitemid 44024656)
15. Czaja Mark J. Cell signaling in oxidative stress-induced liver injury. Semin Liver Dis. 2007;27:378-89.
16. Lee KY, Koh SH, Noh MY, Park KW, Lee YJ, Kim SH. Glycogen synthase kinase-3β activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells. Brain Res. 2007;1129:89-99. (Pubitemid 46048775)
17. Koh SH, Kim SH, Kwon H, Park Y, Kim KS, Song CW, et al. Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells fromoxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3. Mol Brain Res. 2003;118:72-81. (Pubitemid 37238989)
18. Koh SH, Kim SH, Kwon H, Kim JG, Kim JH, Yang KH, et al. Phosphatidylinositol-3 kinase/Akt and GSK-3 mediated cytoprotective effect of epigallocatechin gallate on oxidative stress-injured neuronal-differentiated N18D3 cells. Neurotoxicology. 2004;25:793-802. (Pubitemid 39013328)
19. Schäfer M, Goodenough S, Moosmann B, Behl C. Inhibition of glycogen synthase kinase 3b is involved in the resistance to oxidative stress in neuronal HT22 cells. Brain Res. 2004;1005:84-9. (Pubitemid 38388403)
20. Dal Santo S, Stampfl H, Krasensky J, Kempa S, Gibon Y, Petutschnig E, et al. Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in arabidopsis. Plant Cell. 2012;24:3380-92.
21. Wu ZM, Wen T, Tan YF, Liu Y, Ren F, Wu H. Effects of salvianolic acid A on oxidative stress and liver injury induced by carbon tetrachloride in rats. Basic Clin Pharmacol Toxicol. 2007;100:115-20. (Pubitemid 46146715)
22. Jiyoung H, Margitta L, Anwar F, Hartmut J. Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH -terminal kinase activation. Am J Physiol Gastrointest Liver Physiol. 2009;296:G572-81.
23. Ying J, Miaoyun Z, Wei A. Increased hepatic apoptosis in high-fat diet-induced NASH in rats may be associated with downregulation of hepatic stimulator substance. J Mol Med. 2011;89:1207-17.
24. Pastor A, Collado PS, Almar M, González-Gallego J. Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine. J Hepatol. 1997;27:363-70. (Pubitemid 27366218)
25. Park WH, Han YW, Kim SH, Kim SZ. An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis. J Cell Biochem. 2007;102:98-109.
26. Han YH, Kim SH, Kim SZ, Park WH. Antimycin A as a mitochondria damage agent induces an S phase arrest of the cell cycle in HeLa cells. Life Sci. 2008;83:346-55.
27. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002;192:1-15. (Pubitemid 34587382)
28. Ha HL, Shin HJ, Feitelson MA, Yu DY. Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol. 2010;16:6035-43.
29. Zhu R, Wang Y, Zhang L, Guo Q. Oxidative stress and liver disease. Hepatol Res. 2012;42:741-9.
30. Czaja MJ, Liu H, Wang Y. Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling. Hepatology. 2003;37:1405-13. (Pubitemid 36667321)
31. Rosseland CM, Wierød L, Oksvold MP, Werner H, Ostvold AC, Thoresen GH, et al. Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes. Hepatology. 2005;42:200-7. (Pubitemid 40911328)
32. Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. C-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006;131:165-78. (Pubitemid 44015744)
33. Jones BE, Lo CR, Liu H, Pradhan Z, Garcia L, Srinivasan A, et al. Role of caspases and NF-kB signaling in hydrogen peroxide- and superoxide-induced hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol. 2000;278:G693-9. (Pubitemid 30366421)
34. Chin R, Earnest-Silveira L, Koeberlein B, Franz S, Zentgraf H, Dong X, et al. Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesis. J Hepatol. 2007;47:325-37. (Pubitemid 47189604)