Inhibition of Glycogen Synthase Kinase 3β Ameliorates D-GalN/LPS-Induced Liver Injury by Reducing Endoplasmic Reticulum Stress-Triggered Apoptosis

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Chen, Liyan ^a   Ren, Feng ^b,c   Zhang, Haiyan ^b   Wen, Tao ^b   Piao, Zhengfu ^b   Zhou, Li ^c   Zheng, Sujun ^c   Zhang, Jing ^c   Chen, Yu ^c   Han, Yuanping ^c   Duan, Zhongping ^c   Ma, Yingji ^d  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 12; GALACTOSAMINE; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LIVER FAILURE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG DOSE COMPARISON; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; LIVER CELL; LIVER NECROSIS; LIVER PROTECTION; MALE; MORTALITY; MOUSE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASE 12; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITORS; GALACTOSAMINE; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; INDOLES; LIPOPOLYSACCHARIDES; LIVER; LIVER FAILURE, ACUTE; MALE; MALEIMIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANSAMINASES; TRANSCRIPTION FACTOR CHOP;

MURINAE; MUS;

EID: 84866977080     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045202     Document Type: Article

References (36)

1. Hoofnagle JH, Carithers RLJ, Shapiro C, Ascher N, (1995) Acute hepatic failure: summary of a workshop. Hepatology 21: 240-252.
2. Nakama T, Hirono S, Moriuchi A, Hasuike S, Nagata K, et al. (2001) Etoposideprevents apoptosis inmouse liver with D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure resulting inreduction of lethality. Hepatology 33: 1441-1450.
3. Kuhla A, Eipel C, Siebert N, Abshagen K, Menger MD, et al. (2008) Hepatocellular apoptosis is mediated by TNFa-dependent Fas/FasLigand cytotoxicity in a murine model of acute liver failure. Apoptosis 13: 1427-1438.
4. Eipel C, Kidess E, Abshagen K, Leminh K, Menger MD, et al. (2007) Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide. British Journal of Pharmacology 151: 406-413.
5. Shakil AO, Kramer D, Mazariegos GV, Fung JJ, Rakela J, (2000) Acute liver failure: clinical features, outcome analysis, and applicability of prognostic criteria. Liver Transplant 6: 163-169.
6. Lee WM, (1993) Acute hepatic failure. N Engl J Med 329: 1862-1872.
7. Mignon A, Rouquet N, Fabre M, Martin S, Pagès JC, et al. (1999) LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med 159: 1308-1315.
8. Kaufman RJ, (1999) Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13: 1211-1233.
9. Ron D, Walter P, (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nature Rev. Mol. Cell Biol 8: 519-529.
10. Xu C, Bailly MB, Reed JC, (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664.
11. Rao RV, Ellerby HM, Bredesen DE, (2004) Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11: 372-380.
12. Kezhong Z, Randal JK, (2008) From endoplasmic-reticulum stress to the inflammatory response. Nature 24: 455-462.
13. Cohen P, Goedert M, (2004) GSK3 inhibitors: development and therapeutic potential. Nat Rev Drug Discov 3: 479-487.
14. Rayasam GV, Tulasi VK, Sodhi R, Davis JA, Ray A, (2009) Glycogen synthase kinase 3: more than a namesake. Br J Pharmacol 156: 885-898.
15. Martin M, Rehani K, Jope RS, Michalek SM, (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6: 777-784.
16. Beurel E, Michalek SM, Jope RS, (2010) Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). Trends Immunol 31: 24-31.
17. Wang H, Garcia CA, Rehani K, Cekic C, Alard P, et al. (2008) IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta. J Immunol 181: 6797-6802.
18. Eléonore B, Richard SJ, (2006) The paradoxical pro- and anti-apoptotic actions of GSK-3 in the intrinsic and extrinsic apoptosis signaling pathways. Progress in Neurobiology 79: 173-189.
19. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, et al. (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406: 86-90.
20. Schwabe RF, Brenner DA, (2002) Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol 283: G204-211.
21. Srinivasan S, Ohsugi M, Liu Z, Fatrai S, Bernal ME, et al. (2005) Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-Kinase/Akt and increased Glycogen Synthase Kinase-3β in mouse insulinoma cells. Diabetes 54: 968-975.
22. Tsuneo T, Ryoko Y, Takao O, (2006) Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. Neuroscience Letters, 2006 45: 124-134.
23. Kim AJ, Shi Y, Austin RC, Werstuck GH, (2004) Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. Journal of Cell Science 118: 89-99.
24. Richard SJ, Christopher JY, Eléonore B, (2007) Glycogen synthase sinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 32: 577-595.
25. Jope RS, Johnson GV, (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29: 95-102.
26. Galanos C, Freudenberg MA, Reutter W, (1979) Galactosamine-induces sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci 76: 5939-5943.
27. Hishinuma I, Nagakawa J, Hirota K, Miyamoto K, Tsukidate K, et al. (1990) Involvement of tumor necrosis factor-alpha in development of hepatic injury in galactosamine-sensitizedmice. Hepatology 12: 1187-1191.
28. Feng R, Zhongping D, Cheng Q, Xiuda S, Gao F, et al. (2011) The inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury via an IL-10-mediated immune modulatory mechanism. Hepatology 54: 687-696.
29. Denise MF, David K, (2000) GSK-3: New thoughts on an old enzyme. Developmental Biology 225: 471-479.
30. Rådinger M, Kuehn HS, Kim MS, Metcalfe DD, Gilfillan AM, (2010) Glycogen synthase kinase 3β activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells. J Immunol 184: 564-572.
31. Edwin SV, Theo JC, Johan K, (2003) Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock. Clinical Microbiology Reviews 16: 379-414.
32. Yan CG, Qing X, Zhou XQ, Xu YM, Yu H, et al. (2004) The expression of toll-like receptor 4 in the endotoxin-induced acute hepatic injury. Chinese journal of infectious diseases 22: 189-192.
33. Rust C, Gores GJ, (2000) Apoptosis and liver disease. Am J Med 108: 567-574.
34. Kaplowitz N, (2000) Mechanisms of liver cell injury. J Hepatol 32: 39-47.
35. Nakayama Y, Endo M, Tsukano H, Mori M, Oike Y, et al. (2010) Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway. J Biochem 147: 471-483.
36. Chunli Y, Ling Z, Yuanping H, (2008) Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. Liver International 28: 959-971.