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Volumn 75, Issue 2, 2014, Pages 79-87

Congenital hypogonadotropic hypogonadism and Kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions

Author keywords

AMH; Estradiol; Hypogonadism; Inhibin B; INSL3; Kallmann; Testosterone

Indexed keywords

ESTRADIOL; GONADOTROPIN; INHIBIN B; INSULIN LIKE FACTOR 3; MUELLERIAN INHIBITING FACTOR; PEPTIDE HORMONE; SEX HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG; FOLLITROPIN; HORMONE; INHIBIN; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; RECOMBINANT PROTEIN;

EID: 84901271806     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ando.2014.04.011     Document Type: Article
Times cited : (12)

References (102)
  • 1
    • 84858038527 scopus 로고    scopus 로고
    • Approach to the male patient with congenital hypogonadotropic hypogonadism
    • Young J. Approach to the male patient with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2012, 97:707-718.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 707-718
    • Young, J.1
  • 2
    • 77951665082 scopus 로고    scopus 로고
    • Non-syndromic congenital hypogonadotropic hypogonadism: clinical presentation and genotype-phenotype relationships
    • Brioude F., Bouligand J., Trabado S., Francou B., Salenave S., Kamenicky P., et al. Non-syndromic congenital hypogonadotropic hypogonadism: clinical presentation and genotype-phenotype relationships. Eur J Endocrinol 2010, 162:835-851.
    • (2010) Eur J Endocrinol , vol.162 , pp. 835-851
    • Brioude, F.1    Bouligand, J.2    Trabado, S.3    Francou, B.4    Salenave, S.5    Kamenicky, P.6
  • 8
    • 84867798461 scopus 로고    scopus 로고
    • Kisspeptin and the hypothalamic control of reproduction: lessons from the human
    • George J.T., Seminara S.B. Kisspeptin and the hypothalamic control of reproduction: lessons from the human. Endocrinology 2012, 153:5130-5136.
    • (2012) Endocrinology , vol.153 , pp. 5130-5136
    • George, J.T.1    Seminara, S.B.2
  • 9
    • 84872507024 scopus 로고    scopus 로고
    • Two families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 receptor): clinical evaluation and molecular characterization of a novel mutation
    • Brioude F., Bouligand J., Francou B., Fagart J., Roussel R., Viengchareun S., et al. Two families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 receptor): clinical evaluation and molecular characterization of a novel mutation. PLoS One 2013, 8:e53896.
    • (2013) PLoS One , vol.8
    • Brioude, F.1    Bouligand, J.2    Francou, B.3    Fagart, J.4    Roussel, R.5    Viengchareun, S.6
  • 10
    • 61349091041 scopus 로고    scopus 로고
    • TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction
    • Topaloglu A.K., Reimann F., Guclu M., Yalin A.S., Kotan L.D., Porter K.M., et al. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction. Nat Genet 2009, 41:354-358.
    • (2009) Nat Genet , vol.41 , pp. 354-358
    • Topaloglu, A.K.1    Reimann, F.2    Guclu, M.3    Yalin, A.S.4    Kotan, L.D.5    Porter, K.M.6
  • 12
    • 84876289515 scopus 로고    scopus 로고
    • Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications
    • Young J., George J.T., Tello J.A., Francou B., Bouligand J., Guiochon-Mantel A., et al. Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications. Neuroendocrinology 2013, 97:193-202.
    • (2013) Neuroendocrinology , vol.97 , pp. 193-202
    • Young, J.1    George, J.T.2    Tello, J.A.3    Francou, B.4    Bouligand, J.5    Guiochon-Mantel, A.6
  • 13
    • 0030698188 scopus 로고    scopus 로고
    • A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor
    • de Roux N., Young J., Misrahi M., Genet R., Chanson P., Schaison G., et al. A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. N Engl J Med 1997, 337:1597-1602.
    • (1997) N Engl J Med , vol.337 , pp. 1597-1602
    • de Roux, N.1    Young, J.2    Misrahi, M.3    Genet, R.4    Chanson, P.5    Schaison, G.6
  • 14
    • 84861870846 scopus 로고    scopus 로고
    • Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling
    • Tello J.A., Newton C.L., Bouligand J., Guiochon-Mantel A., Millar R.P., Young J. Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling. PLoS One 2012, 7:e38456.
    • (2012) PLoS One , vol.7
    • Tello, J.A.1    Newton, C.L.2    Bouligand, J.3    Guiochon-Mantel, A.4    Millar, R.P.5    Young, J.6
  • 15
    • 84874866315 scopus 로고    scopus 로고
    • Computed tomography of the anterior skull base in Kallmann syndrome reveals specific ethmoid bone abnormalities associated with olfactory bulb defects
    • Maione L., Benadjaoud S., Eloit C., Sinisi A.A., Colao A., Chanson P., et al. Computed tomography of the anterior skull base in Kallmann syndrome reveals specific ethmoid bone abnormalities associated with olfactory bulb defects. J Clin Endocrinol Metab 2013, 98:E537-E546.
    • (2013) J Clin Endocrinol Metab , vol.98
    • Maione, L.1    Benadjaoud, S.2    Eloit, C.3    Sinisi, A.A.4    Colao, A.5    Chanson, P.6
  • 16
    • 34547527163 scopus 로고    scopus 로고
    • Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis
    • Dodé C., Fouveaut C., Mortier G., Janssens S., Bertherat J., Mahoudeau J., et al. Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis. Hum Mutat 2007, 28:97-98.
    • (2007) Hum Mutat , vol.28 , pp. 97-98
    • Dodé, C.1    Fouveaut, C.2    Mortier, G.3    Janssens, S.4    Bertherat, J.5    Mahoudeau, J.6
  • 17
    • 77952745706 scopus 로고    scopus 로고
    • Clinical genetics of Kallmann syndrome
    • Dode C., Hardelin J.P. Clinical genetics of Kallmann syndrome. Ann Endocrinol (Paris) 2010, 71:149-157.
    • (2010) Ann Endocrinol (Paris) , vol.71 , pp. 149-157
    • Dode, C.1    Hardelin, J.P.2
  • 18
    • 79959916267 scopus 로고    scopus 로고
    • Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory
    • Mitchell A.L., Dwyer A., Pitteloud N., Quinton R. Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory. Trends Endocrinol Metab 2011, 22:249-258.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 249-258
    • Mitchell, A.L.1    Dwyer, A.2    Pitteloud, N.3    Quinton, R.4
  • 20
    • 73249139551 scopus 로고    scopus 로고
    • Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds
    • Scott H.M., Mason J.I., Sharpe R.M. Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds. Endocr Rev 2009, 30(7):883-925.
    • (2009) Endocr Rev , vol.30 , Issue.7 , pp. 883-925
    • Scott, H.M.1    Mason, J.I.2    Sharpe, R.M.3
  • 21
    • 78650742289 scopus 로고    scopus 로고
    • Endocrinology of the mammalian fetal testis
    • O'Shaughnessy P.J., Fowler P.A. Endocrinology of the mammalian fetal testis. Reproduction 2011, 141(1):37-46.
    • (2011) Reproduction , vol.141 , Issue.1 , pp. 37-46
    • O'Shaughnessy, P.J.1    Fowler, P.A.2
  • 24
    • 0026335545 scopus 로고
    • Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone
    • Weiss J., Axelrod L., Whitcomb R.W., Harris P.E., Crowley W.F., Jameson J.L. Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. N Engl J Med 1992, 326:179-183.
    • (1992) N Engl J Med , vol.326 , pp. 179-183
    • Weiss, J.1    Axelrod, L.2    Whitcomb, R.W.3    Harris, P.E.4    Crowley, W.F.5    Jameson, J.L.6
  • 25
    • 10344262033 scopus 로고    scopus 로고
    • Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene
    • Valdes-Socin H., Salvi R., Daly A.F., Gaillard R.C., Quatresooz P., Tebeu P.M., et al. Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene. N Engl J Med 2004, 351(25):2619-2625.
    • (2004) N Engl J Med , vol.351 , Issue.25 , pp. 2619-2625
    • Valdes-Socin, H.1    Salvi, R.2    Daly, A.F.3    Gaillard, R.C.4    Quatresooz, P.5    Tebeu, P.M.6
  • 28
    • 84866148802 scopus 로고    scopus 로고
    • Hypogonadism in a patient with two novel mutations of the luteinizing hormone β-subunit gene expressed in a compound heterozygous form
    • Basciani S., Watanabe M., Mariani S., Passeri M., Persichetti A., Fiore D., et al. Hypogonadism in a patient with two novel mutations of the luteinizing hormone β-subunit gene expressed in a compound heterozygous form. J Clin Endocrinol Metab 2012, 97:3031-3038.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3031-3038
    • Basciani, S.1    Watanabe, M.2    Mariani, S.3    Passeri, M.4    Persichetti, A.5    Fiore, D.6
  • 29
    • 34447515493 scopus 로고    scopus 로고
    • A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome
    • Maffei L., Rochira V., Zirilli L., Antunez P., Aranda C., Fabre B., et al. A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome. Clin Endocrinol (Oxf) 2007, 67:218-224.
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 218-224
    • Maffei, L.1    Rochira, V.2    Zirilli, L.3    Antunez, P.4    Aranda, C.5    Fabre, B.6
  • 30
    • 70350057027 scopus 로고    scopus 로고
    • Genetic and clinical spectrum of aromatase deficiency in infancy, childhood and adolescence
    • Belgorosky A., Guercio G., Pepe C., Saraco N., Rivarola M.A. Genetic and clinical spectrum of aromatase deficiency in infancy, childhood and adolescence. Horm Res 2009, 72:321-330.
    • (2009) Horm Res , vol.72 , pp. 321-330
    • Belgorosky, A.1    Guercio, G.2    Pepe, C.3    Saraco, N.4    Rivarola, M.A.5
  • 31
    • 84893441077 scopus 로고    scopus 로고
    • Aromatase and estrogen receptor α deficiency
    • Bulun S.E. Aromatase and estrogen receptor α deficiency. Fertil Steril 2014, 101:323-329.
    • (2014) Fertil Steril , vol.101 , pp. 323-329
    • Bulun, S.E.1
  • 34
    • 0015222095 scopus 로고
    • Effect of purified luteinizing hormone releasing factor on normal and hypogonadotrophic anosmic men
    • Naftolin F., Harris G.W., Bobrow M. Effect of purified luteinizing hormone releasing factor on normal and hypogonadotrophic anosmic men. Nature 1971, 232:496-497.
    • (1971) Nature , vol.232 , pp. 496-497
    • Naftolin, F.1    Harris, G.W.2    Bobrow, M.3
  • 35
    • 45149083278 scopus 로고    scopus 로고
    • Effects of an early postnatal treatment of hypogonadotropic hypogonadism with a continuous subcutaneous infusion of recombinant follicle-stimulating hormone and luteinizing hormone
    • Bougnères P., François M., Pantalone L., Rodrigue D., Bouvattier C., Demesteere E., et al. Effects of an early postnatal treatment of hypogonadotropic hypogonadism with a continuous subcutaneous infusion of recombinant follicle-stimulating hormone and luteinizing hormone. J Clin Endocrinol Metab 2008, 93:2202-2205.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2202-2205
    • Bougnères, P.1    François, M.2    Pantalone, L.3    Rodrigue, D.4    Bouvattier, C.5    Demesteere, E.6
  • 36
    • 84878735294 scopus 로고    scopus 로고
    • Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach
    • Rey R.A., Grinspon R.P., Gottlieb S., Pasqualini T., Knoblovits P., Aszpis S., et al. Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach. Andrology 2013, 1:3-16.
    • (2013) Andrology , vol.1 , pp. 3-16
    • Rey, R.A.1    Grinspon, R.P.2    Gottlieb, S.3    Pasqualini, T.4    Knoblovits, P.5    Aszpis, S.6
  • 37
    • 84893746947 scopus 로고    scopus 로고
    • Insulin-like peptide 3 (INSL3) in men with congenital hypogonadotropic hypogonadism/Kallmann syndrome and effects of different modalities of hormonal treatment: a single-center study of 281 patients
    • Trabado S., Maione L., Bry-Gauillard H., Affres H., Salenave S., Sarfati J., et al. Insulin-like peptide 3 (INSL3) in men with congenital hypogonadotropic hypogonadism/Kallmann syndrome and effects of different modalities of hormonal treatment: a single-center study of 281 patients. J Clin Endocrinol Metab 2014, 99:E268-E275.
    • (2014) J Clin Endocrinol Metab , vol.99
    • Trabado, S.1    Maione, L.2    Bry-Gauillard, H.3    Affres, H.4    Salenave, S.5    Sarfati, J.6
  • 38
    • 0030856879 scopus 로고    scopus 로고
    • A randomized comparison of the clinical and hormonal effects of two GnRH agonists in patients with prostate cancer
    • Kuhn J.M., Abourachid H., Brucher P., Doutres J.C., Fretin J., Jaupitre A., et al. A randomized comparison of the clinical and hormonal effects of two GnRH agonists in patients with prostate cancer. Eur Urol 1997, 32:397-403.
    • (1997) Eur Urol , vol.32 , pp. 397-403
    • Kuhn, J.M.1    Abourachid, H.2    Brucher, P.3    Doutres, J.C.4    Fretin, J.5    Jaupitre, A.6
  • 39
    • 0030767964 scopus 로고    scopus 로고
    • Treatment of prepubertal gonadotrophin-deficient boys with recombinant human follicle-stimulating hormone
    • Raivio T., Toppari J., Perheentupa A., McNeilly A.S., Dunkel L. Treatment of prepubertal gonadotrophin-deficient boys with recombinant human follicle-stimulating hormone. Lancet 1997, 350:263-264.
    • (1997) Lancet , vol.350 , pp. 263-264
    • Raivio, T.1    Toppari, J.2    Perheentupa, A.3    McNeilly, A.S.4    Dunkel, L.5
  • 40
    • 0033710492 scopus 로고    scopus 로고
    • Effects of human recombinant luteinizing hormone and follicle-stimulating hormone in patients with acquired hypogonadotropic hypogonadism: study of Sertoli and Leydig cell secretions and interactions
    • Young J., Couzinet B., Chanson P., Brailly S., Loumaye E., Schaison G. Effects of human recombinant luteinizing hormone and follicle-stimulating hormone in patients with acquired hypogonadotropic hypogonadism: study of Sertoli and Leydig cell secretions and interactions. J Clin Endocrinol Metab 2000, 85:3239-3244.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3239-3244
    • Young, J.1    Couzinet, B.2    Chanson, P.3    Brailly, S.4    Loumaye, E.5    Schaison, G.6
  • 41
    • 14044272890 scopus 로고    scopus 로고
    • Testicular anti-Mullerian hormone secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism
    • Young J., Chanson P., Salenave S., Noël M., Brailly S., O'Flaherty M., et al. Testicular anti-Mullerian hormone secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2005, 90:724-728.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 724-728
    • Young, J.1    Chanson, P.2    Salenave, S.3    Noël, M.4    Brailly, S.5    O'Flaherty, M.6
  • 42
    • 33847697381 scopus 로고    scopus 로고
    • Treatment of gonadotropin-deficient boys with recombinant human FSH: long-term observation and outcome
    • Raivio T., Wikström A.M., Dunkel L. Treatment of gonadotropin-deficient boys with recombinant human FSH: long-term observation and outcome. Eur J Endocrinol 2007, 156:105-111.
    • (2007) Eur J Endocrinol , vol.156 , pp. 105-111
    • Raivio, T.1    Wikström, A.M.2    Dunkel, L.3
  • 43
    • 79956358038 scopus 로고    scopus 로고
    • Estradiol levels in men with congenital hypogonadotropic hypogonadism and the effects of different modalities of hormonal treatment
    • 2329.e1-3
    • Trabado S., Maione L., Salenave S., Baron S., Galland F., Bry-Gauillard H., et al. Estradiol levels in men with congenital hypogonadotropic hypogonadism and the effects of different modalities of hormonal treatment. Fertil Steril 2011, 95:2324-2329. 2329.e1-3.
    • (2011) Fertil Steril , vol.95 , pp. 2324-2329
    • Trabado, S.1    Maione, L.2    Salenave, S.3    Baron, S.4    Galland, F.5    Bry-Gauillard, H.6
  • 44
    • 84887464802 scopus 로고    scopus 로고
    • Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism
    • Dwyer A.A., Sykiotis G.P., Hayes F.J., Boepple P.A., Lee H., Loughlin K.R., et al. Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2013, 98:E1790-E1795.
    • (2013) J Clin Endocrinol Metab , vol.98
    • Dwyer, A.A.1    Sykiotis, G.P.2    Hayes, F.J.3    Boepple, P.A.4    Lee, H.5    Loughlin, K.R.6
  • 45
    • 1842376911 scopus 로고    scopus 로고
    • Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility
    • Tapanainen J.S., Aittomäki K., Min J., Vaskivuo T., Huhtaniemi I.T. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat Genet 1997, 15:205-206.
    • (1997) Nat Genet , vol.15 , pp. 205-206
    • Tapanainen, J.S.1    Aittomäki, K.2    Min, J.3    Vaskivuo, T.4    Huhtaniemi, I.T.5
  • 46
    • 0027324274 scopus 로고
    • Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone
    • Matthews C.H., Borgato S., Beck-Peccoz P., Adams M., Tone Y., Gambino G., et al. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat Genet 1993, 5:83-86.
    • (1993) Nat Genet , vol.5 , pp. 83-86
    • Matthews, C.H.1    Borgato, S.2    Beck-Peccoz, P.3    Adams, M.4    Tone, Y.5    Gambino, G.6
  • 47
    • 77149162999 scopus 로고    scopus 로고
    • A new FSHbeta mutation in a 29-year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH
    • Kottler M.L., Chou Y.Y., Chabre O., Richard N., Polge C., Brailly-Tabard S., et al. A new FSHbeta mutation in a 29-year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH. Eur J Endocrinol 2010, 162:633-641.
    • (2010) Eur J Endocrinol , vol.162 , pp. 633-641
    • Kottler, M.L.1    Chou, Y.Y.2    Chabre, O.3    Richard, N.4    Polge, C.5    Brailly-Tabard, S.6
  • 48
    • 0031712880 scopus 로고    scopus 로고
    • Follitropin (FSH) deficiency in an infertile male due to FSH beta gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations
    • Lindstedt G., Nyström E., Matthews C., Ernest I., Janson P.O., Chatterjee K. Follitropin (FSH) deficiency in an infertile male due to FSH beta gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations. Clin Chem Lab Med 1998, 36:663-665.
    • (1998) Clin Chem Lab Med , vol.36 , pp. 663-665
    • Lindstedt, G.1    Nyström, E.2    Matthews, C.3    Ernest, I.4    Janson, P.O.5    Chatterjee, K.6
  • 49
    • 0036345561 scopus 로고    scopus 로고
    • FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia
    • Layman L.C., Porto A.L., Xie J., da Motta L.A., da Motta L.D., Weiser W., et al. FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia. J Clin Endocrinol Metab 2002, 87:3702-3707.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3702-3707
    • Layman, L.C.1    Porto, A.L.2    Xie, J.3    da Motta, L.A.4    da Motta, L.D.5    Weiser, W.6
  • 50
    • 0032508059 scopus 로고    scopus 로고
    • Male hypogonadism due to a mutation in the gene for the beta-subunit of follicle-stimulating hormone
    • Phillip M., Arbelle J.E., Segev Y., Parvari R. Male hypogonadism due to a mutation in the gene for the beta-subunit of follicle-stimulating hormone. N Engl J Med 1998, 338:1729-1732.
    • (1998) N Engl J Med , vol.338 , pp. 1729-1732
    • Phillip, M.1    Arbelle, J.E.2    Segev, Y.3    Parvari, R.4
  • 51
    • 0022982030 scopus 로고
    • Testosterone and estradiol are co-secreted episodically by the human testis
    • Winters S.J., Troen P. Testosterone and estradiol are co-secreted episodically by the human testis. J Clin Invest 1986, 78:870-873.
    • (1986) J Clin Invest , vol.78 , pp. 870-873
    • Winters, S.J.1    Troen, P.2
  • 52
    • 0026089986 scopus 로고
    • Cell-cell interactions in the testis
    • Skinner M.K. Cell-cell interactions in the testis. Endocr Rev 1991, 12:45-77.
    • (1991) Endocr Rev , vol.12 , pp. 45-77
    • Skinner, M.K.1
  • 53
    • 0031872496 scopus 로고    scopus 로고
    • Enhancement of long-term testosterone secretion and steroidogenic enzyme expression in human Leydig cells by co-culture with human Sertoli cell-enriched preparations
    • Lejeune H., Sanchez P., Saez J.M. Enhancement of long-term testosterone secretion and steroidogenic enzyme expression in human Leydig cells by co-culture with human Sertoli cell-enriched preparations. Int J Androl 1998, 21:129-140.
    • (1998) Int J Androl , vol.21 , pp. 129-140
    • Lejeune, H.1    Sanchez, P.2    Saez, J.M.3
  • 57
    • 0030852561 scopus 로고    scopus 로고
    • Long-term effect of testosterone therapy on bone mineral density in hypogonadal men
    • Behre H.M., Kliesch S., Leifke E., Link T.M., Nieschlag E. Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab 1997, 82:2386-2390.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2386-2390
    • Behre, H.M.1    Kliesch, S.2    Leifke, E.3    Link, T.M.4    Nieschlag, E.5
  • 58
    • 0025991345 scopus 로고
    • Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men
    • Finkelstein J.S., Whitcomb R.W., O'Dea L.S., Longcope C., Schoenfeld D.A., Crowley W.F. Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab 1991, 73:609-620.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 609-620
    • Finkelstein, J.S.1    Whitcomb, R.W.2    O'Dea, L.S.3    Longcope, C.4    Schoenfeld, D.A.5    Crowley, W.F.6
  • 59
  • 60
    • 0017249260 scopus 로고
    • Pituitary-gonadal relations in infancy: 2. Patterns of serum gonadal steroid concentrations in man from birth to two years of age
    • Winters J.S., Huhgues I.A., Reyes F.I., Faiman C. Pituitary-gonadal relations in infancy: 2. Patterns of serum gonadal steroid concentrations in man from birth to two years of age. J Clin Endocrinol Metab 1976, 42:679-686.
    • (1976) J Clin Endocrinol Metab , vol.42 , pp. 679-686
    • Winters, J.S.1    Huhgues, I.A.2    Reyes, F.I.3    Faiman, C.4
  • 61
    • 0023229654 scopus 로고
    • Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life
    • Bidlingmaier F., Strom T.M., Dörr H.G., Eisenmenger W., Knorr D. Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life. J Clin Endocrinol Metab 1987, 65:862-867.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 862-867
    • Bidlingmaier, F.1    Strom, T.M.2    Dörr, H.G.3    Eisenmenger, W.4    Knorr, D.5
  • 62
    • 33751239108 scopus 로고    scopus 로고
    • Expression of aromatase, estrogen receptor alpha and beta, androgen receptor, and cytochrome P-450scc in the human early prepubertal testis
    • Berensztein E.B., Baquedano M.S., Gonzalez C.R., Saraco N.I., Rodriguez J., Ponzio R., et al. Expression of aromatase, estrogen receptor alpha and beta, androgen receptor, and cytochrome P-450scc in the human early prepubertal testis. Pediatr Res 2006, 60:740-744.
    • (2006) Pediatr Res , vol.60 , pp. 740-744
    • Berensztein, E.B.1    Baquedano, M.S.2    Gonzalez, C.R.3    Saraco, N.I.4    Rodriguez, J.5    Ponzio, R.6
  • 63
    • 23644436186 scopus 로고    scopus 로고
    • Insulin-like factor 3: a novel circulating hormone of testicular origin in humans
    • Ferlin A., Foresta C. Insulin-like factor 3: a novel circulating hormone of testicular origin in humans. Ann N Y Acad Sci 2005, 1041:497-505.
    • (2005) Ann N Y Acad Sci , vol.1041 , pp. 497-505
    • Ferlin, A.1    Foresta, C.2
  • 64
    • 49449083090 scopus 로고    scopus 로고
    • Role of hormones, genes, and environment in human cryptorchidism
    • Foresta C., Zuccarello D., Garolla A., Ferlin A. Role of hormones, genes, and environment in human cryptorchidism. Endocr Rev 2008, 29:560-580.
    • (2008) Endocr Rev , vol.29 , pp. 560-580
    • Foresta, C.1    Zuccarello, D.2    Garolla, A.3    Ferlin, A.4
  • 65
    • 66749130266 scopus 로고    scopus 로고
    • Biology of insulin-like factor 3 in human reproduction
    • Ivell R., Anand-Ivell R. Biology of insulin-like factor 3 in human reproduction. Hum Reprod Update 2009, 15:463-476.
    • (2009) Hum Reprod Update , vol.15 , pp. 463-476
    • Ivell, R.1    Anand-Ivell, R.2
  • 66
    • 79954420469 scopus 로고    scopus 로고
    • Testicular descent: INSL3, testosterone, genes and the intrauterine milieu
    • Bay K., Main K.M., Toppari J., Skakkebæk N.E. Testicular descent: INSL3, testosterone, genes and the intrauterine milieu. Nat Rev Urol 2011, 8:187-196.
    • (2011) Nat Rev Urol , vol.8 , pp. 187-196
    • Bay, K.1    Main, K.M.2    Toppari, J.3    Skakkebæk, N.E.4
  • 67
    • 0032989104 scopus 로고    scopus 로고
    • Cryptorchidism in mice mutant for Insl3
    • Nef S., Parada L.F. Cryptorchidism in mice mutant for Insl3. Nat Genet 1999, 22:295-299.
    • (1999) Nat Genet , vol.22 , pp. 295-299
    • Nef, S.1    Parada, L.F.2
  • 70
    • 35349011589 scopus 로고    scopus 로고
    • Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism
    • Bay K., Virtanen H.E., Hartung S., Ivell R., Main K.M., Skakkebaek N.E., et al. Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism. J Clin Endocrinol Metab 2007, 92:4020-4027.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4020-4027
    • Bay, K.1    Virtanen, H.E.2    Hartung, S.3    Ivell, R.4    Main, K.M.5    Skakkebaek, N.E.6
  • 72
    • 84896351914 scopus 로고    scopus 로고
    • Serum levels of insulin-like factor 3, anti-Mullerian hormone, inhibin B, and testosterone during pubertal transition in healthy boys: a longitudinal pilot study
    • Johansen M.L., Anand-Ivell R., Mouritsen A., Hagen C.P., Mieritz M.G., Søeborg T., et al. Serum levels of insulin-like factor 3, anti-Mullerian hormone, inhibin B, and testosterone during pubertal transition in healthy boys: a longitudinal pilot study. Reproduction 2014, 147:529-535.
    • (2014) Reproduction , vol.147 , pp. 529-535
    • Johansen, M.L.1    Anand-Ivell, R.2    Mouritsen, A.3    Hagen, C.P.4    Mieritz, M.G.5    Søeborg, T.6
  • 73
    • 21244461989 scopus 로고    scopus 로고
    • Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis
    • Bay K., Hartung S., Ivell R., Schumacher M., Jü rgensen D., Jorgensen N., et al. Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis. J Clin Endocrinol Metab 2005, 90:3410-3418.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3410-3418
    • Bay, K.1    Hartung, S.2    Ivell, R.3    Schumacher, M.4    Jü rgensen, D.5    Jorgensen, N.6
  • 75
    • 33644826521 scopus 로고    scopus 로고
    • The effects of gonadotropin suppression and selective replacement on insulin-like factor 3 secretion in normal adult men
    • Bay K., Matthiesson K.L., McLachlan R.I., Andersson A.M. The effects of gonadotropin suppression and selective replacement on insulin-like factor 3 secretion in normal adult men. J Clin Endocrinol Metab 2006, 91:1108-1111.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1108-1111
    • Bay, K.1    Matthiesson, K.L.2    McLachlan, R.I.3    Andersson, A.M.4
  • 76
    • 84898410154 scopus 로고    scopus 로고
    • Insulin-like factor 3 and the HPG axis in the male
    • eCollection 2014
    • Ivell R., Heng K., Anand-Ivell R. Insulin-like factor 3 and the HPG axis in the male. Front Endocrinol (Lausanne) 2014, 5:6. eCollection 2014.
    • (2014) Front Endocrinol (Lausanne) , vol.5 , pp. 6
    • Ivell, R.1    Heng, K.2    Anand-Ivell, R.3
  • 80
    • 0034456281 scopus 로고    scopus 로고
    • Gonadotropins, prolactin, inhibin A, inhibin B, and activin A in human fetal serum from midpregnancy and term pregnancy
    • Debieve F., Beerlandt S., Hubinont C., Thomas K. Gonadotropins, prolactin, inhibin A, inhibin B, and activin A in human fetal serum from midpregnancy and term pregnancy. J Clin Endocrinol Metab 2000, 85:270-274.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 270-274
    • Debieve, F.1    Beerlandt, S.2    Hubinont, C.3    Thomas, K.4
  • 82
    • 0037326355 scopus 로고    scopus 로고
    • Longitudinal studies of inhibin B levels in boys and young adults with Klinefelter syndrome
    • Christiansen P., Andersson A.M., Skakkebaek N.E. Longitudinal studies of inhibin B levels in boys and young adults with Klinefelter syndrome. J Clin Endocrinol Metab 2003, 88:888-891.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 888-891
    • Christiansen, P.1    Andersson, A.M.2    Skakkebaek, N.E.3
  • 83
    • 0032467978 scopus 로고    scopus 로고
    • Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels
    • Andersson A.M., Müller J., Skakkebaek N.E. Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels. J Clin Endocrinol Metab 1998, 83:4451-4458.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 4451-4458
    • Andersson, A.M.1    Müller, J.2    Skakkebaek, N.E.3
  • 84
    • 79961205843 scopus 로고    scopus 로고
    • Differential regulation of inhibin subunits by germ cells in human testes
    • Fujisawa M., Yamazaki T., Fujioka H., Takenaka A. Differential regulation of inhibin subunits by germ cells in human testes. Arch Androl 2004, 50:339-345.
    • (2004) Arch Androl , vol.50 , pp. 339-345
    • Fujisawa, M.1    Yamazaki, T.2    Fujioka, H.3    Takenaka, A.4
  • 85
    • 0037230299 scopus 로고    scopus 로고
    • Immunolocalization of inhibin and activin alpha and betaB subunits and expression of corresponding messenger RNAs in the human adult testis
    • Marchetti C., Hamdane M., Mitchell V., Mayo K., Devisme L., Rigot J.M., et al. Immunolocalization of inhibin and activin alpha and betaB subunits and expression of corresponding messenger RNAs in the human adult testis. Biol Reprod 2003, 68:230-235.
    • (2003) Biol Reprod , vol.68 , pp. 230-235
    • Marchetti, C.1    Hamdane, M.2    Mitchell, V.3    Mayo, K.4    Devisme, L.5    Rigot, J.M.6
  • 86
    • 33749555753 scopus 로고    scopus 로고
    • Time course of the serum gonadotropin surge, inhibins, and anti-Mullerian hormone in normal newborn males during the first month of life
    • Bergada I., Milani C., Bedecarras P., Andreone L., Ropelato M.G., Gottlieb S., et al. Time course of the serum gonadotropin surge, inhibins, and anti-Mullerian hormone in normal newborn males during the first month of life. J Clin Endocrinol Metab 2006, 91:4092-4098.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4092-4098
    • Bergada, I.1    Milani, C.2    Bedecarras, P.3    Andreone, L.4    Ropelato, M.G.5    Gottlieb, S.6
  • 88
    • 0347627641 scopus 로고    scopus 로고
    • Use of progestins in male contraception
    • Nieschlag E., Zitzmann M., Kamischke A. Use of progestins in male contraception. Steroids 2003, 68:965-972.
    • (2003) Steroids , vol.68 , pp. 965-972
    • Nieschlag, E.1    Zitzmann, M.2    Kamischke, A.3
  • 89
    • 0029798598 scopus 로고    scopus 로고
    • Inhibin B secretion in males with gonadotropin-releasing hormone (GnRH) deficiency before and during long-term GnRH replacement: relationship to spontaneous puberty, testicular volume, and prior treatment - a clinical research center study
    • Nachtigall L.B., Boepple P.A., Seminara S.B., Khoury R.H., Sluss P.M., Lecain A.E., et al. Inhibin B secretion in males with gonadotropin-releasing hormone (GnRH) deficiency before and during long-term GnRH replacement: relationship to spontaneous puberty, testicular volume, and prior treatment - a clinical research center study. J Clin Endocrinol Metab 1996, 81:3520-3525.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3520-3525
    • Nachtigall, L.B.1    Boepple, P.A.2    Seminara, S.B.3    Khoury, R.H.4    Sluss, P.M.5    Lecain, A.E.6
  • 90
    • 0029797561 scopus 로고    scopus 로고
    • Inhibin B in males with gonadotropin-releasing hormone (GnRH) deficiency: changes in serum concentration after short-term physiologic GnRH replacement - a clinical research center study
    • Seminara S.B., Boepple P.A., Nachtigall L.B., Pralong F.P., Khoury R.H., Sluss P.M., et al. Inhibin B in males with gonadotropin-releasing hormone (GnRH) deficiency: changes in serum concentration after short-term physiologic GnRH replacement - a clinical research center study. J Clin Endocrinol Metab 1996, 81:3692-3696.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3692-3696
    • Seminara, S.B.1    Boepple, P.A.2    Nachtigall, L.B.3    Pralong, F.P.4    Khoury, R.H.5    Sluss, P.M.6
  • 91
    • 0036149989 scopus 로고    scopus 로고
    • The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism
    • Pitteloud N., Hayes F.J., Boepple P.A., DeCruz S., Seminara S.B., MacLaughlin D.T., et al. The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2002, 87:152-160.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 152-160
    • Pitteloud, N.1    Hayes, F.J.2    Boepple, P.A.3    DeCruz, S.4    Seminara, S.B.5    MacLaughlin, D.T.6
  • 92
    • 77956580208 scopus 로고    scopus 로고
    • The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism
    • Dwyer A.A., Hayes F.J., Plummer L., Pitteloud N., Crowley W.F. The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2010, 95:4235-4243.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4235-4243
    • Dwyer, A.A.1    Hayes, F.J.2    Plummer, L.3    Pitteloud, N.4    Crowley, W.F.5
  • 93
    • 53149087494 scopus 로고    scopus 로고
    • Effects of follicle-stimulating hormone and human chorionic gonadotropin on gonadal steroidogenesis in two siblings with a follicle-stimulating hormone beta subunit mutation
    • Lofrano-Porto A., Casulari L.A., Nascimento P.P., Giacomini L., Naves L.A., da Motta L.D., et al. Effects of follicle-stimulating hormone and human chorionic gonadotropin on gonadal steroidogenesis in two siblings with a follicle-stimulating hormone beta subunit mutation. Fertil Steril 2008, 90:1169-1174.
    • (2008) Fertil Steril , vol.90 , pp. 1169-1174
    • Lofrano-Porto, A.1    Casulari, L.A.2    Nascimento, P.P.3    Giacomini, L.4    Naves, L.A.5    da Motta, L.D.6
  • 94
    • 84866395797 scopus 로고    scopus 로고
    • A rare cause of hypertestosteronemia in a 68-year-old patient: a Leydig cell tumor due to a somatic GNAS (Guanine Nucleotide-Binding Protein, Alpha-Stimulating Activity Popylpetide 1)-activating mutation
    • Libe R., Fratticci A., Lahlou N., Jornayvaz F.R., Tissier F., Louiset E., et al. A rare cause of hypertestosteronemia in a 68-year-old patient: a Leydig cell tumor due to a somatic GNAS (Guanine Nucleotide-Binding Protein, Alpha-Stimulating Activity Popylpetide 1)-activating mutation. J Androl 2012, 33:578-584.
    • (2012) J Androl , vol.33 , pp. 578-584
    • Libe, R.1    Fratticci, A.2    Lahlou, N.3    Jornayvaz, F.R.4    Tissier, F.5    Louiset, E.6
  • 95
    • 0035042212 scopus 로고    scopus 로고
    • Macroorchidism due to autonomous hyperfunction of Sertoli cells and Gsα gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy
    • Coutant R., Lumbroso S., Rey R., Lahlou N., Venara M., Rouleau S., et al. Macroorchidism due to autonomous hyperfunction of Sertoli cells and Gsα gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy. J Clin Endocrinol Metab 2001, 86:1778-1781.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1778-1781
    • Coutant, R.1    Lumbroso, S.2    Rey, R.3    Lahlou, N.4    Venara, M.5    Rouleau, S.6
  • 96
    • 33745751952 scopus 로고    scopus 로고
    • Testicular anti-Mullerian hormone: history, genetics, regulation and clinical applications
    • Josso N., Picard J.Y., Rey R., Clemente N. Testicular anti-Mullerian hormone: history, genetics, regulation and clinical applications. Pediatr Endocrinol Rev 2006, 3:347-358.
    • (2006) Pediatr Endocrinol Rev , vol.3 , pp. 347-358
    • Josso, N.1    Picard, J.Y.2    Rey, R.3    Clemente, N.4
  • 97
    • 57349142537 scopus 로고    scopus 로고
    • Physiologic androgen insensitivity of the foetal, neonatal, and early infantile testis is explained by the ontogeny of the androgen receptor expression in Sertoli cells
    • Chemes H.E., Rey R.A., Nistal M., Regadera J., Musse M., Gonzalez-Peramato P., et al. Physiologic androgen insensitivity of the foetal, neonatal, and early infantile testis is explained by the ontogeny of the androgen receptor expression in Sertoli cells. J Clin Endocrinol Metab 2008, 93:4408-4412.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4408-4412
    • Chemes, H.E.1    Rey, R.A.2    Nistal, M.3    Regadera, J.4    Musse, M.5    Gonzalez-Peramato, P.6
  • 98
    • 66149090735 scopus 로고    scopus 로고
    • Lack of androgen receptor expression in Sertoli cells accounts for the absence of anti-Mullerian hormone repression during early human testis development
    • Boukari K., Meduri G., Brailly-Tabard S., Guibourdenche J., Ciampi M.L., Massin N., et al. Lack of androgen receptor expression in Sertoli cells accounts for the absence of anti-Mullerian hormone repression during early human testis development. J Clin Endocrinol Metab 2009, 94:1818-1825.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1818-1825
    • Boukari, K.1    Meduri, G.2    Brailly-Tabard, S.3    Guibourdenche, J.4    Ciampi, M.L.5    Massin, N.6
  • 99
    • 0344515660 scopus 로고    scopus 로고
    • Anti-Mullerian hormone levels in serum from human foetuses and children: pattern and clinical interest
    • Guibourdenche J., Lucidarme N., Chevenne D., Rigal O., Nicolas M., Luton D., et al. Anti-Mullerian hormone levels in serum from human foetuses and children: pattern and clinical interest. Mol Cell Endocrinol 2003, 211:55-63.
    • (2003) Mol Cell Endocrinol , vol.211 , pp. 55-63
    • Guibourdenche, J.1    Lucidarme, N.2    Chevenne, D.3    Rigal, O.4    Nicolas, M.5    Luton, D.6
  • 100
    • 0023258571 scopus 로고
    • Proliferation of Sertoli cells during development of the human testis assessed by stereological methods
    • Cortes D., Müller J., Skakkebaek N.E. Proliferation of Sertoli cells during development of the human testis assessed by stereological methods. Int J Androl 1987, 10:589-596.
    • (1987) Int J Androl , vol.10 , pp. 589-596
    • Cortes, D.1    Müller, J.2    Skakkebaek, N.E.3
  • 101
    • 0242440967 scopus 로고    scopus 로고
    • Follicle-stimulating hormone increases testicular anti-Mullerian hormone (AMH) production through Sertoli cell proliferation and a nonclassical cyclic adenosine 5_-monophosphatemediated activation of the AMH gene
    • Lukas-Croisier C., Lasala C., Nicaud J., Bedecarras P., Kumar T.R., Dutertre M., et al. Follicle-stimulating hormone increases testicular anti-Mullerian hormone (AMH) production through Sertoli cell proliferation and a nonclassical cyclic adenosine 5_-monophosphatemediated activation of the AMH gene. Mol Endocrinol 2003, 17:550-561.
    • (2003) Mol Endocrinol , vol.17 , pp. 550-561
    • Lukas-Croisier, C.1    Lasala, C.2    Nicaud, J.3    Bedecarras, P.4    Kumar, T.R.5    Dutertre, M.6
  • 102
    • 0027696870 scopus 로고
    • Anti-mullerian hormone and testosterone serum levels are inversely related during normal and precocious pubertal development
    • Rey R., Lordereau-Richard I., Carel J.C., Barbet P., Cate R.L., Roger M., et al. Anti-mullerian hormone and testosterone serum levels are inversely related during normal and precocious pubertal development. J Clin Endocrinol Metab 1993, 77:1220-1226.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1220-1226
    • Rey, R.1    Lordereau-Richard, I.2    Carel, J.C.3    Barbet, P.4    Cate, R.L.5    Roger, M.6


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