Insulin-like factor 3: A novel circulating hormone of testis origin in humans

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 12, 2004, Pages 5952-5958

  Foresta, Carlo ^a   Bettella, Andrea ^a   Vinanzi, Cinzia ^a   Dabrilli, Paolo ^a   Meriggiola, Maria Cristina ^b   Garolla, Andrea ^a   Ferlin, Alberto ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE; INSULIN; INSULIN LIKE FACTOR 3; LUTEINIZING HORMONE; RELAXIN LIKE FACTOR; TESTOSTERONE; UNCLASSIFIED DRUG; CHORIONIC GONADOTROPIN; CYPROTERONE ACETATE; FOLLITROPIN; LEUPRORELIN; LEYDIG INSULIN LIKE PROTEIN; LEYDIG INSULIN-LIKE PROTEIN; PROTEIN; RECOMBINANT PROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; ENZYME SYNTHESIS; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INFERTILITY; LEYDIG CELL; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; TESTIS; TESTIS DISEASE; BLOOD; CASE CONTROL STUDY; DRUG ANTAGONISM; FEMALE; MALE INFERTILITY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ADULT; CASE-CONTROL STUDIES; CHORIONIC GONADOTROPIN; CYPROTERONE ACETATE; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; INFERTILITY, MALE; INSULIN; LEUPROLIDE; LEYDIG CELLS; MALE; PROTEINS; RADIOIMMUNOASSAY; RECOMBINANT PROTEINS; TESTICULAR DISEASES; TESTIS;

EID: 16644365935     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0575     Document Type: Article

References (26)

1. Zimmermann S, Schottler P, Engel W, Adham IM 1997 Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development. Mol Reprod Dev 47:30-38
2. Roche PJ, Butkus A, Wintour EM, Tregear G 1996 Structure and expression of Leydig insulin-like peptide mRNA in the sheep. Mol Cell Endocrinol 121: 171-177
3. Ivell R, Balvers M, Domagalski R, Ungefroren H, Hunt N, Schulze W 1997 Relaxin-like factor: a highly specific and constitutive new marker for Leydig cells in the human testis. Mol Hum Reprod 3:459-466
4. Nef S, Parada LF 1999 Cryptorchidism in mice mutant for Insl3. Nat Genet 22:295-299
5. Zimmermamm S, Steding G, Emmen JM, Brinkmann AO, Nayemia K, Holstein AF, Engel W, Adham IM 1999 Targeted disruption of the Insl3 gene causes bilateral Cryptorchidism. Mol Endocrinol 13:681-691
6. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ 2002 Activation of orphan receptors by the hormone relaxin. Science 295: 671-674
7. Kumagai J, Hsu SY, Matsumi H, Roh JS, Fu P, Wade JD, Bathgate RA, Hsueh AJ 2002 INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem 277:31283-31286
8. Bogatcheva NV, Truong A, Feng S, Engel W, Adham IM, Agoulnik AI 2003 GREAT/LGR8 is the only receptor for insulin-like 3 peptide. Mol Endocrinol 17:2639-2646
9. Overbeek PA, Gorlov IP, Sutherland RW, Houston JB, Harrison WR, Boettger-Tong HL, Bishop CE, Agulnik AI 2001 A transgenic insertion causing cryptorchidism in mice. Genesis 30:26-35
10. Gorlov IP, Kamat A, Bogatcheva NV, Jones E, Lamb DJ, Truong A, Bishop CE, McElreavey K, Agoulnik AI 2002 Mutations of the GREAT gene cause cryptorchidism. Hum Mol Genet 11:2309-2318
11. Ferlin A, Simonato M, Bartoloni L, Rizzo G, Bettella A, Dottorini T, Dallapiccola B, Foresta C 2003 The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. J Clin Endocrinol Metab 88:4273-4279
12. Tomboc M, Lee PA, Mitwally MF, Schneck FX, Bellinger M, Witchel SF 2000 Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. J Clin Endocrinol Metab 85:4013-4018
13. Lim HN, Raipert-de Meyts E, Skakkebaek NE, Hawkins JR, Hughes IA 2001 Generic analysis of the INSL3 gene in patients with maldescent of the testis. Eur J Endocrinol 144:129-137
14. Marin P, Ferlin A, Moro E, Rossi A, Bartoloni L, Rossato M, Foresta C 2001 Novel insulin-like 3 (INSL3) gene mutation associated with human cryptorchidism. Am J Med Genet 103:348-349
15. Canto P, Escudero I, Soderlund D, Nishimura E, Carranza-Lira S, Gutierrez J, Nava A, Mendez JP 2003 A novel mutation of the insulin-like 3 gene in patients with cryptorchidism. J Hum Genet 48:86-90
16. Ivell R, Bathgate RA 2002 Reproductive biology of the relaxin-like factor RLF/INSL3. Biol Reprod 67:699-705
17. Nguyen MT, Showalter PR, Timmons CF, Nef S, Parada LF, Baker LA 2002 Effects of orchidopexy on congenitally cryptorchid insulin-3 knockout mice. J Urol 168:1779-1783
18. Kawamura K, Kumagai J, Sudo S, Chun SY, Pisarska M, Morita H, Toppari J, Fu P, Wade JD, Bathgate RAD, Hsueh AJW 2004 Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Proc Natl Acad Sci USA 101:7323-7328
19. Hombach-Klonisch S, Schön J, Kehlen A, Blottner S, Klonisch T 2004 Seasonal expression of INSL3 and Lgr8/INSL3 receptor transcripts indicates variable differentiation of Ley dig cells in the roe deer testis. Biol Reprod 71:1079-1087
20. Balvers M, Spiess AN, Domagalski R, Hunt N, Kilic E, Mukhopadhyay AK, Hanks E, Charlton HM, Ivell R1998 Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology 139:2960-2970
21. Meriggiola MC, Bremner WJ, Paulsen CA, Valdiserri A, Incorvaia L, Motta R, Pavani A, Capelli M, Flamigni C 1996 A combined regimen of cyproterone acetate and testosterone enanthate as a potentially highly effective male contraceptive. J Clin Endocrinol Metab 81:3018-3023
22. Foresta C, Varotto A 1992 Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the oligospermic subject. Fertil Steril 58:1028-1033
23. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Bathgate RA, Sherwood OD, Hsueh AJ 2003 Relaxin signalling in reproductive tissues. Mol Cell Endocrinol 202:165-170
24. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y 1999 Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 401:168-173
25. Klonisch T, Steger K, Kehlen A, Allen WR, Froehlich C, Kauffold J, Bergmann M, Hombach-Klonisch S 2003 INSL3 ligand-receptor system in the equine testis. Biol Reprod 68:1975-1981
26. Cattanach BM, Iddon CA, Charlton HM, Chiappa SA, Fink G 1977 Gonadotropin releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 269:338-340