Long-term effect of testosterone therapy on bone mineral density in hypogonadal men

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 8, 1997, Pages 2386-2390

  Behre, Hermann M ^a   Kliesch, Sabine ^a   Leifke, Eckhard ^a   Link, Thomas M ^b   Nieschlag, Eberhard ^a,c  

^a Institute of Reproductive Medicine   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c INST OF REPRO MED OF THE UNIV   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; GONADORELIN; GONADORELIN ACETATE; HUMAN MENOPAUSAL GONADOTROPIN; HYDROXYAPATITE; TESTOSTERONE; TESTOSTERONE ENANTATE; TESTOSTERONE UNDECANOATE;

ADULT; AGED; ANDROGEN THERAPY; ARTICLE; BONE DENSITY; BONE MINERAL; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFICACY; HORMONE SUBSTITUTION; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; HYPOPITUITARISM; INTRAMUSCULAR DRUG ADMINISTRATION; KALLMANN SYNDROME; LONG TERM CARE; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROLACTINOMA; TESTOSTERONE BLOOD LEVEL; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0030852561     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.8.4163     Document Type: Article

References (38)

1. Orwoll ES, Klein RF. 1995 Osteoporosis in men. Endocr Rev. 16:87-116.
2. Finkelstein JS. 1996 Androgens and osteoporosis: clinical aspects. In: Bhasin S, Gabelnick HL, Spieler JM, Swerdloff RS, Wang C, Kelly C, eds. Pharmacology, biology, and clinical applications of androgens. Current status and future prospects. New York: Wiley-Liss; 265-277.
3. Jackson JA, Riggs MW, Spiekerman AM. 1992 Testosterone deficiency as a risk factor for hip fractures in men: a case-control study. Am J Med Sci. 304:4-8.
4. Gray A, Feldman HA, McKinlay JB, Longcope C. 1991 Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study. J Clin Endocrinol Metab. 73:1016-1025.
5. Vermeulen A, Kaufman JM. 1995 Ageing of the hypothalamo-pituitary-testicular axis in men. Horm Res. 43:25-28.
6. Meier DE, Orwoll ES, Jones JM. 1984 Marked disparity between trabecular and cortical bone loss with age in healthy men: measurement by vertebral computed tomography and radial photon absorptiometry. Ann Intern Med. 101:605-612.
7. Rudman D, Drinka PJ, Wilson CR, et al. 1994 Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol (Oxf). 40:653-661.
8. Cooper C, Melton III LJ. 1992 Epidemiology of Osteoporosis. Trends Endocrinol Metab. 3:224-229.
9. Cauley JA, Seeley DG, Ensrud K, et al. 1995 Estrogen replacement therapy and fractures in older women. Ann Intern Med. 122:9-16.
10. Turner RT, Riggs BL, Spelsberg TC. 1994 Skeletal effects of estrogen. Endocr Rev. 15:275-300.
11. Felson DT, Zhang Y, Hannan MR, Kiel DP, Wilson PWF, Anderson JJ. 1993 The effect of postmenopausal estrogen therapy on bone density in elderly women. N Engl J Med. 329:1141-1146.
12. Behre HM, Oberpenning F, Nieschlag E. 1990 Comparative pharmacokinetics of testosterone preparations: application of computer analysis and simulation. In. Nieschlag E, Behre HM, eds. Testosterone-action, deficiency, substitution. Berlin, Heidelberg, New York: Springer; 115-135.
13. Bals-Pratsch M, Knuth UA, Yoon YD, Nieschlag E. 1986 Transdermal testosterone substitution therapy for male hypogonadism. Lancet. 2:943-946.
14. Chandolia RK, Weinbauer GF, Simoni M, Behre HM, Nieschlag E. 1991 Comparative effects of chronic administration of the non-steroidal antiandrogens flutamide and casodex on the reproductive system of the adult male rat. Acta Endocrinol (Copenh). 125:547-555.
15. Cann CE, Genant HK. 1980 Precise measurement of vertebral mineral content using computed tomography. J Comput Assist Tomogr. 4:493-500.
16. Glüer CC, Engelke K, Jergas M, Hagiwara S, Grampp S, Genant HK. 1993 Changes in calibration standards for quantitative computed tomography: recommendations for clinical practice. Osteoporosis Int. 3:286-287.
17. Glüer CC, Reiser UJ, Davis CA, Rutt BK, Genant HK. 1988 Vertebral mineral determination by quantitative computed tomography (QCT): accuracy of single and dual energy measurements. J Comput Assist Tomogr. 12:242-258.
18. Cann CE. 1988 Quantitative CT for determination of bone mineral density: a review. Radiology. 166:509-522.
19. Kalender WA, Felsenberg D, Louis O, et al. 1989 Reference values for trabecular and cortical vertebral bone density in single and dual-energy quantitative computed tomography. Eur J Radiol. 9:75-80.
20. Cann CE, Genant HK, Kolb FO, Ettinger B. 1985 Quantitative computed tomography for prediction of vertebral fracture risk. Bone. 6:1-7.
21. Vogler III JB, Genant HK. 1995 Osteoporosis. In: Taveras JM, Ferrucci JT, eds. Radiology-diagnosis, imaging, intervention, 9th ed. Philadelphia: Lippincott; vol 5, chap. 58, pp 1-16.
22. Finkelstein JS, Klibansi A, Neer RM, et al. 1989 Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 69:776-783.
23. Greenspan SL, Oppenheim DS, Klibanski A. 1989 Importance of gonadal steroids to bone mass in men with hyperprolatinemic hypogonadism. Ann Intern Med. 110:526-531.
24. Diamond T, Stiel D, Posen S. 1991 Effects of testosterone and venesection on spinal and peripheral bone mineral in six hypogonadal men with hemochromatosis. J Bone Miner Res. 6:39-43.
25. Devogelaer JP, De Cooman S, Nagant de Deuxchaises C. 1992 Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study. Maturitas. 15:17-23.
26. Isaia G, Mussetta M, Pecchio F, Sciolla A, di Stefano M, Molinatti GM. 1992 Effect of testosterone on bone in hypogonadal males. Maturitas. 15:47-51.
27. Wang C, Eyre DR, Clark R, et al. 1996 Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men-a clinical research center study. J Clin Endocrinol Metab. 81:3654-3662.
28. Nieschlag E, Behre HM. 1997 Testosterone therapy. In: Nieschlag E, Behre HM, eds. Andrology-male reproductive health and dysfunction. Berlin, Heidelberg, New York: Springer; 295-308.
29. Lees B, Pugh M, Siddle N, Stevenson JC. 1995 Changes in bone density in women starting hormone replacement therapy compared with those in women already established on hormone replacement therapy. Osteoporosis Int. 5:344-348.
30. Seeman E, Melton LJ, O'Fallon WM, Riggs BL. 1983 Risk factors for spinal osteoporosis in men. Am J Med. 75:977-983.
31. Nieschlag E, Behre HM, eds. 1990 Testosterone-action, deficiency, substitution. Berlin, Heidelberg, New York: Springer.
32. WHO Special Program of Research, Development, and Research Training in Human Reproduction. 1992 Guidelines for the use of androgens in men. Geneva: WHO.
33. Bhasin S, Gabelnick HL, Spieler JM, Swerdloff RS, Wang C, Kelly C, eds. 1996 Pharmacology, biology, and clinical applications of androgens. Current status and future prospects. New York: Wiley-Liss.
34. Orwoll ES. 1996 Androgens as anabolic agents for bone. Trends Endocrinol Metab. 7:77-84.
35. Wakley GK, Schutte Jr HD, Hannon KS, Turner RT. 1991 Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. J Bone Miner Res. 6:325-330.
36. Smith EP, Boyd J, Frank GR, et al. 1994 Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med. 331:1056-1061.
37. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. 1995 Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogen. J Clin Endocrinol Metab. 80:3689-3698.
38. Lips P, van Kersteren PJM, Asscheman H, Gooren LJG. 1996 The effect of androgen treatment on bone metabolism in female to male transsexuals. J Bone Miner Res. 11:1769-1773.