Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 11, 2013, Pages

  Dwyer, Andrew A ^a,c   Sykiotis, Gerasimos P ^a,d   Hayes, Frances J ^a   Boepple, Paul A ^a   Lee, Hang ^b   Loughlin, Kevin R ^e   Dym, Martin ^f   Sluss, Patrick M ^a,b   Crowley Jr , William F ^a   Pitteloud, Nelly ^a,c  

^a Harvard Reproductive Endocrine Sciences Center   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d UNIVERSITY OF PATRAS   (Greece)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; INHIBIN B; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONGENITAL DISORDER; CONGENITAL HYPOGONADOTROPIC HYPOGONADISM; CONTROLLED STUDY; CYTOSKELETON; EJACULATION; GERM CELL; HISTOLOGY; HORMONE RESPONSE; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; MALE; MALE FERTILITY; MALE INFERTILITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SERTOLI CELL; SPERMATOGONIUM; SPERMATOZOON COUNT; TESTIS SIZE; TREATMENT OUTCOME;

ADULT; FOLLICLE STIMULATING HORMONE, HUMAN; GONADOTROPIN-RELEASING HORMONE; HUMANS; HYPOGONADISM; INFERTILITY, MALE; INHIBINS; MALE; PULSE THERAPY, DRUG; RECOMBINANT PROTEINS; SPERM COUNT; TESTIS;

EID: 84887464802     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-2518     Document Type: Article

References (20)

1. Cortes D, Müller J, Skakkebaek NE. Proliferation of Sertoli cells during development of the human testis assessed by stereological methods. Int J Androl. 1987;10: 589-596.
2. Müller J, Skakkebaek NE. Quantification of germ cells and seminiferous tubules by stereological examination of testicles from 50 boys who suffered from sudden death. Int J Androl. 1983;6: 143-156.
3. Regadera J, Martínez-Garcia F, González-Peramato P, Serrano A, Nistal M, Suárez-Quian C. Androgen receptor expression in Sertoli cells as a function of seminiferous tubule maturation in the human cryptorchid testis. J Clin Endocrinol Metab. 2001;86: 413-421.
4. Andersson AM, Müller J, Skakkebaek NE. Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels. J Clin Endocrinol Metab. 1998;83: 4451-4458.
5. Orth JM, Gunsalus GL, Lamperti AA. Evidence from Sertoli celldepleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development. Endocrinology. 1988;122: 787-794.
6. Pitteloud N, Hayes FJ, Dwyer A, et al. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2002;87: 4128-4136.
7. Kumar PA, Pitteloud N, Andrews PA, et al. Testis morphology in patients with idiopathic hypogonadotropic hypogonadism. Hum Reprod. 2006;21: 1033-1040.
8. Young J, Chanson P, Salenave S, et al. Testicular anti-müllerian hormone secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2005;90: 724-728.
9. Bougnères P, François M, Pantalone L, et al. Effects of an early postnatal treatment of hypogonadotropic hypogonadism with a continuous subcutaneous infusion of recombinant follicle-stimulating hormone and luteinizing hormone. J Clin Endocrinol Metab. 2008;93: 2202-2205.
10. Hoffman AR, Crowley WF Jr. Induction of puberty in men by longterm pulsatile administration of low-dose gonadotropin-releasing hormone. N Engl J Med. 1982;307: 1237-1241.
11. Young J. Approach to the male patient with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2012;97: 707-718.
12. Liu PY, Baker HW, Jayadev V, Zacharin M, Conway AJ, Handelsman DJ. Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome. J Clin Endocrinol Metab. 2009;94: 801-808.
13. Raivio T, Toppari J, Perheentupa A, McNeilly AS, Dunkel L. Treatment of prepubertal gonadotrophin-deficient boys with recombinant human follicle-stimulating hormone. Lancet. 1997;350: 263-264.
14. Raivio T, Wikström AM, Dunkel L. Treatment of gonadotropindeficient boys with recombinanthumanFSH: long-term observation and outcome. Eur J Endocrinol. 2007;156: 105-111.
15. Cooper TG, Noonan E, von Eckardstein S, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010;16: 231-245.
16. Sykiotis GP, Hoang XH, Avbelj M, et al. Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. J Clin Endocrinol Metab. 2010;95: 3019-3027.
17. Schell C, Albrecht M, Mayer C, Schwarzer JU, Frungieri MB, Mayerhofer A. Exploring human testicular peritubular cells: identification of secretory products and regulation by tumor necrosis factoralpha. Endocrinology. 2008;149: 1678-1686.
18. Orth JM. The role of follicle-stimulating hormone in controlling Sertoli cell proliferation in testes of fetal rats. Endocrinology. 1984; 115: 1248-1255.
19. Ramaswamy S, Marshall GR, McNeilly AS, Plant TM. Dynamics of the follicle-stimulating hormone (FSH)-inhibin B feedback loop and its role in regulating spermatogenesis in the adult male rhesus monkey (Macaca mulatta) as revealed by unilateral orchidectomy. Endocrinology. 2000;141: 18-27.
20. Vihko KK, LaPolt PS, Nishimori K, Hsueh AJ. Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats. Endocrinology. 1991;129: 1926-1932.