메뉴 건너뛰기




Volumn 349, Issue 3, 2014, Pages 444-457

Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: Role of vascular endothelial growth factors A and B

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; CANDESARTAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN A; VASCULOTROPIN B;

EID: 84901236192     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.212613     Document Type: Article
Times cited : (24)

References (60)
  • 2
    • 84872693831 scopus 로고    scopus 로고
    • AT1 receptor antagonism is proangiogenic in the brain: BDNF a novel mediator
    • Alhusban A, Kozak A, Ergul A, and Fagan SC (2013) AT1 receptor antagonism is proangiogenic in the brain: BDNF a novel mediator. J Pharmacol Exp Ther 344: 348-359.
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 348-359
    • Alhusban, A.1    Kozak, A.2    Ergul, A.3    Fagan, S.C.4
  • 3
    • 64449086483 scopus 로고    scopus 로고
    • Angiogenesis after cerebral ischemia
    • Beck H and Plate KH (2009) Angiogenesis after cerebral ischemia. Acta Neuropathol 117:481-496.
    • (2009) Acta Neuropathol , vol.117 , pp. 481-496
    • Beck, H.1    Plate, K.H.2
  • 7
    • 84866085470 scopus 로고    scopus 로고
    • Association of cerebral microbleeds in acute ischemic stroke with high serum levels of vascular endothelial growth factor
    • Dassan P, Brown MM, Gregoire SM, Keir G, and Werring DJ (2012) Association of cerebral microbleeds in acute ischemic stroke with high serum levels of vascular endothelial growth factor. Arch Neurol 69:1186-1189.
    • (2012) Arch Neurol , vol.69 , pp. 1186-1189
    • Dassan, P.1    Brown, M.M.2    Gregoire, S.M.3    Keir, G.4    Werring, D.J.5
  • 8
    • 0032890359 scopus 로고    scopus 로고
    • The angiopoietins: Yin and Yang in angiogen-esis
    • Davis S and Yancopoulos GD (1999) The angiopoietins: Yin and Yang in angiogen-esis. Curr Top Microbiol Immunol 237:173-185.
    • (1999) Curr Top Microbiol Immunol , vol.237 , pp. 173-185
    • Davis, S.1    Yancopoulos, G.D.2
  • 10
    • 14044265526 scopus 로고    scopus 로고
    • Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration
    • el-Remessy AB, Bartoli M, Platt DH, Fulton D, and Caldwell RB (2005) Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration. J Cell Sci 118:243-252.
    • (2005) J Cell Sci , vol.118 , pp. 243-252
    • El-Remessy, A.B.1    Bartoli, M.2    Platt, D.H.3    Fulton, D.4    Caldwell, R.B.5
  • 11
    • 1842473651 scopus 로고    scopus 로고
    • The angiotensin II type 1-receptor blocker candesartan increases cerebral blood flow, reduces infarct size, and improves neurologic outcome after transient cerebral ischemia in rats
    • Engelhorn T, Goerike S, Doerfler A, Okorn C, Forsting M, Heusch G, and Schulz R (2004) The angiotensin II type 1-receptor blocker candesartan increases cerebral blood flow, reduces infarct size, and improves neurologic outcome after transient cerebral ischemia in rats. J Cereb Blood Flow Metab 24:467-474.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 467-474
    • Engelhorn, T.1    Goerike, S.2    Doerfler, A.3    Okorn, C.4    Forsting, M.5    Heusch, G.6    Schulz, R.7
  • 12
    • 0029127218 scopus 로고
    • The role of vascular endothelial growth factor in pathological an-giogenesis
    • Ferrara N (1995) The role of vascular endothelial growth factor in pathological an-giogenesis. Breast Cancer Res Treat 36:127-137.
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 127-137
    • Ferrara, N.1
  • 13
    • 15744384141 scopus 로고    scopus 로고
    • Angiogenic protection from focal ischemia with angiotensin II type 1 receptor blockade in the rat
    • Forder JP, Munzenmaier DH, and Greene AS (2005) Angiogenic protection from focal ischemia with angiotensin II type 1 receptor blockade in the rat. Am J Physiol Heart Circ Physiol 288:H1989-H1996.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Forder, J.P.1    Munzenmaier, D.H.2    Greene, A.S.3
  • 15
    • 79955740049 scopus 로고    scopus 로고
    • Acute treatment with candesartan reduces early injury after permanent middle cerebral artery occlusion
    • Guan W, Kozak A, El-Remessy AB, Johnson MH, Pillai BA, and Fagan SC (2011a) Acute treatment with candesartan reduces early injury after permanent middle cerebral artery occlusion. Transl Stroke Res 2:179-185.
    • (2011) Transl Stroke Res , vol.2 , pp. 179-185
    • Guan, W.1    Kozak, A.2    El-Remessy, A.B.3    Johnson, M.H.4    Pillai, B.A.5    Fagan, S.C.6
  • 16
    • 79960680406 scopus 로고    scopus 로고
    • Drug repurposing for vascular protection after acute ischemic stroke
    • Guan W, Kozak A, and Fagan SC (2011b) Drug repurposing for vascular protection after acute ischemic stroke. Acta Neurochir Suppl (Wien) 111:295-298.
    • (2011) Acta Neurochir Suppl (Wien) , vol.111 , pp. 295-298
    • Guan, W.1    Kozak, A.2    Fagan, S.C.3
  • 19
    • 21744449454 scopus 로고    scopus 로고
    • Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia
    • Hosomi N, Nishiyama A, Ban CR, Naya T, Takahashi T, Kohno M, and Koziol JA (2005) Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Neuroscience 134:225-231.
    • (2005) Neuroscience , vol.134 , pp. 225-231
    • Hosomi, N.1    Nishiyama, A.2    Ban, C.R.3    Naya, T.4    Takahashi, T.5    Kohno, M.6    Koziol, J.A.7
  • 20
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
    • Huang LE, Arany Z, Livingston DM, and Bunn HF (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271:32253-32259.
    • (1996) J Biol Chem , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 22
    • 84890309262 scopus 로고    scopus 로고
    • Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke
    • Ishrat T, Pillai B, Ergul A, Hafez S, and Fagan SC (2013) Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke. Neurochem Res 38:2668-2677.
    • (2013) Neurochem Res , vol.38 , pp. 2668-2677
    • Ishrat, T.1    Pillai, B.2    Ergul, A.3    Hafez, S.4    Fagan, S.C.5
  • 23
    • 0037015059 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
    • Jin K, Zhu Y, Sun Y, Mao XO, Xie L, and Greenberg DA (2002) Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA 99:11946-11950.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11946-11950
    • Jin, K.1    Zhu, Y.2    Sun, Y.3    Mao, X.O.4    Xie, L.5    Greenberg, D.A.6
  • 24
    • 0000481740 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia
    • Jin KL, Mao XO, and Greenberg DA (2000) Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci USA 97: 10242-10247.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10242-10247
    • Jin, K.L.1    Mao, X.O.2    Greenberg, D.A.3
  • 25
    • 78751484981 scopus 로고    scopus 로고
    • Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression
    • Kochuparambil ST, Al-Husein B, Goc A, Soliman S, and Somanath PR (2011) Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression. J Pharmacol Exp Ther 336:496-505.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 496-505
    • Kochuparambil, S.T.1    Al-Husein, B.2    Goc, A.3    Soliman, S.4    Somanath, P.R.5
  • 27
    • 52649179928 scopus 로고    scopus 로고
    • Vascular protection with candesartan after experimental acute stroke in hypertensive rats: A dose-response study
    • Kozak W, Kozak A, Johnson MH, Elewa HF, and Fagan SC (2008) Vascular protection with candesartan after experimental acute stroke in hypertensive rats: a dose-response study. J Pharmacol Exp Ther 326:773-782.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 773-782
    • Kozak, W.1    Kozak, A.2    Johnson, M.H.3    Elewa, H.F.4    Fagan, S.C.5
  • 28
    • 0027936452 scopus 로고
    • Role of angiogenesis in patients with cerebral ischemic stroke
    • Krupinski J, Kaluza J, Kumar P, Kumar S, and Wang JM (1994) Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 25:1794-1798.
    • (1994) Stroke , vol.25 , pp. 1794-1798
    • Krupinski, J.1    Kaluza, J.2    Kumar, P.3    Kumar, S.4    Wang, J.M.5
  • 29
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy AP, Levy NS, Wegner S, and Goldberg MA (1995) Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270: 13333-13340.
    • (1995) J Biol Chem , vol.270 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 30
    • 47649122634 scopus 로고    scopus 로고
    • Temporary pretreatment with the angiotensin II type 1 receptor blocker, valsartan, prevents ischemic brain damage through an increase in capillary density
    • Li JM, Mogi M, Iwanami J, Min LJ, Tsukuda K, Sakata A, Fujita T, Iwai M, and Horiuchi M (2008a) Temporary pretreatment with the angiotensin II type 1 receptor blocker, valsartan, prevents ischemic brain damage through an increase in capillary density. Stroke 39:2029-2036.
    • (2008) Stroke , vol.39 , pp. 2029-2036
    • Li, J.M.1    Mogi, M.2    Iwanami, J.3    Min, L.J.4    Tsukuda, K.5    Sakata, A.6    Fujita, T.7    Iwai, M.8    Horiuchi, M.9
  • 31
    • 33845383924 scopus 로고    scopus 로고
    • Modeling the neurovascular niche: VEGF-And BDNF-mediated cross-talk between neural stem cells and endothelial cells: An in vitro study
    • Li Q, Ford MC, Lavik EB, and Madri JA (2006) Modeling the neurovascular niche: VEGF-And BDNF-mediated cross-talk between neural stem cells and endothelial cells: an in vitro study. J Neurosci Res 84:1656-1668.
    • (2006) J Neurosci Res , vol.84 , pp. 1656-1668
    • Li, Q.1    Ford, M.C.2    Lavik, E.B.3    Madri, J.A.4
  • 33
    • 40549090548 scopus 로고    scopus 로고
    • VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats
    • Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, and Fang C, et al. (2008b) VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest 118:913-923.
    • (2008) J Clin Invest , vol.118 , pp. 913-923
    • Li, Y.1    Zhang, F.2    Nagai, N.3    Tang, Z.4    Zhang, S.5    Scotney, P.6    Lennartsson, J.7    Zhu, C.8    Qu, Y.9    Fang, C.10
  • 35
    • 0035344017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades
    • Matsuzaki H, Tamatani M, Yamaguchi A, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, and Tohyama M (2001) Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 15:1218-1220.
    • (2001) FASEB J , vol.15 , pp. 1218-1220
    • Matsuzaki, H.1    Tamatani, M.2    Yamaguchi, A.3    Namikawa, K.4    Kiyama, H.5    Vitek, M.P.6    Mitsuda, N.7    Tohyama, M.8
  • 36
    • 27744471912 scopus 로고    scopus 로고
    • Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro
    • Mould AW, Greco SA, Cahill MM, Tonks ID, Bellomo D, Patterson C, Zournazi A, Nash A, Scotney P, and Hayward NK, et al. (2005) Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro. Circ Res 97:e60-e70.
    • (2005) Circ Res , vol.97
    • Mould, A.W.1    Greco, S.A.2    Cahill, M.M.3    Tonks, I.D.4    Bellomo, D.5    Patterson, C.6    Zournazi, A.7    Nash, A.8    Scotney, P.9    Hayward, N.K.10
  • 37
    • 33644865215 scopus 로고    scopus 로고
    • Chronic angiotensin II AT1 receptor blockade increases cerebral cortical microvessel density
    • Munzenmaier DH and Greene AS (2006) Chronic angiotensin II AT1 receptor blockade increases cerebral cortical microvessel density. Am J Physiol Heart Circ Physiol 290:H512-H516.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Munzenmaier, D.H.1    Greene, A.S.2
  • 38
    • 66749173431 scopus 로고    scopus 로고
    • Mechanisms and targets for angio-genic therapy after stroke
    • Navaratna D, Guo S, Arai K, and Lo EH (2009) Mechanisms and targets for angio-genic therapy after stroke. Cell Adhes Migr 3:216-223.
    • (2009) Cell Adhes Migr , vol.3 , pp. 216-223
    • Navaratna, D.1    Guo, S.2    Arai, K.3    Lo, E.H.4
  • 40
    • 45149112715 scopus 로고    scopus 로고
    • Eryth-ropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF
    • Pillai A, Dhandapani KM, Pillai BA, Terry AV, Jr, and Mahadik SP (2008) Eryth-ropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF. Neuropsychopharmacology 33:1942-1951.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1942-1951
    • Pillai, A.1    Dhandapani, K.M.2    Pillai, B.A.3    Terry, Jr.A.V.4    Mahadik, S.P.5
  • 42
    • 0038300714 scopus 로고    scopus 로고
    • Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics
    • Schulz M and Schmoldt A (2003) Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie 58:447-474.
    • (2003) Pharmazie , vol.58 , pp. 447-474
    • Schulz, M.1    Schmoldt, A.2
  • 43
    • 84871633270 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptor system: Physiological functions in angiogenesis and pathological roles in various diseases
    • Shibuya M (2013) Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. J Biochem 153:13-19.
    • (2013) J Biochem , vol.153 , pp. 13-19
    • Shibuya, M.1
  • 45
    • 30044451865 scopus 로고    scopus 로고
    • Vascular endo-thelial growth factor-B (VEGFB) stimulates neurogenesis: Evidence from knockout mice and growth factor administration
    • Sun Y, Jin K, Childs JT, Xie L, Mao XO, and Greenberg DA (2006) Vascular endo-thelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration. Dev Biol 289:329-335.
    • (2006) Dev Biol , vol.289 , pp. 329-335
    • Sun, Y.1    Jin, K.2    Childs, J.T.3    Xie, L.4    Mao, X.O.5    Greenberg, D.A.6
  • 46
    • 79952167895 scopus 로고    scopus 로고
    • Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and car-diomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart
    • Tao Z, Chen B, Tan X, Zhao Y, Wang L, Zhu T, Cao K, Yang Z, Kan YW, and Su H (2011) Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and car-diomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart. Proc Natl Acad Sci USA 108:2064-2069.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2064-2069
    • Tao, Z.1    Chen, B.2    Tan, X.3    Zhao, Y.4    Wang, L.5    Zhu, T.6    Cao, K.7    Yang, Z.8    Kan, Y.W.9    Su, H.10
  • 51
    • 0036320934 scopus 로고    scopus 로고
    • 2- regulated gene expression
    • 2-regulated gene expression. FASEB J 16:1151-1162.
    • (2002) FASEB J , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 53
    • 0036400306 scopus 로고    scopus 로고
    • Effects of vascular endothelial growth factor (VEGF)A and VEGFB gene transfer on vascular reserve in a conscious rabbit hindlimb ischaemia model
    • Wright CE (2002) Effects of vascular endothelial growth factor (VEGF)A and VEGFB gene transfer on vascular reserve in a conscious rabbit hindlimb ischaemia model. Clin Exp Pharmacol Physiol 29:1035-1039.
    • (2002) Clin Exp Pharmacol Physiol , vol.29 , pp. 1035-1039
    • Wright, C.E.1
  • 54
    • 84876988759 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-B expression in postischemic rat brain
    • Xie L, Mao X, Jin K, and Greenberg DA (2013) Vascular endothelial growth factor-B expression in postischemic rat brain. Vasc Cell 5:8.
    • (2013) Vasc Cell , vol.5 , pp. 8
    • Xie, L.1    Mao, X.2    Jin, K.3    Greenberg, D.A.4
  • 55
    • 77649093444 scopus 로고    scopus 로고
    • Angiogenesis, neurogenesis and brain recovery of function following injury
    • Xiong Y, Mahmood A, and Chopp M (2010) Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Investig Drugs 11:298-308.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 298-308
    • Xiong, Y.1    Mahmood, A.2    Chopp, M.3
  • 56
    • 79955959619 scopus 로고    scopus 로고
    • COMP-Ang1 stimulates HIF-1a-mediated SDF-1 over-expression and recovers ischemic injury through BM-derived progenitor cell recruitment
    • Youn SW, Lee SW, Lee J, Jeong HK, Suh JW, Yoon CH, Kang HJ, Kim HZ, Koh GY, and Oh BH, et al. (2011) COMP-Ang1 stimulates HIF-1a-mediated SDF-1 over-expression and recovers ischemic injury through BM-derived progenitor cell recruitment. Blood 117:4376-4386.
    • (2011) Blood , vol.117 , pp. 4376-4386
    • Youn, S.W.1    Lee, S.W.2    Lee, J.3    Jeong, H.K.4    Suh, J.W.5    Yoon, C.H.6    Kang, H.J.7    Kim, H.Z.8    Koh, G.Y.9    Oh, B.H.10
  • 57
    • 65549139264 scopus 로고    scopus 로고
    • VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
    • Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, and Dong L, et al. (2009) VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci USA 106:6152-6157.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6152-6157
    • Zhang, F.1    Tang, Z.2    Hou, X.3    Lennartsson, J.4    Li, Y.5    Koch, A.W.6    Scotney, P.7    Lee, C.8    Arjunan, P.9    Dong, L.10
  • 58
    • 0036173275 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia
    • Zhang Z and Chopp M (2002) Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia. Trends Cardiovasc Med 12:62-66.
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 62-66
    • Zhang, Z.1    Chopp, M.2
  • 59
    • 0037008879 scopus 로고    scopus 로고
    • Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice
    • Zhang ZG, Zhang L, Croll SD, and Chopp M (2002) Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice. Neuroscience 113:683-687.
    • (2002) Neuroscience , vol.113 , pp. 683-687
    • Zhang, Z.G.1    Zhang, L.2    Croll, S.D.3    Chopp, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.