Vascular protection by angiotensin receptor antagonism involves differential vegf expression in both hemispheres after experimental stroke

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Guan, Weihua ^a,b   Somanath, Payaningal R ^a,b   Koza, Anna ^a,b   Goc, Anna ^a,b   El Remessy, Azza B ^a,b   Ergul, Adviye ^a,b,c   Johnson, Maribeth H ^c   Alhusban, Ahmed ^a,b   Soliman, Sahar ^a,b   Fagan, Susan C ^a,b,c  

^a UNIVERSITY OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANDESARTAN; PROTEIN KINASE B; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN RECEPTOR 1; ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HEMISPHERE; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; UPREGULATION; ANIMAL; BLEEDING; BLOOD VESSEL; BRAIN; CEREBROSPINAL FLUID; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STROKE; VASCULARIZATION; WISTAR RAT;

ANIMALIA;

ANGIOTENSIN RECEPTOR ANTAGONISTS; ANIMALS; BLOOD VESSELS; CEREBRUM; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEMORRHAGE; MALE; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTORS, ANGIOTENSIN; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; STROKE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80052413036     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024551     Document Type: Article

References (21)

1. Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, et al. (2007) Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 38: 1655-1711.
2. Fagan SC, Hess DC, Hohnadel EJ, Pollock DM, Ergul A, (2004) Targets for vascular protection after acute ischemic stroke. Stroke 35: 2220-2225.
3. Sun Y, Jin K, Xie L, Childs J, Mao XO, et al. (2003) VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 111: 1843-1851.
4. Zhang Z, Zhang L, Jiang Q, Zhang R, Davies K, et al. (2000) VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 106: 829-838.
5. Kozak A, Ergul A, El-Remessy AB, Johnson MH, Machado LS, et al. (2009) Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke. Stroke 40: 1870-1876.
6. Ferrara N, Gerber HP, LeCouter J, (2003) The biology of VEGF and its receptors. Nat Med 9: 669-676.
7. Carey JR, Kimberley TJ, Lewis SM, Auerbach EJ, Dorsey L, et al. (2002) Analysis of fMRI and finger tracking training in subjects with chronic stroke. Brain 125: 773-88.
8. Sun Y, Jin K, Childs JT, Xie L, Mao XO, et al. (2004) Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice. J Cereb Blood Flow Metab 24: 1146-1152.
9. Reichelt M, Shi S, Hayes M, Kay G, Batch J, et al. (2003) Vascular endothelial growth factor-B and retinal vascular development in the mouse. Clin Experiment Ophthalmol 31: 61-65.
10. Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, et al. (2008) VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest 118: 913-923.
11. Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, et al. (2009) VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A 106: 6152-157.
12. Abraham D, Taghavi S, Riml P, Paulus P, Hofmann M, et al. (2002) VEGF-A and-C but not-B mediate increased vascular permeability in preserved lung grafts. Transplantation 73: 1703-1706.
13. Brkovic A, Sirois MG, (2007) Vascular permeability induced by VEGF family members in vivo: role of endogenous PAF and NO synthesis. J Cell Biochem 100: 727-737.
14. Igarashi M, Hirata A, Yamaguchi H, Tsuchiya H, Ohnuma H, et al. (2001) Candesartan inhibits carotid intimal thickening and ameliorates insulin resistance in balloon-injured diabetic rats. Hypertension 38: 1255-1259.
15. Kim AH, Khursigara G, Sun X, Franke TF, Chao MV, (2001) Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21: 893-901.
16. Issbrücker K, Marti HH, Hippenstiel S, Springmann G, Voswinckel R, et al. (2003) p38 MAP kinase-a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. FASEB J 17: 262-264.
17. Zhao H, (2009) Ischemic postconditioning as a novel avenue to protect against brain injury after stroke. J Cerebr Blood Flow Metab 29: 873-885.
18. Shin YJ, Choi JS, Choi JY, Hou Y, Cha JH, et al. (2010) Induction of vascular endothelial growth factor receptor-3 mRNA in glial cells following focal cerebral ischemia in rats. J Neuroimmunol 229: 81-90.
19. Shin YJ, Choi JS, Choi JY, Cha JH, Chun MH, et al. (2010) Enhanced expression of vascular endothelial growth factor receptor-3 in the subventricular zone of stroke-lesioned rats. Neurosci Lett 469: 194-198.
20. Zea Longa E, Weinstein PR, Carlson S, Cummins R, (1989) Reversible middle cerebral artery occlusion without craniectomy. Stroke 20: 84-91.
21. Guan W, Kozak A, El-Remessy AB, Johnson MH, Pillai BA, et al. (2011) Acute Treatment with Candesartan Reduces Early Injury After Permanent Middle Cerebral Artery Occlusion. Translational Stroke Research 2: 179-185.