Association of cerebral microbleeds in acute ischemic stroke with high serum levels of vascular endothelial growth factor

Archives of Neurology

Volumn 69, Issue 9, 2012, Pages 1186-1189

  Dassan, Pooja ^a   Brown, Martin M ^a   Gregoire, Simone M ^a   Keir, Geoffrey ^b   Werring, David J ^a  

^a NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

ADULT; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL PERMEABILITY; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN STEM; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; LABORATORY TEST; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; SYMPTOMATOLOGY; THALAMUS;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INTRACRANIAL HEMORRHAGES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; STROKE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84866085470     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2012.459     Document Type: Article

References (10)

1. Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol. 1999;20(4):637-642. (Pubitemid 30429021)
2. Fan YH, Zhang L, Lam WW, Mok VC, Wong KS. Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke. 2003;34(10):2459-2462. (Pubitemid 37221963)
3. Jeon SB, Kwon SU, Cho AH, Yun SC, Kim JS, Kang DW. Rapid appearance of new cerebral microbleeds after acute ischemic stroke. Neurology . 2009;73(20):1638-1644.
4. Smith EE, Gurol ME, Eng JA, et al. White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage. Neurology. 2004;63(9):1606-1612. (Pubitemid 39507576)
5. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain. 2007;130(pt 8):1988-2003. (Pubitemid 47236609)
6. Gregoire SM, Brown MM, Kallis C, Jäger HR, Yousry TA, Werring DJ. MRI detection of new microbleeds in patients with ischemic stroke: five-year cohort fol-low-up study. Stroke. 2010;41(1):184-186.
7. Slevin M, Krupinski J, Slowik A, Kumar P, Szczudlik A, Gaffney J. Serial measurement of vascular endothelial growth factor and transforming growth factor-β1 in serum of patients with acute ischemic stroke. Stroke. 2000;31(8):1863-1870.
8. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18(1):4-25. (Pubitemid 27076453)
9. Gregoire SM, Chaudhary UJ, Brown MM, et al. The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brainmicrobleeds. Neurology. 2009;73(21):1759-1766.
10. Schoch HJ, Fischer S, Marti HH. Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain. 2002;125(pt 11):2549-2557. (Pubitemid 35303512)