Angiogenic Responses of Vascular Endothelial Growth Factors in Periadventitial Tissue

Human Gene Therapy

Volumn 14, Issue 15, 2003, Pages 1451-1462

  Bhardwaj, Shalini ^a   Roy, Himadri ^a   Gruchala, Marcin ^a   Viita, Helena ^a   Kholova, Ivana ^a   Kokina, Ilze ^a   Achen, Marc G ^c   Stacker, Steven A ^c   Hedman, Marja ^a   Alitalo, Kari ^b   Ylä Herttuala, Seppo ^a,d  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; RECOMBINANT VASCULOTROPIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D;

ADVENTITIA; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; GENE TRANSFER; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LYMPH VESSEL; LYMPHOCYTIC INFILTRATION; NONHUMAN; PERICYTE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; CAPILLARIES; CAROTID ARTERIES; CELL DIVISION; ERYTHROCYTES; GENE TRANSFER TECHNIQUES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LIGANDS; LYMPHOCYTES; MACROPHAGES; MICROSCOPY, FLUORESCENCE; NEOVASCULARIZATION, PATHOLOGIC; PROMOTER REGIONS (GENETICS); RABBITS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSFECTION; TRANSGENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR B; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

ADENOVIRIDAE; ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 12444317591     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303403769211664     Document Type: Article

References (41)

1. ACHEN, M.G., JELTSCH, M., KUKK, E., MARINEN, T., VITALI, A., WILKS, A.F., ALITALO, K., and STACKER, S.A. (1998). Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc. Natl. Acad. Sci. U.S.A. 95, 548-553.
2. BAYER, I.M., CANIGGIA, I., ADAMSON, S.L., and LANGILLE, B.L. (2002). Experimental angiogenesis of arterial vasa vasorum. Cell Tissue Res. 307, 303-313.
3. BOOTH, R.F., MARTIN, J.F., HONEY, A.C, HASSAL, D.G., BAASLEY, J.E., and MONCADA, S. (1989). Rapid development of atherosclerosis lesions in the rabbit carotid artery induced by perivascular manipulation. Atherosclerosis 76, 263-264.
4. BYZOVA, T.V., GOLDMAN, C.K., JANKAU, J., CHEN, J., CABRERA, G., ACHEN, M.G., STACKER, S.A., CARNEVALE, A., SIEMONOW, M., DEITCHER, S.R., and DICORLETO, P.E. (2002). Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Blood 99, 4434-4442.
5. FERARRA, N., and DAVIS-SMYTH, T., (1997). The biology of vascular endothelial growth factor. Endocr. Rev. 12, 4-25.
6. FOLKMAN, J. (1995). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-31.
7. HILTUNEN, M.O., LAITINEN, M., TURUNEN, M.P., JELTSCH, M., HARTIKAINEN, J., RISSANEN, T.T., LAUKKANEN, J., NIEMI, M., KOSSILA, M., HAKKINEN, T.P., KIVELA, A., ENHOLM, B., MANSUKOSKI, H., TURUNEN, A.M., ALITALO, K., and YLA-HERTTUALA, S. (2000). Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta. Circulation 102, 2262-2268.
8. INCI, S., and SPETZLER, R.F. (2000). Intracranial aneurysms and arterial hypertension: A review and hypothesis. Surg. Neurol. 53, 530-540.
9. JOUKOV, V., PAJUSOLA, K., KAIPAINEN, A., CHILOV, D., LAHTINEN, I., KUKK, E., SAKSELA, O., KALKKINEN, N., and ALITALO, K. (1996). A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15, 1751.
10. JOUKOV, V., SORSA, T., KUMAR, V., JELTSCH, M., CLAESSON-WELSH, L., CAO, Y., SAKSELA, O., KALKKINEN, N., and ALITALO, K. (1997). Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J. 16, 3898-3911.
11. JUSSILA, L., and ALITALO, K. (2002). Vascular growth factors and lymphangiogenesis. Physiol. Rev. 82, 673-700.
12. KAIPAINEN, A., KORHONEN, J., MUSTONEN, T., VAN HINSBERGH V.W., FANG, G.H., DUMONT, D., BREITMAN, M., and ALITALO, K. (1995). Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Natl. Acad. Sci. U.S.A. 92, 3566-3570.
13. KATO, S., YASUNUGA, A., and UCHIDA, U. (1991). Enzyme-histochemical method for identification of lymphatic capillaries. Lymphology 24, 125-129.
14. KATO, S., MIURA, M., and MIYAUCHI, R. (1993). Structural organization of the initial lymphatics in the monkey mesentry and intestinal wall as revealed by an enzyme-histochemics1 method. Arch. Histol. Cytol. 56, 149-160.
15. KHOLOVA, I., LUDVIKOVA, M., RYSKA, A., and CAP, J. (2002). Dipeptidyl(amino)peptidase IV in differential differential diagnosis of thyroid gland tumor: methods and results of a pilot study of 200 cases. Cesk. Patol. 38, 11-17.
16. LAITINEN, M., and YLA-HERTTUALA, S. (1998). Adventitial gene transfer to arterial wall. Pharmacol. Res. 37, 251-254.
17. LAITINEN, M., PAKKANEN, T., DONETTI, E., BAETTA, R., LUOMA, J., LEHTOLAINEN, P., VIITA, H., AGRAWAL, R., MYANOHARA, A., FRIEDMANN, T., RISAU, W., MARTIN, J.F., SOMA, M., and YLA-HERTTUALA, S. (1997). Gene transfer into the carotid artery using an adventitial collar: Comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses. Hum. Gene Ther. 8, 1645-1650.
18. LAITINEN, M., MANNINEN, H., MATSI, P., KOSSILA, M., AGRAWAL, R.S., PAKKANEN, T., LUOMA, J.S., VIITA, H., HARTIKAINEN, J., ALHAVA, E., LAAKSO, M., and YLA-HERTTUALA, S. (1998). Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia. Hum. Gene Ther. 9, 1481-1486.
19. MAKINEN, K., MANNINEN, H., HEDMAN, M., MATSI, P., MUSSALO, H., ALHAVA, E., and YLA-HERTTUALA, S. (2002). Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol. Ther. 6, 127-133.
20. MAKINEN, T., VEIKKOLA, T., MUSTJOKI, S., KARPANEN, T., CATIMEL, B., NICE, E.C., WISE, L., MERCER, A., KOWALSKI, H., KERJASCHKI, D., STACKER, S.A., ACHEN, M.G., and ALITALO, K. (2001). Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J. 20, 4762-4773.
21. MILLAUER, B., WIZIGMANN-VOOS, S., SCHNURCH, H., MARTINEZ, R., MOLLER, N.P., RISAU, W., and ULLRICH, A. (1993). High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835-846.
22. MINAMIKAWA, T., MIYAKE, T., TAKAMATSU, T., and FUJITA, S. (1987). A new method of lectin histochemistry for the study of brain angiogenesis. Lectin angiography. Histochemistry 87, 317-320.
23. NIKOL, S., ENGELMANN, MG., PELISEK, J., FUCHS, A., GOLDA, A., SHIMIZU, M., MEKKAOUI, C., and ROLLAND, P.H. (2002). Local perivascular application of low amounts of a plasmid encoding for vascular endothelial growth factor (VEGF165) is efficient for therapeutic angiogenesis in pigs. Acta Physiol. Scand. 176, 151-159.
24. OGAWA, S., OKU, A., SAWANO, A., YAMAGUCHI, S., YAZAKI, Y., and SHIBUYA, M. (1998). A novel type of vascular endothelial growth factor, VEGF-E (NZ-7VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitogenic activity without heparin binding domain. J. Biol. Chem. 273, 31273-31282.
25. OLOFSSON, B., KORPELAINEN, E., PEPPER, M.S., MANDRIOTA, S.J., AASE, K., KUMAR, V., GUNJI, Y., JELTSCH, M.M., SHIBUYA, M., ALITALO, K., and ERIKSSON, U. (1998). Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 95, 11709-11714.
26. PARTANEN, T.A., AROLA, J., JUSSILA, L., ORA, A., MIETTINEN, M., STACKER, S.A., AHEN, M.G., and ALITALO, K. (2000). VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues. FASEB J. 14, 2087-2096.
27. RISAU, W. (1997). Mechanisms of angiogenesis. Nature 386, 671-674.
28. SABIN, F.R. (1902). On the origin of the lymphatic system from the veins and the development of the lymph hearts and thoracic duct in the pig. Am. J. Anat. 1, 367-391.
29. SAVORY, L.J., STACKER S.A., FLEMING, S.B., NIVEN, B.E., and MERCER, A.A., (2000). Viral vascular endothelial growth factor plays a critical role in orf virus infection. J. Virol. 74, 10699-10706.
30. SAWANO, A., IWAI, S., SAKURAI, Y., ITO, M., SHITARA, K., NAKAHATA, T., and SHIBUYA, M. (2001). Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood 97, 785-791.
31. SCOTLAND, R.S., VALLANCE, P.J., and AHLUWALIA, A. (2000). Endogenous factors involved in regulation of tone of arterial vasa vasorum: implications for conduit vessel physiology. Cardiovasc. Res. 46, 403-11.
32. SHALABY, F., ROSSANT, J., YAMAGUCHI, T.P., GERTSENSTEIN, M., WU, X.F., BREITMAN, M.L., and SCHUH, A.C. (1995). Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376, 62-66.
33. SLEEMAN, J.P, KRISHNAN, J., KIRKIN, V., and BAUMANN, P. (2001). Markers for the lymphatic endothelium: in search of the holy grail? Microsc. Res. Tech. 55, 61-69.
34. STACKER, S.A., STENVERS, K., CAESAR, C., VITALI, A., DOMAGALA, T., NICE, E., ROUFAlL, S., SIMPSON, R.J., MORITZ, R., KARPANEN, T., ALITALO, K., and ACHEN, M.G. (1999). Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. J. Biol. Chem. 274, 32127-32136.
35. TERMAN, B.I., DOUCHER, V.M., CARRION, M.E., CARRION, M.E., DIMITROV, D., ARMELLINO, D.C., GOSPODAROWICZ, D., and BOHLEN, P. (1992). Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187, 1579-1586.
36. THURSTON, G., SURI, C., SMITH, K., MCCLAIN, J., SATO, T.N., YANCOPOULOS, G.D., and MCDONALD, D.M. (1999). Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 24, 2511-2514.
37. VEIKKOLA, T., JUSSILA, L., MAKINEN, T., KARPANEN, T., JELTSCH, M., PETROVA, T.V., KUBO, H., THURSTON, G., MCDONALD, D.M., ACHEN, M.G., STACKER, S.A., and ALITALO, K. (2001). Signaling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J. 20, 1223-1231.
38. WARD, N.L., and DUMONT, D.J. (2002). The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development. Semin. Cell Dev. Biol. 13, 19-27.
39. WERNER, J.A., SCHUNKE, M., and TILLMANN, B. (1987). Histochemical visualization of lymphatic capillaries in the rat: A comparison of methods demonstrated at the posterior pharyngeal surface. Arch. Histol. Jpn. 50, 505-514.
40. WITMER, A.N., VAN BLIJSWIJK, B.C., DAI, J., HOFMAN, P., PARTANEN, T.A., VRENSEN, G.F., and SCHLINGEMANN, R.O. (2001). VEGFR-3 in adult angiogenesis. J. Pathol. 195, 490-497.
41. YLÄ-HERTTUALA, S., and MARTIN, JF. (2000). Cardiovascular gene therapy. Lancet 355, 213-222.