A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease

Journal of Hepatology

Volumn 60, Issue 6, 2014, Pages 1203-1211

  Nishikawa, Taichiro ^a,f   Bellance, Nadège ^c   Damm, Aaron ^c   Bing, Han ^a   Zhu, Zhen ^d   Handa, Kan ^e   Yovchev, Mladen I ^e   Sehgal, Vasudha ^g   Moss, Tyler J ^g   Oertel, Michael ^e   Ram, Prahlad T ^g   Pipinos, Iraklis I ^d   Soto Gutierrez, Alejandro ^b,e   Fox, Ira J ^a,b   Nagrath, Deepak ^c  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c Rice University   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^g UNIVERSITY OF TEXAS   (United States)

Author keywords

Acute in chronic liver failure; Adenosine 5 triphosphate; Decompensated liver cirrhosis; Glycolysis; Hepatocytes; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBON TETRACHLORIDE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; OXYGEN; PHOSPHOGLUCOMUTASE; REACTIVE OXYGEN METABOLITE; ALCOHOL DEHYDROGENASE; AROMATIC AMINO ACID; BRANCHED CHAIN AMINO ACID; CYTOCHROME P450; GROWTH HORMONE RECEPTOR; MITOCHONDRIAL ENZYME; PHOSPHOGLYCERATE MUTASE; PREALBUMIN; AMINO ACID; ANTICONVULSIVE AGENT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MEMBRANE PROTEIN; PHENOBARBITAL; PTGS1 PROTEIN, RAT; PTGS2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHILD PUGH SCORE; CHRONIC LIVER FAILURE; CONTROLLED STUDY; ENERGY METABOLISM; ENERGY YIELD; ENZYME ACTIVE SITE; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN TISSUE; LIVER CELL; LIVER CIRRHOSIS; LIVER FUNCTION; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; AMINO ACID TRANSPORT; ANAEROBIC GLYCOLYSIS; ANIMAL CELL CULTURE; CELL ISOLATION; DOWN REGULATION; ENZYME ACTIVITY; FOLLOW UP; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLYCOGENOLYSIS; LIVER DISEASE; LIVER FAILURE; LIVER INJURY; METABOLIC ACTIVITY ASSAY; PROTEIN PHOSPHORYLATION; UPREGULATION; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; EXPERIMENTAL LIVER CIRRHOSIS; LEWIS RAT; METABOLISM; MITOCHONDRION; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TOXIC HEPATITIS;

ADENOSINE TRIPHOSPHATE; AMINO ACIDS; ANIMALS; ANTICONVULSANTS; CARBON TETRACHLORIDE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; GLUCOSE; GLYCOLYSIS; HEPATOCYTES; HUMANS; LIVER CIRRHOSIS, EXPERIMENTAL; MEMBRANE PROTEINS; MITOCHONDRIA; OXYGEN CONSUMPTION; PHENOBARBITAL; RATS, INBRED LEW; SEVERITY OF ILLNESS INDEX;

EID: 84901233996     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.02.014     Document Type: Article

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