Oncosecretomics coupled to bioenergetics identifies α-amino adipic acid, isoleucine and GABA as potential biomarkers of cancer: Differential expression of c-Myc, Oct1 and KLF4 coordinates metabolic changes

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1817, Issue 11, 2012, Pages 2060-2071

  Bellance, Nadège ^a,b   Pabst, Lisa ^a,b   Allen, Genevara ^b   Rossignol, Rodrigue ^c   Nagrath, Deepak ^a,b  

^a Laboratory for Systems Biology of Human Diseases   (United States)

^b Rice University   (United States)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Bioenergetics; Glycolysis; Metabolism; Oxidative phosphorylation; Secretomics

Indexed keywords

2 AMINOADIPIC ACID; 4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; BIOLOGICAL MARKER; GLUCOSE; ISOLEUCINE; KRUPPEL LIKE FACTOR 4; LACTIC ACID; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 1;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BIOENERGY; CANCER CELL; CELL RESPIRATION; CONTROLLED STUDY; EMBRYO; GLUCOSE TRANSPORT; GLYCOLYSIS; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; ONCOGENE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

2-AMINOADIPIC ACID; ANIMALS; CELLS, CULTURED; ENERGY METABOLISM; GAMMA-AMINOBUTYRIC ACID; ISOLEUCINE; KRUPPEL-LIKE TRANSCRIPTION FACTORS; METABOLOMICS; MICE; NEOPLASMS; OCTAMER TRANSCRIPTION FACTOR-1; PROTO-ONCOGENE PROTEINS C-MYB; RATS; TUMOR MARKERS, BIOLOGICAL;

EID: 84865683757     PISSN: 00052728     EISSN: 18792650     Source Type: Journal    
DOI: 10.1016/j.bbabio.2012.07.004     Document Type: Article

References (40)

1. N. Bellance, P. Lestienne, and R. Rossignol Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis Front. Biosci. 14 2009 4015 4034
2. C. Jose, N. Bellance, and R. Rossignol Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma? Biochim. Biophys. Acta 1807 2011 552 561
3. D. Nagrath, C. Caneba, T. Karedath, and N. Bellance Metabolomics for mitochondrial and cancer studies Biochim. Biophys. Acta 1807 2011 650 663
4. T.J. Wang, M.G. Larson, R.S. Vasan, S. Cheng, E.P. Rhee, E. McCabe, G.D. Lewis, C.S. Fox, P.F. Jacques, C. Fernandez, C.J. O'Donnell, S.A. Carr, V.K. Mootha, J.C. Florez, A. Souza, O. Melander, C.B. Clish, and R.E. Gerszten Metabolite profiles and the risk of developing diabetes Nat. Med. 17 2011 448 453
5. E.S. Ong, L. Zou, S. Li, P.Y. Cheah, K.W. Eu, C.N. Ong, Metabolic profiling in colorectal cancer reveals signaturemetabolic shifts during tumorigenesis,Mol. Cell. Proteomics (in press).
6. A. Sreekumar, L.M. Poisson, T.M. Rajendiran, A.P. Khan, Q. Cao, J. Yu, B. Laxman, R. Mehra, R.J. Lonigro, Y. Li, M.K. Nyati, A. Ahsan, S. Kalyana-Sundaram, B. Han, X. Cao, J. Byun, G.S. Omenn, D. Ghosh, S. Pennathur, D.C. Alexander, A. Berger, J.R. Shuster, J.T. Wei, S. Varambally, C. Beecher, and A.M. Chinnaiyan Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression Nature 457 2009 910 914
7. M.K. Mateyak, A.J. Obaya, S. Adachi, and J.M. Sedivy Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination Cell Growth Differ. 8 1997 1039 1048
8. A. Shakya, R. Cooksey, J.E. Cox, V. Wang, D.A. McClain, and D. Tantin Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity Nat. Cell Biol. 11 2009 320 327
9. E.G. Hagos, A.M. Ghaleb, W.B. Dalton, A.B. Bialkowska, and V.W. Yang Mouse embryonic fibroblasts null for the Kruppel-like factor 4 gene are genetically unstable Oncogene 28 2009 1197 1205
10. R.C. O'Hagan, M. Ohh, G. David, I.M. de Alboran, F.W. Alt, W.G. Kaelin Jr., and R.A. DePinho Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression Genes Dev. 14 2000 2185 2191
11. D. Kuystermans, and M. Al-Rubeai cMyc increases cell number through uncoupling of cell division from cell size in CHO cells BMC Biotechnol. 9 2009 76
12. C.D. Folmes, T.J. Nelson, A. Martinez-Fernandez, D.K. Arrell, J.Z. Lindor, P.P. Dzeja, Y. Ikeda, C. Perez-Terzic, and A. Terzic Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming Cell Metab. 14 2011 264 271
13. D. Kuystermans, M.J. Dunn, and M. Al-Rubeai A proteomic study of cMyc improvement of CHO culture BMC Biotechnol. 10 2010 25
14. N. Bellance, G. Benard, F. Furt, H. Begueret, K. Smolkova, E. Passerieux, J.P. Delage, J.M. Baste, P. Moreau, and R. Rossignol Bioenergetics of lung tumors: alteration of mitochondrial biogenesis and respiratory capacity Int. J. Biochem. Cell Biol. 41 2009 2566 2577
15. D.R. Wise, R.J. DeBerardinis, A. Mancuso, N. Sayed, X.Y. Zhang, H.K. Pfeiffer, I. Nissim, E. Daikhin, M. Yudkoff, S.B. McMahon, and C.B. Thompson Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction Proc. Natl. Acad. Sci. U. S. A. 105 2008 18782 18787
16. W. Qian, and B. Van Houten Alterations in bioenergetics due to changes in mitochondrial DNA copy number Methods 51 2010 452 457
17. O. Troyanskaya, M. Cantor, G. Sherlock, P. Brown, T. Hastie, R. Tibshirani, D. Botstein, and R.B. Altman Missing value estimation methods for DNA microarrays Bioinformatics 17 2001 520 525
18. M. Barker, and W. Rayens Partial least squares for discrimination J. Chemometr. 17 2003 166 173
19. K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
20. S. Yamanaka, and K. Takahashi Induction of pluripotent stem cells from mouse fibroblast cultures Tanpakushitsu Kakusan Koso 51 2006 2346 2351
21. H. Shim, C. Dolde, B.C. Lewis, C.S. Wu, G. Dang, R.A. Jungmann, R. Dalla-Favera, and C.V. Dang c-Myc transactivation of LDH-A: implications for tumor metabolism and growth Proc. Natl. Acad. Sci. U. S. A. 94 1997 6658 6663
22. M. Yuneva, N. Zamboni, P. Oefner, R. Sachidanandam, and Y. Lazebnik Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells J. Cell Biol. 178 2007 93 105
23. F. Li, Y. Wang, K.I. Zeller, J.J. Potter, D.R. Wonsey, K.A. O'Donnell, J.W. Kim, J.T. Yustein, L.A. Lee, and C.V. Dang Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis Mol. Cell. Biol. 25 2005 6225 6234
24. O. Warburg, F. Wind, and E. Negelein The metabolism of tumors in the body J. Gen. Physiol. 8 1927 519 530
25. O. Warburg On the origin of cancer cells Science 123 1956 309 314
26. C.V. Dang, A. Le, and P. Gao MYC-induced cancer cell energy metabolism and therapeutic opportunities Clin. Cancer Res. 15 2009 6479 6483
27. M.L. Johansen, L.K. Bak, A. Schousboe, P. Iversen, M. Sorensen, S. Keiding, H. Vilstrup, A. Gjedde, P. Ott, and H.S. Waagepetersen The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes Neurochem. Int. 50 2007 1042 1051
28. D. Nagrath, M. Avila-Elchiver, F. Berthiaume, A.W. Tilles, A. Messac, and M.L. Yarmush Soft constraints-based multiobjective framework for flux balance analysis Metab. Eng. 12 2010 429 445
29. D. Nagrath, M. Avila-Elchiver, F. Berthiaume, A.W. Tilles, A. Messac, and M.L. Yarmush Integrated energy and flux balance based multiobjective framework for large-scale metabolic networks Ann. Biomed. Eng. 35 2007 863 885
30. G. D'Antona, M. Ragni, A. Cardile, L. Tedesco, M. Dossena, F. Bruttini, F. Caliaro, G. Corsetti, R. Bottinelli, M.O. Carruba, A. Valerio, and E. Nisoli Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice Cell Metab. 12 2010 362 372
31. S. El-Sayed, T. Bezabeh, O. Odlum, R. Patel, S. Ahing, K. MacDonald, R.L. Somorjai, and I.C. Smith An ex vivo study exploring the diagnostic potential of 1H magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region Head Neck 24 2002 766 772
32. F. Morrish, N. Isern, M. Sadilek, M. Jeffrey, and D.M. Hockenbery c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry Oncogene 28 2009 2485 2491
33. Y. Zhou, W.L. Hofstetter, Y. He, W. Hu, A. Pataer, L. Wang, J. Wang, L. Yu, B. Fang, and S.G. Swisher KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression Cancer Biol. Ther. 9 2010 507 513
34. Z.Y. Chen, J.L. Shie, and C.C. Tseng Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells J. Biol. Chem. 277 2002 46831 46839
35. D.T. Dang, X. Chen, J. Feng, M. Torbenson, L.H. Dang, and V.W. Yang Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity Oncogene 22 2003 3424 3430
36. F. Yu, J. Li, H. Chen, J. Fu, S. Ray, S. Huang, H. Zheng, and W. Ai Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion Oncogene 30 2011 2161 2172
37. M. Takeda, A. Takamiya, J.W. Jiao, K.S. Cho, S.G. Trevino, T. Matsuda, and D.F. Chen alpha-Aminoadipate induces progenitor cell properties of Muller glia in adult mice Invest. Ophthalmol. Vis. Sci. 49 2008 1142 1150
38. X. Chen, D.C. Johns, D.E. Geiman, E. Marban, D.T. Dang, G. Hamlin, R. Sun, and V.W. Yang Kruppel-like factor 4 (gut-enriched Kruppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle J. Biol. Chem. 276 2001 30423 30428
39. R. Almeida, J. Almeida, M. Shoshkes, N. Mendes, P. Mesquita, E. Silva, I. Van Seuningen, C.A. Reis, F. Santos-Silva, and L. David OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells J. Pathol. 207 2005 396 401
40. S. Reymann, and J. Borlak Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network BMC Syst. Biol. 2 2008 46