Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes

Oncotarget

Volumn 5, Issue 9, 2014, Pages 2542-2550

  Habib, Samy L ^a,b   Liang, Sitai ^b  

^a SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^b University of Texas Health Science Center   (United States)

Author keywords

8 OxodG and OGG1; Diabetes; mTOR; RCC; Tuberin

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; KI 67 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; S6 KINASE; TUBERIN; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TUMOR SUPPRESSOR PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; BIOACCUMULATION; CANCER PATIENT; CELL NUCLEUS; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE ASSOCIATION; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE LOCATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CANCER; KIDNEY CELL; KIDNEY CORTEX; KIDNEY TUBULE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANALOGS AND DERIVATIVES; CASE CONTROL STUDY; COMPARATIVE STUDY; DEFICIENCY; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; KIDNEY; KIDNEY NEOPLASMS; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; TUMOR CELL CULTURE; WESTERN BLOTTING;

BLOTTING, WESTERN; CASE-CONTROL STUDIES; DEOXYGUANOSINE; DIABETES MELLITUS; DNA DAMAGE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY; KIDNEY NEOPLASMS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 84901218393     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1833     Document Type: Article

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