Tuberin inhibits production of the matrix protein fibronectin in diabetes

Journal of the American Society of Nephrology

Volumn 23, Issue 10, 2012, Pages 1652-1662

  Habib, Samy L ^a,b   Yadav, Mukesh ^a   Tizani, Shaza ^a   Bhandari, Basant ^a   Valente, Anthony J ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; FIBRONECTIN; GLUCOSE; INSULIN; MATRIX PROTEIN; MESSENGER RNA; PROTEIN KINASE B; TUBERIN;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; CREATININE CLEARANCE; DIABETES MELLITUS; DISEASE ASSOCIATION; FIBROBLAST; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INHIBITION KINETICS; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; KIDNEY MASS; KIDNEY TUBULE EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

EID: 84867163160     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012030285     Document Type: Article

References (32)

1. Brownlee M: The pathobiology of diabetic complications: A unifying mechanism. Diabetes 54: 1615-1625, 2005
2. Phillips AO, Steadman R: Diabetic nephropathy: The central role of renal proximal tubular cells in tubulointerstitial injury. Histol Histopathol 17: 247-252, 2002 (Pubitemid 34116428)
3. Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001
4. Fioretto P, Bruseghin M, Berto I, Gallina P, Manzato E, Mussap M: Renal protection in diabetes: Role of glycemic control. J Am Soc Nephrol 17 [Suppl 2]: S86-S89, 2006
5. Ziyadeh FN, Snipes ER, Watanabe M, Alvarez RJ, Goldfarb S, Haverty TP: High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am J Physiol 259: F704-F714, 1990 (Pubitemid 20359112)
6. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986, 1993
7. Morrisey K, Steadman R, Williams JD, Phillips AO: Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent. Kidney Int 55: 160-167, 1999 (Pubitemid 29004247)
8. Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC: Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10: 151-162, 2002 (Pubitemid 34876569)
9. Inoki K, Li Y, Zhu T, Wu J, Guan KL: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648-657, 2002 (Pubitemid 34993700)
10. Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ: Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 277: 35364-35370, 2002
11. Simone S, Gorin Y, Velagapudi C, Abboud HE, Habib SL: Mechanism of oxidative DNA damage in diabetes: Tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2′-deoxyguanosine-DNA glycosylase. Diabetes 57: 2626-2636, 2008
12. Inoki K, Zhu T, Guan KL: TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590, 2003 (Pubitemid 37506046)
13. Sekulić A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT: A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 60: 3504-3513, 2000 (Pubitemid 30482170)
14. Watson KL, Chou MM, Blenis J, Gelbart WM, Erikson RL: A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene. Proc Natl Acad Sci U S A 93: 13694-13698, 1996 (Pubitemid 26424181)
15. Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 99: 13571-13576, 2002 (Pubitemid 35215423)
16. Kenerson HL, Aicher LD, True LD, Yeung RS: Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res 62: 5645-5650, 2002 (Pubitemid 35204715)
17. Mori H, Inoki K, Masutani K, Wakabayashi Y, Komai K, Nakagawa R, Guan KL, Yoshimura A: The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. Biochem Biophys Res Commun 384: 471-475, 2009
18. Potter CJ, Huang H, Xu T: Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105: 357-368, 2001 (Pubitemid 32455342)
19. Samikkannu T, Thomas JJ, Bhat GJ, Wittman V, Thekkumkara TJ: Acute effect of high glucose on long-term cell growth: A role for transient glucose increase in proximal tubule cell injury. Am J Physiol Renal Physiol 291: F162-F175, 2006 (Pubitemid 43945947)
20. +-ATPase assembly, translocation, and acidi fication of intracellular compartments in renal epithelial cells. Mol Cell Biol 25: 575-589, 2005
21. Uysal H, Hemming FW: Changes in the expression and distribution of fibronectin, laminin and tenascin by cultured fibroblasts from skin lesions of patients with tuberous sclerosis. Br J Dermatol 141: 658-666, 1999 (Pubitemid 29512819)
22. Velagapudi C, Bhandari B, Werner SL, Simone S, Abboud HE, Habib SL: The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes. J Am Soc Nephrol 22: 262-273, 2011
23. White ES, Sagana RL, Booth AJ, Yan M, Cornett AM, Bloomheart CA, Tsui JL, Wilke CA, Moore BB, Ritzenthaler JD, Roman J, Muro AF: Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway. Exp Cell Res 316: 2644-2653, 2010
24. Ong CT, Khoo YT, Mukhopadhyay A, Do DV, Lim IJ, AalamiO, Phan TT: mTOR as a potential therapeutic target for treatment of keloids and excessive scars. Exp Dermatol 16: 394-404, 2007 (Pubitemid 46585367)
25. Danda RS, Habiba NM, Rincon-Choles H, Bhandari BK, Barnes JL, Abboud HE, Pergola PE: Kidney involvement in a nongenetic rat model of type 2 diabetes. Kidney Int 68: 2562-2571, 2005 (Pubitemid 43251001)
26. Habib SL, Riley DJ, Mahimainathan L, Bhandari B, Choudhury GG, Abboud HE: Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol 294: F281-F290, 2008
27. Clontech Laboratories: Adeno-X Expression Systems User Manual. Clontech Laboratories, Mountain View, CA, 2012
28. Habib SL, Bhandari BK, Sadek N, Abboud-Werner SL, Abboud HE: Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells. Carcinogenesis 31: 2022-2030, 2010
29. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976
30. Habib SL, Simone S, Barnes JJ, Abboud HE: Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors. Mol Cancer 7: 10-14, 2008
31. Ye P, Habib SL, Ricono JM, Kim NH, Choudhury GG, Barnes JL, Abboud HE, Arar MY: Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation. Kidney Int 66: 1356-1364, 2004 (Pubitemid 39298367)
32. Dean DC, Bowlus CL, Bourgeois S: Cloning and analysis of the promotor region of the human fibronectin gene. Proc Natl Acad Sci U S A 84: 1876-1880, 1987 (Pubitemid 17054116)