N-acetyl-heparin attenuates acute lung injury caused by acid aspiration mainly by antagonizing histones in mice

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Zhang, Yanlin ^a   Zhao, Zanmei ^a   Guan, Li ^a   Mao, Lijun ^a   Li, Shuqiang ^a   Guan, Xiaoxu ^a   Chen, Ming ^a   Guo, Lixia ^a   Ding, Lihua ^a   Cong, Cuicui ^a   Wen, Tao ^b   Zhao, Jinyuan ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; HEPARIN DERIVATIVE; HISTONE; MYELOPEROXIDASE; N ACETYL HEPARIN; UNCLASSIFIED DRUG; HYDROCHLORIC ACID; N-ACETYLHEPARIN; NUCLEOSOME; PEROXIDASE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BLEEDING; BLOOD GAS ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; DRUG PROTEIN BINDING; ENZYME ACTIVITY; LETHALITY; LUNG EDEMA; MALE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; SURVIVAL RATE; ANALOGS AND DERIVATIVES; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; HISTOLOGY; METABOLISM; NUCLEOSOME; PATHOLOGY; PNEUMONIA, ASPIRATION; TREATMENT OUTCOME; WESTERN BLOTTING;

ACUTE LUNG INJURY; ANALYSIS OF VARIANCE; ANIMALS; BLOOD GAS ANALYSIS; BLOTTING, WESTERN; HEPARIN; HISTOLOGICAL TECHNIQUES; HISTONES; HYDROCHLORIC ACID; MICE; MICE, INBRED C57BL; NUCLEOSOMES; PEROXIDASE; PNEUMONIA, ASPIRATION; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84901218219     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097074     Document Type: Article

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