Pin1 induction in the fibrotic liver and its roles in TGF-β1 expression and Smad2/3 phosphorylation

Journal of Hepatology

Volumn 60, Issue 6, 2014, Pages 1235-1241

  Yang, Jin Won ^a   Hien, Tran Thi ^b   Lim, Sung Chul ^b   Jun, Dae Won ^c   Choi, Hong Seok ^b   Yoon, Jung Hoon ^d   Cho, Il Je ^e   Kang, Keon Wook ^a  

^a Seoul National University   (South Korea)

^b Chosun University   (South Korea)

^c Hanyang University   (South Korea)

^d Wonkwang University   (South Korea)

^e Daegu Haany University   (South Korea)

Author keywords

Liver fibrosis; Pin1; Smad2 3; TGF 1

Indexed keywords

DIMETHYLNITROSAMINE; JUGLONE; KRUPPEL LIKE FACTOR 6; MITOGEN ACTIVATED PROTEIN KINASE 6; NUCLEAR FACTOR I; PEPTIDYLPROLYL ISOMERASE PIN1; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C JUN; PROTEIN KINASE B; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1; ENZYME INHIBITOR; NAPHTHOQUINONE; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; PEPTIDYLPROLYL ISOMERASE; SMAD2 PROTEIN, HUMAN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, HUMAN; SMAD3 PROTEIN, MOUSE; ALPHA SMOOTH MUSCLE ACTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROGENESIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING; ANIMAL; CELL COMMUNICATION; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER CIRRHOSIS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; ANIMAL CELL; CELL LINE; ENZYME ACTIVITY; GENE SILENCING; HUMAN CELL; LIVER INJURY; LX 2 CELL; MOUSE EMBRYONIC FIBROBLAS; PROTEIN FUNCTION;

ANIMALS; CELL COMMUNICATION; CELLS, CULTURED; ENZYME INHIBITORS; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; MALE; MICE, INBRED ICR; MICE, KNOCKOUT; NAPHTHOQUINONES; PEPTIDYLPROLYL ISOMERASE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84901194840     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.02.004     Document Type: Article

References (38)

1. S.L. Friedman Mechanisms of hepatic fibrogenesis Gastroenterology 134 2008 1655 1669
2. C. Kirmaz, E. Terzioglu, O. Topalak, P. Bayrak, O. Yilmaz, and G. Ersoz et al. Serum transforming growth factor-beta1(TGF-beta1) in patients with cirrhosis, chronic hepatitis B and chronic hepatitis C Eur Cytokine Netw 15 2004 112 116
3. M.F. Yuen, S. Norris, L.W. Evans, P.G. Langley, and R.D. Hughes Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis Scand J Gastroenterol 37 2002 233 238
4. J. Wanninger, R. Wiest, S. Bauer, M. Neumeier, K. Eisinger, and S. Farkas et al. Portal levels of latent transforming growth factor-beta are related to liver function in patients with liver cirrhosis Eur J Gastroenterol Hepatol 23 2011 218 223
5. X.Z. Zhou, O. Kops, A. Werner, P.J. Lu, M. Shen, and G. Stoller et al. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins Mol Cell 6 2000 873 883
6. M.R. Kim, H.K. Choi, K.B. Cho, H.S. Kim, and K.W. Kang Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells Cancer Sci 100 2009 1834 1841
7. B.W. Doble, and J.R. Woodgett GSK-3: tricks of the trade for a multi-tasking kinase J Cell Sci 116 2003 1175 1186
8. H.G. Jeong, Y.R. Pokharel, S.C. Lim, Y.P. Hwang, E.H. Han, and J.H. Yoon et al. Novel role of Pin1 induction in type II collagen-mediated rheumatoid arthritis J Immunol 183 2009 6689 6697
9. Z.J. Shen, S. Esnault, and J.S. Malter The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils Nat Immunol 6 2005 1280 1287
10. S. Esnault, R.K. Braun, Z.J. Shen, Z. Xiang, E. Heninger, and R.B. Love et al. Pin1 modulates the type 1 immune response PLoS One 2 2007 e226
11. Z.J. Shen, S. Esnault, L.A. Rosenthal, R.J. Szakaly, R.L. Sorkness, and P.R. Westmark et al. Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis J Clin Invest 118 2008 479 490
12. I.J. Cho, Y.W. Kim, C.Y. Han, E.H. Kim, R.A. Anderson, and Y.S. Lee et al. E-cadherin antagonizes transforming growth factor beta1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation Hepatology 52 2010 2053 2064
13. S.E. Kim, M.Y. Lee, S.C. Lim, T.T. Hien, J.W. Kim, and S.G. Ahn et al. Role of Pin1 in neointima formation: down-regulation of Nrf2-dependent heme oxygenase-1 expression by Pin1 Free Radic Biol Med 48 2010 1644 1653
14. E. Fransvea, U. Angelotti, S. Antonaci, and G. Giannelli Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells Hepatology 47 2008 1557 1566
15. S.J. Kim, A. Glick, M.B. Sporn, and A.B. Roberts Characterization of the promoter region of the human transforming growth factor-beta 1 gene J Biol Chem 264 1989 402 408
16. J.J. Kruse, C.I. Bart, J.W. Leer, and J. Wondergem Detection and quantitative measurement of transforming growth factor-beta1 (TGF-beta1) gene expression using a semi-nested competitive PCR assay Cytokine 11 1999 179 185
17. P. Monje, J. Hernandez-Losa, R.J. Lyons, M.D. Castellone, and J.S. Gutkind Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1 J Biol Chem 280 2005 35081 35084
18. G.M. Wulf, A. Ryo, G.G. Wulf, S.W. Lee, T. Niu, and V. Petkova et al. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1 EMBO J 20 2001 3459 3472
19. C. Weigert, U. Sauer, K. Brodbeck, A. Pfeiffer, H.U. Haring, and E.D. Schleicher AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells J Am Soc Nephrol 11 2000 2007 2016
20. S.J. Lee, J.W. Yang, I.J. Cho, W.D. Kim, M.K. Cho, and C.H. Lee et al. The gep oncogenes, Galpha(12) and Galpha(13), upregulate the transforming growth factor-beta1 gene Oncogene 28 2009 1230 1240
21. K.S. Chun, and Y.J. Surh Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention Biochem Pharmacol 68 2004 1089 1100
22. X. Zhang, B. Jin, and C. Huang The PI3K/AKT pathway and its downstream transcriptional factors as targets for chemoprevention Curr Cancer Drug Targets 7 2007 305 316
23. I. Matsuura, K.N. Chiang, C.Y. Lai, D. He, G. Wang, and R. Ramkumar et al. Pin1 promotes transforming growth factor-beta-induced migration and invasion J Biol Chem 285 2010 1754 1764
24. X. Hua, Z.A. Miller, H. Benchabane, J.L. Wrana, and H.F. Lodish Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene J Biol Chem 275 2000 33205 33208
25. T.A. Wynn Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases J Clin Invest 117 2007 524 529
26. M. Guarino, A. Tosoni, and M. Nebuloni Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition Hum Pathol 40 2009 1365 1376
27. J. Zavadil, and E.P. Bottinger TGF-beta and epithelial-to-mesenchymal transitions Oncogene 24 2005 5764 5774
28. M. Bauer, and D. Schuppan TGFbeta1 in liver fibrosis: time to change paradigms? FEBS Lett 502 2001 1 3
29. Z.J. Shen, R.K. Braun, J. Hu, Q. Xie, H. Chu, and R.B. Love et al. Pin1 protein regulates Smad protein signaling and pulmonary fibrosis J Biol Chem 287 2012 23294 23305
30. Z. Qi, N. Atsuchi, A. Ooshima, A. Takeshita, and H. Ueno Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat Proc Natl Acad Sci U S A 96 1999 2345 2349
31. Y. Kim, V. Ratziu, S.G. Choi, A. Lalazar, G. Theiss, and Q. Dang et al. Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury J Biol Chem 273 1998 33750 33758
32. S. Joshi-Barve, S.S. Barve, K. Amancherla, L. Gobejishvili, D. Hill, and M. Cave et al. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes Hepatology 46 2007 823 830
33. Y. Zhang, and X. Yao Role of c-Jun N-terminal kinase and p38/activation protein-1 in interleukin-1beta-mediated type I collagen synthesis in rat hepatic stellate cells APMIS 120 2012 101 107
34. Y.-C. Liou, X.Z. Zhou, and K.P. Lu Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins Trends Biochem Sci 36 2011 501 514
35. J.M. Ryu, M.Y. Lee, S.P. Yun, and H.J. Han High glucose regulates cyclin D1/E of human mesenchymal stem cells through TGF-beta1 expression via Ca2+/PKC/MAPKs and PI3K/AKT/mTOR signal pathways J Cell Physiol 224 2010 59 70
36. M. Zhang, D. Fraser, and A. Phillips ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells Am J Pathol 169 2006 1282 1293
37. K.A. Rygiel, H. Robertson, H.L. Marshall, M. Pekalski, L. Zhao, and T.A. Booth et al. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease Lab Invest 88 2008 112 123
38. M. Zeisberg, C. Yang, M. Martino, M.B. Duncan, F. Rieder, and H. Tanjore et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition J Biol Chem 282 2007 23337 23347