AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-β1 promoter in mesangial cells

Journal of the American Society of Nephrology

Volumn 11, Issue 11, 2000, Pages 2007-2016

  Weigert, Cora ^a   Sauer, Ulrich ^b   Brodbeck, Katrin ^a   Pfeiffer, Andreas ^c   Häring, Hans U ^a   Schleicher, Erwin D ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; BINDING SITE; CYTOKINE PRODUCTION; DIABETIC NEPHROPATHY; DNA FLANKING REGION; ELECTROPHORETIC MOBILITY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REPORTER GENE; SITE DIRECTED MUTAGENESIS; SWINE;

EID: 0033760187     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Osterby R: Glomerular structural changes in type 1 (insulin-dependent) diabetes mellitus: Causes, consequences, and prevention. Diabetologia 35: 803-819, 1992
2. Mauer SM, Steffes MW, Ellis EN, Sutherland DN, Brown DM, Goetz FC: Structural-functional relationships in diabetic nephropathy. J Clin Investig 74: 1143-1155, 1984
3. Nerlich A, Schleicher E: Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions. Am J Pathol 139: 889-899, 1991
4. The Diabetes Control and Complications Trial Research Group: The effects of intensive insulin treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986, 1993
5. Kreisberg JI, Ayo SH: The glomerular mesangium in diabetes mellitus. Kidney Int 43: 109-113, 1993
6. Heilig CW, Conception LA, Riser BL, Freytag SO, Zhu M, Cordes P: Over-expression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype. J Clin Investig 96: 1802-1814, 1995
7. Ziyadeh FN, Sharma K, Ericksen M, Wolf G: Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. J Clin Investis 93: 536-542, 1994
8. Kolm V, Sauer U, Olgemöller B, Schleicher E: High glucose-induced TGF-β1 regulates mesangial production of heparan sulfate proteoglycan. Am J Physiol 270: F812-F821, 1996
9. Yamamoto T, Nakamura T, Noble NA, Ruoslahti E, Border WA: Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 90: 1814-1818, 1993