Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids

Journal of Hepatology

Volumn 60, Issue 6, 2014, Pages 1259-1267

  Wang, Lirui ^a   Hartmann, Phillipp ^a   Haimerl, Michael ^a   Bathena, Sai P ^b   Sjöwall, Christopher ^c   Almer, Sven ^d   Alnouti, Yazen ^b   Hofmann, Alan F ^a   Schnabl, Bernd ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c LINKÖPING UNIVERSITY   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bacterial translocation; Bile acids transporter; Chronic liver disease; IL 1 ; Microbiome; Renal tubular epithelial cells

Indexed keywords

BILE ACID; CARBON TETRACHLORIDE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 1BETA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; ABCC4 PROTEIN, MOUSE; CARD15 PROTEIN, MOUSE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; ALKALINE PHOSPHATASE; BILIRUBIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BILE DUCT LIGATION; CELL DEATH; CONTROLLED STUDY; INTRAHEPATIC CHOLESTASIS; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; URINARY EXCRETION; WILD TYPE; ANIMAL; DISEASE MODEL; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; KIDNEY TUBULE; KNOCKOUT MOUSE; LIVER CIRRHOSIS; METABOLISM; MICROFLORA; OBSTRUCTIVE JAUNDICE; PHYSIOLOGY; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; BACTERIAL LOAD; BACTERIAL OVERGROWTH; BILIRUBIN BLOOD LEVEL; CHOLESTATIC HEPATITIS; COMPARATIVE STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION; IMMUNOFLUORESCENCE; LIMIT OF DETECTION; LIVER PROTECTION; LIVER TOXICITY; PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION;

ANIMALS; BILE ACIDS AND SALTS; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; HEPATOCYTES; INTERLEUKIN-1BETA; JAUNDICE, OBSTRUCTIVE; KIDNEY TUBULES; LIVER CIRRHOSIS; MICE, KNOCKOUT; MICROBIOTA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NOD2 SIGNALING ADAPTOR PROTEIN;

EID: 84901192408     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.02.012     Document Type: Article

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