Dual effects of miR-155 on macrophages at different stages of atherosclerosis: LDL is the key?

Medical Hypotheses

Volumn 83, Issue 1, 2014, Pages 74-78

  Zhang, Erli ^a   Wu, Yongjian ^a  

^a FUWAI HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN; MICRORNA 155; MICRORNA; MIRN155 MICRORNA, HUMAN;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; DISEASE SEVERITY; FAT INTAKE; FOAM CELL; HUMAN; MACROPHAGE; MACROPHAGE ACTIVATION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ATHEROSCLEROSIS; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES; MICRORNAS;

EID: 84901056089     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2014.04.004     Document Type: Article

References (30)

1. Lloyd-Jones D., Adams R.J., Brown T.M., et al. Executive summary: heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 2010, 121:948-954.
2. Moore K.J., Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell 2011, 145:341-355.
3. Yan D., Wu Y., Yang Y., Belenkaya T.Y., Tang X., Lin X. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development 2010, 137:2033-2044.
4. Tabas I., Li Y., Brocia R.W., Xu S.W., Swenson T.L., Williams K.J. Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. J Biol Chem 1993, 268:20419-20432.
5. Kunjathoor V.V., Febbraio M., Podrez E.A., et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem 2002, 277:49982-49988.
6. Kruth H.S., Jones N.L., Huang W., et al. Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein. J Biol Chem 2005, 280:2352-2360.
7. Sorci-Thomas M.G., Thomas M.J. High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. Arterioscler Thromb Vasc Biol 2012, 32:2561-2565.
8. Medzhitov R. Origin and physiological roles of inflammation. Nature 2008, 454:428-435.
9. Thorp E., Tabas I. Mechanisms and consequences of efferocytosis in advanced atherosclerosis. J Leukoc Biol 2009, 86:1089-1095.
10. Van Vre E.A., Ait-Oufella H., Tedgui A., Mallat Z. Apoptotic cell death and efferocytosis in atherosclerosis. Arterioscler Thromb Vasc Biol 2012, 32:887-893.
11. Faraoni I., Antonetti F.R., Cardone J., Bonmassar E. MiR-155 gene: a typical multifunctional microRNA. Biochim Biophys Acta 2009, 1792:497-505.
12. Nazari-Jahantigh M., Wei Y., Noels H., et al. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Investig 2012, 122:4190-4202.
13. Wei Y., Nazari-Jahantigh M., Chan L., et al. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation 2013, 127:1609-1619.
14. Donners M.M., Wolfs I.M., Stoger L.J., et al. Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice. PLoS ONE 2012, 7:e35877.
15. Drechsler M., Megens R.T., van Zandvoort M., Weber C., Soehnlein O. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation 2010, 122:1837-1845.
16. Gerszten R.E., Garcia-Zepeda E.A., Lim Y.C., et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999, 398:718-723.
17. Carr A.C., McCall M.R., Frei B. Oxidation of LDL by myeloperoxidase and reactive nitrogen species: reaction pathways and antioxidant protection. Arterioscler Thromb Vasc Biol 2000, 20:1716-1723.
18. Eiserich J.P., Baldus S., Brennan M.L., et al. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science 2002, 296:2391-2394.
19. Lau D., Mollnau H., Eiserich J.P., et al. Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc Natl Acad Sci USA 2005, 102:431-436.
20. Tili E., Croce C.M., Michaille J.J. MiR-155: on the crosstalk between inflammation and cancer. Int Rev Immunol 2009, 28:264-284.
21. Dorsett Y., McBride K.M., Jankovic M., et al. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 2008, 28:630-638.
22. Ghorpade D.S., Leyland R., Kurowska-Stolarska M., Patil S.A., Balaji K.N. MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages. Mol Cell Biol 2012, 32:2239-2253.
23. Koch M., Mollenkopf H.J., Klemm U., Meyer T.F. Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis. Proc Natl Acad Sci USA 2012, 109:E1153-E1162.
24. Levitan I., Volkov S., Subbaiah P.V. Oxidized LDL: diversity, patterns of recognition, and pathophysiology. Antioxid Redox Signal 2010, 13:39-75.
25. Boullier A., Li Y., Quehenberger O., et al. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol 2006, 26:1169-1176.
26. Zhu G.F., Yang L.X., Guo R.W., et al. miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells. Mol Cell Biochem 2013, 382:253-261.
27. Wagner J., Riwanto M., Besler C., et al. Characterization of levels and cellular transfer of circulating lipoprotein-bound MicroRNAs. Arterioscler Thromb Vasc Biol 2013, 33:1392-1400.
28. Choi S.H., Harkewicz R., Lee J.H., et al. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res 2009, 104:1355-1363.
29. Ricote M., Valledor A.F., Glass C.K. Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis. Arterioscler Thromb Vasc Biol 2004, 24:230-239.
30. Ak P., Levine A.J. P53 and NF-kappaB: different strategies for responding to stress lead to a functional antagonism. FASEB J 2010, 24:3643-3652.