The role of macromolecular damage in aging and age-related disease

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 69, Issue , 2014, Pages S28-S32

  Richardson, Arlan G ^a   Schadt, Eric E ^b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

DNA oxidative damage; Oxidative stress; Protein oxidative damage

Indexed keywords

PROTEIN; REACTIVE OXYGEN METABOLITE;

AGING; ARTICLE; CHRONIC DISEASE; DNA DAMAGE; DNA OXIDATIVE DAMAGE; GENETICS; HUMAN; MACROMOLECULE; METABOLISM; OXIDATIVE STRESS; OXIDATIVE STRESS.; PROTEIN OXIDATIVE DAMAGE;

DNA OXIDATIVE DAMAGE; OXIDATIVE STRESS.; PROTEIN OXIDATIVE DAMAGE;

AGING; CHRONIC DISEASE; DNA DAMAGE; HUMANS; MACROMOLECULAR SUBSTANCES; OXIDATIVE STRESS; PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 84901054602     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu056     Document Type: Review

References (39)

1. Kirkwood TB. Understanding the odd science of aging. Cell. 2005;120:437-447.
2. Bokov A, Chaudhuri A, Richardson A. The role of oxidative damage and stress in aging. Mech Ageing Dev. 2004;125:811-826.
3. Bokov AF, Lindsey ML, Khodr C, Sabia MR, Richardson A. Longlived Ames dwarf mice are resistant to chemical stressors. J Gerontol A Biol Sci Med Sci. 2009;64:819-827.
4. Brown-Borg H, Johnson WT, Rakoczy S, Romanick M. Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice. J Am Aging Assoc. 2001;24:85-96.
5. Pérez VI, Bokov A, Van Remmen H, et al. Is the oxidative stress theory of aging dead? Biochim Biophys Acta. 2009;1790:1005-1014.
6. Andziak B, O'Connor TP, Qi W, et al. High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging Cell. 2006;5:463-471.
7. Chen Y, Zhu J, Lum PY, et al. Variations in DNA elucidate molecular networks that cause disease. Nature. 2008;452:429-435.
8. Emilsson V, Thorleifsson G, Zhang B, et al. Genetics of gene expression and its effect on disease. Nature. 2008;452:423-428.
9. Leonardson AS, Zhu J, Chen Y, et al. The effect of food intake on gene expression in human peripheral blood. Hum Mol Genet. 2010;19:159-169.
10. Zhu J, Chen Y, Leonardson AS, et al. Characterizing dynamic changes in the human blood transcriptional network. PLoS Comput Biol. 2010;6:e1000671.
11. Stadtman ER. Protein oxidation and aging. Free Radic Res. 2006;40:1250-1258.
12. Koga H, Kaushik S, Cuervo AM. Protein homeostasis and aging: the importance of exquisite quality control. Ageing Res Rev. 2011;10:205-215.
13. Pierce A, Mirzaei H, Muller F, et al. GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis. J Mol Biol. 2008;382:1195-1210.
14. Pérez VI, Buffenstein R, Masamsetti V, et al. Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci USA. 2009;106:3059-3064.
15. Salmon AB, Leonard S, Masamsetti V, et al. The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis. FASEB J. 2009;23:2317-2326.
16. Jones DP. Radical-free biology of oxidative stress. Am J Physiol Cell Physiol. 2008;295:C849-C868.
17. Young A, Lou D, McCormick F. Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov. 2013;3:112-123.
18. Vijg J, Suh Y. Genome instability and aging. Annu Rev Physiol. 2013;75:645-668.
19. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol. 2011;192:547-556.
20. Lupski JR. Genetics. Genome mosaicism-one human, multiple genomes. Science. 2013;341:358-359.
21. Poduri A, Evrony GD, Cai X, Walsh CA. Somatic mutation, genomic variation, and neurological disease. Science. 2013;341:1237758.
22. Vermulst M, Wanagat J, Kujoth GC, et al. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008;40:392-394.
23. Garinis GA, van der Horst GT, Vijg J, Hoeijmakers JH. DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol. 2008;10:1241-1247.
24. Han S, Brunet A. Histone methylation makes its mark on longevity. Trends Cell Biol. 2012;22:42-49.
25. Adams PD. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene. 2007;397:84-93.
26. Schreiber KH, Kennedy BK. When lamins go bad: nuclear structure and disease. Cell. 2013;152:1365-1375.
27. Eriksson M, Brown WT, Gordon LB, et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 2003;423:293-298.
28. Navarro CL, De Sandre-Giovannoli A, Bernard R, et al. Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy. Hum Mol Genet. 2004;13:2493-2503.
29. Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science. 2006;312:1059-1063.
30. Takeuchi H, Rünger TM. Longwave UV light induces the aging-associated progerin. J Invest Dermatol. 2013;133:1857-1862.
31. Ornish D, Lin J, Chan JM, et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013;14:1112-1120.
32. Califano A, Butte AJ, Friend S, Ideker T, Schadt E. Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat Genet. 2012;44:841-847.
33. Zhang B, Gaiteri C, Bodea LG, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell. 2013;153:707-720.
34. Zhu J, Sova P, Xu Q, et al. Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. PLoS Biol. 2012;10:e1001301.
35. Karr JR, Sanghvi JC, Macklin DN, et al. A whole-cell computational model predicts phenotype from genotype. Cell. 2012;150:389-401.
36. Chen R, Mias GI, Li-Pook-Than J, et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012;148:1293-1307.
37. Schadt EE, Björkegren JL. NEW: network-enabled wisdom in biology, medicine, and health care. Sci Transl Med. 2012;4:115rv1.
38. Yang X, Deignan JL, Qi H, et al. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet. 2009;41:415-423.
39. Zhu J, Zhang B, Smith EN, et al. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet. 2008;40:854-861.