Identification of bioactivating enzymes involved in the hydrolysis of laninamivir octanoate, a long-acting neuraminidase inhibitor, in human pulmonary tissue

Drug Metabolism and Disposition

Volumn 42, Issue 6, 2014, Pages 1031-1038

  Koyama, Kumiko ^a   Ogura, Yuji ^a   Nakai, Daisuke ^a   Watanabe, Mihoko ^a   Munemasa, Toshiko ^a   Oofune, Yuka ^a   Kubota, Kazuishi ^a   Shinagawa, Akira ^a   Izumi, Takashi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL PROTEIN THIOESTERASE 1; ESTERASE INHIBITOR; FORMYLGLUTATHIONE HYDROLASE; HYDROLASE; LANINAMIVIR OCTANOATE; PALMOSTATIN B; RECOMBINANT PROTEIN; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG; LANINAMIVIR; SIALIDASE; ZANAMIVIR;

ADULT; AGED; ARTICLE; DRUG HYDROLYSIS; ELUTION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; GEL FILTRATION CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM; LUNG PARENCHYMA; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEOMIC CORRELATION PROFILING; PROTEOMICS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; HYDROLYSIS; INHALATIONAL DRUG ADMINISTRATION; LUNG; METABOLISM; MIDDLE AGED;

ADMINISTRATION, INHALATION; AGED; HUMANS; HYDROLYSIS; LUNG; MALE; MIDDLE AGED; NEURAMINIDASE; ZANAMIVIR;

EID: 84901049722     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.057620     Document Type: Article

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