Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex

Journal of Biological Chemistry

Volumn 289, Issue 20, 2014, Pages 13801-13809

  Mahalingam, Bhuvaneshwari ^a   Van Agthoven, Johannes F ^a   Xiong, Jian Ping ^a   Alonso, José Luis ^a,b   Adair, Brian D ^a   Rui, Xianliang ^a,b   Anand, Saurabh ^a,b   Mehrbod, Mehrdad ^c   Mofrad, Mohammad R K ^c   Burger, Christa ^d,e   Goodman, Simon L ^d,f   Arnaout, M Amin ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MERCK KGAA   (Germany)

^e Discovery Technologies Molecular Pharmacology   (Germany)

^f Therapeutic Innovation Platform Oncology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODIES;

ALLOSTERIC INHIBITOR; ARG GLY ASPS; CLINICAL TRIAL; DIRECT BINDINGS; FAB FRAGMENTS; MOLECULAR MECHANISM; PROTEIN CRYSTAL; STRUCTURAL BASIS;

GLYCOPROTEINS;

ALPHA5 INTEGRIN; ARGININE; ASPARTIC ACID; GLUTAMINE; GLYCINE; IMMUNOGLOBULIN F(AB) FRAGMENT; LYSINE; MANGANESE; MONOCLONAL ANTIBODY 17E6; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; CD51 ANTIGEN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RAT; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PRIMATE; PROTEIN TERTIARY STRUCTURE; SPECIES DIFFERENCE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; INTEGRIN ALPHAV; INTEGRIN ALPHAVBETA3; MANGANESE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PRIMATES; PROTEIN STRUCTURE, TERTIARY; SPECIES SPECIFICITY;

EID: 84901044882     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.546929     Document Type: Article

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