Immunohistochemical analysis of integrin αvβ3 expression on tumor- associated vessels of human carcinomas

International Journal of Cancer

Volumn 71, Issue 3, 1997, Pages 320-324

  Max, Regina ^a,b   Gerritsen, Roland R C M ^a   Nooijen, Peet T G A ^a   Goodman, Simon L ^c   Sutter, Arne ^c   Keilholz, Ulrich ^c   Ruiter, Dirk J ^a   De Waal, Robert M W ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; MONOCLONAL ANTIBODY;

ANGIOGENESIS; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; VASCULAR TUMOR;

EID: 0030993245     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0215(19970502)71:3<320::aid-ijc2>3.0.co;2-%23     Document Type: Article

References (20)

1. BROOKS, PC., CLARK, R.A.F. and CHERESH, D.A., Requirement of vascular integrin αvβ3 for angiogenesis. Science (Wash.), 264, 569-571 (1994a).
2. BROOKS, P.C., MONTGOMERY, A.M.P., ROSENFELD, M., REISFELD, R.A., Hu, T., KLIER, T. and CHERESH, D.A., Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79, 1157-1164 (1994b).
3. BROOKS, P.C., STROEMBLAP, S., KLEMKE, R., VISSCHER, D., SARKAR, F.H. and CHERESH, D.A., Anti-integrin αvβ3 blocks human breast cancer growth and angiosenesis in human skin. J. clin. Invest., 96, 1851-1822 (1995).
4. CHERESH, D.A., Human endothelial cells synthesize and express an Arg-Gly-Asp directed adhesion receptor involved in attachment to fibrinogen and von-Willcbrand factor. Proc. nat. Acad. Sci. (Wash,), 84, 6471-6475 (1987).
5. CHERESH, D.A. and SPIRO, R.C., Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibronectin. and von Wilkbrand factor. J. biol. Chem., 36, 17703-17711 (1987).
6. FOLKMAN, J., The role of anciogertesis in tumor growth. Semin. Cancer Biol., 3, 65-71 (1992).
7. FRIEDLANDER, M., BROOKS, P.C., SCHAFTER, R.W., KINCAID, C.M., VARNER, J.A. and CHERESH, D.A., Definition of two angiogenic pathways by distinct αv integrirts. Science (Wash.). 270, 1500-1502 (1995).
8. GASPARINI, G. and HARRIS, A.L., Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J. Clin. Oncol., 13, 765-782 (1995).
9. GASPARTNI, G., WEIDNER, N., MALUTA, S., POZZA, F., BARACCHT, P., MEZETTI, M., TESTOLIN, A. and BEVILACQUA, P., Intratumoral microvessel density and p53 protein: correlation with metastasis in head-and-neck squamous-cell carcinoma. Int. J. Cancer. 55, 739-744 (1993).
10. INGBER, D., Extracellular matrix and cell shape: potential control points for inhibition of angiogenesis. J. Cell Biochem., 47, 236-241 (1991).
11. LEEK, R.D., HARRIS, A.L. and LEWIS, C,E., Cytokine networks in solid human tumors: regulation of angiogenesis. J. Leukocyte Biol., 56, 423-435 (1994).
12. LUSCINSKAS, F.W. and LAWLER, J., Integrins as dynamic regulators of vascular function. FASEB J., 8, 929-938 (1994).
13. MACCHIARINT, P., FONTANINI, G., HARDIN, M.J., SQUARTINI, F. and ANGELETTI, CA., Relation of neovascularisation to metastasis of non-smallcell lung cancer. Lancet, 340, 145-146 (1992).
14. MAEDA, K., CHUNG, Y., TAKATSUKA, S., OGWA, Y., SAWADA, T., YAMASHITA, Y., KONDO, N., KATO, Y., NITTA, A., ARIMOTO, Y., KONDO, Y. and SOWA, M., Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J. clin. Oncol., 13, 471-481 (1995).
15. MECHTERSHEIMER, G., BARTH, T., HARTSCHUH, W., LEHNERT, T. and MOELLER, P., In situ expression of βl. β3 and β4 integnn subunits in non-neoplastic endothelium and vascular tumors. Virchows Arch., 425, 375-384 (1994).
16. SCHLINGEMANN, R.O., DINGJAN, G.M., EMEIS, J.J., BLOK, J., WARNAAR, S.O. and RUITER, D.J., Monoclonal antibody PAL-E specific for endothelium. Lab. Invest., 52, 71-76 (1985).
17. SCHLINGEMANN, R.O., RlETVELD, F.J.R., KWASPEN, F., VAN DE KERKHOF, P.C.M., DE WAAL, R.M.W. and RUITTER, D.J., Differential expression of markers for endothelial cells, pericytes and basal lamina in the microvasculature of tumors and granulation tissue. Amer. J. Pathol., 138, 1335-1347 (1991).
18. SHWEIKI, D., ITIN, A., SOFFER, D. and KESHET, E., Vascular endothelial srowth factor induced by hypoxia-initiated angiogenesis. Nature (Lond.), 359, 843-845 (1992).
19. SWERLICK, R.A., BROWN, E.J., XUY, Y., LEE, K.H., MANOS, S. and LAWLEY, T.J., Expression and modulation of vitronectin receptor on human dermal microvascular: endothelial cells. J. invest. Dermatol., 99, 715-722 (1993).
20. SRIVASTAVA, A., LAIDLER, P., DAVIES, R.P., MORGAN, K. and HUGHES, L.E., The proenostic stgriiftcance of tumor vascularity in intermediate-thickness (0.76-4.0 mm) skin melanoma. Amer. J. Pcthol., 133, 419-423 (1988).