In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes

Journal of Controlled Release

Volumn 186, Issue , 2014, Pages 1-10

  Rüger, Ronny ^a   Tansi, Felista L ^b   Rabenhold, Markus ^a   Steiniger, Frank ^b   Kontermann, Roland E ^c   Fahr, Alfred ^a   Hilger, Ingrid ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c UNIVERSITY OF STUTTGART   (Germany)

Author keywords

FAP; Fluorescence quenching; Immunoliposomes; NIRF; Optical imaging

Indexed keywords

BIOLOGICAL MATERIALS; CELL CULTURE; CHEMICAL ACTIVATION; DIAGNOSIS; FIBROBLASTS; INFRARED DEVICES; LIPOSOMES; PHOSPHOLIPIDS; QUENCHING; TUMORS;

FAP; FLUORESCENCE-QUENCHING; IMMUNOLIPOSOMES; NIRF; OPTICAL IMAGING;

FLUORESCENCE;

CONTRAST MEDIUM; FIBROBLAST ACTIVATION PROTEIN ALPHA ANTIBODY; IMMUNOLIPOSOME; SEPRASE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; 1,2-DISTEAROYLPHOSPHATIDYLETHANOLAMINE; CARBOCYANINE; DY-676; FLUORESCENT DYE; GELATINASE; INDOLE DERIVATIVE; LIPOSOME; MACROGOL DERIVATIVE; MALEIMIDE DERIVATIVE; MEMBRANE PROTEIN; PHOSPHATIDYLETHANOLAMINE; SERINE PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL IMAGING SYSTEM; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER DIAGNOSIS; CANCER PROGNOSIS; CONFOCAL LASER MICROSCOPY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG ACTIVATION; DRUG BINDING; DRUG DEGRADATION; DRUG STABILITY; DRUG UPTAKE; EMBRYO; FEMALE; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPOSOMAL DELIVERY; MELANOMA CELL LINE; MOLECULAR IMAGING; MOUSE; NEAR INFRARED FLUORESCENCE IMAGING; NEAR INFRARED IMAGING SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; CELL CULTURE; CHEMISTRY; IMMUNOLOGY; METABOLISM; NEAR INFRARED SPECTROSCOPY; NEOPLASM; NUDE MOUSE; TUMOR CELL LINE;

ANIMALS; CARBOCYANINES; CELL LINE, TUMOR; CELLS, CULTURED; FEMALE; FLUORESCENT DYES; GELATINASES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDOLES; LIPOSOMES; MALEIMIDES; MEMBRANE PROTEINS; MICE, NUDE; NEOPLASMS; OPTICAL IMAGING; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; SERINE ENDOPEPTIDASES; SINGLE-CHAIN ANTIBODIES; SPECTROSCOPY, NEAR-INFRARED;

EID: 84901020965     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.04.050     Document Type: Article

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