메뉴 건너뛰기




Volumn 5 APR, Issue , 2014, Pages

Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14

Author keywords

Actin cytoskeleton; Macropinocytosis; MARCKS; Spinocerebellar ataxia type 14; Translocation; PKC

Indexed keywords

F ACTIN; FLUORESCEIN ISOTHIOCYANATE; GREEN FLUORESCENT PROTEIN; MARCKS PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C GAMMA;

EID: 84901005214     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00126     Document Type: Article
Times cited : (14)

References (46)
  • 1
    • 0032778706 scopus 로고    scopus 로고
    • Phorbol ester promotes endocytosis by activating a factor involved in endosome fusion
    • Aballay, A., Stahl, P. D., and Mayorga, L. S. (1999). Phorbol ester promotes endocytosis by activating a factor involved in endosome fusion. J. Cell Sci. 112(Pt 15), 2549-2557.
    • (1999) J. Cell Sci. , vol.112 , Issue.PART 15 , pp. 2549-2557
    • Aballay, A.1    Stahl, P.D.2    Mayorga, L.S.3
  • 2
    • 52049119862 scopus 로고    scopus 로고
    • Protein kinase C modulates synaptic vesicle acidification in a ribbon type nerve terminal in the retina
    • doi: 10.1016/j.neuint.2008.07.004
    • Abreu, B. J., Guimaraes, M., Uliana, L. C., Vigh, J., Von Gersdorff, H., Prado, M. A., et al. (2008). Protein kinase C modulates synaptic vesicle acidification in a ribbon type nerve terminal in the retina. Neurochem. Int. 53, 155-164. doi: 10.1016/j.neuint.2008.07.004
    • (2008) Neurochem. Int. , vol.53 , pp. 155-164
    • Abreu, B.J.1    Guimaraes, M.2    Uliana, L.C.3    Vigh, J.4    Von Gersdorff, H.5    Prado, M.A.6
  • 4
    • 33846967126 scopus 로고    scopus 로고
    • Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes
    • doi: 10.1007/s00018-006-6363-5
    • Alvi, F., Idkowiak-Baldys, J., Baldys, A., Raymond, J. R., and Hannun, Y. A. (2007). Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes. Cell. Mol. Life Sci. 64, 263-270. doi: 10.1007/s00018-006-6363-5
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 263-270
    • Alvi, F.1    Idkowiak-Baldys, J.2    Baldys, A.3    Raymond, J.R.4    Hannun, Y.A.5
  • 5
    • 0036192679 scopus 로고    scopus 로고
    • Origin, originality, functions, subversions and molecular signalling of macropinocytosis
    • doi: 10.1078/1438-4221-00157
    • Amyere, M., Mettlen, M., Van Der Smissen, P., Platek, A., Payrastre, B., Veithen, A., et al. (2002). Origin, originality, functions, subversions and molecular signalling of macropinocytosis. Int. J. Med. Microbiol. 291, 487-494. doi: 10.1078/1438-4221-00157
    • (2002) Int. J. Med. Microbiol. , vol.291 , pp. 487-494
    • Amyere, M.1    Mettlen, M.2    Van Der Smissen, P.3    Platek, A.4    Payrastre, B.5    Veithen, A.6
  • 6
    • 0346732281 scopus 로고    scopus 로고
    • cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes
    • doi: 10.1074/jbc.M305228200
    • Becker, K. P., and Hannun, Y. A. (2003). cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J. Biol. Chem. 278, 52747-52754. doi: 10.1074/jbc.M305228200
    • (2003) J. Biol. Chem. , vol.278 , pp. 52747-52754
    • Becker, K.P.1    Hannun, Y.A.2
  • 7
    • 0036340697 scopus 로고    scopus 로고
    • A new dominant spinocerebellar ataxia linked to chromosome 19q13.4-qter
    • doi: 10.1001/archneur.59.8.1291
    • Brkanac, Z., Bylenok, L., Fernandez, M., Matsushita, M., Lipe, H., Wolff, J., et al. (2002). A new dominant spinocerebellar ataxia linked to chromosome 19q13.4-qter. Arch. Neurol. 59, 1291-1295. doi: 10.1001/archneur.59.8.1291
    • (2002) Arch. Neurol. , vol.59 , pp. 1291-1295
    • Brkanac, Z.1    Bylenok, L.2    Fernandez, M.3    Matsushita, M.4    Lipe, H.5    Wolff, J.6
  • 8
  • 9
    • 0037385006 scopus 로고    scopus 로고
    • Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia
    • doi: 10.1086/373883
    • Chen, D. H., Brkanac, Z., Verlinde, C. L., Tan, X. J., Bylenok, L., Nochlin, D., et al. (2003). Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia. Am. J. Hum. Genet. 72, 839-849. doi: 10.1086/373883
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 839-849
    • Chen, D.H.1    Brkanac, Z.2    Verlinde, C.L.3    Tan, X.J.4    Bylenok, L.5    Nochlin, D.6
  • 10
    • 20144388593 scopus 로고    scopus 로고
    • The clinical and genetic spectrum of spinocerebellar ataxia 14
    • doi: 10.1212/01.WNL.0000156801.64549.6B
    • Chen, D. H., Cimino, P. J., Ranum, L. P., Zoghbi, H. Y., Yabe, I., Schut, L., et al. (2005). The clinical and genetic spectrum of spinocerebellar ataxia 14. Neurology 64, 1258-1260. doi: 10.1212/01.WNL.0000156801.64549.6B
    • (2005) Neurology , vol.64 , pp. 1258-1260
    • Chen, D.H.1    Cimino, P.J.2    Ranum, L.P.3    Zoghbi, H.Y.4    Yabe, I.5    Schut, L.6
  • 11
    • 79961131690 scopus 로고    scopus 로고
    • Spinocerebellar ataxia type 14
    • doi: 10.1016/B978-0-444-51892-7.00036-X
    • Chen, D. H., Raskind, W. H., and Bird, T. D. (2012). Spinocerebellar ataxia type 14. Handb. Clin. Neurol. 103, 555-559. doi: 10.1016/B978-0-444-51892-7.00036-X
    • (2012) Handb. Clin. Neurol. , vol.103 , pp. 555-559
    • Chen, D.H.1    Raskind, W.H.2    Bird, T.D.3
  • 12
    • 67650711138 scopus 로고    scopus 로고
    • Mechanisms of endocytosis
    • doi: 10.1146/annurev.biochem.78.081307.110540
    • Doherty, G. J., and McMahon, H. T. (2009). Mechanisms of endocytosis. Annu. Rev. Biochem. 78, 857-902. doi: 10.1146/annurev.biochem.78.081307.110540
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 857-902
    • Doherty, G.J.1    McMahon, H.T.2
  • 13
    • 49749105225 scopus 로고    scopus 로고
    • Secretory outposts for the local processing of membrane cargo in neuronal dendrites
    • doi: 10.1111/j.1600-0854.2008.00775.x
    • Hanus, C., and Ehlers, M. D. (2008). Secretory outposts for the local processing of membrane cargo in neuronal dendrites. Traffic 9, 1437-1445. doi: 10.1111/j.1600-0854.2008.00775.x
    • (2008) Traffic , vol.9 , pp. 1437-1445
    • Hanus, C.1    Ehlers, M.D.2
  • 14
    • 0026513601 scopus 로고
    • MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin
    • doi: 10.1038/356618a0
    • Hartwig, J. H., Thelen, M., Rosen, A., Janmey, P. A., Nairn, A. C., and Aderem, A. (1992). MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 356, 618-622. doi: 10.1038/356618a0
    • (1992) Nature , vol.356 , pp. 618-622
    • Hartwig, J.H.1    Thelen, M.2    Rosen, A.3    Janmey, P.A.4    Nairn, A.C.5    Aderem, A.6
  • 15
    • 33750348973 scopus 로고    scopus 로고
    • Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4
    • doi: 10.1002/mds.20970
    • Hiramoto, K., Kawakami, H., Inoue, K., Seki, T., Maruyama, H., Morino, H., et al. (2006). Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4. Mov. Disord. 21, 1355-1360. doi: 10.1002/mds.20970
    • (2006) Mov. Disord. , vol.21 , pp. 1355-1360
    • Hiramoto, K.1    Kawakami, H.2    Inoue, K.3    Seki, T.4    Maruyama, H.5    Morino, H.6
  • 16
    • 3242690769 scopus 로고    scopus 로고
    • Secretory trafficking in neuronal dendrites
    • doi: 10.1038/ncb0704-585
    • Horton, A. C., and Ehlers, M. D. (2004). Secretory trafficking in neuronal dendrites. Nat. Cell Biol. 6, 585-591. doi: 10.1038/ncb0704-585
    • (2004) Nat. Cell Biol. , vol.6 , pp. 585-591
    • Horton, A.C.1    Ehlers, M.D.2
  • 17
    • 33746822924 scopus 로고    scopus 로고
    • Dynamic sequestration of the recycling compartment by classical protein kinase C
    • doi: 10.1074/jbc.M512540200
    • Idkowiak-Baldys, J., Becker, K. P., Kitatani, K., and Hannun, Y. A. (2006). Dynamic sequestration of the recycling compartment by classical protein kinase C. J. Biol. Chem. 281, 22321-22331. doi: 10.1074/jbc.M512540200
    • (2006) J. Biol. Chem. , vol.281 , pp. 22321-22331
    • Idkowiak-Baldys, J.1    Becker, K.P.2    Kitatani, K.3    Hannun, Y.A.4
  • 19
    • 69449093728 scopus 로고    scopus 로고
    • Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning
    • doi: 10.1523/JNEUROSCI.2355-09.2009
    • Kolpak, A. L., Jiang, J., Guo, D., Standley, C., Bellve, K., Fogarty, K., et al. (2009). Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. J. Neurosci. 29, 10488-10498. doi: 10.1523/JNEUROSCI.2355-09.2009
    • (2009) J. Neurosci. , vol.29 , pp. 10488-10498
    • Kolpak, A.L.1    Jiang, J.2    Guo, D.3    Standley, C.4    Bellve, K.5    Fogarty, K.6
  • 20
    • 0034717707 scopus 로고    scopus 로고
    • GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism
    • doi: 10.1083/jcb.149.7.1455
    • Laux, T., Fukami, K., Thelen, M., Golub, T., Frey, D., and Caroni, P. (2000). GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J. Cell Biol. 149, 1455-1472. doi: 10.1083/jcb.149.7.1455
    • (2000) J. Cell Biol. , vol.149 , pp. 1455-1472
    • Laux, T.1    Fukami, K.2    Thelen, M.3    Golub, T.4    Frey, D.5    Caroni, P.6
  • 21
    • 0036105015 scopus 로고    scopus 로고
    • Visualization of actin dynamics during macropinocytosis and exocytosis
    • doi: 10.1034/j.1600-0854.2002.030304.x
    • Lee, E., and Knecht, D. A. (2002). Visualization of actin dynamics during macropinocytosis and exocytosis. Traffic 3, 186-192. doi: 10.1034/j.1600-0854.2002.030304.x
    • (2002) Traffic , vol.3 , pp. 186-192
    • Lee, E.1    Knecht, D.A.2
  • 23
    • 58149300222 scopus 로고    scopus 로고
    • Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching
    • doi: 10.1091/mbc.E08-03-0294
    • Li, H., Chen, G., Zhou, B., and Duan, S. (2008). Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching. Mol. Biol. Cell 19, 4804-4813. doi: 10.1091/mbc.E08-03-0294
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4804-4813
    • Li, H.1    Chen, G.2    Zhou, B.3    Duan, S.4
  • 24
    • 80855144226 scopus 로고    scopus 로고
    • Macropinocytosis: an endocytic pathway for internalising large gulps
    • doi: 10.1038/icb.2011.20
    • Lim, J. P., and Gleeson, P. A. (2011). Macropinocytosis: an endocytic pathway for internalising large gulps. Immunol. Cell Biol. 89, 836-843. doi: 10.1038/icb.2011.20
    • (2011) Immunol. Cell Biol. , vol.89 , pp. 836-843
    • Lim, J.P.1    Gleeson, P.A.2
  • 25
    • 0036828324 scopus 로고    scopus 로고
    • Signaling mechanisms that regulate actin-based motility processes in the nervous system
    • doi: 10.1046/j.1471-4159.2002.01185.x
    • Meyer, G., and Feldman, E. L. (2002). Signaling mechanisms that regulate actin-based motility processes in the nervous system. J. Neurochem. 83, 490-503. doi: 10.1046/j.1471-4159.2002.01185.x
    • (2002) J. Neurochem. , vol.83 , pp. 490-503
    • Meyer, G.1    Feldman, E.L.2
  • 26
    • 0033858056 scopus 로고    scopus 로고
    • Protein kinase C(alpha) actively downregulates through caveolae-dependent traffic to an endosomal compartment
    • Prevostel, C., Alice, V., Joubert, D., and Parker, P. J. (2000). Protein kinase C(alpha) actively downregulates through caveolae-dependent traffic to an endosomal compartment. J. Cell Sci. 113(Pt 14), 2575-2584.
    • (2000) J. Cell Sci. , vol.113 , Issue.PART 14 , pp. 2575-2584
    • Prevostel, C.1    Alice, V.2    Joubert, D.3    Parker, P.J.4
  • 28
    • 0023874148 scopus 로고
    • Distribution of protein kinase C-like immunoreactive neurons in rat brain
    • Saito, N., Kikkawa, U., Nishizuka, Y., and Tanaka, C. (1988). Distribution of protein kinase C-like immunoreactive neurons in rat brain. J. Neurosci. 8, 369-382.
    • (1988) J. Neurosci. , vol.8 , pp. 369-382
    • Saito, N.1    Kikkawa, U.2    Nishizuka, Y.3    Tanaka, C.4
  • 29
    • 0031466995 scopus 로고    scopus 로고
    • Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein
    • doi: 10.1083/jcb.139.6.1465
    • Sakai, N., Sasaki, K., Ikegaki, N., Shirai, Y., Ono, Y., and Saito, N. (1997). Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J. Cell Biol. 139, 1465-1476. doi: 10.1083/jcb.139.6.1465
    • (1997) J. Cell Biol. , vol.139 , pp. 1465-1476
    • Sakai, N.1    Sasaki, K.2    Ikegaki, N.3    Shirai, Y.4    Ono, Y.5    Saito, N.6
  • 30
    • 67649650263 scopus 로고    scopus 로고
    • Roles of endosomal trafficking in neurite outgrowth and guidance
    • doi: 10.1016/j.tcb.2009.05.001
    • Sann, S., Wang, Z., Brown, H., and Jin, Y. (2009). Roles of endosomal trafficking in neurite outgrowth and guidance. Trends Cell Biol. 19, 317-324. doi: 10.1016/j.tcb.2009.05.001
    • (2009) Trends Cell Biol. , vol.19 , pp. 317-324
    • Sann, S.1    Wang, Z.2    Brown, H.3    Jin, Y.4
  • 31
    • 0035408170 scopus 로고    scopus 로고
    • Diffusion-limited translocation mechanism of protein kinase C isotypes
    • doi: 10.1096/fj.00-0824fje
    • Schaefer, M., Albrecht, N., Hofmann, T., Gudermann, T., and Schultz, G. (2001). Diffusion-limited translocation mechanism of protein kinase C isotypes. FASEB J. 15, 1634-1636. doi: 10.1096/fj.00-0824fje
    • (2001) FASEB J. , vol.15 , pp. 1634-1636
    • Schaefer, M.1    Albrecht, N.2    Hofmann, T.3    Gudermann, T.4    Schultz, G.5
  • 32
    • 79960431374 scopus 로고    scopus 로고
    • Elucidation of the molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant protein kinase Cgamma
    • doi: 10.1254/jphs.11R04CP
    • Seki, T., Adachi, N., Abe-Seki, N., Shimahara, T., Takahashi, H., Yamamoto, K., et al. (2011). Elucidation of the molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant protein kinase Cgamma. J. Pharmacol. Sci. 116, 239-247. doi: 10.1254/jphs.11R04CP
    • (2011) J. Pharmacol. Sci. , vol.116 , pp. 239-247
    • Seki, T.1    Adachi, N.2    Abe-Seki, N.3    Shimahara, T.4    Takahashi, H.5    Yamamoto, K.6
  • 33
    • 23844524453 scopus 로고    scopus 로고
    • Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death
    • doi: 10.1074/jbc.M501716200
    • Seki, T., Adachi, N., Ono, Y., Mochizuki, H., Hiramoto, K., Amano, T., et al. (2005a). Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death. J. Biol. Chem. 280, 29096-29106. doi: 10.1074/jbc.M501716200
    • (2005) J. Biol. Chem. , vol.280 , pp. 29096-29106
    • Seki, T.1    Adachi, N.2    Ono, Y.3    Mochizuki, H.4    Hiramoto, K.5    Amano, T.6
  • 34
    • 84879037295 scopus 로고    scopus 로고
    • JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis
    • doi: 10.1074/jbc.M113.463406
    • Seki, T., Gong, L., Williams, A. J., Sakai, N., Todi, S. V., and Paulson, H. L. (2013). JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis. J. Biol. Chem. 288, 17145-17155. doi: 10.1074/jbc.M113.463406
    • (2013) J. Biol. Chem. , vol.288 , pp. 17145-17155
    • Seki, T.1    Gong, L.2    Williams, A.J.3    Sakai, N.4    Todi, S.V.5    Paulson, H.L.6
  • 35
    • 15844395343 scopus 로고    scopus 로고
    • Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC
    • doi: 10.1111/j.1365-2443.2005.00830.x
    • Seki, T., Matsubayashi, H., Amano, T., Shirai, Y., Saito, N., and Sakai, N. (2005b). Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC. Genes Cells 10, 225-239. doi: 10.1111/j.1365-2443.2005.00830.x
    • (2005) Genes Cells , vol.10 , pp. 225-239
    • Seki, T.1    Matsubayashi, H.2    Amano, T.3    Shirai, Y.4    Saito, N.5    Sakai, N.6
  • 36
    • 58149490769 scopus 로고    scopus 로고
    • Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells
    • doi: 10.1016/j.nbd.2008.10.013
    • Seki, T., Shimahara, T., Yamamoto, K., Abe, N., Amano, T., Adachi, N., et al. (2009). Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells. Neurobiol. Dis. 33, 260-273. doi: 10.1016/j.nbd.2008.10.013
    • (2009) Neurobiol. Dis. , vol.33 , pp. 260-273
    • Seki, T.1    Shimahara, T.2    Yamamoto, K.3    Abe, N.4    Amano, T.5    Adachi, N.6
  • 37
    • 36248998804 scopus 로고    scopus 로고
    • Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress
    • doi: 10.1111/j.1460-9568.2007.05933.x
    • Seki, T., Takahashi, H., Adachi, N., Abe, N., Shimahara, T., Saito, N., et al. (2007). Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress. Eur. J. Neurosci. 26, 3126-3140. doi: 10.1111/j.1460-9568.2007.05933.x
    • (2007) Eur. J. Neurosci. , vol.26 , pp. 3126-3140
    • Seki, T.1    Takahashi, H.2    Adachi, N.3    Abe, N.4    Shimahara, T.5    Saito, N.6
  • 38
    • 84856747214 scopus 로고    scopus 로고
    • Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron
    • doi: 10.1371/journal.pone.0031232
    • Seki, T., Yoshino, K. I., Tanaka, S., Dohi, E., Onji, T., Yamamoto, K., et al. (2012). Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron. PLoS ONE 7:e31232. doi: 10.1371/journal.pone.0031232
    • (2012) PLoS ONE , vol.7
    • Seki, T.1    Yoshino, K.I.2    Tanaka, S.3    Dohi, E.4    Onji, T.5    Yamamoto, K.6
  • 39
    • 0036855827 scopus 로고    scopus 로고
    • Activation mechanisms of protein kinase C: maturation, catalytic activation, and targeting
    • doi: 10.1093/oxfordjournals.jbchem.a003271
    • Shirai, Y., and Saito, N. (2002). Activation mechanisms of protein kinase C: maturation, catalytic activation, and targeting. J. Biochem. 132, 663-668. doi: 10.1093/oxfordjournals.jbchem.a003271
    • (2002) J. Biochem. , vol.132 , pp. 663-668
    • Shirai, Y.1    Saito, N.2
  • 40
    • 0032435504 scopus 로고    scopus 로고
    • Subspecies-specific targeting mechanism of protein kinase C
    • doi: 10.1254/jjp.78.411
    • Shirai, Y., Sakai, N., and Saito, N. (1998). Subspecies-specific targeting mechanism of protein kinase C. Jpn. J. Pharmacol. 78, 411-417. doi: 10.1254/jjp.78.411
    • (1998) Jpn. J. Pharmacol. , vol.78 , pp. 411-417
    • Shirai, Y.1    Sakai, N.2    Saito, N.3
  • 41
    • 0033385962 scopus 로고    scopus 로고
    • PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS
    • Song, J. C., Hrnjez, B. J., Farokhzad, O. C., and Matthews, J. B. (1999). PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS. Am. J. Physiol. 277, C1239-C1249.
    • (1999) Am. J. Physiol. , vol.277
    • Song, J.C.1    Hrnjez, B.J.2    Farokhzad, O.C.3    Matthews, J.B.4
  • 42
    • 0028790788 scopus 로고
    • Macropinocytosis
    • doi: 10.1016/S0962-8924(00)89101-1
    • Swanson, J. A., and Watts, C. (1995). Macropinocytosis. Trends Cell Biol. 11, 424-428. doi: 10.1016/S0962-8924(00)89101-1
    • (1995) Trends Cell Biol. , vol.11 , pp. 424-428
    • Swanson, J.A.1    Watts, C.2
  • 43
    • 49649093191 scopus 로고    scopus 로고
    • PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling
    • doi: 10.1242/jcs.027698
    • Verbeek, D. S., Goedhart, J., Bruinsma, L., Sinke, R. J., and Reits, E. A. (2008). PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling. J. Cell Sci. 121, 2339-2349. doi: 10.1242/jcs.027698
    • (2008) J. Cell Sci. , vol.121 , pp. 2339-2349
    • Verbeek, D.S.1    Goedhart, J.2    Bruinsma, L.3    Sinke, R.J.4    Reits, E.A.5
  • 44
    • 13544251405 scopus 로고    scopus 로고
    • Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting
    • doi: 10.1093/brain/awh378
    • Verbeek, D. S., Knight, M. A., Harmison, G. G., Fischbeck, K. H., and Howell, B. W. (2005). Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting. Brain 128, 436-442. doi: 10.1093/brain/awh378
    • (2005) Brain , vol.128 , pp. 436-442
    • Verbeek, D.S.1    Knight, M.A.2    Harmison, G.G.3    Fischbeck, K.H.4    Howell, B.W.5
  • 45
    • 0032533260 scopus 로고    scopus 로고
    • The antibody specific for myristoylated alanine-rich C kinase substrate phosphorylated by protein kinase C: activation of protein kinase C in smooth muscle cells in human coronary arteries
    • doi: 10.1006/abbi.1998.0920
    • Yamamoto, H., Matsumura, T., Kugiyama, K., Oishi, Y., Ogata, N., Yasue, H., et al. (1998). The antibody specific for myristoylated alanine-rich C kinase substrate phosphorylated by protein kinase C: activation of protein kinase C in smooth muscle cells in human coronary arteries. Arch. Biochem. Biophys. 359, 151-159. doi: 10.1006/abbi.1998.0920
    • (1998) Arch. Biochem. Biophys. , vol.359 , pp. 151-159
    • Yamamoto, H.1    Matsumura, T.2    Kugiyama, K.3    Oishi, Y.4    Ogata, N.5    Yasue, H.6
  • 46
    • 77953254167 scopus 로고    scopus 로고
    • Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy
    • doi: 10.1111/j.1365-2443.2010.01395.x
    • Yamamoto, K., Seki, T., Adachi, N., Takahashi, T., Tanaka, S., Hide, I., et al. (2010). Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy. Genes Cells 15, 425-438. doi: 10.1111/j.1365-2443.2010.01395.x
    • (2010) Genes Cells , vol.15 , pp. 425-438
    • Yamamoto, K.1    Seki, T.2    Adachi, N.3    Takahashi, T.4    Tanaka, S.5    Hide, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.