Elucidation of the molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant protein kinase Cγ

Journal of Pharmacological Sciences

Volumn 116, Issue 3, 2011, Pages 239-247

  Seki, Takahiro ^a   Adachi, Naoko ^b   Abe Seki, Nana ^a   Shimahara, Takayuki ^a   Takahashi, Hideyuki ^b   Yamamoto, Kazuhiro ^a   Saito, Naoaki ^b   Sakai, Norio ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cerebellar purkinje cell aggregation; Protein kinase C ; Spinocerebellar ataxia

Indexed keywords

CONGO RED; DRUG METABOLITE; MUTANT PROTEIN; PROTEASOME; PROTEIN KINASE C GAMMA; TREHALOSE; UBIQUITIN;

APOPTOSIS; CELL AGGREGATION; CELL STRUCTURE; DRUG EFFECT; DRUG MECHANISM; DRUG PENETRATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE; GENE FUNCTION; GENE LOCUS; GENETIC IDENTIFICATION; HUMAN; HUNTINGTON CHOREA; INDUCED MUTATION; INTRACELLULAR SIGNALING; MISSENSE MUTATION; MOLECULAR DYNAMICS; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN DEFECT; PROTEIN FUNCTION; PROTEIN KINASE C GAMMA GENE; PROTEIN LOCALIZATION; PURKINJE CELL; REVIEW; SPINOCEREBELLAR DEGENERATION;

EID: 79960431374     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11R04CP     Document Type: Review

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