-
2
-
-
33750363298
-
The roles of intracellular protein-degradation pathways in neurodegeneration
-
Rubinsztein DC, (2006) The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443: 780-786.
-
(2006)
Nature
, vol.443
, pp. 780-786
-
-
Rubinsztein, D.C.1
-
3
-
-
4344677922
-
Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease
-
Grune T, Jung T, Merker K, Davies KJ, (2004) Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int J Biochem Cell Biol 36: 2519-2530.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2519-2530
-
-
Grune, T.1
Jung, T.2
Merker, K.3
Davies, K.J.4
-
4
-
-
3142604036
-
The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases
-
Ross CA, Pickart CM, (2004) The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases. Trends Cell Biol 14: 703-711.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 703-711
-
-
Ross, C.A.1
Pickart, C.M.2
-
5
-
-
37349003177
-
The role of autophagy in age-related neurodegeneration
-
McCray BA, Taylor JP, (2008) The role of autophagy in age-related neurodegeneration. Neurosignals 16: 75-84.
-
(2008)
Neurosignals
, vol.16
, pp. 75-84
-
-
McCray, B.A.1
Taylor, J.P.2
-
6
-
-
4344673498
-
Mechanisms of chaperone-mediated autophagy
-
Majeski AE, Dice JF, (2004) Mechanisms of chaperone-mediated autophagy. Int J Biochem Cell Biol 36: 2435-2444.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2435-2444
-
-
Majeski, A.E.1
Dice, J.F.2
-
7
-
-
6344275803
-
Activation of chaperone-mediated autophagy during oxidative stress
-
Kiffin R, Christian C, Knecht E, Cuervo AM, (2004) Activation of chaperone-mediated autophagy during oxidative stress. Mol Biol Cell 15: 4829-4840.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 4829-4840
-
-
Kiffin, R.1
Christian, C.2
Knecht, E.3
Cuervo, A.M.4
-
8
-
-
4344659685
-
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
-
Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D, (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295.
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
9
-
-
53049101345
-
Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy
-
Kabuta T, Furuta A, Aoki S, Furuta K, Wada K, (2008) Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J Biol Chem 283: 23731-23738.
-
(2008)
J Biol Chem
, vol.283
, pp. 23731-23738
-
-
Kabuta, T.1
Furuta, A.2
Aoki, S.3
Furuta, K.4
Wada, K.5
-
10
-
-
58149215720
-
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy
-
Yang Q, She H, Gearing M, Colla E, Lee M, et al. (2009) Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 323: 124-127.
-
(2009)
Science
, vol.323
, pp. 124-127
-
-
Yang, Q.1
She, H.2
Gearing, M.3
Colla, E.4
Lee, M.5
-
11
-
-
78149469728
-
Chaperone-mediated autophagy markers in Parkinson disease brains
-
Alvarez-Erviti L, Rodriguez-Oroz MC, Cooper JM, Caballero C, Ferrer I, et al. (2010) Chaperone-mediated autophagy markers in Parkinson disease brains. Arch Neurol 67: 1464-1472.
-
(2010)
Arch Neurol
, vol.67
, pp. 1464-1472
-
-
Alvarez-Erviti, L.1
Rodriguez-Oroz, M.C.2
Cooper, J.M.3
Caballero, C.4
Ferrer, I.5
-
12
-
-
70349987102
-
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
-
Wang Y, Martinez-Vicente M, Kruger U, Kaushik S, Wong E, et al. (2009) Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet 18: 4153-4170.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4153-4170
-
-
Wang, Y.1
Martinez-Vicente, M.2
Kruger, U.3
Kaushik, S.4
Wong, E.5
-
13
-
-
70349666552
-
Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways
-
Liu H, Wang P, Song W, Sun X, (2009) Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways. FASEB J 23: 3383-3392.
-
(2009)
FASEB J
, vol.23
, pp. 3383-3392
-
-
Liu, H.1
Wang, P.2
Song, W.3
Sun, X.4
-
14
-
-
0037385006
-
Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia
-
Chen DH, Brkanac Z, Verlinde CL, Tan XJ, Bylenok L, et al. (2003) Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia. Am J Hum Genet 72: 839-849.
-
(2003)
Am J Hum Genet
, vol.72
, pp. 839-849
-
-
Chen, D.H.1
Brkanac, Z.2
Verlinde, C.L.3
Tan, X.J.4
Bylenok, L.5
-
15
-
-
20144388593
-
The clinical and genetic spectrum of spinocerebellar ataxia 14
-
Chen DH, Cimino PJ, Ranum LP, Zoghbi HY, Yabe I, et al. (2005) The clinical and genetic spectrum of spinocerebellar ataxia 14. Neurology 64: 1258-1260.
-
(2005)
Neurology
, vol.64
, pp. 1258-1260
-
-
Chen, D.H.1
Cimino, P.J.2
Ranum, L.P.3
Zoghbi, H.Y.4
Yabe, I.5
-
16
-
-
33750348973
-
Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4
-
Hiramoto K, Kawakami H, Inoue K, Seki T, Maruyama H, et al. (2006) Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4. Mov Disord 21: 1355-1360.
-
(2006)
Mov Disord
, vol.21
, pp. 1355-1360
-
-
Hiramoto, K.1
Kawakami, H.2
Inoue, K.3
Seki, T.4
Maruyama, H.5
-
17
-
-
23844524453
-
Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death
-
Seki T, Adachi N, Ono Y, Mochizuki H, Hiramoto K, et al. (2005) Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death. J Biol Chem 280: 29096-29106.
-
(2005)
J Biol Chem
, vol.280
, pp. 29096-29106
-
-
Seki, T.1
Adachi, N.2
Ono, Y.3
Mochizuki, H.4
Hiramoto, K.5
-
18
-
-
58149490769
-
Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells
-
Seki T, Shimahara T, Yamamoto K, Abe N, Amano T, et al. (2009) Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells. Neurobiol Dis 33: 260-273.
-
(2009)
Neurobiol Dis
, vol.33
, pp. 260-273
-
-
Seki, T.1
Shimahara, T.2
Yamamoto, K.3
Abe, N.4
Amano, T.5
-
19
-
-
36248998804
-
Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress
-
Seki T, Takahashi H, Adachi N, Abe N, Shimahara T, et al. (2007) Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress. Eur J Neurosci 26: 3126-3140.
-
(2007)
Eur J Neurosci
, vol.26
, pp. 3126-3140
-
-
Seki, T.1
Takahashi, H.2
Adachi, N.3
Abe, N.4
Shimahara, T.5
-
20
-
-
50349095449
-
Enzymological Analysis of Mutant Protein Kinase C{gamma} Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+ Homeostasis
-
Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, et al. (2008) Enzymological Analysis of Mutant Protein Kinase C{gamma} Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+ Homeostasis. J Biol Chem 283: 19854-19863.
-
(2008)
J Biol Chem
, vol.283
, pp. 19854-19863
-
-
Adachi, N.1
Kobayashi, T.2
Takahashi, H.3
Kawasaki, T.4
Shirai, Y.5
-
21
-
-
49649093191
-
PKC{gamma} mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling
-
Verbeek DS, Goedhart J, Bruinsma L, Sinke RJ, Reits EA, (2008) PKC{gamma} mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling. J Cell Sci 121: 2339-2349.
-
(2008)
J Cell Sci
, vol.121
, pp. 2339-2349
-
-
Verbeek, D.S.1
Goedhart, J.2
Bruinsma, L.3
Sinke, R.J.4
Reits, E.A.5
-
22
-
-
48049092838
-
HaloTag: a novel protein labeling technology for cell imaging and protein analysis
-
Los GV, Encell LP, McDougall MG, Hartzell DD, Karassina N, et al. (2008) HaloTag: a novel protein labeling technology for cell imaging and protein analysis. ACS Chem Biol 3: 373-382.
-
(2008)
ACS Chem Biol
, vol.3
, pp. 373-382
-
-
Los, G.V.1
Encell, L.P.2
McDougall, M.G.3
Hartzell, D.D.4
Karassina, N.5
-
23
-
-
0028839659
-
The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c
-
Gough NR, Hatem CL, Fambrough DM, (1995) The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c. DNA Cell Biol 14: 863-867.
-
(1995)
DNA Cell Biol
, vol.14
, pp. 863-867
-
-
Gough, N.R.1
Hatem, C.L.2
Fambrough, D.M.3
-
24
-
-
0034510572
-
Unique properties of lamp2a compared to other lamp2 isoforms
-
Cuervo AM, Dice JF, (2000) Unique properties of lamp2a compared to other lamp2 isoforms. J Cell Sci 113 Pt 24: 4441-4450.
-
(2000)
J Cell Sci
, vol.113 Pt
, pp. 4441-4450
-
-
Cuervo, A.M.1
Dice, J.F.2
-
25
-
-
0020405985
-
Altered degradation of proteins microinjected into senescent human fibroblasts
-
Dice JF, (1982) Altered degradation of proteins microinjected into senescent human fibroblasts. J Biol Chem 257: 14624-14627.
-
(1982)
J Biol Chem
, vol.257
, pp. 14624-14627
-
-
Dice, J.F.1
-
26
-
-
77955989034
-
Identification of regulators of chaperone-mediated autophagy
-
Bandyopadhyay U, Sridhar S, Kaushik S, Kiffin R, Cuervo AM, (2010) Identification of regulators of chaperone-mediated autophagy. Mol Cell 39: 535-547.
-
(2010)
Mol Cell
, vol.39
, pp. 535-547
-
-
Bandyopadhyay, U.1
Sridhar, S.2
Kaushik, S.3
Kiffin, R.4
Cuervo, A.M.5
-
27
-
-
33645812852
-
Effects of small molecules on chaperone-mediated autophagy
-
Finn PF, Mesires NT, Vine M, Dice JF, (2005) Effects of small molecules on chaperone-mediated autophagy. Autophagy 1: 141-145.
-
(2005)
Autophagy
, vol.1
, pp. 141-145
-
-
Finn, P.F.1
Mesires, N.T.2
Vine, M.3
Dice, J.F.4
-
28
-
-
77951214016
-
Mammalian autophagy: core molecular machinery and signaling regulation
-
Yang Z, Klionsky DJ, (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 124-131
-
-
Yang, Z.1
Klionsky, D.J.2
-
29
-
-
33645829816
-
Consequences of the selective blockage of chaperone-mediated autophagy
-
Massey AC, Kaushik S, Sovak G, Kiffin R, Cuervo AM, (2006) Consequences of the selective blockage of chaperone-mediated autophagy. Proc Natl Acad Sci U S A 103: 5805-5810.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5805-5810
-
-
Massey, A.C.1
Kaushik, S.2
Sovak, G.3
Kiffin, R.4
Cuervo, A.M.5
-
30
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J 19: 5720-5728.
-
(2000)
Embo J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
-
31
-
-
1542283812
-
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
-
Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y, (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1101-1111
-
-
Mizushima, N.1
Yamamoto, A.2
Matsui, M.3
Yoshimori, T.4
Ohsumi, Y.5
-
32
-
-
59249090846
-
Methods to monitor chaperone-mediated autophagy
-
Kaushik S, Cuervo AM, (2009) Methods to monitor chaperone-mediated autophagy. Methods Enzymol 452: 297-324.
-
(2009)
Methods Enzymol
, vol.452
, pp. 297-324
-
-
Kaushik, S.1
Cuervo, A.M.2
-
33
-
-
12744261611
-
Different endocytosis pathways of the C5a receptor and the N-formyl peptide receptor
-
Suvorova ES, Gripentrog JM, Miettinen HM, (2005) Different endocytosis pathways of the C5a receptor and the N-formyl peptide receptor. Traffic 6: 100-115.
-
(2005)
Traffic
, vol.6
, pp. 100-115
-
-
Suvorova, E.S.1
Gripentrog, J.M.2
Miettinen, H.M.3
-
34
-
-
19444382327
-
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes
-
Bampton ET, Goemans CG, Niranjan D, Mizushima N, Tolkovsky AM, (2005) The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy 1: 23-36.
-
(2005)
Autophagy
, vol.1
, pp. 23-36
-
-
Bampton, E.T.1
Goemans, C.G.2
Niranjan, D.3
Mizushima, N.4
Tolkovsky, A.M.5
-
35
-
-
78651423598
-
Microautophagy of cytosolic proteins by late endosomes
-
Sahu R, Kaushik S, Clement CC, Cannizzo ES, Scharf B, et al. (2011) Microautophagy of cytosolic proteins by late endosomes. Dev Cell 20: 131-139.
-
(2011)
Dev Cell
, vol.20
, pp. 131-139
-
-
Sahu, R.1
Kaushik, S.2
Clement, C.C.3
Cannizzo, E.S.4
Scharf, B.5
-
36
-
-
48249091611
-
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy
-
Kaushik S, Massey AC, Mizushima N, Cuervo AM, (2008) Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell 19: 2179-2192.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 2179-2192
-
-
Kaushik, S.1
Massey, A.C.2
Mizushima, N.3
Cuervo, A.M.4
-
37
-
-
77955023765
-
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
-
Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, et al. (2010) Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet 19: 3219-3232.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3219-3232
-
-
Rothenberg, C.1
Srinivasan, D.2
Mah, L.3
Kaushik, S.4
Peterhoff, C.M.5
-
38
-
-
0035911162
-
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
-
Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, et al. (2001) Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 152: 657-668.
-
(2001)
J Cell Biol
, vol.152
, pp. 657-668
-
-
Mizushima, N.1
Yamamoto, A.2
Hatano, M.3
Kobayashi, Y.4
Kabeya, Y.5
-
39
-
-
53049098471
-
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
-
Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L, (2008) Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 283: 23542-23556.
-
(2008)
J Biol Chem
, vol.283
, pp. 23542-23556
-
-
Vogiatzi, T.1
Xilouri, M.2
Vekrellis, K.3
Stefanis, L.4
-
40
-
-
77749319356
-
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
-
Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, et al. (2010) Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein. Nat Biotechnol 28: 256-263.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 256-263
-
-
Bauer, P.O.1
Goswami, A.2
Wong, H.K.3
Okuno, M.4
Kurosawa, M.5
-
41
-
-
0036262777
-
Inducible and brain region-specific CREB transgenic mice
-
Sakai N, Thome J, Newton SS, Chen J, Kelz MB, et al. (2002) Inducible and brain region-specific CREB transgenic mice. Mol Pharmacol 61: 1453-1464.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 1453-1464
-
-
Sakai, N.1
Thome, J.2
Newton, S.S.3
Chen, J.4
Kelz, M.B.5
|