Synthesis and biological evaluation of some 2-(3,5-dimethyl-1H-pyrazol-1- yl)-1-arylethanones: Antibacterial, DNA photocleavage, and anticancer activities

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 267-276

  Kumar, Vinod ^a   Kaur, Kamalneet ^a   Karelia, Deepkamal N ^b   Beniwal, Vikas ^a   Gupta, Girish Kumar ^a   Sharma, Arun K ^b   Gupta, Akhilesh Kumar ^a  

^a MAHARISHI MARKANDESHWAR DEEMED TO BE UNIVERSITY   (India)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Antibacterial; Anticancer; DNA photocleavage; Solvent free conditions

Indexed keywords

1 (2 FLUOROPHENYL) 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL)ETHANONE; 1 (2,4 DI FLUOROPHENYL) 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL)ETHANONE; 1 (3 CHLOROPHENYL) 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL)ETHANONE; 1 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 2 (NAPHTH 1 YL)ETHANONE; 1 (4 BROMOPHENYL) 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL)ETHANONE; 1 (4 CHLOROPHENYL) 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL)ETHANONE; 1 (4 FLUOROPHENYL) 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL)ETHANONE; 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 1 (4 METHYLPHENYL)ETHANONE; 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 1 (4 NITROPHENYL)ETHANONE; 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 1 (NAPHTH 2 YL)ETHANONE; 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 1 PHENYLETHANONE; AMPICILLIN; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CARBOPLATIN; UNCLASSIFIED DRUG; DNA;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DEGRADATION; DNA PHOTOCLEAVAGE ACTIVITY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELEMENTAL ANALYSIS; ENTEROBACTER AEROGENES; ENTEROCOCCUS; EVALUATION STUDY; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; IRRADIATION; MALE; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MTT ASSAY; ONE POT SYNTHESIS; PHOTODEGRADATION; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; ULTRAVIOLET RADIATION; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DNA CLEAVAGE; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH, DEVELOPMENT AND AGING; HCT116 CELL LINE; HT 29 CELL LINE; MICROBIAL SENSITIVITY TEST; PHOTOCHEMISTRY; PLASMID; RADIATION RESPONSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA; DNA CLEAVAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HCT116 CELLS; HT29 CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PHOTOCHEMICAL PROCESSES; PLASMIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901004534     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.004     Document Type: Article

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