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Volumn 1, Issue 6, 2012, Pages 324-332

CAMP elevation down-regulates β3 integrin and focal adhesion kinase and inhibits leptin-induced migration of MDA-MB-231 breast cancer cells

Author keywords

breast cancer cells; cAMP; leptin; migration; novel anticancer therapies

Indexed keywords

BETA3 INTEGRIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FOCAL ADHESION KINASE; FORSKOLIN; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 3; STAT3 PROTEIN;

EID: 84901001741     PISSN: None     EISSN: 21647860     Source Type: Journal    
DOI: 10.1089/biores.2012.0270     Document Type: Article
Times cited : (30)

References (53)
  • 1
    • 0003964361 scopus 로고    scopus 로고
    • American Cancer Society. Atlanta, GA: American Cancer Society
    • American Cancer Society. Cancer Facts and Figures 2011. Atlanta, GA: American Cancer Society; 2011.
    • (2011) Cancer Facts and Figures 2011
  • 3
    • 0041965961 scopus 로고    scopus 로고
    • Road map to metastasis
    • Van't Veer LJ, Weigelt B. Road map to metastasis. Nat Med. 2003;9:999-1000.
    • (2003) Nat Med , vol.9 , pp. 999-1000
    • Van'T Veer, L.J.1    Weigelt, B.2
  • 4
    • 84876678070 scopus 로고    scopus 로고
    • Tumor cell migration in complex microenvironments
    • Aug 25 [Epub ahead of print]; DOI: 10.1007/s00018-012-1115-1121
    • Polacheck WJ, Zervantonakis IK, Kamm RD. Tumor cell migration in complex microenvironments. Cell Mol Life Sci. 2012 Aug 25 [Epub ahead of print]; DOI: 10.1007/s00018- 012-1115-1.
    • (2012) Cell Mol Life Sci
    • Polacheck, W.J.1    Zervantonakis, I.K.2    Kamm, R.D.3
  • 5
    • 80053384610 scopus 로고    scopus 로고
    • Metastatic triple-negative breast cancer
    • Rakha EA, Chan S. Metastatic triple-negative breast cancer. Clin Oncol. 2011;23:587-600.
    • (2011) Clin Oncol , vol.23 , pp. 587-600
    • Rakha, E.A.1    Chan, S.2
  • 6
    • 79151476662 scopus 로고    scopus 로고
    • Triple negative breast cancer: Unmet medical needs
    • Pal SK, Childs BH, Pegram M. Triple negative breast cancer: unmet medical needs. Breast Cancer Res Treat. 2011;125: 627-636.
    • (2011) Breast Cancer Res Treat , vol.125 , pp. 627-636
    • Pal, S.K.1    Childs, B.H.2    Pegram, M.3
  • 7
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372:425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3
  • 8
    • 84862528349 scopus 로고    scopus 로고
    • Deletion of prolyl carboxypeptidase attenuates the metabolic effects of dietinduced obesity
    • Jeong JK, Szabo G, Raso GM, et al. Deletion of prolyl carboxypeptidase attenuates the metabolic effects of dietinduced obesity. Am J Physiol Endocrinol Metab. 2012; 302:E1502-1510.
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Jeong, J.K.1    Szabo, G.2    Raso, G.M.3
  • 9
    • 0032963304 scopus 로고    scopus 로고
    • Model for the regulation of energy balance and adiposity by the central nervous system
    • Schwartz MW, Baskin DG, Kaiyala KJ, Woods SC. Model for the regulation of energy balance and adiposity by the central nervous system. Am J Clin Nutr. 1999;69:584-596.
    • (1999) Am J Clin Nutr , vol.69 , pp. 584-596
    • Schwartz, M.W.1    Baskin, D.G.2    Kaiyala, K.J.3    Woods, S.C.4
  • 11
    • 4143118039 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin
    • Yin N, Wang D, Zhang H, et al. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res. 2004;64:5870-5875.
    • (2004) Cancer Res , vol.64 , pp. 5870-5875
    • Yin, N.1    Wang, D.2    Zhang, H.3
  • 12
    • 3042817487 scopus 로고    scopus 로고
    • Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
    • Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res. 2004;10:4325-4331.
    • (2004) Clin Cancer Res , vol.10 , pp. 4325-4331
    • Ishikawa, M.1    Kitayama, J.2    Nagawa, H.3
  • 13
    • 43849103666 scopus 로고    scopus 로고
    • Leptin and leptin receptor involvement in cancer development: A study on human primary breast carcinoma
    • Jardé T, Caldefie-Chezet F, Damez M, et al. Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma. Oncol Rep. 2008;19: 905-911.
    • (2008) Oncol Rep , vol.19 , pp. 905-911
    • Jardé, T.1    Caldefie-Chezet, F.2    Damez, M.3
  • 14
    • 33646264086 scopus 로고    scopus 로고
    • Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers
    • Revillion F, Charlier M, Lhotellier V, et al. Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers. Clin Cancer Res. 2006;12(7 Pt 1):2088-2094.
    • (2006) Clin Cancer Res , vol.12 , Issue.7 PART. 1 , pp. 2088-2094
    • Revillion, F.1    Charlier, M.2    Lhotellier, V.3
  • 15
    • 33744735674 scopus 로고    scopus 로고
    • Leptin receptor expression and cell signaling in breast cancer
    • Frankenberry KA, Skinner H, Somasundar P, et al. Leptin receptor expression and cell signaling in breast cancer. Int J Oncol. 2006;28:985-993.
    • (2006) Int J Oncol , vol.28 , pp. 985-993
    • Frankenberry, K.A.1    Skinner, H.2    Somasundar, P.3
  • 16
    • 34447266935 scopus 로고    scopus 로고
    • Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status
    • Ray A, Nkhata KJ, Cleary MP. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. Int J Oncol. 2007;30:1499-1509.
    • (2007) Int J Oncol , vol.30 , pp. 1499-1509
    • Ray, A.1    Nkhata, K.J.2    Cleary, M.P.3
  • 17
    • 80052158404 scopus 로고    scopus 로고
    • Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells
    • Knight BB, Oprea-Ilies GM, Nagalingam A, et al. Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells. Endocr Relat Cancer. 2011;18:413-428.
    • (2011) Endocr Relat Cancer , vol.18 , pp. 413-428
    • Knight, B.B.1    Oprea-Ilies, G.M.2    Nagalingam, A.3
  • 18
    • 84859985179 scopus 로고    scopus 로고
    • The multifactorial role of leptin in driving the breast cancer microenvironment
    • Ando S, Catalano S. The multifactorial role of leptin in driving the breast cancer microenvironment. Nat Rev Endocrinol. 2011;8:263-275.
    • (2011) Nat Rev Endocrinol , vol.8 , pp. 263-275
    • Ando, S.1    Catalano, S.2
  • 19
    • 77949566512 scopus 로고    scopus 로고
    • Leptin as a potential therapeutic target for breast cancer prevention and treatment
    • Ray A, Cleary MP. Leptin as a potential therapeutic target for breast cancer prevention and treatment. Expert Opin Ther Targets. 2010;14:443-451.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 443-451
    • Ray, A.1    Cleary, M.P.2
  • 20
    • 68049118791 scopus 로고    scopus 로고
    • Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells
    • Naviglio S, Di Gesto D, Romano M, et al. Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells. Cancer Biol Ther. 2009;8:1183-1190.
    • (2009) Cancer Biol Ther , vol.8 , pp. 1183-1190
    • Naviglio, S.1    Di Gesto, D.2    Romano, M.3
  • 21
    • 77957743528 scopus 로고    scopus 로고
    • Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells
    • Naviglio S, Di Gesto D, Illiano F, et al. Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells. J Cell Physiol. 2010; 225:801-809.
    • (2010) J Cell Physiol , vol.225 , pp. 801-809
    • Naviglio, S.1    Di Gesto, D.2    Illiano, F.3
  • 22
    • 0033801452 scopus 로고    scopus 로고
    • Cyclic nucleotide analogs as biochemical tools and prospective drugs
    • Schwede F, Maronde E, Genieser H, Jastorff B. Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacol Ther. 2000;87:199-226.
    • (2000) Pharmacol Ther , vol.87 , pp. 199-226
    • Schwede, F.1    Maronde, E.2    Genieser, H.3    Jastorff, B.4
  • 23
    • 68049137870 scopus 로고    scopus 로고
    • A new therapeutic strategy against cancer: CAMP elevating drugs and leptin
    • Vitale G, Dicitore A, Mari D, Cavagnini F. A new therapeutic strategy against cancer: cAMP elevating drugs and leptin. Cancer Biol Ther. 2009;8:1190-1196.
    • (2009) Cancer Biol Ther , vol.8 , pp. 1190-1196
    • Vitale, G.1    Dicitore, A.2    Mari, D.3    Cavagnini, F.4
  • 24
    • 33744954408 scopus 로고    scopus 로고
    • Parathyroid hormonerelated protein regulates tumor-relevant genes in breast cancer cells
    • Dittmer A, Vetter M, Schunke D, et al. Parathyroid hormonerelated protein regulates tumor-relevant genes in breast cancer cells. J Biol Chem. 2006;281:14563-14572.
    • (2006) J Biol Chem , vol.281 , pp. 14563-14572
    • Dittmer, A.1    Vetter, M.2    Schunke, D.3
  • 25
    • 34547168365 scopus 로고    scopus 로고
    • Change in TNF-alpha receptor expression is a relevant event in doxorubicininduced H9c2 cardiomyocyte cell death
    • Chiosi E, Spina A, Sorrentino A, et al. Change in TNF-alpha receptor expression is a relevant event in doxorubicininduced H9c2 cardiomyocyte cell death. J Interferon Cytokine Res. 2007;27:589-597.
    • (2007) J Interferon Cytokine Res , vol.27 , pp. 589-597
    • Chiosi, E.1    Spina, A.2    Sorrentino, A.3
  • 26
    • 33746537713 scopus 로고    scopus 로고
    • Inorganic phosphate inhibits growth of human osteosarcoma U2OS cells via adenylate cyclase/ cAMP pathway
    • Naviglio S, SpinaA,Chiosi E, et al. Inorganic phosphate inhibits growth of human osteosarcoma U2OS cells via adenylate cyclase/ cAMP pathway. J Cell Biochem. 2006;98:1584-1596.
    • (2006) J Cell Biochem , vol.98 , pp. 1584-1596
    • Naviglio, S.1    Spina, A.2    Chiosi, E.3
  • 27
    • 78651260241 scopus 로고    scopus 로고
    • Lysophosphatidic acid induces MDA-MB-231 breast cancer cellsmigration through activation of PI3K/PAK1/ERK signaling
    • Du J, Sun C, Hu Z, et al. Lysophosphatidic acid induces MDA-MB-231 breast cancer cellsmigration through activation of PI3K/PAK1/ERK signaling. PLoS One. 2010;5:e15940.
    • PLoS One , vol.2010 , Issue.5
    • Du, J.1    Sun, C.2    Hu, Z.3
  • 28
    • 79952300263 scopus 로고    scopus 로고
    • Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3
    • Kim SH, Nagalingam A, Saxena NK, et al. Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. Carcinogenesis. 2010;32:359-367.
    • (2010) Carcinogenesis , vol.32 , pp. 359-367
    • Kim, S.H.1    Nagalingam, A.2    Saxena, N.K.3
  • 29
    • 46649097870 scopus 로고    scopus 로고
    • CAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation
    • Chen L, Zhang JJ, Huang XY. cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation. J Biol Chem. 2008;283:13799-13805.
    • (2008) J Biol Chem , vol.283 , pp. 13799-13805
    • Chen, L.1    Zhang, J.J.2    Huang, X.Y.3
  • 30
    • 79959255482 scopus 로고    scopus 로고
    • Signaling mechanism of cell adhesion molecules in breast cancer metastasis: Potential therapeutic targets
    • Li DM, Feng YM. Signaling mechanism of cell adhesion molecules in breast cancer metastasis: potential therapeutic targets. Breast Cancer Res Treat. 2011;128:7-21.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 7-21
    • Li, D.M.1    Feng, Y.M.2
  • 31
    • 77956626576 scopus 로고    scopus 로고
    • Focal adhesion kinase and p53 signal transduction pathways in cancer
    • Golubovskaya VM, Cance W. Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci. 2010;15: 901-912.
    • Front Biosci , vol.2010 , Issue.15 , pp. 901-912
    • Golubovskaya, V.M.1    Cance, W.2
  • 32
    • 76849100707 scopus 로고    scopus 로고
    • Focal adhesion kinase: A prominent determinant in breast cancer initiation, progression and metastasis
    • Luo M, Guan JL. Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett. 2010;289:127-139.
    • (2010) Cancer Lett , vol.289 , pp. 127-139
    • Luo, M.1    Guan, J.L.2
  • 33
    • 74149090516 scopus 로고    scopus 로고
    • Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: Activity-dependent positive feedback and cellular migration
    • Chioni AM, Shao D, Grose R, Djamgoz MB. Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration. Int J Biochem Cell Biol. 2010;42:346-358.
    • Int J Biochem Cell Biol , vol.2010 , Issue.42 , pp. 346-358
    • Chioni, A.M.1    Shao, D.2    Grose, R.3    Djamgoz, M.B.4
  • 34
    • 70350439474 scopus 로고    scopus 로고
    • Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner
    • Hansen C, Howlin J, Tengholm A, et al. Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner. J Biol Chem. 2009;284:27533-27543.
    • (2009) J Biol Chem , vol.284 , pp. 27533-27543
    • Hansen, C.1    Howlin, J.2    Tengholm, A.3
  • 35
    • 80054791583 scopus 로고    scopus 로고
    • Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion
    • McKenzie AJ, Campbell SL, Howe AK. Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. PLoS One. 2011;6:e26552.
    • (2011) PLoS One , vol.6
    • McKenzie, A.J.1    Campbell, S.L.2    Howe, A.K.3
  • 36
    • 84855642263 scopus 로고    scopus 로고
    • Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma
    • Fan CF, Mao XY, Wang EH. Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma. Mol Med Rep. 2012;5: 357-362.
    • (2012) Mol Med Rep , vol.5 , pp. 357-362
    • Fan, C.F.1    Mao, X.Y.2    Wang, E.H.3
  • 37
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000;351(Pt 1):95-105.
    • (2000) Biochem J , vol.351 PART. 1 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 38
    • 85006314494 scopus 로고    scopus 로고
    • A novel Epacspecific cAMP analogue demonstrates independent regulation of Rap1 and ERK
    • Enserink JM, Christensen AE, de Rooij J, et al. A novel Epacspecific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002;4:901-906.
    • (2002) Nat Cell Biol , vol.4 , pp. 901-906
    • Enserink, J.M.1    Christensen, A.E.2    De Rooij, J.3
  • 39
    • 80053607298 scopus 로고    scopus 로고
    • Novel molecular mechanisms by inorganic phosphate in osteosarcoma U2OS cells
    • Naviglio S, Di Gesto D, Borrelli V, et al. Novel molecular mechanisms by inorganic phosphate in osteosarcoma U2OS cells. Front Biosci. 2011;E3:1249-1258.
    • (2011) Front Biosci , vol.3 , pp. 1249-1258
    • Naviglio, S.1    Di Gesto, D.2    Borrelli, V.3
  • 40
    • 77954726255 scopus 로고    scopus 로고
    • Emerging targeted therapies for breast cancer
    • Alvarez RH, Valero V, Hortobagyi GN. Emerging targeted therapies for breast cancer. J Clin Oncol. 2010;28:3366-3379.
    • (2010) J Clin Oncol , vol.28 , pp. 3366-3379
    • Alvarez, R.H.1    Valero, V.2    Hortobagyi, G.N.3
  • 41
    • 80051484394 scopus 로고    scopus 로고
    • Triple-negative breast cancers: An updated review on treatment options
    • Reddy KB. Triple-negative breast cancers: an updated review on treatment options. Curr Oncol. 2011;18:173-179.
    • (2011) Curr Oncol , vol.18 , pp. 173-179
    • Reddy, K.B.1
  • 42
    • 80052331618 scopus 로고    scopus 로고
    • Targeting the leptin receptor: A potential new mode of treatment for breast cancer
    • Otvos L Jr, Surmacz E. Targeting the leptin receptor: a potential new mode of treatment for breast cancer. Exp Rev Anticancer Ther. 2011;11:1147-1150.
    • (2011) Exp Rev Anticancer Ther , vol.11 , pp. 1147-1150
    • Otvos Jr., L.1    Surmacz, E.2
  • 43
    • 34047252349 scopus 로고    scopus 로고
    • Increased invasive potential and up-regulation of MMP-2 in MDA-MB-231 breast cancer cells expressing the beta3 integrin subunit
    • Baum O, Hlushchuk R, Forster A, et al. Increased invasive potential and up-regulation of MMP-2 in MDA-MB-231 breast cancer cells expressing the beta3 integrin subunit. Int J Oncol. 2007;30:325-332.
    • (2007) Int J Oncol , vol.30 , pp. 325-332
    • Baum, O.1    Hlushchuk, R.2    Forster, A.3
  • 44
    • 84861592850 scopus 로고    scopus 로고
    • MYC suppresses cancer metastasis by direct transcriptional silencing of av and b3 integrin subunits
    • Liu H, Radisky DC, Yang D, et al. MYC suppresses cancer metastasis by direct transcriptional silencing of av and b3 integrin subunits. Nat Cell Biol. 2012;14:567-574.
    • (2012) Nat Cell Biol , vol.14 , pp. 567-574
    • Liu, H.1    Radisky, D.C.2    Yang, D.3
  • 45
    • 84866452621 scopus 로고    scopus 로고
    • SiRNA-mediated silencing of integrin b3 expression inhibits the metastatic potential of B16 melanoma cells
    • Nasulewicz-Goldeman A, Uszczyń ska B, Szczaurska-Nowak K, Wietrzyk J. siRNA-mediated silencing of integrin b3 expression inhibits the metastatic potential of B16 melanoma cells. Oncol Rep. 2012;28:1567-1573.
    • (2012) Oncol Rep , vol.28 , pp. 1567-1573
    • Nasulewicz-Goldeman, A.1    Uszczyń Ska, B.2    Szczaurska-Nowak, K.3    Wietrzyk, J.4
  • 46
    • 68549133222 scopus 로고    scopus 로고
    • FAK overexpression and p53 mutations are highly correlated in human breast cancer
    • Golubovskaya VM, Conway-Dorsey K, Edmiston SN, et al. FAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer. 2009;125:1735-1738.
    • (2009) Int J Cancer , vol.125 , pp. 1735-1738
    • Golubovskaya, V.M.1    Conway-Dorsey, K.2    Edmiston, S.N.3
  • 47
    • 68449086501 scopus 로고    scopus 로고
    • Focal adhesion kinase (FAK immunocytochemical expression in breast ductal invasive carcinoma DIC): Correlation with clinicopathological parameters and tumor proliferative capacity
    • Theocharis SE, Klijanienko JT, Padoy E, et al. Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): correlation with clinicopathological parameters and tumor proliferative capacity. Med Sci Monit. 2009;15:BR221-BR226.
    • (2009) Med Sci Monit , vol.15
    • Theocharis, S.E.1    Klijanienko, J.T.2    Padoy, E.3
  • 48
    • 0033533746 scopus 로고    scopus 로고
    • Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells
    • Agochiya M, Brunton VG, Owens DW, et al. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene. 1999;18:5646-5653.
    • (1999) Oncogene , vol.18 , pp. 5646-5653
    • Agochiya, M.1    Brunton, V.G.2    Owens, D.W.3
  • 49
    • 0036128068 scopus 로고    scopus 로고
    • The role of mitogenactivated protein (MAP) kinase in breast cancer
    • Santen RJ, Song RX, McPherson R, et al. The role of mitogenactivated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol. 2002;80:239-256.
    • (2002) J Steroid Biochem Mol Biol , vol.80 , pp. 239-256
    • Santen, R.J.1    Song, R.X.2    McPherson, R.3
  • 51
    • 20844444135 scopus 로고    scopus 로고
    • Targeting Stat3 in cancer therapy
    • Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs. 2005;16:601-607.
    • (2005) Anticancer Drugs , vol.16 , pp. 601-607
    • Jing, N.1    Tweardy, D.J.2
  • 52
    • 35348893870 scopus 로고    scopus 로고
    • Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy
    • Germain D, Frank DA. Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res. 2007; 13:5665-5669.
    • (2007) Clin Cancer Res , vol.13 , pp. 5665-5669
    • Germain, D.1    Frank, D.A.2
  • 53
    • 79953208248 scopus 로고    scopus 로고
    • STAT3 signaling: Anticancer strategies and challenges
    • Johnston PA, Grandis Jr. STAT3 signaling: anticancer strategies and challenges. Mol Interv. 2011;11:18-26.
    • (2011) Mol Interv , vol.11 , pp. 18-26
    • Johnston, P.A.1    Grandis, J.R.2


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