Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): Correlation with clinicopathological parameters and tumor proliferative capacity

Medical Science Monitor

Volumn 15, Issue 8, 2009, Pages

  Theocharis, Stamatios E ^a,b   Klijanienko, Jerzy T ^a   Padoy, Elianne ^a   Athanassiou, Stavros ^b   Sastre Garau, Xavier X ^a  

^a INSTITUT CURIE   (France)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Breast ductal invasive carcinoma; Focal adhesion kinase; Immunocytochemistry; Proliferation

Indexed keywords

FOCAL ADHESION KINASE;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CLINICAL FEATURE; CONTROLLED STUDY; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; TUMOR CELL; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL PROLIFERATION; CYTOPLASM; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM INVASIVENESS;

EID: 68449086501     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Clark EA, Brugge JS: Integrins and signal transduction pathways: the road taken. Science (Washington DC), 1995; 268: 233-239
2. Richardson A, Parsons JT: Signal transduction through integrins: a central role for focal adhesion kinase? Bioessays, 1995; 17: 229-236
3. Hanks SK, Polte TR: Signaling through focal adhesion kinase. Bioessays, 1997; 19: 137-145 (Pubitemid 27114962)
4. Juliano R: Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation. Bioessays, 1996; 18: 911-917
5. Jockusch BM, Bubeck P, Giehl K et al: The molecular architecture of focal adhesions. Annu Rev Cell Dev Biol, 1995; 11: 379-416
6. Macphee D, Lye S: Focal adhesion signaling in the rat myometrium is abruptly terminated with onset of labor. Endocrinology, 2000; 141: 274-283 (Pubitemid 32260368)
7. Schaller MD, Borgman CA, Cobb BS et al: pp125 FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA, 1992; 89: 5192-5196
8. Ilic D, Furuta Y, Kanazawa S et al: Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature, 1995; 377: 539-544
9. Cary LA, Chang JF, Guan JL: Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J Cell Sci, 1996; 109: 1787-1794 (Pubitemid 26248624)
10. Guan JL, Trevithick JE, Hynes RO: Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul, 1991; 2: 951-964
11. Kornberg LJ, Earp HS, Turner CE et al: Signal transduction by integrins: increased tyrosine phosphorylation caused by clustering of beta 1 integrins. Proc Natl Acad Sci USA, 1991; 88: 8392-8396
12. Hanks SK, Calalb MB, Harper MC, Patel SK: Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci USA, 1992; 89: 8487-8491
13. Romer LH, McLean N, Turner CE, Burridge K: Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell, 1994; 5: 349-361 (Pubitemid 24116960)
14. Li S, Kim M, Hu YL et al: Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem, 1997; 272: 30455-30462 (Pubitemid 27512256)
15. Levy P, Robin H, Kornprobst M et al: Enterocytic differentiation of human Caco-2 cell line correlates with alterations in integrin signaling. J Cell Physiol, 1989; 177: 618-627
16. Xu LH, Owens LV, Sturge GC et al: Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ, 1996; 7: 413-418
17. Owens LV, Xu L, Craven RJ et al: Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res, 1995; 55: 2752-2755
18. Iravani S, Mao W, Fu L et al: Elevated c-Src protein expression is an early event in colonic neoplasia. Lab Invest, 1998; 78: 365-371 (Pubitemid 28128899)
19. Cobb BS, Schaller MD, Leu TH, Parsons JT: Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol, 1994; 14: 147-155 (Pubitemid 2025326)
20. Weiner TM, Liu ET, Craven RJ, Cance WG: Expression of focal adhesion kinase gene and invasive cancer. Lancet, 1993; 342: 1024-1025
21. Withers BE, Hanks SK, Fry DW: Correlations between the expression, phosphotyrosine content and enzymatic activity of focal adhesion kinase, pp125FAK, in tumor and nontransformed cells. Cancer Biochem Biophys, 1996; 15: 127-139 (Pubitemid 27101211)
22. Judson PL, He X, Cance WG, Van Le L: Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer, 1999; 86: 1551-1556 (Pubitemid 29489790)
23. Weiner TM, Liu ET, Craven RJ, Cance WG: Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors. Ann Surg Oncol, 1994; 1: 18-27
24. Theocharis SE, Kouraklis GP, Kakisis JD et al: Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients. Eur J Surg Oncol, 2003; 29: 571-574
25. Cance WG, Harris JE, Iacocca MV et al: Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res, 2000; 6: 2417-2423
26. Madan R, Smolkin MB, Cocker R et al: Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma. Human Pathol, 2006; 37: 9-15 (Pubitemid 41790497)
27. Oktay MH, Oktay K, Hamele-Bena D et al: Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas. Hum Pathol, 2003; 34: 240-245 (Pubitemid 36356676)
28. Lightfoot HM, Lark A, Livasy CA et al: Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat, 2004; 88: 109-116
29. Lark AL, Livasy CA, Dressler L et al: High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol, 2005; 18: 1289-1294 (Pubitemid 41348647)
30. Schmitz KJ, Grabellus F, Callies R et al: High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but not predict outcome. Breast Cancer Res, 2005; 7: R194-R203
31. Beviglia L, Golubovskaya V, Xu L et al: Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis. Biochem J, 2003; 373: 201-210 (Pubitemid 36819515)
32. Xu LH, Yang X, Bradham CA et al: The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem, 2000; 275: 30597-30604 (Pubitemid 30751384)
33. Vadlamudi RK, Adam L, Nguyen D et al: Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2. J Cell Physiol, 2002; 190: 189-199 (Pubitemid 34027821)
34. Zrihan-Licht S, Avraham S, Jiang S et al: Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells. Int J Oncol, 2004; 24: 153-159
35. Vadlamudi RK, Sahin AA, Adam L et al: Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215. FEBS Lett, 2003; 543: 76-80 (Pubitemid 36577231)
36. Canbay E, Norman M, Kilic E et al: Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells. Biochem J, 1997; 324: 231-236 (Pubitemid 27229387)
37. Golubovskaya V, Beviglia L, Xu LH et al: Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem, 2002; 277: 38978-38987 (Pubitemid 35154764)
38. Lin HM, Lee YJ, Li G et al: Bcl-2 induces cyclin D1 promoter activity in human breast epithelial cells independent of cell anchorage. Cell Death Differ, 2001; 8: 44-50 (Pubitemid 32162220)
39. Guvakova MA, Surmacz E: The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin. Exp Cell Res, 1999; 251: 244-255
40. Perks CM, Newcomb PV, Norman MR, Holly JM: Effect of insulin-like growth factor binding protein-1 on integrin signalling and the induction of apoptosis in human breast cancer cells. J Mol Endocrinol, 1999; 22: 141-150 (Pubitemid 29193102)
41. Planas-Silva MC, Bruggeman RD, Grenko RT, Smith SJ: Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer. Biochem Biophys Res Commun, 2006; 341: 73-81