Visualizing immune responses in fungal infections: Established and novel methods

Human Fungal Pathogens, 2nd Edition

Volumn 12, Issue , 2014, Pages 141-160

  Hasenberg, Mike ^a   Krappmann, Sven ^b   Gunzer, Matthias ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84900988531     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-39432-4_8     Document Type: Chapter

References (75)

1. Barteneva NS, Fasler-Kan E, Vorobjev IA (2012) Imaging flow cytometry: coping with heterogeneity in biological systems. J Histochem Cytochem 60: 723-733
2. Behnsen J, Narang P, Hasenberg M, Gunzer F, Bilitewski U, Klippel N, Rohde M, Brock M, Brakhage AA, Gunzer M (2007) Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog 3: e13
3. Brock M, Jouvion G, Droin-Bergere S, Dussurget O, Nicola MA, Ibrahim-Granet O (2008) Bioluminescent Aspergillus fumigatus, a new tool for drug efficiency testing and in vivo monitoring of invasive aspergillosis. Appl Environ Microbiol 74: 7023-7035
4. Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC (2012) Hidden killers: human fungal infections. Sci Transl Med 4: 165rv13
5. Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche S, Thywißen A, Jeron A, Latge JP, Brakhage AA, Gunzer M (2010) Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by Hydrophobin RodA. PLoS Pathog 6: e1000873
6. Bryan RA, Guimaraes AJ, Hopcraft S, Jiang Z, Bonilla K, Morgenstern A, Bruchertseifer F, Del PM, Torosantucci A, Cassone A, Nosanchuk JD, Casadevall A, Dadachova E (2012) Toward developing a universal treatment for fungal disease using radioimmunotherapy targeting common fungal antigens. Mycopathologia 173: 463-471
7. Coltharp C, Xiao J (2012) Superresolution microscopy for microbiology. Cell Microbiol 14: 1808-1818
8. Denning DW, Hope WW (2010) Therapy for fungal diseases: opportunities and priorities. Trends Microbiol 18: 195-204
9. Donat S, Hasenberg M, Schafer T, Ohlsen K, Gunzer M, Einsele H, Löffler J, Beilhack A, Krappmann S (2012) Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis. Virulence 3: 51-61
10. Doyle TC, Nawotka KA, Kawahara CB, Francis KP, Contag PR (2006) Visualizing fungal infections in living mice using bioluminescent pathogenic Candida albicans strains transformed with the firefly luciferase gene. Microb Pathog 40: 82-90
11. Dumarey N, Egrise D, Blocklet D, Stallenberg B, Remmelink M, Den MV, Van Simaeys G, Jacobs F, Goldman S (2006) Imaging infection with 18FFDG-labeled leukocyte PET/CT: initial experience in 21 patients. J Nucl Med 47: 625-632
12. Eggeling C, Ringemann C, Medda R, Schwarzmann G, Sandhoff K, Polyakova S, Belov VN, Hein B, von Middendorff C, Schonle A, Hell SW (2009) Direct observation of the nanoscale dynamics of membrane lipids in a living cell. Nature 457: 1159-1162
13. Enjalbert B, Rachini A, Vediyappan G, Pietrella D, Spaccapelo R, Vecchiarelli A, Brown AJ, d’Enfert C (2009) A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections. Infect Immun 77: 4847-4858
14. Fiolka R, Shao L, Rego EH, Davidson MW, Gustafsson MG (2012) Time-lapse two-color 3D imaging of live cells with doubled resolution using structured illumination. Proc Natl Acad Sci USA 109: 5311-5315
15. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR, Infectious Diseases Society of America (2011) Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 52: 427-431
16. Friston KJ (2009) Modalities, modes, and models in functional neuroimaging. Science 326: 399-403
17. Gabelmann A, Klein S, Kern W, Kruger S, Brambs HJ, Rieber-Brambs A, Pauls S (2007) Relevant imaging findings of cerebral aspergillosis on MRI: a retrospective case-based study in immunocompromised patients. Eur J Neurol 14: 548-555
18. Gardet E, Addas R, Monteil J, Le GA (2010) Comparison of detection of F-18 fluorodeoxyglucose positron emission tomography and 99mTchexamethylpropylene amine oxime labelled leukocyte scintigraphy for an aortic graft infection. Interact Cardiovasc Thorac Surg 10: 142-143
19. Georgiadou SP, Sipsas NV, Marom EM, Kontoyiannis DP (2011) The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts. Clin Infect Dis 52: 1144-1155
20. Germain RN, Miller MJ, Dustin ML, Nussenzweig MC (2006) Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol 6: 497-507
21. Gomez P, Hackett TL, Moore MM, Knight DA, Tebbutt SJ (2010) Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus. BMC Genomics 11: 358
22. Graute V, Feist M, Lehner S, Haug A, Muller PE, Bartenstein P, Hacker M (2010) Detection of lowgrade prosthetic joint infections using 99mTcantigranulocyte SPECT/CT: initial clinical results. Eur J Nucl Med Mol Imaging 37: 1751-1759
23. Gunzer M, Weishaupt C, Hillmer A, Basoglu Y, Friedl P, Dittmar KE, Kolanus W, Varga G, Grabbe S (2004) A spectrum of biophysical interaction modes between T cells and different antigen presenting cells during priming in 3-D collagen and in vivo. Blood 104: 2801-2809
24. Gustafsson MG (2005) Nonlinear structuredillumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Proc Natl Acad Sci USA 102: 13081-13086
25. Hasenberg M, Behnsen J, Krappmann S, Brakhage A, Gunzer M (2011a) Phagocyte responses towards Aspergillus fumigatus. Int J Med Microbiol 301: 436-444
26. Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek-Burchardt M, Achilles J, Männ L, Baumgart K, Schraven B, Gunzer M (2011b) Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS One 6: e17314
27. Hasenberg M, Köhler A, Bonifatius S, Jeron A, Gunzer M (2011c) Direct observation of phagocytosis and NET-formation by neutrophils in infected lungs using 2-photon microscopy. J Vis Exp 52: e2659. doi: 10.3791/2659
28. Hasenberg M, Stegemann-Koniszewski S, Gunzer M (2013) Cellular immune reactions in the lung. Immunol Rev 251: 189-214
29. Hell SW (2007) Far-field optical nanoscopy. Science 316: 1153-1158
30. Hell SW (2009) Microscopy and its focal switch. Nat Methods 6: 24-32
31. Hohmann-Marriott MF, Uchida M, van de Meene AM, Garret M, Hjelm BE, Kokoori S, Roberson RW (2006) Application of electron tomography to fungal ultrastructure studies. New Phytol 172: 208-220
32. Hot A, Maunoury C, Poiree S, Lanternier F, Viard JP, Loulergue P, Coignard H, Bougnoux ME, Suarez F, Rubio MT, Mahlaoui N, Dupont B, Lecuit M, Faraggi M, Lortholary O (2011) Diagnostic contribution of positron emission tomography with [18 F] fluorodeoxyglucose for invasive fungal infections. Clin Microbiol Infect 17: 409-417
33. Hulett HR, Bonner WA, Barrett J, Herzenberg LA (1969) Cell sorting: automated separation of mammalian cells as a function of intracellular fluorescence. Science 166: 747-749
34. Ibrahim-Granet O, Philippe B, Boleti H, Boisvieux-Ulrich E, Grenet D, Stern M, Latge JP (2003) Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages. Infect Immun 71: 891-903
35. Ibrahim-Granet O, Jouvion G, Hohl TM, Droin-Bergere S, Philippart F, Kim OY, Adib-Conquy M, Schwendener R, Cavaillon JM, Brock M (2010) In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis. BMC Microbiol 10: 105
36. Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM (2012) Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep 2: 1762-1773
37. Jones T, Price P (2012) Development and experimental medicine applications of PET in oncology: a historical perspective. Lancet Oncol 13: e116-e125
38. Jouvion G, Brock M, Droin-Bergere S, Ibrahim-Granet O (2012) Duality of liver and kidney lesions after systemic infection of immunosuppressed and immunocompetent mice with Aspergillus fumigatus. Virulence 3: 43-50
39. Judenhofer MS, Wehrl HF, Newport DF, Catana C, Siegel SB, Becker M, Thielscher A, Kneilling M, Lichy MP, Eichner M, Klingel K, Reischl G, Widmaier S, Rocken M, Nutt RE, Machulla HJ, Uludag K, Cherry SR, Claussen CD, Pichler BJ (2008) Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med 14: 459-465
40. Kauffman CA, Fisher JF, Sobel JD, Newman CA (2011) Candida urinary tract infections-diagnosis. Clin Infect Dis 52(Suppl 6): S452-S456
41. Konig K (2000) Multiphoton microscopy in life sciences. J Microsc 200(Pt 2): 83-104
42. Koning RI, Koster AJ (2009) Cryo-electron tomography in biology and medicine. Ann Anat 191: 427-445
43. Latge JP (1999) Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 12: 310-350
44. Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA (2011) An official American thoracic society statement: treatment of fungal infections in adult pulmonary and critical care patients. Am J Respir Crit Care Med 183: 96-128
45. Lionakis MS, Lim JK, Lee CC, Murphy PM (2011) Organ-specific innate immune responses in a mouse model of invasive candidiasis. J Innate Immun 3: 180-199
46. Marchiori E, Zanetti G, Hochhegger B, Irion KL, Carvalho AC, Godoy MC (2012) Reversed halo sign on computed tomography: state-of-the-art review. Lung 190: 389-394
47. Mech F, Thywissen A, Guthke R, Brakhage AA, Figge MT (2011) Automated image analysis of the hostpathogen interaction between phagocytes and Aspergillus fumigatus. PLoS One 6: e19591
48. Meyer JC, Girit CO, Crommie MF, Zettl A (2008) Imaging and dynamics of light atoms and molecules on graphene. Nature 454: 319-322
49. Michelio PA (1729) Nova plantarum genera iuxta tournefortii methodum disposita. Bernardo Paperini, Florence
50. Moonen CT, van Zijl PC, Frank JA, Le BD, Becker ED (1990) Functional magnetic resonance imaging in medicine and physiology. Science 250: 53-61
51. Muller FM, Trusen A, Weig M (2002) Clinical manifestations and diagnosis of invasive aspergillosis in immunocompromised children. Eur J Pediatr 161: 563-574
52. Mullins ME (2011) Emergent neuroimaging of intracranial infection/inflammation. Radiol Clin North Am 49: 47-62
53. Niesner RA, Andresen V, Neumann J, Spiecker H, Gunzer M (2007) The power of single- and multibeam 2-photon microscopy for high-resolution and high-speed deep tissue and intravital imaging. Biophys J 93: 2519-2529
54. Niesner RA, Andresen V, Gunzer M (2008a) Intravital 2-photon microscopy - focus on speed and time resolved imaging modalities. Immunol Rev 221: 7-25
55. Niesner RA, Narang P, Spiecker H, Andresen V, Gericke KH, Gunzer M (2008b) Selective detection of NADPH oxidase in polymorphonuclear cells by means of NAD(P)H-based fluorescence lifetime imaging. J Biophys 2008: 602639
56. Nitschke C, Garin A, Kosco-Vilbois M, GunzerM(2008) 3-D and 4-D imaging of immune cells in vitro and in vivo. Histochem Cell Biol 130: 1053-1062
57. Peleg AY, Hogan DA, Mylonakis E (2010) Medically important bacterial-fungal interactions. Nat Rev Microbiol 8: 340-349
58. Petrik M, Haas H, Dobrozemsky G, Lass-Flörl C, Helbok A, Blatzer M, Dietrich H, Decristoforo C (2010) 68 Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med 51: 639-645
59. Petrik M, Franssen GM, Haas H, Laverman P, Hortnagl C, Schrettl M, Helbok A, Lass-Flörl C, Decristoforo C (2012) Preclinical evaluation of two (68)Gasiderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging. Eur J Nucl Med Mol Imaging 39: 1175-1183
60. Pichler BJ, Judenhofer MS, Pfannenberg C (2008) Multimodal imaging approaches: PET/CT and PET/MRI. Handb Exp Pharmacol 185: 109-132
61. Romani L (2011) Immunity to fungal infections. Nat Rev Immunol 11: 275-288
62. Ronco F, Simsir S, Czer L, Luo H, Siegel RJ (2010) Incidental finding by two-dimensional echocardiography of a mycotic pseudoaneurysm of the ascending aorta after orthotopic heart transplantation. J Am Soc Echocardiogr 23: 580-583
63. Sandherr M, von Schilling C, Link T, Stock K, von Bubnoff N, Peschel C, Avril N (2001) Pitfalls in imaging Hodgkin’s disease with computed tomography and positron emission tomography using fluorine-18-fluorodeoxyglucose. Ann Oncol 12: 719-722
64. Sasse C, Hasenberg M, Weyler M, Gunzer M, Morschhäuser J (2013) White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion. Eukaryotic Cell, 12(1): 50-58
65. Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke B, Cardoso MC, Agard DA, Gustafsson MG, Leonhardt H, Sedat JW (2008) Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science 320: 1332-1336
66. Schmidt A (1998) Gerog Fresenius and the species Aspergillus fumigatus. Mycoses 41(Suppl 2): 89-91
67. Seshadri N, Kaur B, Balan K (2007) Disseminated cryptococcosis: detection by F-18 FDG PET. Clin Nucl Med 32: 476-478
68. Shrikanthan S, Aydin A, Dhurairaj T, Alavi A, Zhuang H (2005) Intense esophageal FDG activity caused by Candida infection obscured the concurrent primary esophageal cancer on PET imaging. Clin Nucl Med 30: 695-697
69. Steinberg G (2007) Hyphal growth: a tale of motors, lipids, and the Spitzenkorper. Eukaryot Cell 6: 351-360
70. Stoll S, Delon J, Brotz TM, Germain RN (2002) Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296: 1873-1876
71. Vicidomini G, Moneron G, Han KY, Westphal V, Ta H, Reuss M, Engelhardt J, Eggeling C, Hell SW (2011) Sharper low-power STED nanoscopy by time gating. Nat Methods 8: 571-573
72. Waibler Z, Sender LY, Merten C, Hartig R, Kliche S, Gunzer M, Reichardt P, Kalinke U, Schraven B (2008) Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies. PLoS One 3: e1708
73. Walker RC, Jones-Jackson LB, Martin W, Habibian MR, Delbeke D (2007) New imaging tools for the diagnosis of infection. Future Microbiol 2: 527-554
74. Wang J, Gigliotti F, Bhagwat SP, George TC, Wright TW (2010) Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia. PLoS Pathog 6: e1001058
75. Yang Z, Marshall JS (2009) Zymosan treatment of mouse mast cells enhances dectin-1 expression and induces dectin-1-dependent reactive oxygen species (ROS) generation. Immunobiology 214: 321-330