Hemin uptake and release by neurons and glia

Free Radical Research

Volumn 48, Issue 2, 2014, Pages 200-205

  Chen Roetling, J ^a   Cai, Y ^a   Lu, X ^a   Regan, R F ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Heme; Intracerebral hemorrhage; Iron; Ischemia; Stroke; Subarachnoid hemorrhage

Indexed keywords

ALBUMIN; DEFEROXAMINE; HEMIN; IRON 55; MESOPORPHYRIN; PROTOPORPHYRIN TIN;

ANIMAL CELL; ARTICLE; BRAIN CELL CULTURE; CELL DEATH; CELL PROTECTION; CONCENTRATION (PARAMETERS); DRUG CYTOTOXICITY; ERYTHROCYTE; EXTRACELLULAR SPACE; GLIA; MICROGLIA; MIXED CELL CULTURE; MOUSE; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN;

ANIMALS; CELLS, CULTURED; CEREBRAL HEMORRHAGE; CHELATING AGENTS; DEFEROXAMINE; ERYTHROCYTES; HEME OXYGENASE (DECYCLIZING); HEMIN; METALLOPORPHYRINS; MICE; NEUROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PRIMARY CELL CULTURE; PROTOPORPHYRINS;

EID: 84890110688     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2013.859386     Document Type: Article

References (35)

1. PB, Lieberman K, Nagatani K, Haworth RA, Odell GB, DuffTA. Hemin: Levels in experimental subarachnoid hematoma and effects on dissociated vascular smooth muscle cells. J. Neurosurg 1993; 79: 252-255.
2. Khan AA, Quigley JG. Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med 2013; 34: 669-682.
3. Yuan X, Fleming MD, Hamza I. Heme transport and erythropoiesis. Curr Opin Chem Biol 2013; 17: 204-211.
4. Robinson SR, Dang TN, Dringen R, Bishop GM. Hemin toxicity: A preventable source of brain damage following hemorrhagic stroke. Redox Rep 2009; 14: 228-235.
5. Gutteridge JMC, Smith A. Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation. Biochem. J 1988; 256: 861-865.
6. Schipper HM, Song W, Zukor H, Hascalovici JR, Zeligman D. Heme oxygenase-1 and neurodegeneration: Expanding frontiers of engagement. J Neurochem 2009; 110: 469-485.
7. Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, et al. Identification of a human heme exporter that is essential for erythropoiesis. Cell 2004; 118: 757-766.
8. Yang Z, Philips JD, Doty RT, Giraudi P, Ostrow JD, Tiribelli C, et al. Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. J Biol Chem 2010; 285: 28874-28882.
9. Desuzinges-Mandon E, Arnaud O, Martinez L, Huche F, Di Pietro A, Falson P. ABCG2 transports and transfers heme to albumin through its large extracellular loop. J Biol Chem 2010; 285: 33123-33133.
10. Yanatori I, Yasui Y, Miura K, Kishi F. Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity. Blood Cells Mol Dis 2012; 49: 60-66.
11. Lu N, Yi L, Deng Q, Li J, Gao Z, Li H. The interaction between desferrioxamine and hemin: A potential toxicological implication. Toxicol In Vitro 2012; 26: 732-735.
12. Baysal E, Monteiro HP, Sullivan SG, Stern A. Desferrioxamine protects human red blood cells from hemin-induced hemolysis. Free Radic Biol Med 1990; 9: 5-10.
13. Regan RF, Choi DW. The effect of NMDA, AMPA/kainate, and calcium channel antagonists on traumatic cortical neuronal injury in culture. Brain Res 1994; 633: 236-242.
14. Regan RF, Chen M, Li Z, Zhang X, Benvenisti-Zarom L, Chen-Roetling J. Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin. Neurobiol Dis 2008; 31: 242-249.
15. Cai Y, Cho GS, Ju C, Wang SL, Ryu JH, Shin CY, et al. Activated microglia are less vulnerable to hemin toxicity due to nitric oxide-dependent inhibition of JNK and p38 MAPK activation. J Immunol 2011; 187: 1314-1321.
16. Worthington MT, Cohn SM, Miller SK, Luo RQ, Berg CL. Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines. Am J Physiol Gastrointest Liver Physiol 2001; 280: G1172-G1177.
17. Lee MC, Heaney LM, Jacobson RL, Klassen AC. Cerebrospinal fl uid in cerebral hemorrhage and infarction. Stroke 1975; 6: 638-641.
18. Chen-Roetling J, Chen L, Regan RF. Apotransferrin protects cortical neurons from hemoglobin toxicity. Neuropharmacology 2011; 60: 423-431.
19. Regan RF, Rogers B. Delayed treatment of hemoglobin neurotoxicity. J Neurotrauma 2003; 20: 111-120.
20. Koh JY, Choi DW. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase effl ux assay. J Neurosci Meth 1987; 20: 83-90.
21. Appleton SD, Chretien ML, McLaughlin BE, Vreman HJ, Stevenson DK, Brien JF, et al. Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations. Drug Metab Disp 1999; 27: 1214-1219.
22. Nakamura T, Keep RF, Hua Y, Schallert T, HoffJT, Xi G. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg 2004; 100: 672-678.
23. Wu H, Wu T, Xu X, Wang J. Iron toxicity in mice with collagenase-induced intracerebral hemorrhage. J Cereb Blood Flow Metab 2011; 31: 1243-1250.
24. Chen-Roetling J, Liu W, Regan RF. Iron accumulation and neurotoxicity in cortical cultures treated with holotransferrin. Free Radic Biol Med 2011; 51: 1966-1974.
25. Regan RF, Chen J, Benvenisti-Zarom L. Heme oxygenase-2 gene deletion attenuates oxidative stress in neurons exposed to extracellular hemin. BMC Neurosci 2004; 5: 34.
26. Zhao X, Sun G, Zhang J, Strong R, Song W, Gonzales N, et al. Hematoma resolution as a target for intracerebral hemorrhage treatment: Role for peroxisome proliferatoractivated receptor gamma in microglia/macrophages. Ann Neurol 2007; 61: 352-362.
27. Cable H, Lloyd JB. Cellular uptake and release of two contrasting iron chelators. J Pharm Pharmacol 1999; 51: 131-134.
28. De Domenico I, Ward DM, Kaplan J. Specific iron chelators determine the route of ferritin degradation. Blood 2009; 114: 4546-4551.
29. Chou AC, Fitch CD. Mechanism of hemolysis induced by ferriprotoporphyrin IX. J Clin Invest 1981; 68: 672-677.
30. Lamb NJ, Quinlan GJ, Mumby S, Evans TW, Gutteridge JMC. Haem oxygenase shows pro-oxidant activity in microsomal and cellular systems: Implications for the release of lowmolecular-mass iron. Biochem J 1999; 344: 153-158.
31. Loban A, Kime R, Powers H. Iron-binding antioxidant potential of plasma albumin. Clin Sci (Lond) 1997; 93: 445-451.
32. Wang J, Zhuang H, Dor é S. Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage. Neurobiol Dis 2006; 22: 473-476.
33. Hamori CJ, Vreman HJ, Stevenson DK. Suppression of carbon monoxide excretion by zinc mesoporphyrin in adult Wistar rats: Evidence for potent in vivo inhibition of bilirubin production. Res Commun Chem Pathol Pharmacol 1988; 62: 41-48.
34. Light WR III, Olson JS. Transmembrane movement of heme. J Biol Chem 1990; 265: 15623-15631.
35. Khan AA, Quigley JG. Control of intracellular heme levels: Heme transporters and heme oxygenases. Biochim Biophys Acta 2011; 1813: 668-682.