Characterization of Spink6 in mouse skin: The conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury

Journal of Investigative Dermatology

Volumn 134, Issue 5, 2014, Pages 1305-1312

  Fischer, Jan ^a   Wu, Zhihong ^a   Kantyka, Tomasz ^b   Sperrhacke, Maria ^a   Dimitrieva, Olga ^a   Koblyakova, Yulia ^a   Ahrens, Kerstin ^a   Graumann, Nina ^a   Baurecht, Hansjörg ^a   Reiss, Karina ^a   Schröder, Jens Michael ^a   Proksch, Ehrhardt ^a   Meyer Hoffert, Ulf ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; GAMMA INTERFERON; INTERLEUKIN 1BETA; KALLIKREIN; KALLIKREIN 1; KALLIKREIN 12; KALLIKREIN 13; KALLIKREIN 14; KALLIKREIN 2; KALLIKREIN 4; KALLIKREIN 5; KALLIKREIN 6; NEUROPSIN; RETINOIC ACID; SERINE PROTEASE INHIBITOR KAZAL TYPE 6; SERINE PROTEINASE; STRATUM CORNEUM CHYMOTRYPTIC ENZYME; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKERATIN 10; EPIDERMAL GROWTH FACTOR; KALLIKREIN INHIBITOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME SUBSTRATE; EPIDERMIS; HAIR FOLLICLE; HAIR ROOT; KERATINOCYTE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SEQUENCE ALIGNMENT; SKIN APPENDAGE; SKIN FUNCTION; SKIN INJURY; NEWBORN; PRIORITY JOURNAL; SKIN;

AMINO ACID SEQUENCE; ANIMALS; BODY WATER; CELLS, CULTURED; EPIDERMIS; FEMALE; HUMANS; INTERFERON-GAMMA; KALLIKREINS; KERATINOCYTES; KERATOLYTIC AGENTS; MALE; MICE; MICE, HAIRLESS; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROTEINASE INHIBITORY PROTEINS, SECRETORY; RNA, MESSENGER; SOLUBILITY; TRETINOIN; TUMOR NECROSIS FACTOR-ALPHA; WATER LOSS, INSENSIBLE;

EID: 84900851787     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.502     Document Type: Article

References (41)

1. Ahrens K, Schunck M, Podda GF et al. (2011) Mechanical and metabolic injury to the skin barrier leads to increased expression of murine betadefensin-1,-3, and-14. J Invest Dermatol 131:443-52
2. Altschul SF, Madden TL, Schaffer AA et al. (1997) Gapped BLAST and PSIBLAST: A new generation of protein database search programs. Nucleic Acids Res 25:3389-402
3. Bavandi A, Meingassner JG, Becker S (1992) Diet-induced dermatitis response of hairless rats to systemic treatment with cyclosporin A (Sandimmun), cyclosporin H and FK506. Exp Dermatol 1:199-205
4. Bibel DJ, Miller SJ, Brown BE et al. (1989) Antimicrobial activity of stratum corneum lipids from normal and essential fatty acid-deficient mice. J Invest Dermatol 92:632-8
5. Borgono CA, Michael IP, Komatsu N et al. (2007) A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. J Biol Chem 282:3640-52
6. Brattsand M, Stefansson K, Hubiche T et al. (2009) SPINK9: A selective, skin-specific Kazal-Type serine protease inhibitor. J Invest Dermatol 129:1656-65
7. Briot A, Deraison C, Lacroix M et al. (2009) Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med 206:1135-47
8. Caubet C, Jonca N, Brattsand M et al. (2004) Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/ hK5 and SCCE/KLK7/hK7. J Invest Dermatol 122:1235-44
9. Chavanas S, Bodemer C, Rochat A et al. (2000) Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 25: 141-2
10. Descargues P, Deraison C, Bonnart C et al. (2005) Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Nat Genet 37:56-65
11. Eissa A, Amodeo V, Smith CR et al. (2011) Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade. J Biol Chem 286:687-706
12. Fischer J, Meyer-Hoffert U (2013) Regulation of kallikrein-related peptidases in the skin-from physiology to diseases to therapeutic options. Thromb Haemost 110:442-9
13. Flohr S, Randl SA, Ostermann N et al. (2010) Kallikrein 7 modulators. US patent US 2010/0256144 A1
14. Furio L, Hovnanian A (2011) When activity requires breaking up: LEKTI proteolytic activation cascade for specific proteinase inhibition. J Invest Dermatol 131:2169-73
15. Griffiths WAD, Leigh IM, Judge MR (1998) Disorders of keratinization. In: Textbook of Dermatology (Champion RH, Breathnach SM, Burns DA, Burton JL eds), Vol. 2Oxford: Blackwell Science1486-588
16. Hachem JP, Houben E, Crumrine D et al. (2006) Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol 126:2074-86
17. Hansson L, Backman A, Ny A et al. (2002) Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: A model for chronic itchy dermatitis. J Invest Dermatol 118:444-9
18. Kantyka T, Fischer J, Wu Z et al. (2011) Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-Type 6. Peptides 32:1187-92
19. Komatsu N, Saijoh K, Toyama T et al. (2005) Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases. Br J Dermatol 153:274-81
20. Komatsu N, Takata M, Otsuki N et al. (2003) Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages. J Invest Dermatol 121:542-9
21. Laskowski Jr. M., Qasim MA, Yi Z (2003) Additivity-based prediction of equilibrium constants for some protein-protein associations. Curr Opin Struct Biol 13:130-9
22. Magert HJ, Standker L, Kreutzmann P et al. (1999) LEKTI, a novel 15-domain type of human serine proteinase inhibitor. J Biol Chem 274:21499-502
23. Meyer-Hoffert U (2009) Reddish, scaly, and itchy: How proteases and their inhibitors contribute to inflammatory skin diseases. Arch Immunol Ther Exp (Warsz) 57:345-54
24. Meyer-Hoffert U, Schroder JM (2011) Epidermal proteases in the pathogenesis of rosacea. J Investig Dermatol Symp Proc 15:16-23
25. Meyer-Hoffert U, Wu Z, Kantyka T et al. (2010) Isolation of SPINK6 in human skin: Selective inhibitor of kallikrein-related peptidases. J Biol Chem 285:32174-81
26. Meyer-Hoffert U, Wu Z, Schroder JM (2009) Identification of lympho-epithelial Kazal-Type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor. PLoS One 4:e4372
27. Meyer-Hoffert U, Zimmermann A, Czapp M et al. (2011) Flagellin delivery by Pseudomonas aeruginosa rhamnolipids induces the antimicrobial protein psoriasin in human skin. PLoS One 6:e16433
28. Olsson AY, Lundwall A (2002) Organization and evolution of the glandular kallikrein locus in Mus musculus. Biochem Biophys Res Commun 299:305-11
29. Pavlopoulou A, Pampalakis G, Michalopoulos I et al. (2010) Evolutionary history of tissue kallikreins. PLoS One 5:e13781
30. Proksch E, Feingold KR, Elias PM (1992) Epidermal HMG CoA reductase activity in essential fatty acid deficiency: Barrier requirements rather than eicosanoid generation regulate cholesterol synthesis. J Invest Dermatol 99:216-20
31. Reiss K, Meyer-Hoffert U, Fischer J et al. (2011) Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2. Exp Dermatol 20:905-10
32. Schultz J, Milpetz F, Bork P et al. (1998) SMART, a simple modular architecture research tool: Identification of signaling domains. Proc Natl Acad Sci USA 95:5857-64
33. Simon M, Jonca N, Guerrin M et al. (2001) Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation. J Biol Chem 276: 20292-9
34. Sotiropoulou G, Pampalakis G (2012) Targeting the kallikrein-related peptidases for drug development. Trends Pharmacol Sci 33:623-34
35. Stefansson K, Brattsand M, Roosterman D et al. (2008) Activation of proteinaseactivated receptor-2 by human kallikrein-related peptidases. J Invest Dermatol 128:18-25
36. Steinhoff M, Buddenkotte J, Shpacovitch V et al. (2005) Proteinase-Activated receptors: Transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 26:1-43
37. Tatusova TA, Madden TL (1999) BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences. FEMS Microbiol Lett 174:247-50
38. Voegeli R, Doppler S, Joller P et al. (2011) Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin. Int J Cosmet Sci 33:560-5
39. Voegeli R, Rawlings AV, Breternitz M et al. (2009) Increased stratum corneum serine protease activity in acute eczematous atopic skin. Br J Dermatol 161:70-7
40. Wines DR, Brady JM, Pritchett DB et al. (1989) Organization and expression of the rat kallikrein gene family. J Biol Chem 264:7653-62
41. Wu Z, Meyer-Hoffert U, Reithmayer K et al. (2009) Highly complex peptide aggregates of the S100 fused-Type protein hornerin are present in human skin. J Invest Dermatol 129:1446-58