Endothelium-independent hypoxic contraction of porcine coronary arteries may be mediated by activation of phosphoinositide 3-kinase/Akt pathway

Vascular Pharmacology

Volumn 61, Issue 2-3, 2014, Pages 56-62

  Liu, Huixia ^a,c   Chen, Zhengju ^a   Liu, Juan ^a   Liu, Limei ^a,b   Gao, Yuansheng ^a,b   Dou, Dou ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c Heze Medical College   (China)

Author keywords

Contractility; Coronary circulation; Hypoxia; Myosin; Vasospasm

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NIFEDIPINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; AMIDE; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE; PYRIDINE DERIVATIVE; RHO KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CORONARY ARTERY CONSTRICTION; CORONARY ARTERY DILATATION; CORONARY ARTERY SPASM; ENDOTHELIUM INDEPENDENT HYPOXIC CONTRACTION; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SWINE; WESTERN BLOTTING; ANIMAL; ANOXIA; CORONARY BLOOD VESSEL; DRUG EFFECTS; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TIME; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

AMIDES; ANIMALS; ANOXIA; CHROMONES; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; SWINE; TIME FACTORS; VASOCONSTRICTION;

EID: 84900851731     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2014.03.005     Document Type: Article

References (44)

1. Kawano H., Node K. The role of vascular failure in coronary artery spasm. J Cardiol 2011, 57:2-7.
2. Lanza G.A., Careri G., Crea F. Mechanisms of coronary artery spasm. Circulation 2011, 124:1774-1782.
3. Karmazyn M., Beamish R.E., Dhalla N.S. Involvement of calcium in coronary vasoconstriction due to prolonged hypoxia. Am Heart J 1984, 107:293-297.
4. Van Neuten J.M., Van Beek J., Vanhoutte P.M. Inhibitory effect of lidoflazine on contractions of isolated canine coronary arteries caused by norepinephrine, 5-hydroxytryptamine, high potassium, anoxia and ergonovine maleate. J Pharmacol Exp Ther 1980, 213:179-187.
5. Weir E.K., Archer S.L. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J 1995, 9:183-189.
6. Vanhoutte P.M. Effects of anoxia and glucose depletion on isolated veins of the dog. Am J Physiol 1976, 230:1261-1268.
7. Chan C.K., Mak J., Gao Y., Man R.Y., Vanhoutte P.M. Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries. Am J Physiol Heart Circ Physiol 2011, 301:H2313-H2321.
8. De Mey J.G., Vanhoutte P.M. Contribution of the endothelium to the response to anoxia in the canine femoral artery. Arch Int Pharmacodyn Ther 1981, 253:325-326.
9. Dhein S., Salameh A., Klaus W. A new endothelium-dependent vasoconstricting factor (EDCF) in pig coronary artery. Eur Heart J 1989, 10(Suppl. F):82-85.
10. Graeser T., Vanhoutte P.M. Hypoxic contraction of canine coronary arteries: role of endothelium and cGMP. Am J Physiol 1991, 261:H1769-H1777.
11. Pearson P.J., Lin P.J., Schaff H.V., Vanhoutte P.M. Augmented endothelium-dependent constriction to hypoxia early and late following reperfusion of the canine coronary artery. Clin Exp Pharmacol Physiol 1996, 23:634-641.
12. Tang E.H., Ku D.D., Tipoe G.L., Feletou M., Man R.Y., Vanhoutte P.M. Endothelium-dependent contractions occur in the aorta of wild-type and COX2-/- knockout but not COX1-/- knockout mice. J Cardiovasc Pharmacol 2005, 46:761-765.
13. Kok K., Geering B., Vanhaesebroeck B. Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem Sci 2009, 34:115-127.
14. Morello F., Perino A., Hirsch E. Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc Res 2009, 82:261-271.
15. Oudit G.Y., Sun H., Kerfant B.G., Crackower M.A., Penninger J.M., Backx P.H. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 2004, 37:449-471.
16. Sata M., Nagai R. Phosphatidylinositol 3-kinase: a key regulator of vascular tone?. Circ Res 2002, 91:273-275.
17. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., Zeiher A.M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999, 399:601-605.
18. 2+ channels by phosphatidylinositol 3,4,5-trisphosphate. Circ Res 2004, 95:300-307.
19. 2+ channels. Circ Res 2001, 89:692-699.
20. Quignard J.F., Mironneau J., Carricaburu V., Fournier B., Babich A., Nurnberg B., et al. Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes. J Biol Chem 2001, 276:32545-32551.
21. 2+ channels. Br J Pharmacol 2011, 132:669-676.
22. Miao L., Dai Y., Zhang J. Mechanism of RhoA/Rho kinase activation in endothelin-1- induced contraction in rabbit basilar artery. Am J Physiol Heart Circ Physiol 2002, 283:H983-H989.
23. 2+-dependent activation of phosphoinositide 3-kinase class IIα isoform-Rho axis in blood vessels of spontaneously hypertensive rats. Hypertension 2010, 56:934-941.
24. Wehrwein E.A., Northcott C.A., Loberg R.D., Watts S.W. Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther 2004, 309:1011-1019.
25. Dou D., Guo Y., Ying L., Liu J., Xu X., Yu X., et al. Inhibition of PI3K potentiates relaxation of porcine coronary arteries induced by nitroglycerin via decreasing PDE5 activity. Circ J 2012, 76:230-237.
26. Belaiba R.S., Bonello S., Zähringer C., Schmidt S., Hess J., Kietzmann T., et al. Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells. Mol Biol Cell 2007, 18:4691-4697.
27. Dou D., Ma H., Zheng X., Ying L., Guo Y., Yu X., et al. Degradation of leucine zipper-positive isoform of MYPT1 may contribute to development of nitrate tolerance. Cardiovasc Res 2010, 86:151-159.
28. Dou D., Zheng X., Qin X., Qi H., Liu L., Raj J.U., et al. Role of cGMP-dependent protein kinase in development of tolerance to nitroglycerine in porcine coronary arteries. Br J Pharmacol 2008, 153:497-507.
29. Sylvester J.T., Shimoda L.A., Aaronson P.I., Ward J.P. Hypoxic pulmonary vasoconstriction. Physiol Rev 2012, 92:367-520.
30. Alessi D.R., Andjelkovic M., Caudwell B., Cron P., Morrice N., Cohen P., et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996, 15:6541-6551.
31. Chan T.O., Rittenhouse S.E., Tsichlis P.N. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 1999, 68:965-1014.
32. Viard P., Exner T., Maier U., Mironneau J., Nürnberg B., Macrez N. Gbetagamma dimers stimulate vascular L-type Ca2+ channels via phosphoinositide 3-kinase. FASEB J 1999, 13:685-694.
33. Rubanyi G.M., Vanhoutte P.M. Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J Physiol 1985, 364:45-56.
34. Walsh M.P. Vascular smooth muscle myosin light chain diphosphorylation: mechanism, function, and pathological implications. IUBMB Life 2011, 63:987-1000.
35. Kimura K., Ito M., Amano M., Chihara K., Fukata Y., Nakafuku M., et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996, 273:245-248.
36. Gao Y., Portugal A.D., Negash S., Zhou W., Longo L.D., Raj J.U. Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia. Am J Physiol Lung Cell Mol Physiol 2007, 292:L678-L684.
37. Hofmann F., Bernhard D., Lukowski R., Weinmeister P. cGMP regulated protein kinases (cGK). Handb Exp Pharmacol 2009, 191:137-162.
38. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003, 83:1325-1358.
39. Ye L., Liu J., Liu H., Ying L., Dou D., Chen Z., et al. Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates the relaxation of porcine pulmonary arteries to nitric oxide. Pflugers Arch 2013, 465:333-341.
40. Ishizaki T., Uehata M., Tamechika I., Keel J., Nonomura K., Maekawa M., et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 2000, 57:976-983.
41. Do e Z., Fukumoto Y., Sugimura K., Miura Y., Tatebe S., Yamamoto S., et al. Rho-kinase activation in patients with heart failure. Circ J 2013, 77(10):2542-2550.
42. Nihei T., Takahashi J., Kikuchi Y., Takagi Y., Hao K., Tsuburaya R., et al. Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake. Circ J 2012, 76(12):2892-2894.
43. Komiyama K., Tejima T., Tanabe Y., Nishimura T., Kitamura K., Watanabe T., et al. The impact of Rho-kinase inhibitor, "Fasudil", intracoronary bolus administration to improve refractory coronary vasospasm. Cardiovasc Intervent Ther 2011, 26:281-285.
44. Takeda M., Shiba N., Takahashi J., Shimokawa H. A case report of very late stent thrombosis with peri-stent coronary artery aneurysm and stent-related coronary vasospasm. Cardiovasc Intervent Ther 2013, 28(3):272-278.